RÉSUMÉ
PURPOSE: To explore the use of autologous astigmatic lenticule reshaping and rotation surgery to correct high astigmatism in conjunction with excimer laser technology to correct residual refractive error. METHODS: Six patients with high astigmatism (8 eyes, all with astigmatism from -5.50 to -11.00 diopters [D]) seeking refractive error correction were enrolled. The following methods were used to correct refractive errors that could not be corrected by a single conventional surgery: (1) cutting of a customized lens using FLEx technology, (2) lifting of the corneal flap and reshaping the autologous astigmatic lenticule in situ using an excimer laser, and (3) rotation of the autologous astigmatic lenticule by 90°. Uncorrected distance visual acuity, subjective refraction, corneal topography, and anterior segment optical coherence tomography were performed preoperatively and postoperatively. RESULTS: The efficacy and safety indices at 6 months postoperatively were 0.93 ± 0.18 and 1.06 ± 0.11, respectively, the spherical equivalent remained stable and close to emmetropia (-0.13 ± 0.70 D) from 1 to 6 months postoperatively, postoperative astigmatism was generally mildly undercorrected (-1.22 ± 0.43 D), and the difference in corneal curvatures at 2 mm from the apex of the cornea was significantly reduced compared to preoperatively (P < .05); however, the corresponding values at 1 and 3 mm showed no difference. CONCLUSIONS: Correction of high astigmatism with autologous astigmatic lenticule reshaping and rotation surgery is tissue-sparing, predictable, and significantly improves postoperative visual acuity and quality. This method is feasible and safe, with predictability requiring further study. This novel surgical approach has potential for patients with high astigmatism that cannot be corrected by conventional refractive surgery. [J Refract Surg. 2024;40(8):e554-e561.].
Sujet(s)
Astigmatisme , Stroma de la cornée , Topographie cornéenne , Lasers à excimères , Réfraction oculaire , Lambeaux chirurgicaux , Tomographie par cohérence optique , Acuité visuelle , Humains , Astigmatisme/physiopathologie , Astigmatisme/chirurgie , Acuité visuelle/physiologie , Réfraction oculaire/physiologie , Lasers à excimères/usage thérapeutique , Mâle , Stroma de la cornée/chirurgie , Adulte , Femelle , Jeune adulte , Rotation , Adulte d'âge moyen , Kératomileusis in situ avec laser excimère/méthodesRÉSUMÉ
Purpose: The purpose of this study was to explore the optimal shape of customized lenticules for stromal lenticule addition keratoplasty (SLAK) for off-centered ectasia. Methods: Two different methods to create ex vivo models of eccentric-keratoconus were investigated. Twelve human corneas were used to create model 1 by a hyperopic photorefractive keratectomy (PRK), and model 2 by masked phototherapeutic keratectomy (PTK) on the anterior corneal surface, whereas both types received myopic ablation of the posterior surface. Keratoconus models underwent a modified femtosecond laser (FSL) flap-cut to create stromal pockets. Sixteen human corneas underwent FSL dissection to obtain four lenticule types: type I (planar) and type II (negative) lenticules were used without modifications, whereas type III (customized-planar), and type IV (customized-negative) lenticules underwent further masked-PRK to obtain an asymmetric bow-tie shape. Topographic, aberrometric analysis, and anterior segment optical coherence tomography (AS-OCT) were performed in all recipient corneas before and after lenticule implantation. Results: Keratoconus model was successfully reproduced. Tomographic analysis showed a significant inferiorly decentered corneal steepening with coherent stromal thinning. Model 2 reproduced better the curvature of real keratoconus. Lenticules type I implantation induced a homogeneous corneal thickening, type III produced higher thickening in the inferior half of the cornea. Type II determined a maximal peripheral pachymetric increase, with a gradual reduction toward the center, and type IV presented an asymmetric peripheral thickening. Topographic assessment showed a cone apex flattening in all cases, but it was significantly higher in types II and IV. Customized lenticules improved significantly corneal surface regularity regarding types I and II. Conclusions: The approach of customizing lenticules by increasing their asymmetry and tailoring the re-shaping effects, may improve SLAK outcomes in eccentric keratoconus.
