RESUMEN
OBJECTIVE: The purpose of this study was to evaluate the influence of different illuminants on the perceptibility and acceptability of surface gloss variations and to determine limiting values. METHODS: Eight composite resin specimens and one human tooth specimen were polished to obtain composite resin specimens with different gloss units (GU) of 10, 20, 30, 40, 50, 60, 70, and 80 and a human tooth specimen of 80 GU. Sixty observers compared the surface gloss of the specimens in a light booth. For perceptibility testing, the specimens were randomly positioned two at a time. The acceptability of the gloss variation was determined by comparing the composite resin specimens with the tooth specimen. The observers answered specific questions to determine the level and perceptibility and acceptability limits of gloss variations. All analysis was done with two illuminants (D65 and fluorescent light) used randomly. Data were submitted to a nonlinear probit model and nonlinear probit regression estimation (α=0.05). RESULTS: Significant differences in illuminants were observed for perceptibility (p<0.001) and acceptability (p=0.045). The perceptibility limit for D65 was 7.0 GU and 6.8 GU for fluorescent illuminant. The acceptability limit for D65 was 34.2 GU and 37.1 GU for fluorescent illuminant. CONCLUSIONS: More accurate perceptibility and acceptability judgments of the surface gloss of composite resin were made when the specimens were illuminated with D65 light.
Asunto(s)
Resinas Compuestas , Color , Humanos , Ensayo de Materiales , Propiedades de SuperficieRESUMEN
OBJECTIVE: To assess the visual perception of observers regarding perceptibility and acceptability of surface gloss variations of resin composites and to determine the limit of perceptibility and acceptability of gloss variations. METHODS: Eight resin composite specimens and one human tooth specimen were fabricated. The resin specimens were polished to reach a surface gloss, in gloss units (GUs), of 10 GU, 20 GU, 30 GU, 40 GU, 50 GU, 60 GU, 70 GU, and 80 GU, and the human tooth specimen had a surface gloss of 80 GU. Sixty observers were selected to compare the surface gloss of the specimens in a light booth. For the perceptibility assessment, specimens were randomly displayed two at a time. Each observer performed a total of 144 observations. Observers answered two specific questions for determining the level and limit of perceptibility of gloss variations. The acceptability limit of gloss was determined by comparing the resin specimens with the tooth specimen. The observations were performed with dental practice scenarios (illuminant conditions, visualization field, and observers' education). Data were submitted to a nonlinear probit model and nonlinear regression estimation probit (5%). RESULTS: Differences in perceptibility and acceptability were observed for surface gloss variations (ΔGU) (p<0.001). Perceptibility increased with ΔGU (10<20<30<40<50=60=70), while acceptability decreased with ΔGU (0=10>20>30>40>50>60=70). Acceptability and perceptibility limits were 6.4 GU and 35.7 GU, respectively. CONCLUSIONS: Perceptibility and acceptability of surface gloss are influenced by gloss variations. A variation of 6.4 GU was required for 50% of observers to notice gloss variations. Concerning acceptability, observers required a variation of 35.7 GU to consider differences in gloss not acceptable.
Asunto(s)
Resinas Compuestas , Odontología , Estética Dental , Humanos , Ensayo de Materiales , Propiedades de Superficie , Percepción VisualRESUMEN
The consumption of probiotic-enriched dairy products has been associated with many health benefits, including anti-hyperglycemic activity. The effect on health is dependent on the type of probiotic culture used and the dairy product consumed. This study evaluated the effect of different probiotic-enriched dairy matrices (Minas Frescal cheese, Prato cheese, and whey dairy beverage) containing Lactobacillus casei on in vitro and in vivo anti-hyperglycemic activity. For this purpose, in vitro anti-hyperglycemic activity was determined by the inhibition of α-glucosidase and α-amylase activities, and a human study was performed with healthy individuals (n = 15, consumption of bread as a control; bread + Minas Frescal cheese; bread + Prato cheese; bread + dairy beverage) to assess the effects of different probiotic foods on postprandial glycemia. In vitro data showed that Prato cheese presented the highest lipid (36.9 g/100 g) and protein (26.5 g/100 g) contents as well as the highest α-amylase (60.7%) and α-glucosidase (52.6%) inhibition. The consumption of Prato cheese resulted in a lesser increase in blood glucose level (13 mg/dL) compared with the consumption of bread alone (19 mg/dL), Minas Frescal cheese (20 mg/dL), and whey dairy beverage (30 mg/dL), with glycemic indices similar to that observed for the control. The present results demonstrated a good correlation between in vitro and in vivo data, in which the type of dairy matrix affects the anti-hyperglycemic activity. It is concluded that the consumption of probiotic Prato cheese can contribute to the reduction of postprandial glycemia in healthy individuals.
