A neutral mononuclear rhenium(I) complex with a rare in situ-generated triazolyl ligand for the luminescence "turn-on" detection of histidine.

A rare in situ-generated mononuclear rhenium complex [Re(bpt)(CO)3(NH3)] (1, bpt = 3,5-bis(2-pyridyl)-1,2,4-triazolate) can be used as a "turn-on" luminescent probe for selectively sensing L-histidine against other amino acids. Compound 1 was prepared by reacting Re2(CO)10, 2-cyanopyridine and hydrazine with an in situ formed bpt ligand through cyclization via C-N and N-N couplings with its single-side chelating mode arrayed with respect to the Re center. Compound 1 was highly stable and showed a green light MLCT emission in DMF solution at 507 nm upon excitation at 360 nm. Interestingly, the emission from 1 could be quenched by the addition of metal ions such as Ni2+ and Cu2+ but the emission efficiently recovered with the introduction of histidine. However, histidine could only be selectively detected when a combination of compound 1 and Ni2+ was used. Therefore, the luminescence response of the Ni2+-modified compound 1 could be utilized as a "turn-on" probe for the selective detection of histidine. This work provides a simple method for developing new sensing platforms of a discrete metal complex based on rare in situ generation.

Ring-Opening Polymerization of ε-Caprolactone and Styrene Oxide-CO2 Coupling Reactions Catalyzed by Chelated Dehydroacetic Acid-Imine Aluminum Complexes.

A series of chelated dehydroacetic acid-imine-based ligands L1H~L4H was synthesized by reacting dehydroacetic acid with 2-t-butylaniline, (S)-1-phenyl-ethylamine, 4-methoxylbenzylamine, and 2-(aminoethyl)pyridine, respectively, in moderate yields. Ligands L1H~L4H reacted with AlMe3 in toluene to afford corresponding compounds AlMe2L1 (1), AlMe2L2 (2), AlMe2L3 (3), and AlMe2L4 (4). All the ligands and aluminum compounds were characterized by IR spectra, 1H and 13C NMR spectroscopy. Additionally, the ligands L1H~L4H and corresponding aluminum derivatives 1, 3, and 4 were characterized by single-crystal X-ray diffractometry. The catalytic activities using these aluminum compounds as catalysts for the ε-caprolactone ring-opening polymerization (ROP) and styrene oxide-CO2 coupling reactions were studied. The results show that increases in the reaction temperature and selective solvent intensify the conversions of ε-caprolactone to polycaprolactone. Regarding the coupling reactions of styrene oxide and CO2, the conversion rate is over 90% for a period of 12 h at 90 °C. This strategy dispenses the origination of cyclic styrene carbonates, which is an appealing concern because of the transformation of CO2 into an inexpensive, renewable and easy excess carbon feedstock.

Structural Determination of Ruthenium Complexes Containing Bi-Dentate Pyrrole-Ketone Ligands.

A series of ruthenium compounds containing a pyrrole-ketone bidentate ligand, 2-(2'-methoxybenzoyl)pyrrole (1), have been synthesized and characterized. Reacting 1 with [(η6-cymene)RuCl2]2 and RuHCl(CO)(PPh3)3 generated Ru(η6-cymene)[C4H3N-2-(CO-C6H4-2-OMe)]Cl (2) and {RuCl(CO)(PPh3)2[C4H3N-2-(COC6H4-2-OMe)]} (3), respectively, in moderate yields. Successively reacting 2 with sodium cyanate and sodium azide gave {Ru(η6-cymene)[C4H3N-2-(CO-C6H4-2-OMe)]X} (4, X=OCN; 5, X=N3) with the elimination of sodium chloride. Compounds 2-5 were all characterized by ¹H and 13C-NMR spectra and their structures were also determined by X-ray single crystallography.

Catalytic transfer hydrogenation and anticancer activity of arene-ruthenium compounds incorporating bi-dentate precursors.

