[The use of oscillatory respiratory therapy with positive expiratory pressure (PEP-therapy) to restore the functional state of the lungs in patients after cardiac surgery]. / Primenenie ostsillyatornoi respiratornoi terapii s polozhitel'nym davleniem na vydokhe (PEP-terapii) dlya vosstanovleniya funktsional'nogo sostoyaniya legkikh u bol'nykh posle kardiokhirurgicheskikh operatsii.

Postoperative pulmonary complications in cardiac surgery patients occur in 10-35% of cases, depending on differences in their definition, patient characteristics and type of surgical intervention, most of them are associated with ineffective coughing and evacuation of bronchial secretions. OBJECTIVE: To determine the effectiveness of stimulating the evacuation of bronchial secretions with the help of oscillating PEP therapy carried out during the first three days. MATERIAL AND METHODS: A randomized prospective study of 60 adult patients after elective cardiac surgery was performed (Clinical Trials.gov. protocol number NCT05159401). Oscillatory PEP-therapy was performed in 30 patients using Acapella DHGreen device (SmithMedicalASD, USA) 10-12 hours after tracheal extubation 3 times a day for 3 days after surgery. The control group (30 patients). The inclusion criteria: age over 18 years, spontaneous breathing after tracheal extubation, clear consciousness and productive contact with the patient, the ability to maintain adequate gas exchange on the low-flow oxygen inhalation, adequate analgesia (<2 points of VAS). Exclusion criteria: the need for re-intubation and mechanical ventilation, non-invasive mask ventilation, high-flow oxygen therapy, acute cerebrovascular accident, ongoing bleeding, cardiac insufficiency (inotropic index >10), shocks syndrome of various etiologies, the use of any extracorporeal support, any neuromuscular disorders, pneumothorax, hydro-or hemothorax. Before each session and 20 minutes after its end, when breathing air, blood oxygen saturation was recorded using a pulse oximeter (SpO2), the maximum inspiratory capacity (MIC) was measured using a Coach-2 incentive spirometer from SmithsMedical and spirometry with a portable ultrasonic spirometer Spiro Scout (Schiller, Switzerland). For the purposes of this work, the total index of the spirometry maximum inspiratory capacity (SMIC) was used - the sum of the respiratory volume and the reserve volume of inspiration in ml. RESULTS: Difficulties in evacuation of sputum were noted in 90% of patients. Three-day sessions of oscillating PEP- therapy are accompanied by a significant improvement in the passage of sputum, as evidenced by a 3-fold increase in the number of patients with productive cough. The increase in MIC in the main group was 46.9% and 21.3%, respectively (p=0.042), and the number of patients with values greater than MICo. 1500 ml increased from 23.3% to 7.6% (p<0.001). The effectiveness of oscillatory PEP-therapy is confirmed by a 7-fold decrease in the frequency of radiological changes in the lungs at the end of sessions (p<0.001), while in the control group the frequency of their occurrence practically did not change and remained at a high level. The total number of patients with respiratory insufficiency (SpO2≤92%) decreased by 8.6 times after completion of all PEP- therapy sessions (p=0.001), however, without statistically significant difference with the control group. CONCLUSIONS: Oscillatory PEP- therapy in cardiac surgery patients has a positive effect on sputum passage, ventilation parameters and oxygenating lung function. The procedure was well tolerated and there were no complications associated with it.

[Aortic arch debranching in hybrid thoracic aortic replacement]. / Pereklyucheniya vetvei dugi pri gibridnykh vmeshatel'stvakh na grudnoi aorte.

OBJECTIVE: To analyze the outcomes of aortic arch debranching in hybrid thoracic aortic replacement. MATERIAL AND METHODS: There were 107 patients who underwent hybrid thoracic aortic repair with debranching of supra-aortic vessels between 2015 and 2021. Patients underwent total and partial debranching (subtotal debranching and subclavian-carotid anastomosis/bypass). Debranching was performed in patients with type 3 dissection, type B aneurysms, post-traumatic aortic isthmus and arch aneurysms, thoracoabdominal aneurysms type A and DeBakey type 1 dissections. RESULTS: One patient (0.9%) died from thoracic aorta rupture after retrograde dissection. There was a moderate decrease of blood flow velocity through the left vertebral artery after subtotal debranching without severe hemodynamic disorders. Despite mild surgical trauma, subtotal and especially total debranching are characterized by higher risk of thrombosis of branches with potential fatal outcomes. In young patients requiring subtotal aortic arch debranching, open reconstruction or repair with fenestrated stents is preferred. We recommend a Bavaria type II hybrid procedure for patients with high surgical risk. In our opinion, more physiological hybrid interventions with anatomical arrangement of supra-aortic vessels such as Elephant Trunk and Frozen Elephant Trunk procedures are preferred.

