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1.
Intern Med ; 62(24): 3679-3683, 2023 Dec 15.
Article in English | MEDLINE | ID: mdl-37164677

ABSTRACT

A 39-year-old vegan man was admitted with diabetic ketoacidosis. He had also developed pneumonia that was unresponsive to antibiotics. Based on bronchoscopy findings, the diagnosis of Candida pneumonia was made, and the pulmonary shadow disappeared rapidly after antifungal therapy. Candida pneumonia has been mostly reported in severely immunocompromised patients. This is a rare case of Candida pneumonia that was found in a young vegan man with diabetes mellitus (DM). Although malnutrition caused by DM or an unbalanced diet is often underestimated as a cause of immunodeficiency, these conditions can be risk factors for serious opportunistic infections, including Candida pneumonia.


Subject(s)
Candidiasis , Diabetes Mellitus , Diabetic Ketoacidosis , Pneumonia , Male , Humans , Adult , Diabetic Ketoacidosis/complications , Vegans , Pneumonia/complications , Pneumonia/diagnosis , Candida
2.
Intern Med ; 62(5): 769-773, 2023 Mar 01.
Article in English | MEDLINE | ID: mdl-35871578

ABSTRACT

A 50-year-old woman who had previously undergone right hemicolectomy and chemotherapy for colorectal cancer was hospitalized with respiratory failure. Chest computed tomography showed reticulonodular opacities and enlarged lymph nodes. A transbronchial biopsy revealed adenocarcinoma with epidermal growth factor receptor (EGFR) mutations T790M and L861Q. Treatment with the EGFR-tyrosine kinase inhibitor (TKI) osimertinib was started, and she achieved a partial response. We diagnosed her with metastatic lung tumors from colorectal cancer based on additional immunohistochemical staining and the EGFR mutation status (L861Q) of the specimens. Although cases with EGFR mutations have been rarely reported, an EGFR-TKI can be an effective treatment option for colorectal cancer.


Subject(s)
Colorectal Neoplasms , Lung Neoplasms , Female , Humans , Middle Aged , Lung Neoplasms/drug therapy , ErbB Receptors/genetics , Protein Kinase Inhibitors/therapeutic use , Mutation , Colorectal Neoplasms/drug therapy
3.
Intern Med ; 61(15): 2339-2341, 2022 Aug 01.
Article in English | MEDLINE | ID: mdl-35022350

ABSTRACT

A 57-year-old man with lung adenocarcinoma was treated with chemotherapy and immune checkpoint blockade. After two cycles of carboplatin, pemetrexed, and pembrolizumab, he developed a persistent fever. Chest computed tomography (CT) suggested inflammation of the aortic wall. We treated the patient with corticosteroids. After four cycles of carboplatin, pemetrexed, and pembrolizumab, chest CT showed an aneurysm in the ascending aorta. We diagnosed him with inflammatory thoracic aortic aneurysm induced by pembrolizumab and performed surgical replacement of the ascending aorta. Although this might be a very rare case, we should be aware of aortitis as a potential adverse effect of pembrolizumab.


Subject(s)
Adenocarcinoma of Lung , Aortic Aneurysm, Thoracic , Lung Neoplasms , Adenocarcinoma of Lung/drug therapy , Adenocarcinoma of Lung/pathology , Antibodies, Monoclonal, Humanized , Aorta, Thoracic/pathology , Aortic Aneurysm, Thoracic/complications , Aortic Aneurysm, Thoracic/diagnostic imaging , Aortic Aneurysm, Thoracic/drug therapy , Carboplatin/therapeutic use , Humans , Lung Neoplasms/complications , Lung Neoplasms/drug therapy , Lung Neoplasms/pathology , Male , Middle Aged , Pemetrexed/therapeutic use
4.
Thorac Cancer ; 11(8): 2357-2360, 2020 08.
Article in English | MEDLINE | ID: mdl-32567218

