ABSTRACT
Doses of procaine for dental purposes have been assessed previously as a result of studies of circulating blood levels of procaine after injection of the drug at body sites other than the mouth. This paper reports results of a study of circulating procaine levels in ten healthy volunteers who received 1.8 ml injections of 2% procaine hydrochloride at a defined peri-oral site. General dental practice conditions were simulated as closely as possible. In addition, procaine pharmacokinetics following peri-oral administration were studied. The serum concentration-time data were found to obey the one-compartment open model adequately with first-order absorption and elimination rates.
Subject(s)
Procaine/blood , Adult , Biological Availability , Half-Life , Humans , Injections , Kinetics , Male , Mouth , Procaine/administration & dosage , Procaine/metabolismABSTRACT
Salivary estradiol 17 beta (E2-17 beta) and progesterone (P) were determined by using radioimmunoassay techniques in 30 pregnant females in the first, second and third trimesters as well as in 10 non-pregnant controls during the luteal phase of the menstrual cycle. Plaque index (P.I.), gingival index (G.I.) and retention index (R.I.) were measured in all cases. The data obtained showed that the levels of the two hormones in saliva were significantly increasing during the 3 trimesters of pregnancy. P.I. and R.I. did not change, however, G.I. was significantly higher in the second and third trimesters when compared with controls. A correlation between both E2--17 beta and P during pregnancy and gingival changes is suggested.