[The chemotherapy problems of staphylococcal sepsis]. / Nekotorye voprosy khimioterapii stafilokokkovogo sepsisa.

The author discusses the problem of chemotherapy of staphylococcal sepsis with consideration of the action mechanism of the drugs used, namely bactericidity and bacteriostatic effect, methods of administration of the drugs. Parenteral administration of chemotherapeutic agents and their combinations proved highly efficient. The value of using immune agents and unspecific drugs is emphasized.

[Improved method of using antibiotics in the nutrient media for isolating Shigella (the 3-band method)]. / Usovershenstvovannyi sposob ispol'zovaniia antibiotikov v pitatel'nykh sredakh dlia vydeleniia shigell (method 3 polosok).

A modified procedure for the use of antibiotics in nutrient media for isolation of Shigella is described. The procedure is designated as the method of 3 strips. It implies introduction of 3 different antibiotics, i. e. levomycetin, streptomycin and one of tetracyclines to definite areas of the nutrient medium in a petri dish. The antibiotics diffuse into the medium from 3 strips of filter paper. The greatest part of the medium contains minor amounts of the antibiotics and is used for isolation of the antibiotics sensitive Shigella strains. The procedure is simple and economic. It excludes the most frequent mistakes due to incorrect selection of antibiotics. The preliminary trials showed that the procedure may be used in the routine studies.

[Increase in novobiocin activity and an expansion of its antimicrobial action spectrum]. / Povyshenie aktivnosti novobiotsina i rasshirenie spektra ego antimikrobnogo deistviia.

It was found that with an increase in the medium acidity (pH 6.0 - 6.2) the antistaphylococcal effect of novobiocin significantly rose and the drug began to inhibit gram-negative bacteria, in particular, P. aeruginosa and Proteus. The method efficacy was demonstrated on a limited number of patients with urological infections caused by P. aeruginosa and increased acidity of the urine (because of cranberry juice use). Wider observations in patients with urological and some other diseases caused by gram-negative bacteria are advisable.

[Sensitivity to chemotherapeutic preparations of microflora isolated in chronic posttraumatic osteomyelitis]. / Chuvstvitel'nost' k khimioterapevticheskim preparatam mikroflory, vydeliaemoi u bol'nykh khronicheskim posttavmaticheskim osteomielitom.

Chronic post-traumatic osteomyelitis was mainly caused (59.3 per cent) by various gramnegative bacteria. Staphylococcus, Proteus and P. aeruginosa was most frequent. Bacteria were most frequently isolated from associations of 2-5 species and not from monocultures. However, when the patient microflora was studied in dynamics, the whole associations could not be detected in every of the cases. Sensitivity of the causative agents to 23 antibacterial drugs was tested and it was found that the majority of the organisms were sensitive to gentamicin, rifampicin, biseptol, hydroxyquinolines (5-NOK, enteroseptol), furazolidon (except P. aeruginosa). P. aeruginosa was in addition sensitive to polymyxin. Proteus and other enterobacteria were sensitive to nevigramon, staphylococci and other grampositive bacteria were sensitive to oxacillin, lincomycin, novobiocin and fusidin.