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pH-Dependent ion permeability control of a modified amphotericin B channel through metal complexation.
Koshiyama, Tomomi; Inoue, Yuki; Asada, Sana; Kawahara, Koki; Ide, Shogo; Yasuhara, Kazuma; Ohba, Masaaki.
Chem Commun (Camb) ; 57(23): 2895-2898, 2021 Mar 18.
Article in English | MEDLINE | ID: mdl-33606865

ABSTRACT

Amphotericin B incorporating 2,2'-bipyridine (bpy-AmB) forms a membrane channel exhibiting pH-dependent Ca2+ ion permeability with a selective response to Cu2+ ions. The coordination structure at bpy sites depends on the pH and metal ions can control the association state of bpy-AmB in the membrane.


Subject(s)
Amphotericin B/metabolism , Coordination Complexes/chemistry , Coordination Complexes/metabolism , Ion Channels/metabolism , Lipid Bilayers/metabolism , 2,2'-Dipyridyl/chemistry , Calcium/chemistry , Calcium/metabolism , Copper/chemistry , Copper/metabolism , Hydrogen-Ion Concentration , Permeability , Structure-Activity Relationship
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