ABSTRACT
OBJECTIVE: As in Brazil cancer registries are mostly based on large cities, there are no estimates per state or per region and information on the disease incidence in the vast in-land areas is very scarce. An incidence survey was conducted in 18 major cities of the state of São Paulo, excluding the capital, aiming to collect information about cancer incidence in the state of São Paulo. METHODS: Of the 18 cities in state of São Paulo included in the survey, all had available resources for cancer management. Data from the year of 1991 were collected by the personnel of the Instituto Brasileiro de Geografia e Estatística (Brazilian Institute of Statistics), who were especially trained by the study coordinators at the Fundação Oncocentro de São Paulo (Cancer Center of São Paulo). The collected data were processed and analyzed at the Oncocentro. Data collection, processing, and analyses were performed according to the recommendations of the International Agency for Research on Cancer. RESULTS: Although some discrepancies were observed in cancer incidence rates between the cities, results obtained for all 18 cities combined were remarkably close to those recently found for the city of São Paulo in the year 1993. One remarkable finding was the relatively high cancer incidence rates in both sexes in the city of Santos. CONCLUSIONS: The very similar all-sites cancer incidence rates found in the year 1991, when compared to those for the city of São Paulo in the year 1993, are suggestive that all regions have common cancer-related factors. Nevertheless, other explanations, such as the inclusion in the study of prevalent cases, as well as of non-residents, may have occurred in both studies, biasing the results. There is a need of further studies to confirm the high cancer incidence in Santos.
Subject(s)
Neoplasms/epidemiology , Urban Health/statistics & numerical data , Brazil/epidemiology , Confidence Intervals , Female , Humans , Incidence , Male , RegistriesABSTRACT
OBJETIVOS. Apresentar os resultados do inquérito sobre a prevalência atual de fumantes entre os médicos do Brasil, segundo suas especialidades, realizado no período de maio a outubro de 1996. MÉTODO. A amostra utilizada foi de respostas espontâneas, constituída por 11.909 médicos associados pagantes da Associaçäo Médica Brasileira, das várias Unidades da Federaçäo e especialidades médicas. RESULTADOS. Constatou-se que 759 (6,4 por cento) säo fumantes regulares e 11.150 (93,6 por cento) säo näo-fumantes; 4.085 médicos (34,3 por cento) säo ex-fumantes. Os maiores índices de näo-fumantes estäo entre os associados de sociedades de especialidades que possuem programas efetivos de controle do tabagismo (pneumologia, cancerologia, cardiologia e otorrinolaringologia). As regiöes geográficas do Norte, Nordeste e Centro-Oeste apresentaram as maiores prevalências de fumantes. O início do fumar está mais presente no grupo de 10-19 anos (72,6 por cento), com distribuiçäo semelhante entre os sexos. Nenhum médico do sexo feminino iniciou o seu vício de fumar antes dos 10 anos de idade. CONCLUSÃO. É de grande importância os médicos receberem informaçöes sobre tabagismo, bem como a realizaçäo de programas de seu controle na sociedades de especialidades e nas federadas da Associçäo Médica Brasileira.
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Physicians , Smoking , Health Surveys , Brazil , Prevalence , MedicineABSTRACT
OBJECTIVES: To present the results of the study of the current prevalence of smoking among Brazilian physicians, according to field of specialization. The study was performed in the period from May to October 1996. METHOD: Data were collected by spontaneous reply from 11,909 physicians registered in Brazilian Medical Association, in the various States of Brazil and medical specializations. RESULTS: The results indicated that 759 (6.4%) are regular smokers, 11,150 (93.6%) are non-smokers and that 4,085 (34.3%) are former smokers. The highest rates of non smoking were found among the societies of specialties that have effective smoking control programs (pneumology, oncology, cardiology and otorhinolaryngology). The northern, northeastern and mid-western regions of the country presented the highest prevalences of smoking. The onset of smoking occurs more frequently in the 10-19 years age group (72.6%), with similar distribution in both sexes. There were no female physicians who began smoking before 10 years of age. CONCLUSION: It is very important that physicians receive information regarding smoking as well as to have the development of smoking control programs in the specialty societies and in the regional associations federated to the Brazilian Medical Association.