Ruthenium based organometallic compounds are presently a subject of great attention as anticancer drugs and appear to work reasonably well on tumor cells. We develop a series of mononuclear arene-ruthenium compounds incorporating N,O and N,N bidentate ligands, and their activity as anticancer drugs against human hormone-refractory metastatic prostate cancer (HRMPCs) cell lines are investigated. The ruthenium compounds also act as effective catalysts in the transfer hydrogenation of the -C[double bond, length as m-dash]O- → -CH(OH)- system. Three types of ligands, namely, sodium glutamate, C4H3NH(2-CH2NH(t)Bu), and C4H3NH(2-CH[double bond, length as m-dash]NR) are separately coupled with [(η(6)-cymene)RuCl2]2 () (cymene = 4-isopropyltoluene) to synthesize five Ru-derivatives: [(η(6)-cymene)RuCl(κ(2)-N,O-OOCCHNH2CH2CH2COOH)] (), {(η(6)-cymene)RuCl[C4H3N(2-CH2NH(t)Bu)]} (), {(η(6)-cymene)RuCl[C4H3N(2-CH[double bond, length as m-dash]NCH2Ph)]} (), {(η(6)-cymene)RuCl{C4H3N[2-CH[double bond, length as m-dash]NCH2(C4H7O)]}} () and {(η(6)-cymene)RuCl[C4H3N(2-CH(n)BuNHCH2(C4H7O))]} (). To the best of our knowledge, the aforementioned Ru compounds are not only characterized by (1)H and (13)C NMR spectroscopy, but for the first time their structures have been established by single crystal X-ray diffractometry. Compound influences a concentration-dependent apoptosis in PC-3 cells and initiates the conversion rate in transfer hydrogenation.

Doubly end-on azido bridged mixed-valence cobalt trinuclear complex: Spectral study, VTM, inhibitory effect and antimycobacterial activity on human carcinoma and tuberculosis cells.

Doubly end-on azido-bridged mixed-valence trinuclear cobalt complex, [Co3(L)2(N3)6(CH3OH)2] (1) is afforded by employing a potential monoanionic tetradentate-N2O2 Schiff base precursor (2-[{[2-(dimethylamino)ethyl]imino}methyl]-6-methoxyphenol; HL). Single crystal X-ray structure reveals that in 1, the adjacent Co(II) and Co(III) ions are linked by double end-on azido bridges and thus the full molecule is generated by the site symmetry of a crystallographic twofold rotation axis. Complex 1 is subjected on different spectral analysis such as IR, UV-vis, emission and EPR spectroscopy. On variable temperature magnetic study, we observe that during cooling, the χMT values decrease smoothly until 15K and then reaches to the value 1.56 cm(3) K mol(-1) at 2 K. Complex 1 inhibits the cell growth on human lung carcinoma (A549 cells), human colorectal (COLO 205 and HT-29 cells), and human heptacellular (PLC5 cells) carcinoma cells. Complex 1 exhibits anti-mycobacterial activity and considerable efficacy on Mycobacterium tuberculosis H37Rv ATCC 27294 and H37Ra ATCC 25177 strains.

A mixed valent heterometallic Cu(II)/Na(I) coordination polymer with sodium-phenyl bonds.

A mixed valent heterometallic Cu(II)/Na(I) coordination polymer (1) is generated by the reaction of a Schiff base ligand, (6,6'-(1E,1'E)-(2-hydroxypropane-1,3-diyl)bis(azan-1-yl-1-ylidene)bis(methan-1-yl-1-ylidene)bis(2-methoxyphenol)) with copper(II) acetate and sodium perchlorate. In addition to the presence of alcohol oxygen-sodium coordination bonds, the single crystal X-ray structure reveals that the 1D coordination polymer is stabilised by the formation of phenyl-sodium η2-bonds, face-to-face π-π contacts and Cu-π interactions.

(Azido-κN){(E)-2-[1-(pyridin-2-yl)ethyl-idene-amino]-phenolato-κ(3) N,N',O}copper(II).

In the title complex, [Cu(C13H11N2O)(N3)], the Cu(II) cation is four-coordinated by an N2O donor set of the tridentate Schiff base ligand and by the terminal N atom of the azide anion, forming a slightly distorted square-planar configuration.

{5,5'-Dihydroxy-2,2'-[(2-hydroxypropane-1,3-diyl)bis(nitrilomethanylyli-dene)]diphenolato}nickel(II) dihydrate.

In the title complex, [Ni(C17H16N2O5)]·2H2O, the Ni(II) ion is four-coordinated by two azomethine N and two phenolato O atoms of the tetradentate Schiff base ligand in a slightly distorted square-planar geometry. In the six-membered ring containing the metal, the azomethine N atoms and the three C atoms of the connecting 1,3-di-amino-propane-2-ol, all atoms except the metal are disordered over two sets of sites with an occupacy ratio of 0.566 (3):0.434 (3). The central C atom of the major component is significantly out of the mean plane of the remaing atoms while the conformation of this ring in the minor component is noticeably different. In the crystal, O-H⋯O hydrogen bonds involving the lattice water mol-ecules and the hy-droxy groups are observed.

