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Nephrology (Carlton) ; 24(7): 696-702, 2019 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-30146772

RESUMEN

AIM: To investigate if calcification and intimal media thickness (IMT) of arteries are present in children and adolescents with end-stage renal disease and to describe the risk factors associated with these alterations. METHODS: In an observational, cross-sectional prospective study, 68 patients were evaluated at the time of renal transplantation. A fragment of the inferior epigastric artery was removed during surgery for histopathological analysis to verify the presence or not of arterial calcification. Two outcomes were considered: the presence of calcium deposition and the measurement of the IMT of the artery. The potential exposure variables were: age, chronic kidney disease aetiology, diagnosis time, systolic blood pressure (SBP), use of oral active vitamin D, homocysteine and C-reactive protein. RESULTS: No arterial calcification was observed in the studied sample. The median value of the IMT of the inferior epigastric artery was 166 µm (interquartile range = 130-208). SBP standard deviation score and age were the only factors associated with this outcome. There was no statistical interaction between SBP and age with the IMT (P = 0.280). CONCLUSION: Arterial calcification is rare in children and adolescents with end-stage renal disease. The factors associated with IMT were age and SBP.


Asunto(s)
Fallo Renal Crónico/complicaciones , Calcificación Vascular/etiología , Adolescente , Factores de Edad , Niño , Estudios Transversales , Femenino , Humanos , Masculino , Estudios Prospectivos , Sístole , Túnica Íntima/patología , Túnica Media/patología
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