Asunto(s)
Glucemia/metabolismo , Productos Lácteos , Hiperglucemia/prevención & control , Periodo Posprandial , Probióticos , Adulto , Animales , Queso , Femenino , Índice Glucémico , Humanos , Hiperglucemia/sangre , Lacticaseibacillus casei/metabolismo , Masculino , Persona de Mediana Edad , Adulto JovenRESUMEN
Fermented whey dairy beverages are dairy products obtained by fermentation from a mixture of milk and whey. These beverages have important health benefits, which could be improved with the addition of probiotic cultures. This study assessed the protective effect of the cosupplementation of a probiotic culture (Lactobacillus casei 01) with a fermented whey dairy beverage against infection by Salmonella enterica ssp. enterica serovar Typhimurium in a murine model. Two fermented whey dairy beverages were prepared: conventional (FWB; starter culture) and probiotic (PFWB; starter and probiotic cultures). In the first set of experiments, Balb/C female mice were treated with FWB or PFWB, challenged with Salmonella Typhimurium, and analyzed for clinical signs, weight loss, and mortality for 20 d postinfection. In the second set of experiments, mice were treated with FWB or PFWB, challenged with Salmonella Typhimurium, and killed on d 10 postinfection. The liver, colon, and ileum were used for myeloperoxidase, eosinophil peroxidase, and histological analysis and translocation to the liver. The contents from the small intestine were used for secretory IgA determination. The FWB treatment showed a better effect on animal survival (70%), translocation of the pathogen to the liver (2 out of 10), histopathology (fewer lesions), and inflammation than PFWB, which presented 50% animal survival, translocation in 5 out of 10 animals, and higher lesions. The control group presented 40% animal survival, translocation in 6 out of 10 animals, and severe lesions. Therefore, FWB was deemed to have a greater protective effect against Salmonella Typhimurium infection in the murine model compared with PFWB.
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Productos Lácteos Cultivados , Salmonelosis Animal/prevención & control , Salmonella typhimurium , Suero Lácteo , Animales , Bebidas , Femenino , Promoción de la Salud , Inmunoglobulina A Secretora/análisis , Inflamación/prevención & control , Intestino Delgado/inmunología , Intestino Delgado/patología , Lacticaseibacillus casei/fisiología , Hígado/microbiología , Hígado/patología , Ratones , Ratones Endogámicos BALB C , Probióticos , Salmonelosis Animal/inmunología , Salmonelosis Animal/patología , Proteína de Suero de LecheRESUMEN
The sanitary conditions of 13 animal houses in nine public institutions in Minas Gerais, and the presence of endo and ectoparasites of mice and rats colonies kept in these facilities were evaluated. Data about barriers to prevent the transmission of diseases and a program of sanitary monitoring were obtained through a questionnaire and local visit. Parasitological methods were performed for diagnosing mite, lice, helminthes, and protozoa parasites in 344 mice and 111 rats. Data have shown that the majority of the animal houses had neither proper physical environment nor protection barriers to prevent the transmission of infections. Parasitological results have shown that only one animal house (7.7 percent) had parasite free animals, whereas the others have presented infected animals and the prevalences of parasites in the mice colonies were: Myobia musculi (23.1 percent); Myocoptes musculinus (38.5 percent); Radfordia affinis (15.4 percent); Syphacia obvelata (92.3 percent); Aspiculuris tetraptera (23.1 percent); Hymenolepis nana (15.4 percent); Spironucleus muris (46.2 percent); Giardia muris (46.2 percent); Tritrichomonas muris (53.8 percent); Trichomonas minuta (61.5 percent); Hexamastix muris (7.7 percent); and Entamoeba muris (84.6 percent). As for the rat colonies, the prevalences were: Poliplax spinulosa (8.1 percent); Syphacia muris (46.2 percent); Trichosomoides crassicauda (28.6 percent); Spironucleus muris (85.7 percent); Tritrichomonas muris (85.7 percent); Trichomonas minuta (85.7 percent); Hexamastix muris (14.3 percent) and Entamoeba muris (85.7 percent)
Avaliaram-se as condições sanitárias de 13 biotérios de nove instituições públicas do estado de Minas Gerais, bem como a presença de endo e ectoparasitos nos camundongos e ratos criados nesses biotérios. Os dados sobre barreiras contra infecções e sobre o programa de monitoramento sanitário dos animais foram obtidos por meio de um questionário e de visitas aos biotérios. Métodos parasitológicos foram utilizados para o diagnóstico de ácaros, piolhos, helmintos e protozoários em 344 camundongos e 111 ratos. A maioria dos biotérios não possuía espaços físicos adequados nem barreiras de proteção que pudessem impedir a transmissão de infecções. Os resultados parasitológicos mostraram que em apenas um biotério não foram encontrados animais parasitados. A prevalência de parasitos encontrados em camundongos nos outros biotérios foi: Myobia musculi (23,1 por cento), Myocoptes musculinus (38,5 por cento), Radfordia affinis (15,4 por cento), Syphacia obvelata (92,3 por cento), Aspiculuris tetraptera (23,1 por cento), Hymenolepis nana (15,4 por cento), Spironucleus muris (46,2 por cento), Giardia muris (46,2 por cento), Tritrichomonas muris (53,8 por cento), Trichomonas minuta (61,5 por cento), Hexamastix muris (7,7 por cento) e Entamoeba muris (84,6 por cento). E nas colônias de ratos foram encontrados: Poliplax spinulosa (8,1 por cento), Syphacia muris (46,2 por cento), Trichosomoides crassicauda (28,6 por cento), Spironucleus muris (85,7 por cento), Tritrichomonas muris (85,7 por cento), Trichomonas minuta (85,7 por cento), Hexamastix muris (14,3 por cento) e Entamoeba muris (85,7 por cento)
Asunto(s)
Animales , Ratones , Ratas , Animales de Laboratorio/parasitología , Vigilancia SanitariaRESUMEN
The influence of nutritional status and hormonal growth activity on the impaired somatic development of adolescents with the hepatosplenic clinical form of Schistosoma mansoni infection (HS), the intestinal form with high (IH) or low (IL) egg output and non-infected (NI) individuals was evaluated (in Comercinho, Minas Gerais State, Brazil, in 1996-97) by measuring body mass index (BMI), insulin-like growth promoting factor (IGF-I) and its carrier protein (IGFBP-3). BMI, IGF-I and IGFBP-3 concentrations were significantly lower in the HS group compared with the IH and the NI groups, irrespective of age. BMI did not remain associated with the clinical form in the bi-variate model that included IGF-I and BMI or IGFBP-3 and BMI, suggesting that in these groups IGF-I and IGFBP-3 levels were related to the clinical form but independent of nutritional status. It is suggested that physical growth impairment in hepatosplenic S. mansoni infection results from the synergistic action of both hepatic damage and nutritional restriction.