Di-aqua-{2,2'-dimeth-oxy-6,6'-[(1E,1'E)-propane-1,3-diylbis(aza-nylyl-idene)bis-(methanylyl-idene)]diphenolato}nickel(II).

In the mol-ecule of the title compound, [Ni(C19H20N2O4)(H2O)2], the central Ni(II) ion lies on a mirror plane and is surrounded by an N2O4 coordination set in the form of a distorted octa-hedron defined by the O atoms of two water mol-ecules and by two phenolic O and two imine N atoms of the tetra-dentate Schiff base ligand. In the crystal, O-H⋯O hydrogen bonds between the water mol-ecules and the phenolic and meth-oxy O atoms of neighbouring mol-ecules lead to the formation of rods propagating parallel to [100].

Aluminum complexes incorporating symmetrical and asymmetrical tridentate pincer type pyrrolyl ligands: synthesis, characterization and reactivity study.

A series of aluminum complexes incorporating substituted symmetrical and asymmetrical tridentate pyrrolyl ligands are synthesized conveniently and the treatment of the derivatives with small organic molecules are analyzed. The reaction of lithiated [C4H2NH(2-CH2NH(t)Bu)(5-CH2NR1R2)], where for 1, R1 = R2 = Me; 2, R1 = H, R2 = (t)Bu, with AlCl3 in diethyl ether affords Al[C4H2N(2-CH2NH(t)Bu)(5-CH2NMe2)]Cl2 (3) and Al[C4H2N(2,5-CH2NH(t)Bu)2]Cl2 (4), respectively, in high yields. Furthermore, subjecting 3 and 4 to reaction with one equiv. of LiNMePh in diethyl ether generates Al[C4H2N(2-CH2NH(t)Bu)(5-CH2NMe2)][NMePh]Cl (5) and Al[C4H2N(2,5-CH2NH(t)Bu)2][NMePh]Cl (6), respectively, while eliminating one equiv. of LiCl. The reaction between compound 4 with two equiv. of LiO-Ph-4-Me in diethyl ether yields the aluminum di-phenoxide compound Al[C4H2N(2,5-CH2NH(t)Bu)2](O-Ph-4-Me)2 (7) whereas the combination of 3 and two equiv. of LiNH(t)Bu, produces Al[C4H2N(2-CH2N(t)Bu)(5-CH2NMe2)](NH(t)Bu)(NH2(t)Bu) (8). Additionally, the mixing of 1 and one equiv. of AlMe3 renders Al[C4H2N(2-CH2NH(t)Bu)(5-CH2NMe2)]Me2 (9). Adding one more equiv. of AlMe3 with 9 affords {Al[C4H2N(2-CH2NH(t)Bu)(5-CH2NMe2)AlMe3]Me2} (10), which can also be obtained by treating 1 with two equiv. of AlMe3 directly. The treatment of 9 with one equiv. of 2,6-dimethylphenol in diethyl ether gives the aluminum alkoxide derivative, Al[C4H2N(2-CH2NH(t)Bu)(5-CH2NMe2)](O-C6H3-2,6-Me2)Me (11). Furthermore, the reaction between 9 and one equiv. of 1-ethyl-1-phenyl ketene, initiates the aluminum dimethyl complex Al{C4H2N[2-CH2CEtPh-C(=O)-NH(t)Bu](5-CH2NMe2)}Me2 (12) with a C-N bond breakage and a C-C bond formation. All the Al-derivatives are characterized by (1)H and (13)C NMR spectroscopy and the molecular structures are determined by single crystal X-ray diffractometry in solid state.

Zirconium complexes incorporated with asymmetrical tridentate pincer type mono- and di-anionic pyrrolyl ligands: mechanism and reactivity as catalytic precursors.

