1.
Elife
; 82019 12 24.
Article
in English
| MEDLINE
| ID: mdl-31872799
ABSTRACT
C-tactile afferents form a distinct channel that encodes pleasant tactile stimulation. Prevailing views indicate they project, as with other unmyelinated afferents, in lamina I-spinothalamic pathways. However, we found that spinothalamic ablation in humans, whilst profoundly impairing pain, temperature and itch, had no effect on pleasant touch perception. Only discriminative touch deficits were seen. These findings preclude privileged C-tactile-lamina I-spinothalamic projections and imply integrated hedonic and discriminative spinal processing from the body.
Subject(s)
Pleasure-Pain Principle , Pleasure/physiology , Touch Perception/physiology , Touch/physiology , Afferent Pathways/physiology , Aged , Cordotomy , Emotions/physiology , Female , Humans , Male , Mechanoreceptors/metabolism , Mechanoreceptors/physiology , Middle Aged , Nerve Fibers, Unmyelinated/metabolism , Nerve Fibers, Unmyelinated/physiology , Physical Stimulation , Pruritus/physiopathology , Skin/physiopathology , Spinothalamic Tracts/metabolism , Spinothalamic Tracts/physiology
2.
Can J Neurol Sci
; 45(3): 354-356, 2018 05.
Article
in English
| MEDLINE
| ID: mdl-29386077