Asunto(s)
Trastornos del Crecimiento/etiología , Proteína 3 de Unión a Factor de Crecimiento Similar a la Insulina/metabolismo , Factor I del Crecimiento Similar a la Insulina/metabolismo , Parasitosis Hepáticas/complicaciones , Estado Nutricional , Esquistosomiasis mansoni/complicaciones , Enfermedades del Bazo/complicaciones , Adolescente , Adulto , Análisis de Varianza , Índice de Masa Corporal , Estudios de Casos y Controles , Niño , Estudios Transversales , Femenino , Trastornos del Crecimiento/metabolismo , Humanos , Parasitosis Hepáticas/metabolismo , Masculino , Recuento de Huevos de Parásitos , Esquistosomiasis mansoni/metabolismo , Enfermedades del Bazo/metabolismoRESUMEN
Under laboratory conditions, latex from Euphorbia splendens has shown promise as a plant molluscicide for control of Biomphalaria species, intermediate hosts for Schistosoma mansoni. The purpose of this study was to evaluate its efficiency under field conditions. Application of filtered latex at 12 ppm to one stream in an endemic rural area in Minas Gerais state, Brazil, in September 1995, did result in a reduction in snail density as compared to an untreated stream but the snail population recovered quickly. However, two applications with a two-week interval of unfiltered E. splendens latex at 5 ppm in November 1996 in the same stream resulted in complete disappearance of B. glabrata and snails did not reappear until the 14th month after the applications. In the control stream, without treatment, the snails were found during all months. Laboratory studies confirmed that unfiltered latex is a more potent molluscicide than filtered latex. Considering the advantages of the latex such as its low toxicity to other aquatic animals and its photobiodegradability, as well as the simple method of application, this natural product is promising as an effective molluscicide.
Asunto(s)
Biomphalaria/efectos de los fármacos , Euphorbiaceae , Extractos Vegetales/farmacología , Esquistosomiasis/prevención & control , Esquistosomicidas/farmacología , Animales , Brasil , Dosificación Letal Mediana , Estudios Longitudinales , Extractos Vegetales/aislamiento & purificación , Esquistosomiasis/transmisión , Estaciones del AñoRESUMEN
This work was carried out with the purpose of determining the prevalence of intestinal parasitoses in the school children of Bambuí, through parasitological examinations (direct and Kato-Katz methods) and reevaluating the snails' breeding places described in the county. Of the 2,091 school children examined, 20.1% had at least one parasitic infection. Giardia lamblia, Entamoeba coli, Ascaris lumbricoides and hookworm are the most frequent parasites, with a prevalence of 6.2%, 6.2%, 4.8% and 1.4%, respectively. The hookworms were significantly more frequent among students from the rural area and in those aged over 14 years, while the prevalence of E. coli was greater in the urban area and the G. lamblia was more frequent in children under 6 years old. Only three children shed eggs of Schistosoma mansoni. The only intermediate host found was Biomphalaria glabrata and none of them was shedding cercariae of S. mansoni. When these data were compared with data from other surveys previously effected in the county, a decline was observed in the prevalence of all parasites. Some hypotheses which may explain this decline are discussed, such as: intense urbanization process and improvement of social-sanitary conditions of the county.
Asunto(s)
Parasitosis Intestinales/epidemiología , Esquistosomiasis/epidemiología , Adolescente , Brasil , Niño , Preescolar , Femenino , Humanos , Lactante , Masculino , Prevalencia , Población Rural , Población UrbanaRESUMEN
The use of questionnaires has been recommended for identifying, at a lower cost, individuals at risk for schistosomiasis. In this study, validity of information obtained by questionnaire in the screening for Schistosoma mansoni infection was assessed in four communities in the State of Minas Gerais, Brazil. Explanatory variables were water contact activities, sociodemographic characteristics and previous treatment for schistosomiasis. From 677, 1474, 766 and 3290 individuals eligible for stool examination in the communities, 89 to 97% participated in the study. The estimated probability of individuals to be infected, if they have all characteristics identified as independently associated with S.mansoni infection, varied from 15% in Canabrava, to 42% in Belo Horizonte, 48% in Comercinho and 80% in São José do Acácio. Our results do not support the hypothesis that a same questionnaire on risk factors could be used in screening for S.mansoni infection in different communities.