The reactions of Zr(NR(2))(4) (1, R = Me; 2, R = Et) with an asymmetrical tridentate pincer type pyrrole ligand precursor [C(4)H(2)NH(2-CH(2)NH(t)Bu)(5-CH(2)NMe(2))] and treatment of the derivatives with either PhNCS or PhNCO have been carried out and characterized. Reacting Zr(NR(2))(4) (1, R = Me; 2, R = Et) with [C(4)H(2)NH(2-CH(2)NH(t)Bu)(5-CH(2)NMe(2))] generates Zr[C(4)H(2)N(2-CH(2)N(t)Bu)(5-CH(2)NMe(2))](NR(2))(2) (3, R = Me; 4, R = Et) in high yield along with the elimination of 2 equiv of dimethylamine or diethylamine, respectively. Interestingly, while changing the solvent from Et(2)O to CH(2)Cl(2), the complex Zr[C(4)H(2)N(2-CH(2)N(t)Bu)(5-CH(2)NMe(2))][C(4)H(2)N(2-CH(2)NH(t)Bu)(5-CH(2)NMe(2))]Cl (5) is produced by undergoing C-Cl bond cleavage. Furthermore, reaction of either 3 or 4 with 1 or 2 equiv of PhNCS or PhNCO yields Zr[C(4)H(2)N(2-CH(2)N(t)Bu)(5-CH(2)NMe(2))](NMe(2))[PhNC(NMe(2))S] (6), Zr[C(4)H(2)N(2-CH(2)N(t)Bu)(5-CH(2)NMe(2))](NEt(2))[PhNC(NEt(2))O] (7) and Zr[C(4)H(2)N(2-CH(2)NH(t)Bu)(5-CH(2)NMe(2))][PhNC(NEt(2))O](3) (8), respectively. All the aforementioned complexes were characterized by (1)H and (13)C NMR spectrometry and the molecular structures of 5, 6, and 8 have been determined by single-crystal X-ray diffractometry. Complexes 4, 5, and 7 initiated the ethylene polymerization in the presence of MAO as the co-catalyst.

End-to-End Thiocyanato-Bridged Helical Chain Polymer and Dichlorido-Bridged Copper(II) Complexes with a Hydrazone Ligand: Synthesis, Characterisation by Electron Paramagnetic Resonance and Variable-Temperature Magnetic Studies, and Inhibitory Effects on Human Colorectal Carcinoma Cells.

The reactions of the tridentate hydrazone ligand, N'-[1-(pyridin-2-yl)ethylidene]acetohydrazide (HL), obtained by condensation of 2-acetylpyridine with acetic hyadrazide, with copper nitrate trihydrate in the presence of thiocyanate, or with CuCl2 produce two distinct coordination compounds, namely a one-dimensional helical coordination chain of [CuL(NCS)] n (1) units, and a doubly chlorido-bridged dinuclear complex [Cu2L2Cl2] (2) (where L=CH3C(O)=N-N=CCH3C5H4N). Single-crystal X-ray structural determination studies reveal that in complex 1, a deprotonated hydrazone ligand L(-) coordinates a copper(II) ion that is bridged to two neighbouring metal centres by SCN(-) anions, generating a one-dimensional helical coordination chain. In complex 2, two symmetry-related, adjacent copper(II) coordination entities are doubly chlorido-bridged, producing a dicopper entity with a Cu⋅⋅⋅Cu distance of 3.402 (1) Å. The two coordination compounds have been fully characterised by elemental analysis, spectroscopic techniques including IR, UV-vis and electron paramagnetic resonance, and variable-temperature magnetic studies. The biological effects of 1 and 2 on the viability of human colorectal carcinoma cells (COLO-205 and HT-29) were evaluated using an MTT assay, and the results indicate that these complexes induce a decrease in cell-population growth of human colorectal carcinoma cells with apoptosis.

Dichlorido{N'-[(pyridin-2-yl)methyl-idene-κN]acetohydrazide-κN',O}copper(II).

In the title compound, [CuCl(2)(C(8)H(9)N(3)O)], the Cu(II) atom has a distorted square-pyramidal CuCl(2)N(2)O coordination geometry. The tridentate acetohydrazide ligand occupies three basal positions, the fourth basal position being defined by a chloride anion at a distance of 2.2116 (6) Å. The second chloride anion is in the apical position and forms a longer Cu-Cl distance of 2.4655 (7) Å. Inter-molecular N-H⋯Cl hydrogen bonds are present in the crystal, leading to the formation of chains along [10[Formula: see text]].

{N'-[1-(2-Pyrid-yl)ethyl-idene-κN]benzo-hydrazidato-κN',O}{N'-[1-(2-pyrid-yl)ethyl-idene-κN]benzohydrazide-κN',O}copper(II) trichloro-acetate.

