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1.
Int Ophthalmol ; 44(1): 160, 2024 Mar 27.
Artículo en Inglés | MEDLINE | ID: mdl-38536560

RESUMEN

PURPOSE: To compare anterior chamber angle (ACA) parameters measured by Anterior Segment Optical Coherence Tomography (ASOCT) and biometric parameters measured by Swept-Source (SS) OCT-based biometry among patients with suspected occludable angles and open angles. METHODS: An analytical, cross-sectional study was performed on subjects attending our ophthalmology outpatient department with suspected occludable angles (van Herick grades 0, 1, and 2) in group 1, and with open angles (van Herick grades 3 and 4) in group 2. Each subject underwent a complete ophthalmic examination to exclude any intraocular pathology like cataract. We recruited 128 eyes of 64 subjects, 34 in group 1 and 30 in group 2. Each eye was henceforth subjected to ASOCT (Spectralis, Heidelberg Engineering, Heidelberg) and SS-OCT-based optical biometry (IOL Master 700, Carl Zeiss Meditec AG). Anatomical parameters were recorded and compared between the two groups. RESULTS: The main outcome measures of the study included nine ASOCT parameters (central corneal thickness [CCT], lens vault, AOD750, ACA, TISA750 [nasal and temporal], and ACW) and five optical biometric parameters (CCT, ACD, WTW, LT, and axial length). We found a significant difference (p < 0.05) among all the anatomical parameters between the two groups, except CCT which was not significantly different (p = 0.297). CONCLUSIONS: ASOCT and SSOCT biometry overcome the challenges of gonioscopy and allow screening for angle closure disease in otherwise normal subjects. ASOCT may serve as an alternative to gonioscopy as it clearly separates occludable angles from open angles in a non-invasive and objective manner.


Asunto(s)
Glaucoma de Ángulo Cerrado , Tomografía de Coherencia Óptica , Humanos , Tomografía de Coherencia Óptica/métodos , Estudios Transversales , Presión Intraocular , Glaucoma de Ángulo Cerrado/diagnóstico , Glaucoma de Ángulo Cerrado/patología , Cámara Anterior/diagnóstico por imagen , Cámara Anterior/patología , Biometría , Gonioscopía , Segmento Anterior del Ojo/diagnóstico por imagen , Segmento Anterior del Ojo/patología
2.
Indian J Ophthalmol ; 72(2): 190-194, 2024 Feb 01.
Artículo en Inglés | MEDLINE | ID: mdl-38099361

RESUMEN

PURPOSE: There has been a sudden increase in the number of rhino-orbital mucormycosis cases, primarily affecting patients recovering from COVID-19 infection. The local health authorities have declared the current situation an epidemic. In this study, we assess the role of exenteration in preventing disease progression and improving survival in patients with rhino-orbital mucormycosis. METHODS: The patients undergoing exenteration were grouped into the exenteration arm and those denying exenteration were grouped into the nonexenteration arm. The patients were followed at 1 month and 3 months. The 6-month survival data were collected telephonically. Continuous data were presented as Mean ± SD/Median (IQR) depending on the normality distribution of data, whereas the frequency with percentages was used to present the categorical variables. Kaplan-Meier survival curves were created to estimate the difference in survival of patients with exenteration in rhino-orbital mucormycosis versus those without exenteration. RESULTS: A total of 14 patients were recruited for our study based on the inclusion and exclusion criteria. All the patients were qualified for exenteration; however, only eight patients underwent exenteration and six patients did not consent to exenteration. At the end of 3 months in the exenteration group, four (50%) patients died. Two patients died within a week of exenteration, whereas two patients died after 2 weeks of exenteration. The deaths in the first week were attributed to septic shock and the deaths happening beyond 2 weeks were attributed to severe meningitis. The Kaplan-Meier survival analysis showed the cumulative probability of being alive at 1 month in the exenteration arm to be 85%, and it decreased to 67% by 53 days and subsequently remained stable until the end of 3 months. CONCLUSION: The Kaplan-Meier survival analysis did not show a survival benefit of exenteration at 3 months and 6 months in COVID-associated rhino-orbital mucormycosis.


