1.
Usp Fiziol Nauk
; 43(4): 59-72, 2012.
Article
in Russian
| MEDLINE
| ID: mdl-23227722
ABSTRACT
Alzheimer's disease is the most common neurodegenerative disorder characterized by progressive memory and cognitive abilities loss. The etiology of Alzheimer's disease is poorly understood. In this regard, there is no effective treatment for the disease. Various hypotheses to explain the nature of the pathology of Alzheimer's disease led to the development of appropriate therapeutics. Despite of decades of research and clinical trials available therapeutics, at best, can only slow down the progression of the disease, but cannot cure it. This review dedicated to the one of modern hypotheses of Alzheimer's disease pathogenesis implied the impairment of calcium homeostasis as a key event for the development of neurodegenerative processes.
Subject(s)
Alzheimer Disease/metabolism , Calcium Channels/metabolism , Calcium Signaling , Calcium/metabolism , Presenilin-1/metabolism , Alzheimer Disease/pathology , Amyloid beta-Peptides/genetics , Amyloid beta-Peptides/metabolism , Apolipoproteins E/genetics , Apolipoproteins E/metabolism , Calcium Channels/genetics , Cerebral Cortex/metabolism , Cerebral Cortex/pathology , Cognition , Genetic Markers , Hippocampus/metabolism , Hippocampus/pathology , Homeostasis , Humans , Memory , Presenilin-1/genetics , tau Proteins/genetics , tau Proteins/metabolism
2.
Probl Tuberk
; (10): 17-20, 1984 Oct.
Article
in Russian
| MEDLINE
| ID: mdl-6240060