[Pseudo-conduction block in nonsystemic vasculitic neuropathy]. / Pseudobloqueo de conducción en vasculitis aislada del sistema nervioso periférico.

SUMMARY: Introduction. Nonsystemic vasculitic neuropathy (NSVN) is an inflammatory disorder of the vasa nervorum which usually is expressed as a mononeuritis multiplex. We present a patient with NSVN with histological confirmination focused on the neurophysiological findings at the early stages. CASE REPORT: A 36 years-old woman presented with paresthesia and weakness in her right hand followed by left footdrop. The first neurophysiologic examination showed low amplitude of the right median nerve (RMN) CMAP with proximal stimulation. A second examination showed signs of axonal damage in several nerves, including the RMN. CONCLUSIONS: The acute ischemic damage of a nerve can give a pattern of conduction block in the electroneurographic study as in the RMN of the presented case. This phenomenon is referred as "pseudo-conduction block", since it is transient and evolves towards a definite pattern of axonal neuropathy. When a vasculitic neuropathy is suspected, repeated neurophysiologic studies are necessary in order to ensure a proper (appropriate) characterization of the lesional patterns.

Pseudobloqueo de conducción en vasculitis aislada del sistema nervioso periférico / Pseudo-conduction block in nonsystemic vasculitic neuropath

Fundamento. La vasculitis aislada del sistema nerviosoperiférico (VASNP) afecta selectivamente a los vasanervorum, expresándose generalmente como una mononeuropatíamúltiple. Presentamos un caso de VASNPconfirmado histológicamente, destacando los hallazgosneurofisiológicos en fase aguda.Observación clínica. Mujer de 36 años con parestesiasy debilidad en mano derecha seguidas de paresia parala dorsiflexión del pie izquierdo. El primer estudio neurofisiológicomostraba amplitud reducida del potencialmotor del mediano derecho con estímulos proximales.Un segundo estudio mostraba signos de lesión axonalen varios nervios, incluyendo el mediano derecho.Conclusiones. La lesión isquémica aguda de un nerviopuede dar lugar a un patrón electroneurográfico debloqueo de conducción, como en el mediano derechodel caso descrito. Este fenómeno es conocido como“pseudobloqueo”, dado su carácter transitorio, conevolución a un patrón de neuropatía axonal. La sospechade VASNP requiere estudios neurofisiológicosseriados para una correcta tipificación de los patrones lesionales(AU)

Summary. Introduction. Nonsystemic vasculitic neuropathy(NSVN) is an inflammatory disorder of the vasanervorum which usually is expressed as a mononeuritismultiplex. We present a patient with NSVN with histologicalconfirmination focused on the neurophysiologicalfindings at the early stages.Case report. A 36 years-old woman presented with paresthesiaand weakness in her right hand followed byleft footdrop. The first neurophysiologic examinationshowed low amplitude of the right median nerve (RMN)CMAP with proximal stimulation. A second examinationshowed signs of axonal damage in several nerves, includingthe RMN.Conclusions. The acute ischemic damage of a nerve cangive a pattern of conduction block in the electroneurographicstudy as in the RMN of the presented case. Thisphenomenon is referred as “pseudo-conduction block”,since it is transient and evolves towards a definite patternof axonal neuropathy. When a vasculitic neuropathyis suspected, repeated neurophysiologic studiesare necessary in order to ensure a proper (appropriate)characterization of the lesional patterns(AU)

Condroblastoma de escafoides carpiano / Chondroblastoma of the carpal scaphoids

El condroblastoma es un tumor benigno de origen cartilaginoso que representa menos del 1% de todos los tumores óseos primarios. Se localiza típicamente en la epífisis de los huesos largos. Un 10% de los condroblastomas afectan a huesos del pie y de la mano. El asiento de esta lesión en el carpo es extraordinariamente raro. Se presenta un caso de condroblastoma del escafoides del carpo que fue tratado mediante curetaje de la lesión y relleno con injerto óseo autólogo de cresta iliaca (AU)

A chondroblastoma is a benign tumour of cartilaginous origin which represents less than 1% of all primary osseous tumours. It is typically localised in the epiphysis of the long bones. Some 10% of chondroblastomas affect the bones of the foot and the hand. It is extremely rare for the seat of this lesion to be in the carpal bones. We present a case of chondroblastoma of the carpal scaphoids that was treated through curretage of the lesion and filling with autologous osseous graft from the iliac crest (AU)

[Chondroblastoma of the carpal scaphoids]. / Condroblastoma de escafoides carpiano.

A chondroblastoma is a benign tumour of cartilaginous origin which represents less than 1% of all primary osseous tumours. It is typically localised in the epiphysis of the long bones. Some 10% of chondroblastomas affect the bones of the foot and the hand. It is extremely rare for the seat of this lesion to be in the carpal bones. We present a case of chondroblastoma of the carpal scaphoids that was treated through curretage of the lesion and filling with autologous osseous graft from the iliac crest.