Asunto(s)
Tamizaje Masivo , Esquistosomiasis mansoni/epidemiología , Encuestas y Cuestionarios , Agua/parasitología , Adolescente , Brasil/epidemiología , Niño , Enfermedades Endémicas , Femenino , Humanos , Masculino , Análisis Multivariante , Prevalencia , Reproducibilidad de los Resultados , Factores de Riesgo , Salud Rural , Esquistosomiasis mansoni/prevención & control , Sensibilidad y Especificidad , Abastecimiento de AguaRESUMEN
Eighteen patients with acute Schistosoma mansoni infection were followed up for 2 years after treatment with praziquantel or oxamniquine. Cure rates, clinical features, abdominal ultrasonographic findings, and specific humoral responses were determined at 2-, 6-, and 24-month follow-ups. Fourteen patients (77.8%) were considered parasitologically cured. Levels of IgA antibody to soluble egg antigen (SEA) and IgM antibody to keyhole limpet hemocyanin (KLH) became negative or decreased to the cutoff level for chronic infection 2 months after treatment, while levels of IgG antibody to KLH declined between 12 and 24 months after treatment. Levels of IgM and IgG antibodies to saline worm adult protein as well as IgM and IgG antibodies to SEA remained positive during the follow-up period. Discrete lymph node enlargement and hepatomegaly were still present in six of the eight cured children 2 years after treatment, while complete regression was observed in adults. In our group of patients, in addition to presenting with more intense clinical manifestations, children were cured less often and had slower abatement of symptomatology after treatment than adults.
Asunto(s)
Anticuerpos Antihelmínticos/sangre , Schistosoma mansoni/inmunología , Esquistosomiasis mansoni/inmunología , Abdomen/diagnóstico por imagen , Adolescente , Adulto , Factores de Edad , Animales , Antiplatelmínticos/uso terapéutico , Niño , Femenino , Humanos , Lactante , Hígado/diagnóstico por imagen , Ganglios Linfáticos/diagnóstico por imagen , Masculino , Oxamniquina/uso terapéutico , Praziquantel/uso terapéutico , Esquistosomiasis mansoni/diagnóstico por imagen , Esquistosomiasis mansoni/tratamiento farmacológico , UltrasonografíaRESUMEN
Following the positive results obtained regarding the molluscicidal properties of the latex of Euphorbia splendens that were corroborated in laboratory and field tests under restricted conditions, a field study was conducted in experimental streams located in an endemic area. After recording the average annual fluctuations of vectors in three streams, a solution of E. splendens latex at 12 ppm was applied in stream A, a solution of niclosamide at 3 ppm that was applied in stream B and a third stream (C) remained untreated for negative control. Applications of E. splendens and niclosamide resulted in a mortality of 100% among the snails collected in the streams A and B. No dead snails were found in the negative control stream. A monthly follow-up survey conducted during three consecutive months confirmed the return of vectors to both experimental streams treated with latex and niclosamide. This fact has called for a need to repeat application in order to reach the snails that remained buried in the mud substrate or escaped to the water edge, as well as, newly hatched snails that did not respond to the concentration of these molluscicides. Adults snails collected a month following treatment led us to believe that they had migrate from untreated areas of the streams to those previously treated.
Asunto(s)
Látex/administración & dosificación , Látex/farmacología , Moluscocidas , Esquistosomiasis/epidemiología , Animales , Biomphalaria , Brasil/epidemiología , Femenino , Humanos , MasculinoRESUMEN
BACKGROUND: Schistosomiasis (Schistosoma mansoni) is classically described as a rural disease that occurs in areas with poor sanitary conditions. This cross-sectional study was undertaken in a suburban area of a large industrialized city in Brazil (Belo Horizonte), aiming at examining epidemiological characteristics of schistosomiasis in an urban setting. METHODS: A simple random sample of 658/1896 dwellings was selected and 3049/3290 (92.7%) residents were submitted to stool examination. Of 518 eligible infected cases and 518 uninfected controls, 87.1% and 89.9% participated in the study, respectively. RESULTS: The prevalence of S. mansoni infection was 20%, predominantly low egg counts in stools; no cases of splenomegaly were found. Signs and symptoms associated with infection were bloody stools (odds ratio [OR] = 8.0) and hardened palpable liver at the middle clavicular and at the middle sternal life (OR = 5.5 and 8.0 respectively). Sociodemographic variables and water contacts predictive of infection were age (10-19 and > or = 20 yrs; OR = 7.1 and 3.3, respectively), gender (male; OR = 3.1), contacts for swimming and/or playing (twice a month or less and more than twice a month; OR = 2.2 and 3.0, respectively) and residence in Belo Horizonte (born in the City; OR = 2.5). Ninety per cent of dwellings had a piped water supply; no association between water supply and infection was found. CONCLUSION: Our results emphasize the need for schistosomiasis control measures focusing on water contacts for leisure purposes in this industrialized urban area.