In the title complex, [Cu(C(14)H(13)N(3)O)(C(14)H(12)N(3)O)](CCl(3)COO), the central Cu(II) ion exhibits a distorted octa-hedral geometry with the two ligands coordinating in an meridional format. The N(4)O(2) ligand environment is defined by two benzoyl O atoms, two pyridyl N atoms and imino N atoms. As evidenced by the bond lengths, the two benzohydrazone ligands exist in distinctively different forms, one of them as a regular neutral ligand and the other as an anionic enolate arising from deprotonation. The much longer Cu-O bond and longer Cu-N bond lengths in the neutral benzohydrazone ligand imply weak ligation in comparison with the anionic enolate form. The acute angles of the five-membered rings cause a significant deviation from a regular octa-hedral geometry.

Aluminium complexes containing bidentate and symmetrical tridentate pincer type pyrrolyl ligands: synthesis, reactions and ring opening polymerization.

A series of aluminium derivatives containing substituted bidentate and symmetrical tridentate pyrrolyl ligands, [C(4)H(3)NH(2-CH(2)NH(t)Bu)] and [C(4)H(2)NH(2,5-CH(2)NH(t)Bu)(2)], in toluene or diethyl ether were synthesized. Their reactivity and application for the ring opening polymerization of ε-caprolactone have been investigated. The reaction of AlMe(3) with one equiv. of [C(4)H(3)NH(2-CH(2)NH(t)Bu)] in toluene at room temperature affords [C(4)H(3)N(2-CH(2)NH(t)Bu)]AlMe(2) (1) in 70% yield by elimination of one equiv. of methane. Interestingly, while reacting AlMe(3) with one equiv. of [C(4)H(3)NH(2-CH(2)NH(t)Bu)] in toluene at 0 °C followed by refluxing at 100 °C, [{C(4)H(3)N(2-CH(2)N(t)Bu)}AlMe](2) (2) has been isolated via fractional recrystalliztion in 30% yield. Similarly, reacting AlMe(3) with two equiv. of C(4)H(3)NH(2-CH(2)NH(t)Bu) generates [C(4)H(3)N(2-CH(2)NH(t)Bu)](2)AlMe (3) in a moderate yield. Furthermore, complex 1 can be transformed to an aluminium alkoxide derivative, [C(4)H(3)N(2-CH(2)NH(t)Bu)][OC(6)H(2)(-2,6-(t)Bu(2)-4-Me)]AlMe (4) by reacting 1 with one equiv. of HOC(6)H(2)(-2,6-(t)Bu(2)-4-Me) in toluene via the elimination of one equiv. of methane. The reaction of AlR(3) with one equiv. of [C(4)H(2)NH(2,5-CH(2)NH(t)Bu)(2)] in toluene at room temperature affords [C(4)H(2)N(2,5-CH(2)NH(t)Bu)(2)]AlR(2) (5, R = Me; 6, R = Et) in moderate yield. Surprisingly, from the reaction of two equiv. of [C(4)H(2)NH(2,5-CH(2)NH(t)Bu)(2)] with LiAlH(4) in diethyl ether at 0 °C, a novel complex, [C(4)H(2)N(2-CH(2)N(t)Bu)(5-CH(2)NH(t)Bu)](2)AlLi (7) has been isolated after repeating re-crystallization. Furthermore, reacting one equiv. of C(4)H(2)NH(2,5-CH(2)NH(t)Bu)(2) with AlH(3)·NMe(3) in diethyl ether generates an aluminium dihydride complex, [C(4)H(2)N(2,5-CH(2)NH(t)Bu)(2)]AlH(2) (8), in high yield. Additionally, treating 8 with one equiv. of HOC(6)H(2)(-2,6-(t)Bu(2)-4-Me) in methylene chloride produces [C(4)H(2)N(2,5-CH(2)NH(t)Bu)(2)][OC(6)H(2)(-2,6-(t)Bu(2)-4-Me)]AlH (9) with the elimination of one equiv. of H(2). The aluminium alkoxide complex 4 shows moderate reactivity toward the ring opening polymerization of ε-caprolatone in toluene.

Synthesis and structural studies of lithium and sodium complexes with OOO-tridentate bis(phenolate) ligands: effective catalysts for the ring-opening polymerization of L-lactide.

