ABSTRACT
While the elucidation of regulatory mechanisms of folded proteins is facilitated due to their amenability to high-resolution structural characterization, investigation of these mechanisms in disordered proteins is more challenging due to their structural heterogeneity, which can be captured by a variety of biophysical approaches. Here, we used the transcriptional master corepressor CtBP, which binds the putative metastasis suppressor RAI2 through repetitive SLiMs, as a model system. Using cryo-electron microscopy embedded in an integrative structural biology approach, we show that RAI2 unexpectedly induces CtBP polymerization through filaments of stacked tetrameric CtBP layers. These filaments lead to RAI2-mediated CtBP nuclear foci and relieve its corepressor function in RAI2-expressing cancer cells. The impact of RAI2-mediated CtBP loss-of-function is illustrated by the analysis of a diverse cohort of prostate cancer patients, which reveals a substantial decrease in RAI2 in advanced treatment-resistant cancer subtypes. As RAI2-like SLiM motifs are found in a wide range of organisms, including pathogenic viruses, our findings serve as a paradigm for diverse functional effects through multivalent interaction-mediated polymerization by disordered proteins in healthy and diseased conditions.
Subject(s)
Alcohol Oxidoreductases , Polymerization , Prostatic Neoplasms , Humans , Male , Prostatic Neoplasms/metabolism , Prostatic Neoplasms/genetics , Prostatic Neoplasms/pathology , Alcohol Oxidoreductases/metabolism , Alcohol Oxidoreductases/genetics , Alcohol Oxidoreductases/chemistry , Cryoelectron Microscopy , Cell Line, Tumor , DNA-Binding Proteins/metabolism , DNA-Binding Proteins/genetics , DNA-Binding Proteins/chemistry , Protein Binding , HEK293 Cells , Adaptor Proteins, Signal Transducing/metabolism , Adaptor Proteins, Signal Transducing/genetics , Adaptor Proteins, Signal Transducing/chemistry , Amino Acid Motifs , Co-Repressor Proteins/metabolism , Co-Repressor Proteins/geneticsABSTRACT
INTRODUCTION: Currently narcissism is considered one of the most widespread phenomenon. As a consequence, its different types (grandiose and vulnerable narcissism) have been investigated from several different perspectives. The present research attempts to explore the differences between the two types of narcissism and their links with different cognitive components that are connected to these personality traits. The primary aim of our study is to investigate the possible connections among maladaptive schemas (entitlement, vulnerability, emotional deprivation) and cognitive evaluation systems (self-esteem, systemizing-empathizing) and narcissism. METHODS: We applied both correlation and path analyses to explore the hypothesized associations. RESULTS: The results show that early maladaptive schemas are strongly associated with narcissism and the empathizing system. The different subtypes of narcissism have different connections with self-esteem. CONCLUSION: Our results show that the two types of narcissism have different manifestations and connections with the early maladaptive schemas, Emphatizing Quotient, and self-esteem. Our empirical results serve as important and empirically supported inputs to counseling and clinical practice.
Subject(s)
Emotional Regulation , Narcissism , Self Concept , Humans , Male , Female , Adult , Emotional Regulation/physiology , Young Adult , Empathy/physiology , Personality Disorders/psychology , Personality Disorders/diagnosis , Adolescent , Cognition/physiologyABSTRACT
The current study investigates attitudes toward one form of sex for resources: the so-called sugar relationships, which often involve exchanges of resources for sex and/or companionship. The present study examined associations among attitudes toward sugar relationships and relevant variables (e.g., sex, sociosexuality, gender inequality, parasitic exposure) in 69,924 participants across 87 countries. Two self-report measures of Acceptance of Sugar Relationships (ASR) developed for younger companion providers (ASR-YWMS) and older resource providers (ASR-OMWS) were translated into 37 languages. We tested cross-sex and cross-linguistic construct equivalence, cross-cultural invariance in sex differences, and the importance of the hypothetical predictors of ASR. Both measures showed adequate psychometric properties in all languages (except the Persian version of ASR-YWMS). Results partially supported our hypotheses and were consistent with previous theoretical considerations and empirical evidence on human mating. For example, at the individual level, sociosexual orientation, traditional gender roles, and pathogen prevalence were significant predictors of both ASR-YWMS and ASR-OMWS. At the country level, gender inequality and parasite stress positively predicted the ASR-YWMS. However, being a woman negatively predicted the ASR-OMWS, but positively predicted the ASR-YWMS. At country-level, ingroup favoritism and parasite stress positively predicted the ASR-OMWS. Furthermore, significant cross-subregional differences were found in the openness to sugar relationships (both ASR-YWMS and ASR-OMWS scores) across subregions. Finally, significant differences were found between ASR-YWMS and ASR-OMWS when compared in each subregion. The ASR-YWMS was significantly higher than the ASR-OMWS in all subregions, except for Northern Africa and Western Asia.
