Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 21
Filtrar
1.
Can J Pain ; 7(1): 2156331, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-36874229

RESUMEN

Background: Balance between benefits and harms of using opioids for the management of chronic noncancer pain (CNCP) must be carefully considered on a case-by-case basis. There is no one-size-fits-all approach that can be executed by prescribers and clinicians when considering this therapy. Aim: The aim of this study was to identify barriers and facilitators for prescribing opioids for CNCP through a systematic review of qualitative literature. Methods: Six databases were searched from inception to June 2019 for qualitative studies reporting on provider knowledge, attitudes, beliefs, or practices pertaining to prescribing opioids for CNCP in North America. Data were extracted, risk of bias was rated, and confidence in evidence was graded. Results: Twenty-seven studies reporting data from 599 health care providers were included. Ten themes emerged that influenced clinical decision making when prescribing opioids. Providers were more comfortable to prescribe opioids when (1) patients were actively engaged in pain self-management, (2) clear institutional prescribing policies were present and prescription drug monitoring programs were used, (3) long-standing relationships and strong therapeutic alliance were present, and (4) interprofessional supports were available. Factors that reduced likelihood of prescribing opioids included (1) uncertainty toward subjectivity of pain and efficacy of opioids, (2) concern for the patient (e.g., adverse effects) and community (i.e., diversion), (3) previous negative experiences (e.g., receiving threats), (4) difficulty enacting guidelines, and (5) organizational barriers (e.g., insufficient appointment duration and lengthy documentation). Conclusions: Understanding barriers and facilitators that influence opioid-prescribing practices offers insight into modifiable targets for interventions that can support providers in delivering care consistent with practice guidelines.


Contexte: L'équilibre entre les avantages et les inconvénients de l'utilisation d'opioïdes pour la prise en charge de la douleur chronique non cancéreuse (CNCP) doit être soigneusement examiné au cas par cas. Il n'existe pas d'approche uniforme pouvant être adoptée par les prescripteurs et les cliniciens lorsqu'ils envisagent cette thérapie.Objectif: L'objectif de cette étude était de recenser les obstacles et les facilitateurs pour la prescription d'opioïdes pour la douleur chronique non cancéreuse par une revue systématique de la littérature qualitative.Méthodes: Six bases de données ont été consultées pour la période allant de leur création jusqu'en juin 2019 afin d'y repérer les rapports d'études qualitatives sur les connaissances, les attitudes, les croyances ou les pratiques des prestataires en matière de prescription d'opioïdes pour la douleur chronique non cancéreuse en Amérique du Nord. Les données ont été extraites, le risque de biais a été évalué et la confiance envers les données probantes a été notée.Résultats: Vingt-sept études faisant état de données provenant de 599 prestataires de soins de santé ont été incluses. Dix thèmes influençant la prise de décision clinique lors de la prescription d'opioïdes ont émergé. Les prestataires étaient plus à l'aise pour prescrire des opioïdes lorsque (1) les patients étaient activement engagés dans la prise en charge de la douleur, (2) des politiques de prescription institutionnelles claires et des programmes de surveillance des médicaments d'ordonnance étaient en place, (3) des relations de longue date et une alliance thérapeutique forte étaient présentes, et (4) du soutien interprofessionnel était disponible. Les facteurs qui réduisaient la probabilité de la prescription d'opioïdes comprenaient (1) l'incertitude à l'égard de la subjectivité de la douleur et de l'efficacité des opioïdes, (2) une préoccupation pour le patient (p. ex., effets indésirables) et la collectivité (p. ex., détournement), (3) des expériences négatives antérieures (p. ex., recevoir des menaces), (4) des difficultés à adopter des lignes directrices et (5) des obstacles organisationnels (p. ex., durée insuffisante des rendez-vous et longueur de la documentation).Conclusions: La compréhension des obstacles et des facilitateurs qui influencent les pratiques de prescription d'opioïdes permet d'avoir un aperçu des cibles modifiables pour les interventions qui peuvent aider les prestataires à fournir des soins conformes aux directives de pratique.