[Surgical treatment of DeBakey type 1 aortic dissection]. / Opyt khirurgicheskogo lecheniia bol'nykh s rassloeniem aorty 1-go tipa po DeBakey.

The article is devoted to the founder of Russian Research Center for Surgery, academician B.V. Petrovsky, who created a multi-field surgical institution of the highest world standards. Treatment of thoracoabdominal aortic aneurysms and dissections being the most difficult and laborious has been solved at the Russian Research Center for Surgery from initial procedures to the most difficult hybrid interventions and total aortic repair.

[Subclavian-carotid replacement in chronic cerebrovascular insufficiency management]. / Podkliuchichno-vnutrennesonnoe protezirovanie v lechenii khronicheskoi ishemii golovnogo mozga.

AIM: To present own experience of subclavian-carotid replacement for chronic cerebrovascular insufficiency management. MATERIAL AND METHODS: For 12 years 7 subclavian-carotid reconstructions were performed that was 1.2% of all carotid repairs during this period. Great saphenous vein was always used as a graft. Carotid endarterectomy from proximal internal carotid artery was additionally performed if it was necessary. Patients had severe advanced lesion of supra-aortic vessels including bilateral carotid lesion and significant stenosis of ipsilateral proximal common carotid artery. The vast majority of them had cerebrovascular insufficiency grade 3-4. RESULTS: All patients underwent surgery without significant complications despite initially severe state due to advanced lesion of brachiocephalic arteries. Long-term postoperative patency of the grafts was satisfactory within the period from 12 years to 1.5 months. There were no neurological impairment and stroke. CONCLUSION: Subclavian-carotid grafting is an effective alternative for carotid endarterectomy in patients with advanced atherosclerotic lesion of common and internal carotid arteries.

[Angina Recurrence After Coronary Artery Bypass Grafting Caused by the Coronary-Subclavian Steal Syndrome].

We present two cases of surgical treatment of patients with coronary artery steal syndrom and multifocal atherosclerosis, who previously underwent coronary artery bypass grafting using left internal mammary artery. In both cases carotid-subclavian bypass was performed through supraclavicular access using synthetic prosthesis. This method allowed to restore blood flow in the left internal mammary artery, eliminate recurrent angina pectoris, and improve patients quality of life. The article also contains descriptions of possible methods of surgical correction of this pathology, their advantages and disadvantages.

[Twenty Years' Experience of the Surgical Treatment of Giant Ascending Aortic Aneurysms].

Giant ascending aortic aneurysm is one of the worst lesions of the cardiovascular system. Timely surgical treatment provides the only chance to prolong the lives of such patients. Life expectancy without surgery in these patients is minimal; they die from a ruptured aneurysm or decompensation of organs and systems. In this paper, based on two decades' experience of treating patients with giant aneurysms of ascending aorta and aortic arch in B.V. Petrovsky National Research Center of Surgery we have assessed evaluated immediate results of surgery and proposed measures for prevention of possible complications. Out of 53 patients with giant. ascending aortic aneurysms spontaneous rupture after sternotomy or opening of the pericardium occurred in 5 cases. Overall hospital mortality was 1.9%. Our results indicate that with the right tactics surgical repair of giant ascending aortic aneurysms can be performed with a low mortality. Preliminary cardiopulmonary bypass with peripheral cannulation and cooling prior to sternotomy for the possibility of circulatory arrest is a prerequisite of the prevention of fatal massive hemorrhage.

[Twenty Years Experience of the Surgical Treatment of Giant Ascending Aortic Aneurysms].