Sujet(s)
Stroma de la cornée , Topographie cornéenne , Kératocône , Photokératectomie réfractive , Tomographie par cohérence optique , Humains , Stroma de la cornée/chirurgie , Stroma de la cornée/transplantation , Kératocône/chirurgie , Kératocône/physiopathologie , Photokératectomie réfractive/méthodes , Lasers à excimères/usage thérapeutique , Femelle , Mâle , Adulte , Lambeaux chirurgicaux , Aberrométrie , Réfraction oculaire/physiologie , Transplantation de cornée/méthodes , Adulte d'âge moyenRÉSUMÉ
PURPOSE: This study aimed to compare the safety, efficacy, and visual outcomes of 80-microns LASIK versus 100-microns LASIK in managing myopia and myopic astigmatism. The study was conducted at a tertiary care hospital in North India. METHODS: This was a prospective contralateral eye study that included patients with myopia and myopic astigmatism seeking refractive correction. The eligibility criteria included normal corneal topography, an epithelial thickness less than 60 microns, a calculated percentage tissue ablation (with 100-microns flap) less than 40%, a calculated residual stromal bed thickness (with 100-microns flap) more than 300 microns, and willingness to participate and follow up. Patients with glaucoma, cataracts, other visually disabling ocular pathologies, and a history of past ocular surgery were excluded. All patients underwent LASIK with 80-microns LASIK in one eye and 100-microns LASIK in the other eye. The patients were followed up for 6 months, and the results were analyzed. RESULTS: The study included 216 eyes of 108 patients. The mean preoperative spherical equivalent in the 80-microns group and the 100-microns group was -3.53 ± 1.81 and -3.69 ± 1.32 diopters, respectively (P = 0.78). The mean 6 months decimal postoperative UCVA was 0.98 ± 0.13 in the 80-microns group and 0.97 ± 0.14 in the 100-microns group (P = 0.99). The postoperative change in the higher-order aberration profile was comparable in both groups (P = 0.78). The percentage tissue ablation was significantly lower in the 80-microns group (P = 0.002). The incidence of flap micro striae and OBL was higher in the 80-microns group, while neither of these had any visual implications. CONCLUSION: The study concluded that 80-microns LASIK is an efficacious and safe alternative to 100-micron LASIK, especially useful in patients with higher myopia.
Sujet(s)
Astigmatisme , Topographie cornéenne , Kératomileusis in situ avec laser excimère , Lasers à excimères , Myopie , Réfraction oculaire , Lambeaux chirurgicaux , Acuité visuelle , Humains , Kératomileusis in situ avec laser excimère/méthodes , Myopie/chirurgie , Myopie/physiopathologie , Astigmatisme/chirurgie , Astigmatisme/physiopathologie , Études prospectives , Mâle , Femelle , Acuité visuelle/physiologie , Adulte , Réfraction oculaire/physiologie , Études de suivi , Jeune adulte , Lasers à excimères/usage thérapeutique , Résultat thérapeutique , Stroma de la cornée/chirurgieRÉSUMÉ
This case series reports eight eyes with keratoconus treated with laser implantation of one or two segments of progressive thickness corneal intrastromal ring (PT-ICRS). In this case series, it was evident that the insertion of PT-ICRS induces more pronounced corneal flattening at the thickest point, causing a reduction in distortion (coma) and lower astigmatism, resulting in a remarkable improvement in vision. Compared to the implementation of traditional intrastromal rings, the PT-ICRS variant showed superior results despite the small sample size. However, the same degree of asymmetry enhancement was not observed in cases in which a 330° PT-ICRS was implanted, despite the improvement in visual results when replacing a 320° traditional ring with a 330° PT-ICRS. These conclusions are limited as this is a case series with few cases.