Subject(s)
Sexual Behavior , Sugars , Humans , Male , Female , Interpersonal Relations , Sex Characteristics , AttitudeABSTRACT
The study aimed to reveal physical exercise conditions and catecholamine response-dependent differences while an individual experiences a flow state (FS) following noncompetitive and competitive running drills. Urine laboratory catecholamine levels were measured using a standard clinical method during pre- and post-physical exercises. The noncompetitive task involved intermittent running drills, from an absolute beginning up through exhaustion. Initially, the drill is performed individually then later competing alongside other runners. Twenty-two males (mean age: 40.27; SD: 5.4; min-max: 31-49 years) were selected in accordance to the following criterion: healthy status without using medication, routine forms of training (running, cycling or swimming) ideally performed with regularity, at least three times per week, 45 min per session. During the noncompetitive task, a high FS experience was associated with a low level of catecholamines, (noradrenaline and adrenaline) while in parallel, the high FS was associated with a low concentration of homovallinic acid. During competitive conditions, the FS-related catecholamine level changes have not yet been found. In conclusion, the low concentration of the circulating catecholamines supports the transient hypofrontality hypothesis regarding the FS experiences. Furthermore, synchronized noradrenaline and adrenaline neurosecretion play an essential role in the manifestation and the prolongation of FS in noncompetitive exercise conditions.
Subject(s)
Running , Male , Humans , Adult , Epinephrine , Norepinephrine , Catecholamines , SwimmingABSTRACT
In contrast to the well-studied canonical regulatory mechanisms, the way by which the recently discovered Src N-terminal regulatory element (SNRE) modulates Src activity is not yet well understood. Phosphorylation of serine and threonine residues modulates the charge distribution along the disordered region of the SNRE and may affect a fuzzy complex with the SH3 domain that is believed to act as an information transduction element. The pre-existing positively charged sites can interact with the newly introduced phosphate groups by modulating their acidity, introducing local conformational restrictions, or by coupling various phosphosites into a functional unit. In this paper, we use pH-dependent NMR measurements combined with single point mutations to identify the interactions of basic residues with physiologically important phosphorylated residues and to characterize the effect of these interactions in neighbor residues, thus providing insight into the electrostatic network in the isolated disordered regions and in the entire SNRE. From a methodological point of view, the linear relationships observed between the mutation-induced pKa changes of the phosphate groups of phosphoserine and phosphothreonine and the pH-induced chemical shifts of the NH groups of these residues provide a very convenient alternative to identify interacting phosphate groups without the need to introduce point mutations on specific basic residues.
Subject(s)
Proto-Oncogene Proteins pp60(c-src) , src Homology Domains , Phosphorylation , Phosphoserine , SerineABSTRACT
Touch is the primary way people communicate intimacy in romantic relationships, and affectionate touch behaviors such as stroking, hugging and kissing are universally observed in partnerships all over the world. Here, we explored the association of love and affectionate touch behaviors in romantic partnerships in two studies comprising 7880 participants. In the first study, we used a cross-cultural survey conducted in 37 countries to test whether love was universally associated with affectionate touch behaviors. In the second study, using a more fine-tuned touch behavior scale, we tested whether the frequency of affectionate touch behaviors was related to love in romantic partnerships. As hypothesized, love was significantly and positively associated with affectionate touch behaviors in both studies and this result was replicated regardless of the inclusion of potentially relevant factors as controls. Altogether, our data strongly suggest that affectionate touch is a relatively stable characteristic of human romantic relationships that is robustly and reliably related to the degree of reported love between partners.