ABSTRACT

The patient in this report was a 57-year-old man with metastatic non-small cell lung cancer (NSCLC). After no response to two lines of systemic chemotherapy, he was treated with nivolumab as third-line therapy, which resulted in a partial response. After 17 months of nivolumab treatment, he developed bone metastasis in his left femur which was treated with radiation therapy. Nivolumab was restarted after radiation therapy. Four months after radiation therapy, he developed another metastatic lesion in the small intestine which was surgically resected. Because there were no recurrent NSCLC lesions after surgical resection, nivolumab was restarted again. At 18 months after surgery, there were no recurrent NSCLC lesions. Immunohistochemical analysis of peritumoral T lymphocytes showed higher expression of T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) and lymphocyte activation gene 3 (LAG-3) in recurrent lesions of bone and small intestine than in primary lesions. Upregulation of TIM-3 and LAG-3 could be associated with mechanisms of adaptive resistance to nivolumab in this case. Here, we report a successful case of continued nivolumab therapy with remission after local treatments consisting of radiation therapy and surgical resection for oligometastases. Continuation of immune checkpoint inhibitor (ICI) treatment may be worth considering if oligometastases can be controlled. KEY POINTS: Significant findings of the study We report a successful case of continued nivolumab treatment with remission after local treatment (radiation therapy and surgical resection) for oligometastases. What this study adds Upregulation of T cell immunoglobulin and mucin domain-containing protein 3 and lymphocyte-activation gene 3 could be associated with mechanisms of adaptive resistance to nivolumab.


Subject(s)
Antineoplastic Agents, Immunological/therapeutic use , Carcinoma, Non-Small-Cell Lung/drug therapy , Lung Neoplasms/drug therapy , Nivolumab/therapeutic use , Antineoplastic Agents, Immunological/pharmacology , Carcinoma, Non-Small-Cell Lung/pathology , Humans , Lung Neoplasms/pathology , Male , Middle Aged , Neoplasm Metastasis , Nivolumab/pharmacology
5.
Intern Med ; 59(4): 569-572, 2020 Feb 15.
Article in English | MEDLINE | ID: mdl-31666468

ABSTRACT

The patient was a 73-year-old woman with lung adenocarcinoma and systemic lupus erythematosus (SLE) who was treated with pembrolizumab. After six cycles of pembrolizumab, she developed symptoms suggestive of neuropsychiatric SLE, such as resting tremor, confusional state, depression, mood disorder, and anxiety disorder. In addition, her cerebrospinal fluid level of interleukin-6 was elevated. Her symptoms resolved one month after the discontinuation of pembrolizumab. This is the first report of neuropsychiatric symptoms in a patient with lung cancer and SLE on immune checkpoint blockade therapy.


Subject(s)
Adenocarcinoma of Lung/drug therapy , Antibodies, Monoclonal, Humanized/adverse effects , Antibodies, Monoclonal, Humanized/therapeutic use , Antineoplastic Agents, Immunological/adverse effects , Antineoplastic Agents, Immunological/therapeutic use , Carcinoma, Non-Small-Cell Lung/drug therapy , Lupus Erythematosus, Systemic/drug therapy , Mood Disorders/chemically induced , Aged , Female , Humans
6.
Intern Med ; 57(1): 43-48, 2018 Jan 01.
Article in English | MEDLINE | ID: mdl-29033427

ABSTRACT

A 63-year-old man was admitted to our department following a secondary medical examination. Blood tests showed high levels of liver enzymes, IgG, IgG4, and antinuclear antibody. Computed tomography showed tumors in the bilateral lower lobes of the lungs and pleural thickening. After pleural and liver biopsy procedures, he was conclusively diagnosed with IgG4-related lung pseudotumor and pleural inflammation with autoimmune hepatitis. We started treatment with prednisolone 40 mg/day, and chest radiograph and blood tests showed signs of improvement. This was a rare case that suggested an association between IgG4-related disease and autoimmune hepatitis.


Subject(s)
Anti-Inflammatory Agents/therapeutic use , Hepatitis, Autoimmune/drug therapy , Inflammation/drug therapy , Lung Neoplasms/diagnostic imaging , Lung Neoplasms/drug therapy , Prednisolone/therapeutic use , Biopsy , Humans , Immunoglobulin G/blood , Lung/physiopathology , Lung Neoplasms/diagnosis , Male , Middle Aged , Pleura/physiopathology , Treatment Outcome
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