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Vestn Oftalmol ; 116(6): 20-3, 2000.
Article in Russian | MEDLINE | ID: mdl-11196208

ABSTRACT

The efficiency of 1% dioxidine and 5% urotropin solutions in suppurative penetrating corneal wounds was studied in 2 experimental series on 54 rabbits. In series A toxic effects of these drugs on eyeball tissues were studied on 6 rats, in series B drug effects were studied on a model of suppurative penetrating corneal wounds. A 21-day course of therapy with these drugs (instillations and subconjunctival parabulbar injections) caused no toxic changes in ocular tissues. Therapy with 1% dioxidine and 5% urotropin accelerated clinical cure by 4-6 days in comparison with other methods of treatment. Clinical cure was observed 3-5 days sooner after combined use of both drugs in comparison with their individual application, during during combined use their antibacterial effect was synergistic. Hence, a combination of 1% dioxidine and 5% urotropin solutions is an effective method for treating suppurative penetrating wounds of the cornea.


Subject(s)
Anti-Bacterial Agents/administration & dosage , Corneal Injuries , Eye Injuries, Penetrating/drug therapy , Methenamine/administration & dosage , Quinoxalines/administration & dosage , Animals , Cornea/microbiology , Cornea/pathology , Drug Therapy, Combination , Eye Infections, Bacterial/drug therapy , Eye Infections, Bacterial/microbiology , Eye Infections, Bacterial/pathology , Eye Injuries, Penetrating/pathology , Keratitis/drug therapy , Keratitis/microbiology , Keratitis/pathology , Rabbits , Staphylococcal Infections/drug therapy , Staphylococcal Infections/microbiology , Staphylococcal Infections/pathology , Staphylococcus aureus/isolation & purification , Staphylococcus aureus/pathogenicity , Wound Infection/drug therapy , Wound Infection/microbiology , Wound Infection/pathology
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