Subject(s)
Love , Touch Perception , Humans , Touch , Sexual Behavior , Sexual Partners , Interpersonal RelationsABSTRACT
Although fear plays a vital role in survival, an overly active threat detection system could be maladaptive due to its negative health consequences. Putatively maladaptive emotion regulation (ER) strategies are a core problem in phobias. In contrast, adaptive ER strategies could help downregulate the emotion elicited by a threatening stimulus and decrease anxiety. Yet, the number of studies directly examining the pattern of ER strategies linked to various phobias is still scarce. Thus, this study sought to map the patterns of adaptive and maladaptive ER strategies linked to the three most common phobias (social, animal, and blood-injection-injury [BII]). A total of 856 healthy participants filled out our survey including self-reported measures of social anxiety, snake-, spider-, BII phobia, and cognitive ER strategies. Structural equation modeling was used to test the effects between the variables. The results show that social anxiety and animal phobia were linked to both adaptive and maladaptive ER strategies, while BII was only associated with maladaptive ones. Further analyses showed that the most prominent ER strategies differed by subtype. This is in line with previous neuroimaging studies claiming that the neurocognitive mechanisms underlying phobias are also different. Theoretical as well as practical implications are discussed.
Subject(s)
Emotional Regulation , Phobic Disorders , Animals , Phobic Disorders/psychology , Emotions/physiology , Fear/psychology , CognitionABSTRACT
BACKGROUND: Studies on person perception showed that stereotypes can be activated by presenting either characteristic traits of group members, or labels associated to these groups. However, it is not clear whether these pieces of semantic information activate negative and positive stereotypes directly, or via an indirect cognitive pathway leading through brain regions responsible for affective responses. Our main objective with this study was to disentangle the effects of semantic and affective contents. To this end, we intended to scrutinize whether the representation of occupational labels is independent of the emotions they evoke. METHODS: Participants (N = 73, M = 27.0, SD = 9.1, 31 men 42 women,) were asked to complete two tasks presented online. In the first task they had to arrange 20 occupational labels-randomly chosen from a pool of 60 items-in a two-dimensional space, moving the mouse pointer along two undefined axes. In a second task the axes' names were defined a priori. Subjects were asked to arrange the labels according to valence, the extent to which the word evoked pleasant or unpleasant feelings, and arousal, the extent to which the word evoked excitement or calmness. RESULTS: Based on the final coordinates of the labels, two cluster analyses were carried out separately in the two tasks. The two clusters were compared with Fisher's exact test, which revealed that the cluster structures overlap significantly. CONCLUSIONS: The results suggest that the spontaneous categorization and the semantic representation of occupations rely largely on the affective state they evoke. We propose that affective content might have a primacy over detailed semantic information in many aspects of person perception, including social categorization.
Subject(s)
Emotions , Semantics , Arousal/physiology , Brain , Emotions/physiology , Female , Humans , StereotypingABSTRACT
This study explores the personal predispositions and dependencies while individuals use digital media and communication devices and analyses the statistical features of the Immersive Tendencies Questionnaire (ITQ) that is popular in assessing the personality trait-dependent reaction to mediated environments. The study evaluated 781 healthy graduates and postgraduates, of which 192 were men (average age: 28.6 years) and 589 were women (average age: 28.4 years). We applied several questionnaires to measure immersive tendencies in a mediated environment, adaptive and maladaptive personality predispositions, and problematic Internet use and Facebook addiction scales. We analyze the statistical features of the long and short forms of the Immersive Tendencies Questionnaire. The data obtained support the reliable usage of the short form of the instrument. The factor structure of the questionnaire presents dual facets. First, it indicates an absorptive and immersive tendency in any case of maladaptive tendencies. Second, it reflects an intensive capability to focus on the mediated environment with adequate cognitive control to avoid any contingency of being addicted. The short form of the ITQ is reliable and adequate to assess the relationship between the self-referred and environment-dependent psychological functions.