Giant ascending aortic aneurysm is one of the worst lesions of the cardiovascular system. Timely surgical treatment provides the only chance to prolong the lives of such patients. Life expectancy without surgery in these patients is minimal; they die from a ruptured aneurysm.

[Surgical treatment for fibro-muscular dysplasia].

AIM: To present the results of surgical treatment of patients with fibro-muscular dysplasia. MATERIAL AND METHODS: Our experience of treatment of 144 patients with fibro-muscular dysplasia is presented in the article. 118 (82%) patients suffered from stenoses, kinking and aneurysms of internal carotid arteries, 21 (14.5%) patients had lesion of renal arteries, 5 (3.5%) patients--azygous visceral arteries lesion. It was performed 157 reconstructive operations in the Department of cardiac surgery N(o)1 (aortic surgery) of acad. B.V. Petrovskiy Russian Research Center for Surgery for the period from 1993 to 2014. Clinical features of fibro-muscular dysplasia, surgical tactics and technique depending to the localization of lesion are described. RESULTS: Immediate and remote surgical results were studied. There were no any severe intraoperative and immediate postoperative complications. Follow-up after carotid surgery was 104.49±68.68 months (6-247 months). Strokes were not observed. Hemodynamically insignificant re-stenoses were diagnosed in 7 (5.5%) cases. Mean follow-up after renal reconstructions was 139.24±63.96 months (28-239 months). Persistent blood pressure normalization was achieved in 11 (73.3%) cases. Patients with azygous visceral arteries dysplasia have been examined for the period of 103.4±69.6 months (35-205 months). There were no recurrent aneurysms and abdominal ischemia in the remote postoperative period. Hospital and remote mortality was absent. Based on own experience and colleagues' data we consider that surgical treatment of patients with some forms of fibro-muscular dysplasia provides satisfactory results if advisable strategy is selected.

[Valve-sparing technique for type a aortic dissection with insufficiency of aortic valve].

This article describes clinical experience of surgical treatment of aortic insufficiency in type A aortic dissection using valve-sparing technique. Results of treatment are presented.

[Clinical management of patients with abdominal aortic aneurysms combined with coronary artery disease and multifocal atherosclerosis].

We have analyzed clinical management of 137 patients with atherosclerotic aneurysms of the abdominal aorta combined with coronary artery disease treated during last 10 years in the First Cardiac Surgery Department (Surgery of the Aorta and its Branches) of the Petrovsky National Research Center of Surgery. All patients were subjected to surgery involving both vascular regions: in 130 patients (94.9%) the procedures were staged while 7 patients underwent myocardial revascularization simultaneously with the reconstruction of the abdominal aorta from the minimal access. According to our results staged procedures are safer for patients with atherosclerotic aneurysms of the abdominal aorta combined with coronary artery disease given the organism's limited capacity due to age and comorbidities. Endovascular repair techniques applied both to the coronary arteries and to the abdominal aorta should be always regarded primarily as a gentle form of intervention. In cases where open surgery is required one should try to avoid blood loss, reduce the duration of the procedure and use minimal access surgery when applicable. The overall mortality rate in patients treated for this disorder over the last 10 years was 2.1%.

[One-stage carotid and coronary artery surgeries in the treatment of multifocal atherosclerosis].

One of the most severe forms of multifocal atherosclerosis often accompanied by heart attacks and strokes is concomitant coronary and carotid artery disease. Unfortunately to date there have been no qualitative randomized trials allowing us to develop a unified optimal approach to the treatment of this pathology. We have analyzed the treatment of 128 patients with coronary artery disease and atherosclerotic carotid stenosis operated on the two vascular territories over the past 10 years in the Department of Surgery of the Aorta and its Branches of the Petrovsky National Research Center of Surgery. One-stage reconstruction in two arterial basins was performed on the majority (75%) of patients. Other patients underwent multistage procedures including the use of endovascular techniques. The absence of any significant differences in mortality and postoperative complications between groups subjected to single- and multi-stage treatment, doubtless reduction of risk of vascular complications in uncorrected arterial bed by one-stage reconstruction allows us to consider this treatment strategy the method of choice in the management of this pathology. Overall surgical mortality of patients with combined coronary and carotid artery involvement subjected to our strategy was 0.8%.

