1.
Electrophoresis
; 28(15): 2675-82, 2007 Aug.
Artículo
en Inglés
| MEDLINE
| ID: mdl-17597468
RESUMEN
This paper deals with the use of Cu(II) complexes of L-tartaric acid or L-threonine as selectors for the chiral separation of drugs containing amino alcohol structure by ligand-exchange CE. Using Cu(II) ions as a complexing agent, a series of sympathomimetics and beta-blockers were resolved. It was found that the resolution strongly depends on selector concentration and pH. The optimum pH for complexation was 12.