2.
Can J Pain ; 7(1): 2111993, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-36643864

RESUMEN

Background: Chronic pain affects approximately one in every five Canadians and has a substantial impact on psychological well-being, relationships, ability to attend work or school, and overall functioning.The Ottawa Hospital Pain Clinic introduced orientation sessions, with the aim of providing new patients with pain education to help prepare patients for engagement with multimodal pain management strategies. This report summarizes the results of a formative evaluation of the orientation session at The Ottawa Hospital Pain Clinic to determine whether patients perceived the orientation session as beneficial. Methods: Interviews were conducted, transcribed, and then thematically analyzed to understand patients' perspectives on the orientation session. Coding was done by two team members using the constant comparison analyses method with key ideas, concepts, and patterns identified and compared to identify similarities. Results: Between September 6 and October 18, 2019, 18 patients attended an orientation session and 12 consented to participation and completed telephone interviews. The six themes identified included (1) feeling of community, (2) participants feeling heard by providers, (3) appreciation of the holistic approach, (4) availability of community resources, (5) barriers to access, and (6) discordant feelings of preparedness for the physician appointment. Conclusion: Results from this evaluation indicate that the orientation session offered at The Ottawa Hospital Pain Clinic improves chronic pain literacy, reduces feeling of isolation, and instills hope. As such, it appears to be a valuable component of pain clinic programs.


Contexte: La douleur chronique touche environ un Canadien sur cinq et a des répercussions sur le bien-être psychologique, les relations, la capacité à aller au travail ou à l'école, et l'ensemble du fonctionnement. La Clinique de la douleur de l'Hôpital d'Ottawa a lancé des séances d'orientation, dans le but de fournir aux nouveaux patients une formation sur la douleur pour les aider à se préparer à adopter des stratégies multimodales de prise en charge de la douleur. Ce rapport résume les résultats d'une évaluation formative de la séance d'orientation à la Clinique de la douleur de l'Hôpital d'Ottawa visant à déterminer si les patients perçoivent la session d'orientation comme bénéfique.Méthodes: Les entrevues ont été menées, transcrites, puis analysées de maniére thématique pour comprendre les points de vue des patients sur la séance d'orientation. Le codage a été effectué par deux membres de l'équipe à l'aide d'une méthode d'analyse par comparaison constante avec des idées, des concepts et des modéles clés répertoriés et par rapport à l'identification de similitudes.Résultats: Entre le 6 septembre et le 18 octobre 2019, 18 patients ont assisté à une séance d'orientation. Parmi ceux-ci, 12 ont accepté de participer et ont complété des entrevues téléphoniques. Les six thémes répertoriés comprenaient (1) le sentiment de communauté, (2) le sentiment des participants d'étre entendus des prestataires, (3) l'appréciation de l'approche holistique, (4) la disponibilité des ressources communautaires, (5) les obstacles à l'accés, et (6) des sentiments discordants de préparation pour le rendez-vous chez le médecin.Conclusion: Les résultats de cette évaluation indiquent que la séance d'orientation offerte à la Clinique de la douleur de l'Hôpital d'Ottawa améliore la littératie en matiére de douleur chronique, réduit le sentiment d'isolement et suscite l'espoir. Ainsi, elle semble étre un élément précieux des programmes de la Clinique de la douleur.

3.
Vet Anim Sci ; 13: 100194, 2021 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-34458644

RESUMEN

Despite being ranked 33 in Americas most popular breeds (American Kennel Club, 2020), there is a lack of research addressing longevity and death related health problems of Mastiff dog breeds and specifically commonly kept Bull Mastiffs and English Mastiffs. Likely a result of small founder populations and minimal breeding geographical locations, limited genetic variation is found making it important to determine key health concerns which may reduce longevity. The purpose of this study was to report findings from an online global survey of owners of deceased Mastiffs detailing breed, age at death, and if known, cause of death. Owner information was also collected including location by continent and country and the owners breeding or hobbyist experience. A closed-question survey was used via an online network of global Mastiff clubs and associations totalling a useable sample of 1036 dogs across a range of breeds. Notably, it is reported that age and cause of death varied dependant on breed. Results indicate that the median age of death for all dogs was 8 years with mean age of death in Europe as 7.72 years and 8.17 years in North America. The most common cause of death identified for all dogs was cancer (47%), old age (16%), cardiac problems (8%) and gastric problems including GDV and bloat (7%). The mean age of death for cancer dogs was 7.85 years with 23 types of cancer stated with Osteosarcoma being the most commonly recorded and specifically for neutered animals. As the survey was aimed at hobbyist and registered breeders, study findings contribute to knowledge of Mastiff mortality with the aim of promoting welfare of the breed.