Subject(s)
Health Surveys , Physicians , Smoking/epidemiology , Adult , Aged , Brazil , Female , Humans , Male , Middle Aged , PrevalenceABSTRACT
OBJETIVOS. De uma casuística de 1.900 pacientes portadores de câncer de esôfago, matriculados no Hospital A.C. Camargo, Sao Paulo, SP, no período de 1947 a 1986, foram estudados 234 casos submetidos a ressecçao cirúrgica. Durante estas quatro décadas aconteceram modificaçoes marcantes na filosofia da terapêutica destas neoplasias. MÉTODO. Foram identificadas cinco diferentes séries históricas e scus resultados apresentados. RESULTADOS. O primeiro grupo (1947-60) consistiu de 47 casos, que somente foram submetidos a cirurgia. 0 segundo grupo (1961-70), com 56 casos, teve radioterapia pré e pós-operatória em baixas doses. A reconstruçao do trânsito foi realizada com cólon subcutâneo. De 1971-75, o mesmo esquema terapêutico foi usado, exceto para a radioterapia pré-operatória, que foi administrada em altas doses (31 casos). No quarto grupo (1976-82), com 68 casos, houve associaçao da quimioterapia à radioterapia. No último grupo (1983-86), com 32 casos, o esquema foi: quimioterapia pré-operatória, ressecçao cirúrgica com reconstruçao pelo estômago, seguida de radioterapia em altas doses no leito cirúrgico e quimioterapia. Os fatores prognósticos estudados que demonstraram significância estatística foram o diâmetro do tumor e o comprometimento linfonodal periesofágico. CONCLUSAO. A sobrevida de cinco anos dos pacientes com este último planejamento terapêutico permitiu uma evoluçao de 3,7 por cento para 9,0 por cento, conseguindo-se, igualmente, sobrevivência de dez anos.
Subject(s)
Humans , Adult , Middle Aged , Carcinoma, Squamous Cell/therapy , Esophageal Neoplasms/therapy , Brazil , Treatment Outcome , Combined Modality Therapy , Carcinoma, Squamous Cell/complications , Carcinoma, Squamous Cell/mortality , Postoperative Complications , Esophageal Neoplasms/complications , Esophageal Neoplasms/mortality , Esophageal Neoplasms/pathologyABSTRACT
OBJECTIVES: From 1947-1986 we reviewed a historical series of 1,900 cases of esophageal cancers registered at the A.C. Camargo Hospital, São Paulo, Brazil. Two hundred and thirty four cases were submitted to surgical resection. During these 4 decades the treatment philosophy of these tumors has changed. METHOD: Five different historical groups were identified and the results are presented. RESULTS: The first group (1947-60) consisted of 47 cases only submitted to surgical resection. The second group (1961-70) of 56 cases had pre and pos surgery radiotherapy in low doses and the reconstruction was made using subcutaneous colon. From 1971-75 the same approach was used except with high dose preoperative radiotherapy (31 cases). In the 4th group (1976-82) of 68 cases preoperative radiotherapy (high dose) and chemotherapy were used. In the last group (1983-86) composed of 32 cases the treatment was preoperative chemotherapy, surgical resection with gastric reconstruction followed with high doses radiotherapy in the surgical bed and chemotherapy. The only significant prognostic factors in the statistical analysis were tumor size and involvement peri-esophageal lymph nodes. CONCLUSION: A five year survival from 3.7% to 9.0% was obtained through the use of the fifth group treatment planning.
Subject(s)
Carcinoma, Squamous Cell/therapy , Esophageal Neoplasms/therapy , Adult , Aged , Brazil , Carcinoma, Squamous Cell/complications , Carcinoma, Squamous Cell/mortality , Combined Modality Therapy , Esophageal Neoplasms/complications , Esophageal Neoplasms/mortality , Female , Humans , Male , Middle Aged , Postoperative Complications , Retrospective Studies , Treatment OutcomeABSTRACT
The association between esophageal cancer and smoking and drinking habits, instruction and nutritional factors was examined by means of the utilization of data of a case-control study which was undertaken in the city of S. Paulo (Brazil). Eighty five cases were compared with two hundred and ninety two hospital controls, with different diseases, including other kinds of cancer. The crude estimations of the odds ratios were calculated for all the variables. Logistic regression was used in the next steps of the analysis. The drinking habit [odds ratio = 3.68, 95% confidence interval (1.74 - 7.78)], the smoking habit [odds ratio 4.86; 95% confidence interval (1.95 - 12.13)] and the frequent eating of hot pepper [odds ratio = 2.48; 95% confidence interval (1.46 - 4.23)] are important risk factors for the disease. The estimate of odds ratio for smoking ordinary cigarette was 3.43 (1.31-8.97) and for smoking of corn straw hand-rolled cigarrette was of 4.18 (1.38-12.66).