PIP: During 1991-1992 in the Gorduras district of Belo Horizonte, the capital of Minas Gerais State in Brazil, data on 451 persons over 2 years old who carried Schistosoma mansoni eggs, as detected on at least 1 of 4 slides, were compared with data on 465 same-age persons who were free of such eggs to describe the epidemiology of schistosomiasis in this urban area. The schistosome host, Biomphalaria glabrata, was present at all 11 monitored points along streams. Snails infected with S. mansoni were found at 6 points. Sewerage was entering the streams at 2 points. 92.7% of households had a piped water supply. 89.4% had a sewerage system. 20% of the 3049 sampled peoples had schistosomiasis. The geometric mean of S. mansoni eggs stood at 70.8 eggs/gram. Only 4.7% of persons infected with S. mansoni eggs had bloody stools. Less than 3% had a hardened enlarged liver. No one had splenomegaly or splenectomy. Signs and symptoms independently associated with S. mansoni infection included bloody stools (odds ratio [OR] = 8), palpable hardened liver at the middle clavicular line (OR = 5.5), and palpable hardened liver at the middle sternal line (OR = 8). Sociodemographic variables and reasons for water contact independently associated with S. mansoni infection were age (OR = 7.1 for 10-19 years; OR = 3.3 for =or + 20 years), being male (OR = 3.1), swimming and/or playing in water (OR = 2.2 for =or- 2 times/month; OR = 3 for 2 times/month), and living in Belo Horizonte (OR = 2.5). There was no association between infection and water supply. These findings suggest a need for schistosomiasis control measures centering on water contacts for leisure in this area.
Asunto(s)
Schistosoma mansoni/aislamiento & purificación , Esquistosomiasis mansoni/epidemiología , Adolescente , Adulto , Animales , Ascaris lumbricoides/aislamiento & purificación , Brasil/epidemiología , Niño , Preescolar , Estudios Transversales , Demografía , Heces/parasitología , Femenino , Humanos , Masculino , Morbilidad , Recuento de Huevos de Parásitos , Prevalencia , Factores de Riesgo , Esquistosomiasis mansoni/diagnóstico , Esquistosomiasis mansoni/etiología , Conducta Social , Trichuris/aislamiento & purificación , Población Urbana , Agua/parasitologíaRESUMEN
In this study, the results obtained in a control programme of schistosomiasis in Ravena (Sabará, Minas Gerais) between 1980 and 1992 are evaluated. Control measures used in this programme were: specific treatment of the people infected with Schistosoma mansoni at four year-intervals (1980/84/88) and the supply of tap water to 90% of the residences in 1980. A significant reduction of the prevalence (36.7% to 11.5%, p < or = 0.05) and of the intensity of the infection (228.9 eggs per gram of feces (epg), s = 3.7 to 60.3 epg, s = 3.5, p < or = 0.05) was observed. No cases of the severe form of the disease were diagnosed in the area. Factors independently associated with the infection were in 1980 daily sand extraction and the lack of tap water in residences and in 1992 daily sand extraction and fishing and weekly swimming. Concluding, the supply of tap water together with quadrennial treatments significantly diminished both the prevalence and intensity of the S. mansoni infection, with the additional gain of persistent low indices even after four-year intervals between the treatments.
Asunto(s)
Esquistosomiasis mansoni/prevención & control , Abastecimiento de Agua , Brasil/epidemiología , Humanos , Prevalencia , Esquistosomiasis mansoni/tratamiento farmacológico , Esquistosomiasis mansoni/epidemiologíaRESUMEN
A clinical study of 34 previously healthy young patients simultaneously infected in an endemic area of schistosomiasis mansoni is presented, emphasizing the initial phase of the infection. Its intensity was established according to the occurrence, intensity, and duration of the signs and symptoms in order to investigate the possible correlations between the worm burden (estimated by the number of eggs in faeces), the blood eosinophilia and specific levels of IgE (estimated by the area of immediate intradermal reaction), with the clinical manifestations. A significant but low-level association was found between the worm burden and morbidity, suggesting that multiple factors, besides worm burden itself, may contribute to the pathogenesis of the disease.