4.
Am J Prev Med ; 60(1): e15-e26, 2021 01.
Artículo en Inglés | MEDLINE | ID: mdl-33229143

RESUMEN

CONTEXT: This study is a systematic review of interventions to improve adherence to guideline recommendations for prescribing opioids for chronic noncancer pain. EVIDENCE ACQUISITION: Investigators searched CINAHL, Embase, MEDLINE, PsycINFO, the Cochrane Library, and Joanna Briggs Institute Evid Based Pract database from inception until June 3, 2019. Interventional studies to improve adherence to recommendations made by opioid guidelines for chronic noncancer pain in North America were eligible if outcomes included adherence to guideline recommendations or change in quantity of opioids prescribed. Data were extracted independently and in duplicate. Quantitative synthesis was performed using random effects meta-analysis. Confidence in evidence was determined using the Grades of Recommendation, Assessment, Development, and Evaluation. EVIDENCE SYNTHESIS: A total of 20 studies (8 controlled and 12 prospective cohort) involving 1,491 providers and 72 clinics met inclusion. Interventions included education, audit and feedback, interprofessional support, shared decision making, and multifaceted strategies. Multifaceted interventions improved the use of urine drug testing (n=2, or =2.31, 95% CI=1.53, 3.49, z=3.98, p<0.01; high-certainty evidence), treatment agreements (n=2, or =1.96, 95% CI=1.47, 2.61, z=4.56, p<0.01; moderate-certainty evidence), and mental health screening (n=2, 2.57-fold, 95% CI=1.56, 4.24, z=2.32, p=0.02; low-certainty evidence) when prescribing opioids for chronic noncancer pain. Very low-certainty evidence suggests that several interventions improved the use of treatment agreements, urine drug testing, and prescription drug monitoring programs. CONCLUSIONS: Mostly very low-certainty evidence supports a number of interventions for improving adherence to risk management strategies when prescribing opioids for chronic noncancer pain; however, the effect on patient important outcomes (e.g., overdose, addiction, death) is uncertain.


Asunto(s)
Analgésicos Opioides , Dolor Crónico , Analgésicos Opioides/uso terapéutico , Dolor Crónico/tratamiento farmacológico , Humanos , América del Norte , Pautas de la Práctica en Medicina , Estudios Prospectivos
5.
BMJ Open ; 10(2): e033350, 2020 02 28.
Artículo en Inglés | MEDLINE | ID: mdl-32114466

RESUMEN

INTRODUCTION: Approximately one-third of adults with chronic pain also report clinically relevant levels of depression. Internet-delivered psychological therapies such as Cognitive Behavioural Therapy (iCBT) and Acceptance and Commitment Therapy (iACT) have been developed to overcome barriers of access to services and ensure the timely delivery of care. The objective of this trial is to collect data on feasibility, acceptability and range of probable effect sizes for iCBT and iACT interventions tailored towards the treatment of depression and chronic pain using a randomised controlled patient-preference design. METHODS AND ANALYSIS: Community dwelling adults with chronic non-cancer pain (CNCP) and major depression will be recruited from pain clinics and primary care providers in Newfoundland and Labrador, Canada. The study is a randomised controlled patient-preference trial. Eligible patients will be randomly assigned to a 'preference' or 'no-preference' arm during the first step of randomisation and to intervention or control in the second step of randomisation. Two interventions (ie, iCBT or iACT) will be evaluated relative to attention control. iCBT and iACT involve the completion of 7-weekly online modules augmented with one session of motivational enhancement and weekly therapy sessions. Primary outcomes include (1) feasibility and acceptability parameters and (2) change in symptoms of depression. Secondary outcomes include pain, physical function, emotional function and quality of life. We will recruit 60 participants and examine the range of effect sizes obtained from the trial but will not conduct significance testing as per recommendations for behavioural trial development. ETHICS AND DISSEMINATION: Ethics was approved by the provincial Health Research Ethics Board. Dissemination of results will be published in a peer-reviewed academic journal and presented at scientific conferences. TRIAL REGISTRATION NUMBER: NCT04009135.