Subject(s)
Esophageal Neoplasms/epidemiology , Adult , Aged , Aged, 80 and over , Alcohol Drinking/adverse effects , Brazil/epidemiology , Case-Control Studies , Esophageal Neoplasms/etiology , Feeding Behavior , Female , Humans , Logistic Models , Male , Middle Aged , Multivariate Analysis , Odds Ratio , Risk Factors , Sex Factors , Smoking/adverse effects , Urban HealthABSTRACT
This study investigated social class differentials in cancer mortality in São Paulo county, Brazil, for the period 1978 to 1982. A measure of socioeconomic status based on education was used, and cancer risk by level of education was estimated by a case-control approach in which other cancers were considered as controls. For most cancers, the socioeconomic differences in risk were similar to those found in western Europe and North America. For lung cancer, however, the highest risk was observed in men and women with the most education. Other cancers related to tobacco--cancer of the larynx, pharynx, and esophagus--showed a negative association with education. The differences between social classes in consumption habits of alcohol and maté and the use of black tobacco are probably responsible for these contrasting patterns. For breast and cervix uteri cancer the social class patterns were similar to those found in developed countries--a positive relationship for breast and a negative one for cervix uteri cancer. The magnitude of the differences observed between social classes for these cancers was frequently greater in South America than in the United States or western Europe.
Subject(s)
Educational Status , Neoplasms/mortality , Adult , Brazil/epidemiology , Case-Control Studies , Europe/epidemiology , Female , Humans , Male , Middle Aged , Risk Factors , Social Class , United States/epidemiologySubject(s)
Emigration and Immigration , Neoplasms/epidemiology , Adolescent , Adult , Aged , Brazil/epidemiology , Female , Humans , Incidence , Italy/epidemiology , Italy/ethnology , Logistic Models , Male , Middle Aged , Neoplasms/ethnology , Neoplasms/mortality , Regression Analysis , Risk Factors , Sex FactorsABSTRACT
Using both mortality and incidence data, cancer risk in Italian, Spanish and Portuguese migrants to São Paulo were compared with those in the Brazil-born population, and with those in their countries of origin. Italian and Spanish migrants show changes in cancer risks which are rather similar to those observed in migrants of the same origin in other parts of South America: they increase their rates of oropharyngeal, oesophageal, cervical and breast cancers and they decrease their rates of lung cancers. However, for cancer of the oesophagus, the changes are greater in São Paulo, where migrants acquire rates similar to those of the natives. For colon cancer, rates in Italian migrants decrease in the low risk area of São Paulo and increase in the high risk area of Argentina. Changes in Portuguese migrants are less evident: their rates of colorectal cancer remain high, and, as found for Japanese migrants in São Paulo, they also retain their higher risks of stomach cancer.
Subject(s)
Neoplasms/mortality , Adult , Aged , Brazil/epidemiology , Female , Humans , Incidence , Italy/ethnology , Male , Middle Aged , Neoplasms/epidemiology , Portugal/ethnology , Risk Factors , Spain/ethnologyABSTRACT
Data from the São Paulo Cancer Registry (Brazil) for the period 1969-1974 are used to investigate ethnic differentials in cancer risk. Risks for specific cancers were estimated for mulattos and blacks relative to whites, using a case-control approach with other cancers as controls. For both sexes, blacks and mulattos are at higher risk than whites for cancer of the esophagus, stomach, and liver and for myeloma; for prostate cancer in males; and for gall bladder, pancreas, and cervix uteri cancers in females. Blacks and mulattos are at lower risk than whites for cancer of the colon, lung, larynx (males only), bladder, bone, testis, breast, and corpus uteri and for melanoma and leukemia. Except for lung and colon cancers, for which life-style habits are the main risk factors, these ethnic differences are similar to those observed in the United States.