Modulación en la expresión de biomarcadores (RE, RP y C-erbB2) en cáncer de mama tras tratamiento neoadyuvante / Modulation of biomarkers expression (OR, PR and C-erbB2) in breast

Introducción. El tratamiento oncológico pre ypostoperatorio en pacientes con carcinoma de mamaestá condicionado entre otros factores, por el resultadodel estudio inmunohistoquímico de los receptoreshormonales y por la expresión de c-erbB2. El objetivodel estudio es determinar la influencia del tratamientoneoadyuvante en la expresión de receptores de estrógeno(RE), progesterona (PR) y c-erbB2.Material y métodos. Estudiamos 53 pacientes concáncer de mama diagnosticadas mediante biopsia“trucut”. Las pacientes con carcinoma localmenteavanzado (20) se someten a quimioterapia preoperatoria.Se realiza extirpación quirúrgica en todos loscasos. Comparamos la expresión de receptores deestrógeno (RE), receptores de progesterona (PR) y cerbB2,en la biopsia”trucut” y en la pieza quirúrgica.Resultados. Encontramos diferencias significativasen la expresión de RE, RP entre biopsia/pieza quirúrgica,comparando el grupo de pacientes sometidasa tratamiento neoadyuvante frente al grupo de pacientessin tratamiento oncológico prequirúrgico.Encontramos diferencias de signo (positivizacióny negativización) entre un 10 y un 40% de casos en laexpresión inmunohistoquímica para RE, RP y c-erbB2entre la biopsia”trucut” y la resección quirúrgica en laspacientes tratadas con neoadyuvancia. Estas diferenciasde signo no tienen significación estadística

Introduction. Pre and post-operative oncological therapy in patients with breast cancer is determined, amongst other factors, by hormone receptor status and by c-erbB2 expression. The aim of this study is to determine the influence of neoadjuvant therapy on the expression of oestrogen receptor (OR), progesterone receptor (PR) and c-erbB2. Methods. Fifty-three patients with breast cancer diagnosed by tru-cut biopsy were studied. Patients with locally advanced carcinoma (20) had preoperative treatment. All patients underwent surgical resection. Expression of OR, PR and c-erbB2 in both the tru-cut biopsy and the gross specimen was compared. Results: We found significant differences in OR, PR expression in both biopsy and gross specimen, between the group of patients who underwent neoadjuvant treatment and the group without pre-surgical treatment. Changes in PR, OR and c-erbB2 status were found between the tru-cut biopsy and the gross specimen, in about 10 to 40% of the cases who received neoadjuvant therapy. These changes had no statistical significance

[Modulation of biomarkers expression (OR, PR and C-erbB2) in breast cancer following neoadjuvant treatment]. / Modulación en la expresión de biomarcadores (RE, RP y C-erbB2) en cáncer de mama tras tratamiento neoadyuvante.

INTRODUCTION: Pre and post-operative oncological therapy in patients with breast cancer is determined, amongst other factors, by hormone receptor status and by c-erbB2 expression. The aim of this study is to determine the influence of neoadjuvant therapy on the expression of oestrogen receptor (OR), progesterone receptor (PR) and c-erbB2. METHODS: Fifty-three patients with breast cancer diagnosed by tru-cut biopsy were studied. Patients with locally advanced carcinoma (20) had preoperative treatment. All patients underwent surgical resection. Expression of OR, PR and c-erbB2 in both the tru-cut biopsy and the gross specimen was compared. RESULTS: We found significant differences in OR, PR expression in both biopsy and gross specimen, between the group of patients who underwent neoadjuvant treatment and the group without pre-surgical treatment. Changes in PR, OR and c-erbB2 status were found between the tru-cut biopsy and the gross specimen, in about 10 to 40% of the cases who received neoadjuvant therapy. These changes had no statistical significance.

Delitos sexuales: relevamiento de las solicitudes de cotejo durante el 2001 / Sexual offenses: relevance of comparison requests for 2001

El Laboratorio de Inmunogenética es un organismo dependiente de la Suprema Corte de Justicia de la provincia de Buenos Aires. Durante el año 2001 ingresaron 295 pedidos de delitos sexuales, abarcando violaciones (41,4 por ciento), violaciones agravadas (18,7 por ciento), violaciones seguidas de muerte (2,2 por ciento), abuso sexual (28,4 por ciento), abuso deshonesto (7,2 por ciento) y estupro (2,1 por ciento). En un 22 por ciento las víctimas fueron menores. En un 34 por ciento el autor permanece desconocido. En el 45 por ciento del total de los casos analizados, se observó correspondencia entre el genotipo detectado en las evidencias y el imputado, mientras que un 20 por ciento resultaron exclusiones. Como conclusión del relevamiento surge la necesidad de implementar una base de datos (AU)