Asunto(s)
Terapia de Aceptación y Compromiso , Atención , Dolor Crónico , Terapia Cognitivo-Conductual , Depresión , Prioridad del Paciente , Adulto , Dolor Crónico/terapia , Depresión/terapia , Estudios de Factibilidad , Humanos , Internet , Terranova y Labrador , Calidad de Vida , Ensayos Clínicos Controlados Aleatorios como Asunto , Resultado del Tratamiento
6.
Health Psychol ; 39(5): 430-451, 2020 May.
Artículo en Inglés | MEDLINE | ID: mdl-31999179

RESUMEN

OBJECTIVE: This review quantified prescriber adherence to opioid prescribing guidelines for chronic noncancer pain (CNCP). METHOD: We searched CINAHL, Embase, MEDLINE, PsycINFO, the Cochrane Library, and the Joanna Briggs Institute EBP Database from inception until June 3, 2019. Studies that focused on provider adherence to opioids guidelines for CNCP in North America were eligible. Four reviewers screened studies, extracted data, and assessed study quality. RESULTS: Thirty-eight studies were eligible, comprising 17 cross-sectional studies (n = 11,835 providers) and 22 chart reviews (n = 22,512 patients). Survey data indicated that adherence was 49% (95% CI [40, 59]) for treatment agreements, 33% (95% CI [19%, 47%]) for urine drug testing, 48% (95% CI [26%, 71%]) for consultation with drug monitoring program, 57% (95% CI [35%, 79%]) for assessing risk of aberrant medication-taking behavior, and 61% (95% CI [35%, 87%]) for mental health screening. Chart review data indicated that the proportion of patients with documentation was 40% (95% CI [29, 51]) for treatment agreements, 41% (95% CI [32%, 50%]) for urine drug testing, 40% (95% CI [2%, 78%]) for consultation with drug monitoring program, 41% (95% CI [20%, 64%]) for assessing risk of aberrant medication-taking behavior, and 22% (95% CI [9%, 33%]) for mental health screening. Year of publication, practice guideline referenced, and risk of bias explained significant heterogeneity. No study evaluated whether nonadherence to recommendations reflected well-justified deviations to care. CONCLUSIONS: Adherence to guideline recommendations for opioids for CNCP is low. It is unclear whether nonadherence reflects thoughtful deviations in care. (PsycInfo Database Record (c) 2020 APA, all rights reserved).


Asunto(s)
Analgésicos Opioides/uso terapéutico , Dolor Crónico/tratamiento farmacológico , Pautas de la Práctica en Medicina/normas , Analgésicos Opioides/farmacología , Estudios Transversales , Humanos
7.
Can J Pain ; 4(1): 168-178, 2020 Aug 13.
Artículo en Inglés | MEDLINE | ID: mdl-33987496

RESUMEN

BACKGROUND: Access to multidisciplinary pain management treatment in Canada is limited, with wait times up to 4 years. Stepped care approaches to mental health treatment have led to substantial reduction and elimination of wait times and may be applicable to chronic pain settings. There is no unifying framework for stepped care chronic pain programs. A systematic review of the efficacy of stepped care in chronic pain management conducted by the Canadian Agency for Drugs and Technologies reported varied results that may be due to heterogeneous stepped care models across facilities. AIM: We propose a unifying framework for multidisciplinary stepped care chronic pain programs and present its application at The Ottawa Hospital Pain Clinic. The Ottawa Hospital stepped care framework is an eight-tiered approach that allows patients the opportunity to decide collaboratively with a health care professional which treatment program will best suit their needs for the management of chronic pain. As levels of stepped care increase, the time and resource commitment to each step will also increase. Treatment is stepped up or down, depending on patient needs. METHOD: This is a descriptive case study. RESULTS: Implementing the interprofessional model of care with the stepped care program has eliminated wait times for access to The Ottawa Hospital Pain Clinic Interprofessional Chronic Pain Management Program and has improved communication between professions of the interprofessional team, resulting in better care for patients. CONCLUSION: More research is needed to further develop and evaluate the clinical efficacy of stepped care to manage chronic pain.