ABSTRACT
The aim of this study was to reveal whether increased reward dependence (RD) plays a role in the catecholamine neurotransmitter release and testosterone hormone regulation during physical activities among healthy trained participants. Twenty-two male participants (mean age: 40.27 ± 5.4 years) participated in this study. Two conditions were constructed, namely, a noncompetitive and a competitive running task (RT), which were separated by a 2-week interval. Urine and blood samples were collected prior to and following the running tasks. Noradrenaline (NA), adrenaline (A), dopamine (D), and their metabolites, vanillylmandelic acid (VMA) and homovanillic acid (HVA), were measured from urine, while testosterone levels were analyzed from blood samples. RD was assessed using the Cloninger's Personality Inventory (PI). Mental health was evaluated using the WHO Well-Being, Beck Depression, and Perceived Life Stress Questionnaires. According to our findings, levels of NA, A, D, VMA, and testosterone released underwent an increase following physical exertion, independently from the competitive condition of the RT, while HVA levels experienced a decrease. However, we found that testosterone levels showed a significantly lower tendency to elevate in the competitive RT, compared with the noncompetitive condition (p = 0.02). In contrast, HVA values were higher in the competitive compared with the noncompetitive condition (p = 0.031), both before and after the exercise. Considering the factor RD, in noncompetitive RT, its higher values were associated with elevated NA levels (p = 0.007); however, this correlation could not be detected during the competitive condition (p = 0.233). Among male runners, the NA and testosterone levels could be predicted to the degree of RD by analyzing competitive and noncompetitive physical exercises.
ABSTRACT
The aim of the present study was to evaluate the factor structure and validity of the Hungarian versions of the Dimensions for Identity Development Scale (DIDS) and Utrecht-Management of Identity Commitments Scale (U-MICS). Both models assume that the iterative process of exploring and evolving commitments occurs in two distinct cycles. The sample for testing the factor structure of DIDS consisted of 808 adolescents (357 boys and 451 girls) aged between 14 and 21 years (Mage = 16.86; SD = 1.35). The sample for testing the factor structure of U-MICS consisted of 803 adolescents (353 boys and 450 girls) aged between 14 and 21 years (Mage = 16.88; SD = 1.34). Results indicated a five factor model of DIDS in the present sample. All the five dimensions correlated as hypothesized both internally and externally. In line with previous research, six clusters emerged based on the dimensions of DIDS, including ruminative moratorium. Regarding U-MICS, results indicated a three factor model in the present sample. All the three dimensions were internally and externally correlated as hypothesized regarding both ideological and interpersonal identity domains. With regard to the identity status cluster solution, five clusters emerged in both the educational and friendship domains. We found specific variation regarding identity clusters in the two identity domains. Our results support the use of these two measurements in Hungarian context. Further, our results confirm the divergent developmental dynamics of ideological and interpersonal identity domains.
ABSTRACT
BACKGROUND AND AIMS: Separation from parents and finding an identity are among the most important tasks of adolescence. To successfully solve these tasks parental and family support are essential. Parental socialization goals are a set of values that offers adolescents to identify with on the one hand and affects the parent-child relationship on the other hand. Through identification and relational processes, parental socialization goals could be related to adolescents' satisfaction with life. In our study, we investigated the organization of parental socialization goals in parents of adolescents. On the other hand, we wanted to reveal the potential link between parental socialization goals and adolescents' satisfaction with life. METHOD: Ninety-eight families with two biological parents and adolescents (51 boys and 47 girls) participated in our study. Both parents completed a questionnaire on parental socialization goals. We also used a questionnaire to have adolescents report their satisfaction with life. RESULTS: Maternal and paternal socialization goals with regard to interdependence formed two components. The two components were labelled obedience-oriented parenting goals and other-oriented parenting goals. Maternal and paternal socialization goals with regard to independence formed two components based on the person of the parent. We labelled these components maternal identity-oriented parenting goals and paternal identity-oriented parenting goals. Adolescents' satisfaction with life positively correlated with obedience-oriented parenting goals. CONCLUSIONS: Results are discussed with regard to age-relevant characteristics of the relationship between adolescents and their families. The unexpected positive link between obedience-oriented parenting goals and adolescents' satis faction with life can be solved with a focus on concepts relevant to adolescence (identity development), parenting (parenting practices), and family (family relational schemata).
