ABSTRACT
Amphotericin B incorporating 2,2'-bipyridine (bpy-AmB) forms a membrane channel exhibiting pH-dependent Ca2+ ion permeability with a selective response to Cu2+ ions. The coordination structure at bpy sites depends on the pH and metal ions can control the association state of bpy-AmB in the membrane.
Subject(s)
Amphotericin B/metabolism , Coordination Complexes/chemistry , Coordination Complexes/metabolism , Ion Channels/metabolism , Lipid Bilayers/metabolism , 2,2'-Dipyridyl/chemistry , Calcium/chemistry , Calcium/metabolism , Copper/chemistry , Copper/metabolism , Hydrogen-Ion Concentration , Permeability , Structure-Activity RelationshipABSTRACT
A composite containing a liposome and a lipophilic ruthenium complex was synthesized to regulate an O2 evolution reaction using cerium(IV) ammonium nitrate as an oxidizing reagent. We found that the surrounding environment of the reaction centre is an important factor for controlling the O2 evolution catalytic reaction. We successfully regulated the reaction activity using the linker length of the lipophilic ligand and using the head groups of the phospholipid component.