Contexte: L'accès à la prise en charge multidisciplinaire de la douleur au Canada est limité, avec des délais d'attente pouvant aller jusqu'à quatre ans. Les approches de soins de santé mentale par paliers ont donné lieu à une réduction et une élimination des temps d'attente et peut être applicable aux contextes de soins pour la douleur chronique. Il n'existe pas de cadre unificateur pour les programmes de soins par paliers pour la douleur chronique. Un examen systématique de l'efficacit' des soins par paliers dans la prise en charge de la douleur chronique menée par l'Agence canadienne des médicaments et des technologies de la santé a fait état de résultats variés qui peuvent être attribuables à l'hétérogénéité des modèles de soins par paliers dans les vtablissements.Objectifs: Nous proposons un cadre unificateur pour les programmes de soins multidisciplinaires par paliers pour la douleur chronique et présentons son application à la Clinique de la douleur de l'Hôpital d'Ottawa. Le cadre de soins par paliers de l'Hôpital d'Ottawa est une approche à huit niveaux qui donne aux patients la possibilité de décider, en collaboration avec un professionnel de la santé, du programme de traitement qui répondra le mieux à leurs besoins pour la prise en charge de leur douleur chronique. À mesure que les niveaux de soins par paliers augmentent, le temps et les ressources nécessaires à chaque palier augmentent également. Le traitement est intensifié ou réduit, en fonction des besoins du patient.Méthodes: Il s'agit d'une étude de cas descriptive.Résultats: La mise en œuvre du modèle interprofessionnel de soins avec le programme de soins par paliers a éliminé les délais d'attente pour l'accès au programme de prise en charge interprofessionnelle de la douleur chronique de la clinique de la douleur de l'Hôpital d'Ottawa et a amélioré la communication entre les professions de l'équipe interprofessionnelle, ce qui a donné lieu à une meilleure prise en charge des patients.Conclusions: Des recherches supplémentaires sont nécessaires pour développer et évaluer davantage l'efficacité clinique des soins par paliers pour la prise en charge de la douleur chronique.

8.
Psychol Health Med ; 19(3): 303-15, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-23822617

RESUMEN

The relationship between mental health, self-esteem and unemployment is well established. Emerging research suggests that interventions such as Cognitive Behavioural Therapy (CBT) can counter the negative effects of unemployment and may improve re-employment. This study evaluated the effectiveness of a manual-based programme, which combines CBT with job skills training, in improving the psychological health and job- seeking skills of unemployed individuals within the UK. One hundred and nine unemployed individuals, suffering mild to moderate mental health problems, were referred to the programme. Of these, 47 completed the programme and 32 attended follow-up. The impact of the manualised course was evaluated using a randomised control trial with a waiting list control. On completion of the programme, participants showed improvements in mental health, self- esteem and job-search self-efficacy as well as a reduction in the occurrence of negative automatic thoughts. Twenty participants gained employment and improvements persisted at follow-up. Considering the initial levels of psychological distress and mental health problems among the unemployed sample, the need for adequate service provision for the unemployed is recommended.