Subject(s)
Personal Satisfaction , Socialization , Adolescent , Female , Goals , Humans , Male , Parenting , ParentsABSTRACT
Using the same methodology as Meston and Buss (2007), three studies were conducted on a Hungarian sample (total N = 4913) which corroborate previous findings on the universal diversity of sexual motivation. Study 1 (N = 2728; 1069 women and 1659 men) identified 197 reasons for having sex based on participants' free responses. In Study 2 (N = 1161; 820 women and 341 men), participants indicated the extent to which each of the 197 reasons had led them to have sexual intercourse. Factor analyses yielded three factors and 24 subfactors. This differed from the original YSEX? four-factor questionnaire. In Study 3 (N = 1024; 578 women and 446 men), a reliable and valid 73-item short form version of the YSEX? questionnaire was developed in a Hungarian sample (YSEX?-HSF). In addition to similarities and differences in the factor structure, we found important links between reasons for having sex and age, gender, personality, and mating strategy. For example, number of reasons for having sex tended be higher in younger compared to older participants. Men exceeded women on having sex for novelty-seeking and infidelity opportunities, whereas women exceeded men on having sex for relationship commitment and mate retention. Extraversion and neuroticism were linked with reasons for having sex, and those who pursued a short-term mating strategy reported having sex for a larger variety of reasons.
Subject(s)
Motivation , Sexual Behavior , Female , Gender Identity , Humans , Hungary , Male , Sex Factors , Sexual PartnersABSTRACT
The aims of the present study were to evaluate the efficacy of a brief intervention, and to determine for whom the treatment works. 73 children between 3 and 8 years of age with significant nighttime fears were enrolled in an intervention group (n = 36) or in a waitlist group (n = 37). The intervention involved a 5-week parent delivered therapy. Assessments took place at baseline, post-treatment, and 20 weeks following baseline. In the intervention group, compared with the waitlist group, nighttime-related fears and phobic symptoms decreased more, whereas adaptive nighttime behavior increased to a greater extent. The more time children spent with exposure and relaxation games during the intervention, the more their separation anxiety and maladaptive nighttime behavior were reduced. Girls' fear of darkness was reduced to a greater extent. The present study provides support for the use of parent-delivered therapy in the treatment of childhood nighttime fears.
Subject(s)
Crisis Intervention , Fear , Child , Child, Preschool , Female , Humans , Hungary , Parents , Phobic DisordersABSTRACT
A sugar relationship is a monetary-based liaison between a wealthier older and an attractive younger person, the latter receiving expensive gifts or financial compensation in exchange for her or his sexual companionship. Attachment, motivation, and self-esteem are all integrative parts of adult romantic and sexual relationships. There is relatively little empirical research on the psychological correlates of accepting attitudes toward sugar relationships. The research aimed to explore the relationship among the acceptance of sugar relationship, attachment (avoidance and anxiety), motivation (extrinsic and intrinsic), and self-esteem. A total of 2,409 Hungarian adults including 1,980 younger participants (1,804 women, 175 men, mean age = 21.17) and 429 older participants (290 men, 138 women, mean age = 48.86) completed an online test battery comprising four self-report measures. In the younger subsample, the only significant association obtained for the acceptance of sugar relationships was its positive correlation with extrinsic motivation. In the older subsample, the acceptance of sugar relationships was positively correlated with all tested variables except self-esteem. Subsequent analysis revealed that attachment avoidance but not anxiety moderated the associations between the variables. Among younger participants, the negative effect of self-esteem and intrinsic motivation on accepting sugar relationships decreased with increasing attachment avoidance. Among older participants, the positive effect of extrinsic motivation on accepting sugar relationships decreased with increasing attachment avoidance. The results are discussed with regard to relational and sexual goals associated with adult attachment orientations.
