Open, Observational, Single-Arm, Multicenter Study Assessing the Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine for Osteoarthritis Pain Reduction.

Osteoarthritis (OA) is an age-related degenerative joint disease with a great impact on patients' well-being and quality of life. This is an observational, open, single-arm multicenter study aimed to evaluate the effectiveness of a nutritional supplement in patients with knee and/or hip OA. A total of 186 patients were recruited from Spanish centers and received a supplement containing hydrolyzed collagen (3000 mg), chondroitin sulfate (800 mg), glucosamine sulfate (700 mg), turmeric extract (250 mg) and devil's claw (150 mg), once daily during 6 months. The primary outcome was the patients' self-perceived pain in the affected joints measured with a visual analogue scale (VAS). Secondary outcome was the patient's functioning, measured with the Lequesne Functional Index and the Western Ontario and McMaster Universities Arthritis Index (WOMAC). Participants showed a significant reduction in self-perceived pain after 3 (mean reduction ± standard deviation, 1.99 ± 1.05) and 6 months (3.57 ± 1.39) of treatment (p < 0.0001 in both comparisons). Lequesne Functional Index score was significantly reduced at 3 months (3.86 ± 2.94) and at 6 months (6.73 ± 4.30) of treatment (p < 0.0001 in both comparisons). The WOMAC index was also significantly reduced after 3 (14.24 ± 10.04) and 6 months (26.43 ± 17.35) of treatment (p < 0.0001 in both comparisons). Significant reductions in WOMAC subdomains (p < 0.0001 in all comparisons) were observed. No severe adverse events were reported during the study. The main results arising from this study show that this nutritional supplementation can improve OA-related symptoms and physical function with a good safety profile in patients with hip and/or knee OA.

Reconstrucción con aloinjerto tendinoso en rotura crónica de tendón de Aquiles. A propósito de un caso / Reconstruction with allograft tendon in chronic torn of Achilles tendon. A case report

Las rupturas del tendón de Aquiles son cada vez más comunes en los pacientes de edad avanzada que realizan ejercicio físico ocasional. Inicialmente esta lesión puede pasar desapercibida. Tras seis semanas se considera una ruptura crónica y el diagnóstico es complejo pero importante pues este tipo de lesión puede ser invalidante. No existe consenso en el tratamiento de las rupturas crónicas del tendón de Aquiles siendo el tratamiento con aloinjerto tendinoso crioconservado una opción válida en grandes roturas. Presentamos el caso de un paciente con una ruptura crónica del tendón de Aquiles tratada por medio de reconstrucción con aloinjerto crioconservado. Tras tres años de seguimiento el paciente se mantiene asintomático y realizando actividad física. Las puntuaciones de los cuestionarios Mazur y AOFAS mejoraron ostensiblemente

The Achilles tendon ruptures are increasingly common in elderly patients who perform intense physical exercise. Initially this injury may go unnoticed. Once past six weeks is considered a chronic rupture and diagnosis is complex but important because this type of injury is crippling. No consensus exists in the treatment of chronic Achilles tendon ruptures. Treatment with tendon allograft is an option in large tendon ruptures. We report the case of a patient with a chronic Achilles tendon rupture treated with cryopreserved allograft tendon. After three years of follow-up the patient is asymptomatic and doing fitness exercise. The score questionnaires Mazur and AOFAS improved markedly