Asunto(s)
Anticuerpos Antihelmínticos/sangre , Eosinofilia/parasitología , Inmunoglobulina E/sangre , Recuento de Huevos de Parásitos , Schistosoma mansoni/inmunología , Esquistosomiasis mansoni/inmunología , Esquistosomiasis mansoni/parasitología , Enfermedad Aguda , Adolescente , Adulto , Animales , Heces/parasitología , Humanos , Personal Militar , Esquistosomiasis mansoni/sangre , Índice de Severidad de la Enfermedad , Pruebas CutáneasRESUMEN
O efeito da cor da morbidade associada ao Schistosoma mansoni foi estudado em duas areas endemicas situadas no Estado de Minas Gerais, Brasil. Dos 2773 habitantes elegiveis, 1971 (71,1 por cento) participaram do estudo: 545 (27,6 por cento) foram classificados como brancos, 719 (36,5 por cento) como intermediarios e 707 (35,9 por cento) como negros. Os sinais e sintomas dos individuos que eliminavam ovos de S. mansoni nas fezes (casos) foram comparados aos daqueles que nao apresentavam ovos do parasita neste exame (controles). As razoes de chance foram ajustadas por idade, genero, tratamento anterior para a esquistossomose, area endemica e qualidade do domicilio. Nao houve evidencia de um efeito modificador da cor para a ocorrencia de diarreia, sangue nas fezes ou dor abdominal. Um efeito modificador da cor foi evidente entre aqueles com maiores contagens de ovos nas fezes (>=400opg), no que se refere a hepatomegalia: as razoes de chance foram menores entre individuos classificados como negros (5,4 e 6,5 para presenca de figado palpavel nas linhas hemiclavicular e metodo esternal, respectivamente) e maiores entre aqueles classificados como brancos...
Asunto(s)
Humanos , Esquistosomiasis mansoni/epidemiología , Signos y Síntomas , Brasil , Morbilidad , Recuento de Huevos de Parásitos , Esquistosomiasis mansoni/complicaciones , Esquistosomiasis mansoni/parasitologíaRESUMEN
The effect of the colour group on the morbidity due to Schistosoma mansoni was examined in two endemic areas situated in the State of Minas Gerais, Brazil. Of the 2773 eligible inhabitants, 1971 (71.1%) participated in the study: 545 (27.6%) were classified as white, 719 (36.5%) as intermediate and 707 (35.9%) as black. For each colour group, signs and symptoms of individuals who eliminated S.mansoni eggs (cases) were compared to those who did not present eggs in the faeces (controls). The odds ratios were adjusted by age, gender, previous treatment for schistosomiasis, endemic area and quality of the household. There was no evidence of a modifier effect of colour on diarrhea, bloody faeces or abdominal pain. A modifier effect of colour on hepatomegaly was evident among those heaviest infected (> or = 400 epg): the adjusted odds ratios for palpable liver at the middle clavicular and the middle sternal lines were smaller among blacks (5.4 and 6.5, respectively) and higher among whites (10.6 and 12.9) and intermediates (10.4 and 10.1, respectively). These results point out the existence of some degree of protection against hepatomegaly among blacks heaviest infected in the studied areas.
Asunto(s)
Sangre Oculta , Grupos Raciales , Esquistosomiasis mansoni/epidemiología , Brasil/epidemiología , Femenino , Humanos , Parasitosis Hepáticas/genética , Masculino , Oportunidad Relativa , Proyectos de Investigación , Esquistosomiasis mansoni/genética , Factores SocioeconómicosRESUMEN
An analysis of 25 individuals simultaneously exposed to cercariae of Schistosoma mansoni showed that morbidity (measured by the clinical/sonographic index) was more severe in patients with high-level egg output, irrespective of age or intensity of water contact. High levels of IgM and IgG antibodies to keyhole limpet hemocyanin and of IgA antibody to soluble egg antigen were documented predominantly during the acute phase of illness. Increased levels of these antibodies and of IgM antibody to soluble egg antigen correlated positively with morbidity after adjustment for age and intensity of water contact.