Subject(s)
Black or African American/statistics & numerical data , Neoplasms/ethnology , White People/statistics & numerical data , Adult , Black People , Brazil/epidemiology , Case-Control Studies , Female , Humans , Incidence , Life Style/ethnology , Male , Middle Aged , Neoplasms/epidemiology , Odds Ratio , Registries , Risk Factors , Socioeconomic FactorsABSTRACT
The percentual distributions of selected sites of cancer cases according to origin, sex and age are compared. Data were obtained from the Registry of Cancer of S. Paulo (School of Public Health of the University of S. Paulo, Brazil). The reference period for inhabitants of Japanese descent was 1969/78 and for those of Brazilian descent, the period was 1969/75. Standardized Proportionate Incidence Ratios (SPIR) with approximate 95% Confidence Intervals (CI) were evaluated using age specific Incidence Ratios of S. Paulo, 1973, as standards. The results agree with findings of previous works on mortality, but show different patterns according to origin. The well known fact that some sub-groups of a population may be different from the overall group is once again brought to the fore. Attention should be drawn to the differences detected for stomach, skin and prostate, in males, and for stomach, skin, cervix and uterus in females.
Subject(s)
Neoplasms/ethnology , Age Factors , Brazil/epidemiology , Cohort Studies , Female , Humans , Japan/ethnology , Male , Portugal/ethnology , Registries , Sex FactorsABSTRACT
Cancer incidence rates among first-generation Japanese immigrants in the city of São Paulo, Brazil, were estimated from the data of the São Paulo Cancer Registry during the years 1969 to 1978. From all registered cases, 2,179 cancer cases of Japan-born residents (1,288 males, 891 females) were selected and age-specific and summary age-adjusted incidence rates (AAIR) were calculated for the selected sites of cancer. The AAIR for all sites except non-melanoma skin cancer was 195.2 per 100,000 population (95 percent confidence interval: 176.4-214.1) in males and 147.3 (134.6-160.0) in females. Stomach cancer had the highest incidence rate of all cancers in both sexes (males, 69.3; females, 32.0). This was followed by cancer of the lung (22.5), esophagus (10.2), colon (8.3), and prostate (7.1) in males; and by breast (24.0), cervix (18.0), colon (8.4), and lung (7.2) in females. When these rates were compared with those among Japanese in Japan, cancer of the stomach and rectum revealed significantly lower rates, while non-melanoma skin cancer, and prostate and breast cancer showed higher rates. No significant increase of colorectal cancer was recognized among Japanese immigrants in São Paulo, contrary to the remarkably high rates of colorectal cancer being observed among Japanese immigrants in the US.
Subject(s)
Neoplasms/ethnology , Adolescent , Adult , Aged , Brazil/epidemiology , Breast Neoplasms/ethnology , Child , Female , Gastrointestinal Neoplasms/ethnology , Humans , Incidence , Japan/ethnology , Lung Neoplasms/ethnology , Male , Middle Aged , Prostatic Neoplasms/ethnology , Skin Neoplasms/ethnologyABSTRACT
In an effort to assess the relative importance of age at first birth, age at subsequent births, and total parity to the occurrence of breast cancer, reproductive data from 4,225 women with breast cancer and 12,307 hospitalized women without breast cancer were analyzed by a multiple logistic regression model. Age at first birth was confirmed to be the most important reproductive risk indicator; it was associated with a 3.5% increase of relative risk for every year of increase in age at first birth (the 95% confidence interval of this estimate was 2.3 to 4.7% increase per year). However, age at any birth after the first was also an independent and statistically significant risk indicator; it was associated with a 0.9% increase of relative risk for every year of increase in age at any (and every) birth (the 95% confidence interval of this estimate was 0.4 to 1.5% increase per year). There is evidence that the age of approximately 35 years represents for every birth a critical point; before this age any full-term pregnancy confers some degree of protection; after this age any full-term pregnancy appears to be associated with increase in breast cancer risk. The effect of parity is determined by the age of occurrence of the component pregnancies. While most pregnancies occur under the age of 35, the distribution varies from population to population, and this may account for the differences between populations in whether or not a protective effect is seen for births after the first, and if it is seen, its extent.