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Growing evidence shows that diagnosing and treating borderline personality disorder (BPD) is of high relevance for affected youths. Although identity crisis is part of the normative developmental process, identity diffusion is a potential candidate for being an appropriate concept in further developing screening tools and interventions for BPD treatment in adolescence. We hypothesized that severity of borderline traits (as indicated by the strength of their associations with identity diffusion) would be negatively associated with non-clinical adolescents' endorsement of borderline features' presence. We also hypothesized that identity diffusion had a central role in the network of borderline personality traits and could be conceived of as a latent organizing principle of borderline personality disorder. In our study, 169 non-clinical adolescents (81 girls and 88 boys; M age = 15.38; SDage = 1.52) filled out self-report measures of borderline personality features and identity diffusion. According to our results, having strong feelings and interpersonal sensitivity were the two most endorsed borderline personality features. Borderline personality features were positively correlated with identity diffusion. The more severe a borderline personality feature was, the less relevant it was for non-clinical adolescents. According to a network analysis, identity diffusion was the most central and least redundant element of the network of borderline personality traits. Results are discussed from a clinical point of view, further encouraging professionals to use identity diffusion screening tools to detect BPD in adolescence.
ABSTRACT
Sugar relationships can be considered contemporary forms of transactional sex, that is, offering sexual services for material resources or other benefits. Considering the common age differences in these relationships, sugar relationships might be of relevance for older adults as well on the mating market. As a sequel to Birkás et al. (2020), in the present study, an attitude scale was developed to assess older women's and men's acceptance of sugar relationships. We also explored whether the acceptance of sugar relationships was associated with love styles, sociosexual orientation, sexual motivation, and certain socially aversive personality traits. In two online studies with a total number of 836 participants (N = 277 women and 559 men), the results showed that the Acceptance of Sugar Relationships in Older Men and Women Scale (ASR-OMWS) proved to be a reliable and conceptually valid measure of older individuals' attitude toward sugar relationships. A more accepting attitude toward sugar relationships was found to be associated with more unrestricted sociosexuality, preference to engage in playful love relationships and more self-focused sexual motivation (study 1; N = 481, 167 women and 314 men), and with more pronounced Dark Triad and borderline traits (study 2; N = 355, 110 women and 245 men). Our findings are discussed in an evolutionary framework.
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Background: This study aimed to examine magical ideation and absorption traits across non-clinical and clinical groups to determine their potential adaptive and maladaptive functions. Method: We enrolled 760 healthy participants from neighboring communities (female = 53.2%). Moreover, we recruited 318 patients (female = 66.5%), which included 25, 183, and 110 patients with schizophrenia spectrum disorders, anxiety disorders, and mood disorders, respectively. Potentially adaptive and maladaptive sociocognitive functions were measured to determine the role of magical ideation and self-absorption in patients with psychiatric disorders. Results: The degree of magical ideation and absorption gradually increased in the following order: anxiety disorders, mood disorders, and schizophrenia spectrum disorders. Furthermore, enhanced self-absorption-related enhanced consciousness traits were essential indicators of the presence of self-integration weakness in patients with schizophrenia spectrum disorders. Conclusion: Magical ideation and psychological absorption may be considered as mental model construction functions, which result in both gains and handicaps in social adaptation.
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Previous studies have demonstrated that the angle of women's lumbar curvature affects men's attractiveness judgments of them. The theoretically optimal angle of lumbar curvature provides better resistance against both hyperlordosis and hypolordosis as biomechanical costs of a bipedal fetal load that could impair a woman's fertility. Since men find this attribute attractive, women aim to emphasize it by wearing high-heeled shoes. The primary objective of the present study was to test this evolutionary hypothesis using short videos presenting women walking by the camera. In line with previous findings based on static stimuli (photographs), dynamic stimuli (videos) presenting women walking in high-heeled shoes were expected to elicit increased attractiveness ratings as compared to women wearing flat shoes, which would be associated with the angle of lumbar curvature. Videos were taken of 52 female models walking in two conditions (i.e., wearing either high-heeled or flat shoes). A total of 108 participants (61 males, 47 females) rated the walking models' physical attractiveness in an online setting. Each model's lumbar curvature was measured both in high heels and in flat shoes using photographs taken of them prior to each video recording. The results showed that wearing high heels consistently increased the models' attractiveness, regardless of whether or not it decreased their natural difference from the theoretically optimal angle of lumbar curvature. Both male and female observers showed this positive effect. Furthermore, a negative correlation was found between the models' body mass index (BMI) and their perceived attractiveness scores in both conditions.