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Am J Dermatopathol ; 43(1): 60-62, 2021 Jan 01.
Article in English | MEDLINE | ID: mdl-32472771

ABSTRACT

ABSTRACT: Flame figures represent a characteristic but nondiagnostic histological finding in eosinophilic dermatoses. Some bullous autoimmune diseases with a predominant eosinophilic infiltrate, such as bullous pemphigoid, pemphigoid gestationis, and pemphigus vegetans, may show them. However, it is rare to find them in predominant neutrophilic bullous dermatoses such as linear immunoglobulin A. We present a 60-year-old man with a history of chronic urticaria, which presented a bullous disease after an acute parvovirus B19 infection. The histological findings showed an exceptional linear immunoglobulin A bullous dermatosis with an eosinophilic infiltrate in the dermis forming "flame figures." The clinical and histopathological findings for this entity may be identical to those of other dermatoses. For this reason, combining these findings with direct immunofluorescence analysis is essential for correct diagnosis of this bullous disease.


Subject(s)
Eosinophils/immunology , Erythema Infectiosum/immunology , Linear IgA Bullous Dermatosis/immunology , Parvovirus B19, Human/immunology , Skin/immunology , Adrenal Cortex Hormones/therapeutic use , Anti-Allergic Agents/therapeutic use , Antibodies, Viral/blood , Eosinophils/drug effects , Eosinophils/virology , Erythema Infectiosum/diagnosis , Erythema Infectiosum/virology , Histamine Antagonists/therapeutic use , Host-Pathogen Interactions , Humans , Immunoglobulin M/blood , Linear IgA Bullous Dermatosis/drug therapy , Linear IgA Bullous Dermatosis/pathology , Linear IgA Bullous Dermatosis/virology , Male , Middle Aged , Parvovirus B19, Human/pathogenicity , Skin/drug effects , Skin/pathology , Skin/virology , Treatment Outcome
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