Asunto(s)
Conducta de Elección , Terapia Cognitivo-Conductual/métodos , Trastornos Mentales/terapia , Autoimagen , Desempleo/psicología , Adulto , Trastornos de Ansiedad/psicología , Trastornos de Ansiedad/terapia , Trastorno Depresivo/psicología , Trastorno Depresivo/terapia , Femenino , Humanos , Masculino , Manuales como Asunto , Trastornos Mentales/psicología , Satisfacción Personal , Autoeficacia , Estrés Psicológico/psicología , Estrés Psicológico/terapia , Resultado del Tratamiento , Reino Unido , Orientación Vocacional/métodos , Listas de Espera
9.
Diabetes Metab Res Rev ; 27(8): 838-43, 2011 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-22069270

RESUMEN

BACKGROUND: The genetic basis of the autoimmune disease type 1 diabetes (T1D) has now been largely determined, so now we can compare these findings with emerging genetic knowledge of disorders and phenotypes that have been negatively or positively associated with T1D historically. Here, we assessed the role in T1D of variants previously reported to be associated with atopic diseases and epithelial barrier function, profilaggrin (FLG), and those that affect the expression levels of the proinflammatory cytokines tumour necrosis factor (TNF)-α, interleukin (IL)-1ß, interferon (IFN)γ and IL-18. METHODS: We genotyped single nucleotide polymorphisms (SNPs): -105/rs28665122 in SELS or SEPS1 (selenoprotein), three single nucleotide polymorphisms in IL18 (-105/rs360717, +183/rs5744292 and +1467/rs574456) and R501X/rs61816761 in FLG, the major locus associated with atopic dermatitis and predisposing to asthma, in a minimum of 6743 T1D cases and 7864 controls. RESULTS: No evidence of T1D association was found for any of the SNPs we genotyped at FLG, SELS or IL18 (p≥0.03), nor with haplotypes of IL18 (p=0.82). Review of previous T1D genome-wide association results revealed that four (human leucocyte antigen (HLA), gasdermin B/ORM1 (Saccharomyces cerevisiae)-like/gasdermin B/, GSDMB/ORMDL3/GSDMA and IL2RB) of ten loci recently reported to be associated with asthma were associated with T1D (p≤0.005). CONCLUSIONS: These results show that there are shared genetic associations for atopy-related traits and T1D, and this might help in the future to understand the mechanisms, pathways and environmental factors that underpin the rapid rise in incidence of both disorders in children.


Asunto(s)
Diabetes Mellitus Tipo 1/genética , Hipersensibilidad Inmediata/genética , Asma/genética , Niño , Diabetes Mellitus Tipo 1/inmunología , Proteínas Filagrina , Predisposición Genética a la Enfermedad , Estudio de Asociación del Genoma Completo , Humanos , Hipersensibilidad Inmediata/inmunología , Interferón gamma/genética , Interleucina-18/genética , Proteínas de Filamentos Intermediarios/genética , Proteínas de la Membrana/genética , Polimorfismo de Nucleótido Simple , Selenoproteínas/genética , Factor de Necrosis Tumoral alfa/genética
10.
J Immunol ; 175(10): 6713-22, 2005 Nov 15.
Artículo en Inglés | MEDLINE | ID: mdl-16272327

RESUMEN

Despite a growing understanding of the role of cytokines in immunity to the parasitic helminth Trichuris muris, the local effector mechanism culminating in the expulsion of worms from the large intestine is not known. We used flow cytometry and immunohistochemistry to characterize the phenotype of large intestinal intraepithelial lymphocytes (IEL) and lamina propria leukocytes (LPL) from resistant and susceptible strains of mouse infected with T. muris. Leukocytes accumulated in the epithelium and lamina propria after infection, revealing marked differences between the different strains of mouse. In resistant mice, which mount a Th2 response, the number of infiltrating CD4+, CD8+, B220+, and F4/80+ IEL and LPL was generally highest around the time of worm expulsion from the gut, at which point the inflammation was dominated by CD4+ IEL and F4/80+ LPL. In contrast, in susceptible mice, which mount a Th1 response, the number of IEL and LPL increased more gradually and was highest after a chronic infection had developed. At this point, CD8+ IEL and F4/80+ LPL were predominant. Therefore, this study reveals the local immune responses underlying the expulsion of worms or the persistence of a chronic infection in resistant and susceptible strains of mouse, respectively. In addition, for the first time, we illustrate isolated lymphoid follicles in the large intestine, consisting of B cells interspersed with CD4+ T cells and having a central zone of rapidly proliferating cells. Furthermore, we demonstrate the organogenesis of these structures in response to T. muris infection.