A series of lithium and sodium complexes with OOO-tridentate bis(phenolate) ligands have been synthesized and fully characterized. The reaction of 2,2'-dihydroxy-3,3',5,5'-tetrakis[(1-methyl-1-phenyl)ethyl]dibenzyl ether (L(1)-H(2)) with different ratios of (n)BuLi in toluene or tetrahydrofuran (THF) gave [Li(2)(L(1)-H)(2)] (1), [Li(4)L(1)(2)] (2), and [Li(2)L(1)(THF)(3)] (3), respectively. Similarly, [Na(L(1)-H)(THF)] (4), [Na(2)(L(1)-H)](2) (5), and [Na(4)L(1)(2)] (6) were prepared by the reaction of L(1)-H(2) and NaN[Si(CH(3))(3)](2) or sodium metal. In addition, the reaction of 2,2'-dihydroxy-3,3',5,5'-tetra-tert-butyldibenzyl ether (L(2)-H(2)) with (n)BuLi in toluene or THF yields Li(2)(L(2)-H)(2)] (7) and [Li(2)(L(2)-H)(2)(THF)(2)] (8), respectively. Further treatment of 7 with 2 mol equiv of benzyl alcohol provides [Li(2)(L(2)-H)(2)(BnOH)(2)] (9). Complexes 1-4 and 6-9 have been structurally characterized by single-crystal X-ray analysis. The dinuclear nature of complexes 1 and 3 was confirmed from their molecular structure. Complexes 2 and 6 illustrate tetranuclear species; however, complex 4 shows a mononuclear feature. A p-π interaction exists from the phenyl ring of the 2-(methyl-1-phenylethyl) groups to the central metal in complexes 2, 4, and 6, which could effectively stabilize the metal center. Among them, complexes 1, 2, and 5-9 displayed efficient catalytic behavior for the ring-opening polymerization of L-lactide in the presence of benzyl alcohol. Experimental results indicate that among these alkali-metal complexes, the sodium compound 6 displays a rapid catalytic polymerization of L-lactide in "living" fashion, yielding poly(L-lactide) with a controlled molecular weight and narrow polydispersity indices for a wide range of monomer-to-initiator ratios.

Azido-(benzoyl-acetonato-κO,O')[1-phenyl-3-(2-pyridylmethyl-imino)but-1-en-1-olato-κN,N',O]cobalt(III).

In the title complex, [Co(C(16)H(15)N(2)O)(C(10)H(9)O(2))(N(3))], the Co(II) atom adopts an octa-hedral coordination geometry by a tridentate Schiff base, a bidentate benzoyl-acetonate and an azide ligand. The imine N atom of the tridentate ligand is trans to the benzoyl O atom of the bidentate ligand and the azide ligand is trans to the acetyl O atom of the bidentate ligand. Non-classical intra-molecular C(ar-yl)-H⋯O hydrogen bonds are present in the structure.

Bis{N'-[1-(2-pyrid-yl)ethyl-idene-κN]benzohydrazidato-κN',O}nickel(II).

In the title complex, [Ni(C(14)H(12)N(3)O)(2)], the Ni(II) atom lies at the centre of a distorted octahedron formed by two tridentate hydrazone ligands. Inter-molecular hydrogen bonds of the type C-H⋯X (X = N, O) link the complexes into a two-dimensional network.

Di-µ-azido-bis-({N'-[1-(2-pyrid-yl-κN)ethyl-idene]acetohydrazidato-κN',O}dicopper(II)).

The dimeric title compound, [Cu(2)(C(9)H(10)N(3)O)(2)(N(3))(2)], is located on a crystallographic inversion center. The Cu atom is coordinated by a tridentate anionic hydrazone ligand and two bridging azide ligands in a distorted square-pyramidal coordination geometry. The non-bonding Cu⋯Cu distance is 3.238 (1) Å. Non-classical inter-molecular C-H⋯N hydrogen bonds link the dimers into chains along the c axis.

Dichlorido{N'-[1-(2-pyridin-2-yl)ethyl-idene]acetohydrazide-κN',O}copper(II).

In the title compound, [CuCl(2)(C(9)H(11)N(3)O)], the Cu(II) atom is in a distorted square-pyramidal CuCl(2)N(2)O coordination geometry. The tridentate acetohydrazide ligand chelates in a meridional fashion. The chloride ligand in the axial position forms a long Cu-Cl distance of 2.4892 (9) Å. In contrast, the Cu-Cl distance from the equatorial chloride ligand is much shorter [2.2110 (7) Å]. Inter-molecular N-H⋯Cl and C-H⋯Cl hydrogen bonds link the complexes into a three-dimensional network.