[Surgical treatment of the aortic dissection type B: analysis of 15 years' experience].

65 patients with the aortic dissection type B were operated on in the period 1995-2010. The proximal local aortic prosthetics proved to be the method of choice in treatment of such patients. The method allowed the reduction of the hospital lethality on 5,7 ± 3,9% and considerably decrease the overall hospital stay.

[Intima-preserving exoprosthetics of ascending aortic aneurism: 15 years of experience].

Short- and long-term follow-up results of intima-preserving exoprosthetics of ascending aortic aneurism in 50 patients were studied. The group of control consisted of 54 patients, whom traditional linear prosthetics of ascending aortic aneurism had been performed. Time of artificial circulation and myocardial ischemia was significantly shorter in first group: 60,3±2,6 min and 21±1,7min, respectively. Patients of both groups showed no significant aortic distension postoperatively (34,5±0,7 - 36,6±0,8 mm). Thus, a dosed resection of the ascending aortic aneurism with intima-preserving exoprosthetics proved to be relatively simple and promising technique.

[Common sense in operative treatment of thoracoabdominal aortic aneurysms].

Treatment approaches of patients with thoracoabdominal aneurysms and aortic dissections type B should be individual. Risk ratio of surgery itself and progression of non-operated disease, such as aneurysm rupture, is the determining factor in defining pro et contra surgical treatment.

[Long-term results of descending and thoracoabdominal aortic aneurisms treatment].

Long-term treatment results of 53 patients operated on thoracoabdominal aortic aneurisms and 7 patients, treated conservatively, were analyzed. Efficacy and choicelessness of operative treatment are demonstrated. 5-year general survival and complication free period for the operated patients were 0.59+/-0.09 and 0,67+/-0,1, correspondingly. 10-year survival and complication free period was 0.51+/-0.1 and 0,34+/-0,14. Unfavourable outcomes are cased by rupture or dissection of non-operated parts of aorta (40%); progressive coronary and carotid arteries occlusion (33,3%); septic complications (13,3%). Possibilities of long-term outcomes improvement after operative treatment of thoracoabdominal aortic aneurisms are proposed.

[Early postoperative complications of surgical treatment of thoracoabdominal aortic aneurisms and dissections].

Early postoperative complications and lethality after 166 operations on the thoracoabdominal aneurisms were analyzed. Overall frequency of the early complications was 31,9+/-3,6%, though some complications could cause the lethality of 88,9+/-10,5%. Thorough evaluation of pre- and intraoperative risk factors and individual patient-defined surgical tactics should lead to the decrease of early complications frequency.

[Staging treatment of aorta aneurysm disease].

Overall 13 patients with aorta aneurysm disease underwent staging operations with 2 weeks - 12 years interval. Surgical treatment of aneurismal lesion of the whole of aorta is very difficult due to severity of the disease and non-typical surgical technique, and characterized by high complications rate and lethality. Individual approach to each patients and staging surgery permitted to achieve the positive results of surgical treatment with 10% lethality.

[Methods to protect the spinal cord and visceral organs in surgery of distal aortic dissections].

The problem of protecting the spinal cord and visceral organs in surgery of distal aortic dissections becomes increasingly important today because of a comparatively high incidence rate of complications. Paraparesis in type 3 dissecting aortic aneurysm (DAA) is noted to occur in ischaemia of the spinal cord lasting more than 56.5+/-12 min and the inclusion into the blood flow of less than two responsible intercostal arteries. Multiple-organ insufficiency in type 3 DAA is observed in ischaemia of the visceral organs lasting more than 36.4+/-6.9 min. While using profound hypothermia and circulatory arrest, fatal haemorrhage appears when the duration of the hypothermic arrest is more than 48+/-13.5 min. The used methods aimed at protecting the spinal cord and visceral organs (perfusion-free technique with cerebrospinal fluid drainage, left artio-femoral bypass, circulation arrest with deep hypothermia), optimization of the scope and technique of the operation, shortened duration of ischaemia, inclusion of the maximum number of the spinal arteries into the blood flow, the use of the system of collection and return of blood make it possible to expect a decreased number of complications.