Asunto(s)
Intestino Grueso/inmunología , Linfocitos/inmunología , Tricuriasis/inmunología , Animales , Linfocitos B/inmunología , Linfocitos T CD4-Positivos/inmunología , Linfocitos T CD8-positivos/inmunología , Mucosa Intestinal/inmunología , Mucosa Intestinal/patología , Intestino Grueso/parasitología , Intestino Grueso/patología , Activación de Linfocitos , Recuento de Linfocitos , Linfocitos/patología , Tejido Linfoide/inmunología , Tejido Linfoide/patología , Masculino , Ratones , Ratones Endogámicos AKR , Ratones Endogámicos BALB C , Especificidad de la Especie , Células TH1/inmunología , Células Th2/inmunología , Tricuriasis/parasitología , Tricuriasis/patología , Trichuris/inmunología , Trichuris/patogenicidad
11.
Artículo en Inglés | MEDLINE | ID: mdl-16167656

RESUMEN

PURPOSE: Hidden camera television documentaries filmed in care home settings have shown evidence of the abuse of vulnerable adults, been widely discussed in the mass media and have brought the attention of the mass population to the importance of these issues. Governmental documents have also emphasised the need to protect vulnerable adults. It is therefore known that vulnerable adults exist and require protection from abuse in any shape or form. However, this paper aims to argue that protecting vulnerable adults and the current mechanisms for encouraging such individuals to make their views known to services are not mutually compatible. The main technique vulnerable adults may use, the complaints procedure, currently may not be sufficient to enable vulnerable adults to express themselves and their anxieties adequately. DESIGN/METHODOLOGY/APPROACH: The paper provides a case study which clearly demonstrates the nature of the problems, and then recognises and describes a number of levels which could be explored to learn more about these issues. RESEARCH LIMITATIONS/IMPLICATIONS: Potential solutions are explored by the authors, who draw conclusions about the need for further research into this area. ORIGINALITY/VALUE: This paper defines a gap between adult protection and complaints procedures, questioning both their efficacy and abilities to meet their stated aims. The paper also highlights that the nature of these may not sufficiently enable complaining vulnerable adults to express their views of services.


Asunto(s)
Abuso de Ancianos/prevención & control , Servicio Social/organización & administración , Anciano , Servicios de Atención de Salud a Domicilio , Humanos , Estudios de Casos Organizacionales , Medicina Estatal , Reino Unido
12.
J Invest Dermatol ; 125(1): 98-107, 2005 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-15982309

RESUMEN

Epidermodysplasia verruciformis (EV)-type human papillomavirus (HPV) DNA have been detected by PCR in squamous cell carcinomas (SCC) from both organ transplant recipients (OTR) and immunocompetent individuals. Their role in skin cancer remains unclear, and previous studies have not addressed whether the viruses are transcriptionally active. We have used in situ hybridization to investigate the transcriptional activity and DNA localization of HPV. EV-HPV gene transcripts were demonstrated in four of 11 (36%) OTR SCC, one of two (50%) IC SCC, and one of five (20%) OTR warts positive by PCR. Viral DNA co-localized with E2/E4 early region gene transcripts in the middle or upper epidermal layers. Non-EV cutaneous HPV gene transcripts were demonstrated in one of five (20%) OTR SCC and four of 10 (40%) OTR warts. In mixed infections transcripts for both types were detected in two of six (33%) cases. Our results provide evidence of EV-HPV gene expression in SCC; although only a proportion of tumors were positive, the similarly low transcriptional activity in warts suggests this is an underestimate. These observations, together with emerging epidemiological and functional data, provide further reason to focus on the contribution of EV-HPV types to the pathogenesis of cutaneous SCC.