Asunto(s)
COVID-19 , Oftalmopatías , Infecciones Fúngicas del Ojo , Mucormicosis , Enfermedades Orbitales , Humanos , Mucormicosis/complicaciones , Mucormicosis/diagnóstico , Mucormicosis/cirugía , Enfermedades Orbitales/diagnóstico , Enfermedades Orbitales/cirugía , Enfermedades Orbitales/tratamiento farmacológico , Infecciones Fúngicas del Ojo/tratamiento farmacológico , COVID-19/complicaciones , Antifúngicos/uso terapéutico
3.
Indian J Ophthalmol ; 71(1): 249-256, 2023 01.
Artículo en Inglés | MEDLINE | ID: mdl-36588245

RESUMEN

Purpose: To report the clinico-demographic profile of rhino-orbito-cerebral mucormycosis (ROCM) in patients during the "second wave" of the COVID-19 pandemic in eastern India, and their ophthalmic manifestations at presentation to our tertiary institute. Methods: Cross-sectional study amongst patients presenting to our center based on their hospital records. Demographic information, history related to COVID-19, records of detailed ocular examination, and microbiological, radiological, and histopathological investigation were entered into an online worksheet and analyzed using SPSS 26.0. Results: A total of 219 patients with ROCM were treated from May to September 2021, and 110 of these had ocular manifestations at presentation (50.2%). The age of patients ranged from 22 to 83 years and the mean ± standard deviation (SD) age was 49.9 ± 12.9 years. Ninety (81.8%) patients had been diagnosed with diabetes mellitus, 31 (34%) had hypertension, and 10 had other comorbidities. The duration between the onset of COVID-19 and mucormycosis symptoms was 0 to 60 days with a mean ± SD interval of 20.9 ± 12.6 days. Fifty-six (50.9%) patients had a history of steroid use. Unrelenting ocular or facial pain was the most common presenting symptom, ptosis was the most common anterior segment manifestation, and ophthalmic artery occlusion was the most common posterior segment manifestation. Conclusion: Our data from eastern India reinforces the relationship between COVID-19, diabetes, corticosteroid use, and ROCM. Knowledge of various presenting anterior and posterior segment manifestations of the disease as described in the present study will guide clinicians to recognize the disease early and make every effort to prevent complications.


Asunto(s)
COVID-19 , Mucormicosis , Enfermedades Orbitales , Humanos , Adulto Joven , Adulto , Persona de Mediana Edad , Anciano , Anciano de 80 o más Años , Mucormicosis/diagnóstico , Mucormicosis/epidemiología , Estudios Transversales , Centros de Atención Terciaria , Pandemias , COVID-19/complicaciones , COVID-19/epidemiología , Factores de Riesgo
4.
FEMS Microbiol Lett ; 206(1): 39-43, 2002 Jan 02.
Artículo en Inglés | MEDLINE | ID: mdl-11786254

RESUMEN

An in vitro system using Ri T-DNA transformed carrot roots as the host bearing simultaneously different arbuscular mycorrhizal (AM) fungi belonging to two genera Glomus intraradices (Smith and Schenck) and Gigaspora margarita (Becker and Hall) was developed. Co-existence appeared healthy and harmonious, as both the generic species showed extensive hyphal proliferation and sporulation. The co-culture model under the in vitro system appears especially appropriate for further investigations on the competition and on the interaction mechanism involved in such types of associations occurring in nature and also as a model approach towards mass production of multiple mycorrhizal fungal isolates. This is a first report of successful co-culture of two genera of AM fungi under in vitro conditions.


Asunto(s)
ADN Bacteriano/genética , Daucus carota/microbiología , Hongos/crecimiento & desarrollo , Raíces de Plantas/microbiología , Medios de Cultivo , Daucus carota/genética , Daucus carota/crecimiento & desarrollo , Técnicas Microbiológicas , Raíces de Plantas/genética , Raíces de Plantas/crecimiento & desarrollo , Esporas Fúngicas/crecimiento & desarrollo , Simbiosis , Transformación Genética
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