Subject(s)
Breast Neoplasms/epidemiology , Maternal Age , Adolescent , Adult , Female , Humans , Parity , Pregnancy, High-Risk , Regression Analysis , RiskSubject(s)
Esophageal Neoplasms/epidemiology , Adult , Age Factors , Aged , Brazil , Female , Humans , Male , Middle Aged , Risk , Sex FactorsABSTRACT
Os autores analisam 100 casos de cancer primitivo de pulmao, atendidos no periodo de 1957 - 1976, no Departamento de Cirurgia Toracica do Hospital A.C. Camargo da Fundacao Antonio Prudente, cujo primeiro exame realizado foi a abreugrafia. Apenas 6 casos (6,0%) nao apresentavam sintomatologia pulmonar e, desses, 2 casos eram do ECI. Em 28,0% dos casos a abreugrafia nao foi acompanhada de relatorio medico e em 29,2% dos casos o diagnostico foi discordante de cancer de pulmao. A deteccao precoce dessas neoplasias malignas, atraves de exame radiologico dos pulmoes e exame citologico oncotico de escarro a cada 4 meses, deve ser incentivada, apesar da maioria dos estudos nao ter mostrado uma melhoria da sobrevida dos pacientes; o aumento da ressecabilidade do tumor justifica essas medidas, especialmente entre nos cuja inoperabilidade a primeira consulta e ainda elevada, com uma ressecabilidade pequena. Um maior aprimoramento tecnico e controle dos servicos de abreugrafia poderiam ser de grande utilidade para a utilizacao desse exame, associado a citologia oncotica de escarro, num programa de deteccao de cancer de pulmao em grupos de alto risco, pelo seu menor custo
Subject(s)
Humans , Male , Female , Lung Neoplasms , PhotofluorographyABSTRACT
From January 1974 to December 1976 122 exploratory laparotomies were performed in patients with primary lung cancer. With this method detection of asymptomatic abdominal metastases was achieved in 23.8% of the cases. The more frequent sites of metastases were the abdominal lymph nodes and the liver. The most common histological findings were oat-cell carcinoma (50%) and adenocarcinoma (35.7%). The detection of asymptomatic abdominal metastases using this procedure permitted the modification of the clinical staging (adopted by the UICC) in 9.8% of the cases, with emphasis on clinical stage I and II. This diagnostic procedure is harmless: no patient died during the period of the study. The authors recommended inclusion of exploratory laparotomy as an adequate routine means both for the detection of abdominal metastases and for the surgical and clinical staging of primary lung cancer, with emphasis on female patients and clinical stages I and II.
Subject(s)
Abdominal Neoplasms/secondary , Adenocarcinoma/pathology , Carcinoma, Small Cell/pathology , Lung Neoplasms/pathology , Abdominal Neoplasms/diagnosis , Abdominal Neoplasms/pathology , Female , Humans , Liver Neoplasms/secondary , Lymphatic Metastasis/diagnosis , MaleABSTRACT
O autor apresenta a casuistica de 23 casos de cancer de esofago toracico, que foram submetidos a resseccao radical e colonplastia pre-estemal na reconstrucao do transito esofago-gastrico. A mortalidade pos-operatoria imediata foi de 17,4% (4 casos) e as complicacoes imediatas (fistulas e necrose) ocorreram em 82,3% dos casos. A sobrevida a 3 e 5 anos foi respectivamente de 8,7% e 4,3%
Subject(s)
Adult , Middle Aged , Humans , Male , Female , Colon , Esophageal Neoplasms , Esophagoplasty , GastrostomyABSTRACT
Data from a large international case-control study of breast cancer suggested that women born to young mothers had a 25% lower risk of breast cancer. The association was not secondary to a tendency for these women themselves to have had children at early ages. The data provided no indication of a meaningful association between breast cancer risk and birth rank. Confounding was controlled by stratification according to a summary confounder score.