Asunto(s)
Anticuerpos Antihelmínticos/sangre , Esquistosomiasis mansoni/inmunología , Enfermedad Aguda , Adolescente , Adulto , Animales , Especificidad de Anticuerpos , Brasil/epidemiología , Niño , Heces/parasitología , Femenino , Humanos , Inmunoglobulina A/sangre , Inmunoglobulina G/sangre , Inmunoglobulina M/sangre , Ganglios Linfáticos/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Morbilidad , Schistosoma mansoni/inmunología , Esquistosomiasis mansoni/epidemiología , Esquistosomiasis mansoni/etiología , Ultrasonografía , Agua/parasitologíaRESUMEN
The clinical and radiological pulmonary manifestations in the initial phase of schistosomiasis mansoni were studied in thirty previously healthy individuals who were simultaneously infected. The findings were compared with those concerning a control group and related to possible pathogenetic factors. The respiratory manifestations were of light or of moderate intensity, the dry cough being the most common symptom. The significant radiological alterations were: thickening of bronchial walls and beaded micronodulation, predominantly localized in the lower pulmonary fields. It was observed significant association between wheezing and IgE levels, estimated by the area of immediate intradermal reaction, as well as between the number of blood eosinophils and the occurrence of radiological changes. Moreover, there was correlation between the worm burden and the presence of wheezing, thoracic pain and beaded micronodulation. Thus, the clinical and radiological pulmonary manifestations described are significant part of the initial phase of schistosomiasis mansoni and present the worm burden, eosinophilia and levels of IgE as probable pathogenetic factors.
Asunto(s)
Enfermedades Pulmonares Parasitarias/parasitología , Esquistosomiasis mansoni/parasitología , Adolescente , Adulto , Humanos , Enfermedades Pulmonares Parasitarias/diagnóstico por imagen , Masculino , Recuento de Huevos de Parásitos , Radiografía , Esquistosomiasis mansoni/diagnóstico por imagenRESUMEN
Abdominal ultrasonography was performed on eight children and four adults with acute schistosomiasis mansoni, 12 chronically infected patients, and 12 noninfected individuals from the endemic area, who were paired by age and sex with the acute group. In all acute patients, lymphadenomegaly as well as liver and spleen enlargement were detected. Lymph nodes surrounding the portal vein and the hepatic artery in the hepatic hilus were visualized. In the children, the right lobe of the liver was statistically significantly larger in the acute group than in the noninfected group. The portal and splenic vein diameters were significantly larger in children with acute schistosomiasis than in the chronically infected and negative control groups. The left hepatic lobe and a longitudinal scan of the spleen in acute adult patients were statistically significantly larger than in the chronically infected and negative control groups. Ultrasonography is shown to be a useful tool for the differential diagnosis of acute schistosomiasis mansoni.
Asunto(s)
Esquistosomiasis mansoni/diagnóstico por imagen , Abdomen , Enfermedad Aguda , Adolescente , Adulto , Niño , Femenino , Arteria Hepática/diagnóstico por imagen , Humanos , Hígado/diagnóstico por imagen , Ganglios Linfáticos/diagnóstico por imagen , Masculino , Venas Mesentéricas/diagnóstico por imagen , Vena Porta/diagnóstico por imagen , Bazo/diagnóstico por imagen , Vena Esplénica/diagnóstico por imagen , UltrasonografíaRESUMEN
Os autores relatam um caso de aneurisma subvalvar mitral pós meningite bacteriana aguda, em crianças de cor branca. O aneurisma ventricular surgiu como complicaçäo de uma miopericardite, três semanas após a relaizaçäo de uma pericardiocentese. Foi realizada a resseçäo cirúrgica do aneurisma e a funçäo do ventrículo esquerdo penaneceu inalterada. Säo discutidas as possíveis causas de aneurisma ventricular.