Asunto(s)
Carcinoma de Células Escamosas/virología , ADN Viral/aislamiento & purificación , Inmunocompetencia , Huésped Inmunocomprometido , Papillomaviridae/metabolismo , Neoplasias Cutáneas/virología , Carcinoma de Células Escamosas/patología , Epidermodisplasia Verruciforme/patología , Epidermodisplasia Verruciforme/virología , Femenino , Expresión Génica , Humanos , Hibridación in Situ , Masculino , Reacción en Cadena de la Polimerasa , Neoplasias Cutáneas/patología
13.
Artículo en Inglés | MEDLINE | ID: mdl-15974503

RESUMEN

PURPOSE: This article aims to describe the research process, and the development of the instrument now employed in auditing patients' perceptions of quality improvement in a community health care trust in a coastal town in Essex, England. DESIGN/METHODOLOGY/APPROACH: The new instrument is currently being implemented and the findings thus far are described. FINDINGS: The instrument has measured health outcomes in terms of quality improvement from the users' perspective, and has also highlighted gaps between what the service offers in terms of quality and users' perceptions of what is delivered. The study demonstrates the importance of the professional role in quality improvement. ORIGINALITY/VALUE: Patient-centred quality improvement audit should be undertaken regularly so that both non-clinical managers and health care professionals can establish whether or not they are providing services that are patient-friendly and effective from the user's viewpoint. In the course of their work, professionals and managers discuss patients and speak on their behalf in various forums, and knowing what patients actually expect and perceive before speaking on their behalf may be of great benefit in such instances.


Asunto(s)
Auditoría Administrativa , Satisfacción del Paciente/estadística & datos numéricos , Atención Dirigida al Paciente , Gestión de la Calidad Total , Anciano , Inglaterra , Humanos , Encuestas y Cuestionarios
14.
Eur J Pain ; 9(1): 69-78, 2005 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-15629877

RESUMEN

Patients and clinicians sometimes take coping with chronic pain primarily as a process of gaining more control over pain. An alternate approach might include helping the pain sufferer to discriminate parts of their situation that can be effectively controlled from those that cannot. When faced with situations that do not yield to attempts at direct control patients may gain better results from leaving those situations as they are and investing their efforts elsewhere. This study was designed to examine this type of expanded view of coping with pain, a view that includes both attempts at control and acceptance. 200 adults seeking treatment for chronic pain were the subjects of this investigation. They completed a number of self-report inventories including a measure called the Brief Pain Coping Inventory, an inventory assessing accepting responses to pain as well as pain management responses standardly targeted by cognitive-behavioral treatment methods. Preliminary results showed that the BPCI yields scores with adequate temporal consistency and validity. Further results showed that a number of the responses assessed by the BPCI were reliable predictors of patient functioning. In general less frequent struggling to control pain, fewer palliative and avoidant coping responses, and more explicit persistence with activity despite acknowledged pain were associated with less depression and anxiety and greater life functioning. These results demonstrate that, in some instances, attempts at avoidance and control of chronic pain may be less helpful compared with a willingness to experience pain and focus on functioning.


Asunto(s)
Adaptación Psicológica , Dimensión del Dolor/métodos , Dolor/psicología , Encuestas y Cuestionarios/normas , Actividades Cotidianas/psicología , Adulto , Ansiedad/etiología , Ansiedad/psicología , Enfermedad Crónica , Depresión/etiología , Depresión/psicología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Manejo del Dolor , Valor Predictivo de las Pruebas , Reproducibilidad de los Resultados
15.
Artículo en Inglés | MEDLINE | ID: mdl-15552396

RESUMEN

Through a literature review, this paper demonstrates that there is a lack of knowledge about quality management within the mental health services. Ideas about quality from the wider services sector are then discussed, and a case study of a mental health scenario is provided. It is argued that health service generally, and mental health services in particular, have much to gain from becoming more closely aligned with the wider field of knowledge of quality management. Concludes that the wider techniques of managing service quality may prove useful, particularly in mental health services, due to the nature of such services and their inherent variability.


Asunto(s)
Investigación sobre Servicios de Salud , Servicios de Salud Mental/normas , Gestión de la Calidad Total , Bibliometría , Humanos , Estudios de Casos Organizacionales , Publicaciones Periódicas como Asunto
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...