ABSTRACT
The ketogenic diet (KD) is a similar diet fasting state that is high in fat and low carbohydrate.KD is used in the treatment of refractory epilepsy,but the mechanism is not completely clear.According to the current research progress,the mechanism of KD is antiepilepsy.This paper reviewed the progress of the application of KD in the elucidation of several metabolic diseases and epilepsy syndrome caused by epilepsy.With the further development of the antiepilepsy mechanism of KD in the future,it will not only guide the application of more diseases,but also provide a scientific theoretical basis for the discovery of new antiepileptic drugs.
ABSTRACT
@# ObjectiveTo observe the effects of local mild hypothermia at different time on dopamine (DA) and 5-hydroxytryptamine (5-HT) concentration in rabbits brain basal ganglion with bilirubin encephalopathy. MethodsThe model of bilirubin encephalopathy was established, and treated with mild hypothermia for different time. The DA and 5-HT in the basal ganglion were detected with fluorescence spectrophotometry. ResultsThe DA and the 5-HT decreased in the basal ganglion significantly after modeling (P<0.01), and increased when treated for 6 h, 12 h or 24 h (P<0.01). ConclusionLocal mild hypothermia can significantly reduce the disorder of DA and 5-HT during bilirubin encephalopathy. The longer the hypothermia, the better the effect is.