PHYSICAL AND FUNCTIONAL CHANGES IN MIDDLE AND LONG DISTANCE RUNNERS UNDER VARIOUS CONDITIONS.

The changes in the physical properties and functional shifts of middle and long distance runners in Tbilisi and Bakuriani conditions during the identical physical exercises are given in this paper. For comparison the analogous data of judokas are presented. The difference between the background indices (Tbilisi) and in the conditions of Bakuriani has been established during training and the state of rest. Based on the relief peculiarities of Georgia, the action of trainings conducted at different heights (Tbilisi - 550 m and Bakuriani - 1750 m from sea level) on heart rate and respiratory rate, lung vital capacity at the state of rest, the hand and lumbar muscles strength, general and special endurance of the high qualification sportsmen (among them 32 athletes and 40 judokas) have been studied. The above-said data were recorded in accordance with the training processes (preparatory, basic and transition) at the state of rest and in the intervals between physical exercises (warming up, control and official competitions) and in the first minutes of recovery period after completing the exercises. Also, the duration of adaptation period was established at the state of rest and physical training of sportsmen, and there were almost no data in the literature about this till conducting Olympic Games in Mexico City (1968). The observations were conducted on athletes and judokas in Tbilisi (550 m from sea level) and Bakuriani (1750 m). The training sessions lasted 20-22 days. Thus, the features of physical and functional shifts in athletes are revealed, depending on various types of sports employment, training periods, rest and climatic conditions that must be taken into account when conducting sports training.

A COMPUTER MODELING STUDY OF BINDING PROPERTIES OF CHIRAL NUCLEOPEPTIDE FOR BIOMEDICAL APPLICATIONS.

Nucleopeptides often show interesting properties of molecular binding that render them good candidates for development of innovative drugs for anticancer and antiviral therapies. In this work we present results of computer modeling of interactions between the molecules of hexathymine nucleopeptide (T6) and poly rA RNA (A18). The results of geometry optimization calculated using Hyperchem software and our own computer program for molecular docking show that molecules establish stable complexes due to the complementary-nucleobase interaction and the electrostatic interaction between the negative phosphate group of poly rA and the positively-charged residues present in the cationic nucleopeptide structure. Computer modeling makes it possible to find the optimal binding configuration of the molecules of a nucleopeptide and poly rA RNA and to estimate the binding energy between the molecules.