Mean arterial pressure and the endothelin-1 levels in preeclampsia.

OBJECTIVE: This study aims to determine the correlation between Endothelin-1 levels and mean arterial pressure (MAP) with preeclampsia so that their combination can be used as the predictor of PE in early pregnancy. METHOD: This study used a cross-sectional study with a case-control design carried out in February to June 2020 in several hospitals and health centers in Makassar city, namely Dr. Wahidin Soedirohusodo General Hospital, Hasanuddin University State University Hospital, health center Bara Baraya, health center Mamajang, and health center Antang. Respondents in this study were divided into 37 pregnant women with preeclampsia and 53 pregnant women with normotension. This study's criteria for respondents were 20-35 years old, single pregnancy with > 20 weeks gestational. Data collected included education, body mass index (BMI), parity, the interval of pregnancy, and gestational age. ET-1 levels were determined using th ET-1 Elisa Kit with the ELISA method, and MAP was collected by measuring blood pressure when pregnant women came to health facilities. RESULTS: The mean serum ET-1 levels in the preeclampsia were highest than normotensive with a significant p-value of 0.001 (p<0.05). The MAP in the preeclampsia was highest than normotensive too, with a significant value of p-value 0.001 (p<0.05), and there is a positive correlation between ET-1 and MAP with r=0.34 and p-value 0.001 (p<0.05). CONCLUSION: The combination of ET-1 and MAP can be considered as a prognostic factor to detect PE in early pregnancy.

Comparison of nitric oxide levels, roll over test value, and body mass index in preeclampsia and normotension.

OBJECTIVE: The study aims to compare levels NO, the ROT, and BMI values in preeclampsia and normotension. METHOD: This study was an observational analytical study that combined the draft case-control study and a cross-sectional study (hybrid method) conducted in February-June 2020. This study was conducted in the Hospital Dr. Wahidin Sudirohusodo Makasar, Antang Health Center, Barabaraya Health Center, and Mamajang Health Center. Respondents in this study were pregnant women divided into two groups, 108 mothers with normal pregnancies and 42 mothers with preeclampsia. The criteria of the study respondents were single pregnancies, pregnancy of more than 20 weeks, and the gestational age of 20-35 years old. Data collected includes age, parity, gestational age, pregnancy interval, body mass index (BMI), and education. In addition, Nitric oxide levels are determined using Elisa Kit, and roll over test is collected by performing blood pressure measurements at two different positions. RESULTS: The mean serum NO levels in the preeclampsia 176.43±50.8 and 152.75±51.3 in normotension, and there is a meaningful relationship p=0.012. Mean value of ROT in preeclampsia 23.21±8.54 and 19.63±8.85 in normotension p=0.026. There is a meaningful difference in IMT with preeclampsia p=0.003. CONCLUSION: NO, ROT and BMI are significantly higher in pregnant mothers with preeclampsia than in normal pregnancies.

Factors associated with and mode of delivery in prelabour rupture of membrane at secondary health care.

OBJECTIVE: The study aimed to explore factors associated with prelabor rupture of membrane (PROM) and mode of delivery of PROM at secondary health care. METHODS: It was a retrospective case-control study within a year observational period. Data were collected from medical records at St. Khadijah I Mother and Child Hospital Makassar. RESULTS: There were 4003 samples with 259 cases with PROM. Parity and body mass index (BMI) were factors associated with PROM with p=0.000 and .032 consecutively; among them, BMI was more prominent than parity with OR=2.392, and 95% CI=1.052-5.442. Cesarean section is not associated with PROM, p=.000. CONCLUSION: Primigravidae and obesity were factors associated with PROM, and BMI was more strongly associated with PROM than parity. PROM is not an indication for cesarean section.

Mean arterial pressure and the endothelin-1 levels in preeclampsia

Objective: This study aims to determine the correlation between Endothelin-1 levels and mean arterial pressure (MAP) with preeclampsia so that their combination can be used as the predictor of PE in early pregnancy. Method: This study used a cross-sectional study with a case-control design carried out in February to June 2020 in several hospitals and health centers in Makassar city, namely Dr. Wahidin Soedirohusodo General Hospital, Hasanuddin University State University Hospital, health center Bara Baraya, health center Mamajang, and health center Antang. Respondents in this study were divided into 37 pregnant women with preeclampsia and 53 pregnant women with normotension. This study's criteria for respondents were 20–35 years old, single pregnancy with > 20 weeks gestational. Data collected included education, body mass index (BMI), parity, the interval of pregnancy, and gestational age. ET-1 levels were determined using th ET-1 Elisa Kit with the ELISA method, and MAP was collected by measuring blood pressure when pregnant women came to health facilities. Results: The mean serum ET-1 levels in the preeclampsia were highest than normotensive with a significant p-value of 0.001 (p < 0.05). The MAP in the preeclampsia was highest than normotensive too, with a significant value of p-value 0.001 (p < 0.05), and there is a positive correlation between ET-1 and MAP with r = 0.34 and p-value 0.001 (p < 0.05). Conclusion: The combination of ET-1 and MAP can be considered as a prognostic factor to detect PE in early pregnancy. (AU)

Comparison of nitric oxide levels, roll over test value, and body mass index in preeclampsia and normotension

Objective: The study aims to compare levels NO, the ROT, and BMI values in preeclampsia and normotension. Method: This study was an observational analytical study that combined the draft case–control study and a cross-sectional study (hybrid method) conducted in February–June 2020. This study was conducted in the Hospital Dr. Wahidin Sudirohusodo Makasar, Antang Health Center, Barabaraya Health Center, and Mamajang Health Center. Respondents in this study were pregnant women divided into two groups, 108 mothers with normal pregnancies and 42 mothers with preeclampsia. The criteria of the study respondents were single pregnancies, pregnancy of more than 20 weeks, and the gestational age of 20–35 years old. Data collected includes age, parity, gestational age, pregnancy interval, body mass index (BMI), and education. In addition, Nitric oxide levels are determined using Elisa Kit, and roll over test is collected by performing blood pressure measurements at two different positions. Results: The mean serum NO levels in the preeclampsia 176.43 ± 50.8 and 152.75 ± 51.3 in normotension, and there is a meaningful relationship p = 0.012. Mean value of ROT in preeclampsia 23.21 ± 8.54 and 19.63 ± 8.85 in normotension p = 0.026. There is a meaningful difference in IMT with preeclampsia p = 0.003. Conclusion: NO, ROT and BMI are significantly higher in pregnant mothers with preeclampsia than in normal pregnancies. (AU)

Factors associated with and mode of delivery in prelabour rupture of membrane at secondary health care

Objective: The study aimed to explore factors associated with prelabor rupture of membrane (PROM) and mode of delivery of PROM at secondary health care. Methods: It was a retrospective case-control study within a year observational period. Data were collected from medical records at St. Khadijah I Mother and Child Hospital Makassar. Results: There were 4003 samples with 259 cases with PROM. Parity and body mass index (BMI) were factors associated with PROM with p = 0.000 and .032 consecutively; among them, BMI was more prominent than parity with OR = 2.392, and 95% CI = 1.052–5.442. Cesarean section is not associated with PROM, p = .000. Conclusion: Primigravidae and obesity were factors associated with PROM, and BMI was more strongly associated with PROM than parity. PROM is not an indication for cesarean section. (AU)