Sujet(s)
Stroma de la cornée , Topographie cornéenne , Kératocône , Prothèses et implants , Implantation de prothèse , Acuité visuelle , Humains , Kératocône/chirurgie , Kératocône/diagnostic , Stroma de la cornée/chirurgie , Mâle , Adulte , Femelle , Implantation de prothèse/méthodes , Réfraction oculaire/physiologie , Jeune adulte , Conception de prothèse , Études de suiviSujet(s)
Kératomileusis in situ avec laser excimère , Lasers à excimères , Myopie , Humains , Kératomileusis in situ avec laser excimère/méthodes , Kératomileusis in situ avec laser excimère/effets indésirables , Lasers à excimères/usage thérapeutique , Myopie/chirurgie , Mâle , Stroma de la cornée/chirurgie , Stroma de la cornée/anatomopathologie , Lambeaux chirurgicaux , Adulte , Acuité visuelleRÉSUMÉ
PURPOSE: ReLEx (Refractive Lenticule Extraction) Small Incision Lenticule Extraction (SMILE), the second generation of ReLEx Femtosecond Lenticule Extraction (FLEx), is a minimally invasive, flapless procedure designed to treat refractive errors such as myopia, hyperopia, presbyopia, and astigmatism. This review aims to provide a comprehensive overview of the methods for preserving SMILE-derived lenticules and discusses their potential future applications. METHODS: A narrative literature review was conducted using PubMed, Scopus, and Web of Science databases, focusing on articles published up to January 2024 and available in English. The authors also evaluated the reference lists of the collected papers to identify any additional relevant research. RESULTS: No standardized protocols currently exist for the storage or clinical application of SMILE-derived lenticules. However, these lenticules present a promising resource for therapeutic uses, particularly in addressing the shortage of donor corneal tissues. Their potential applications include inlay and overlay additive keratoplasty, as well as other ocular surface applications. Further research is needed to establish reliable protocols for their preservation and clinical use. CONCLUSION: SMILE-derived lenticules offer significant potential as an alternative to donor corneal tissues. Standardizing their storage and application methods could enhance their use in clinical settings.
Sujet(s)
Stroma de la cornée , Banques des yeux , Humains , Stroma de la cornée/chirurgie , Stroma de la cornée/anatomopathologie , Banques des yeux/méthodes , Transplantation de cornée/méthodes , Chirurgie de la cornée par laser/méthodes , Donneurs de tissus , Lasers à excimères/usage thérapeutique , Réfraction oculaire/physiologieRÉSUMÉ
PURPOSE: To compare early changes in the corneal biomechanical parameters after photorefractive keratectomy (PRK) and small incision lenticule extraction (SMILE) and their correlations with corneal shape parameters. METHODS: One hundred twenty four eyes received myopic PRK and SMILE for similar amounts of myopia. Corneal tomography with Pentacam HR, biomechanical parameters using Corvis ST, and Ocular Response Analyzer (ORA) were evaluated before and 2 weeks after surgery. The change in each parameter was compared between groups, while the difference in central corneal thickness and cornea-compensated intraocular pressure measured before and after surgery were considered as covariates. RESULTS: A significant reduction was seen in the corneal stiffness parameter at first applanation, and an increase in deformation amplitude ratio (DAR), and integrated inverse radius (IIR) in both groups after surgery (p < 0.001) Changes in DAR, and IIR were significantly greater in the SMILE than in the PRK group (p < 0.001) Corneal hysteresis (CH) and corneal resistance factor (CRF) decreased in both SMILE and PRK groups after surgery, (p < 0.001) with no statistically significant difference between groups (p > 0.05) Among new Corvis ST parameters, DAR showed a significant correlation with changes in Ambrosio relational thickness in both groups (p < 0.05). CONCLUSIONS: Both techniques caused significant changes in corneal biomechanics in the early postoperative period, with greater elastic changes in the SMILE group compared to the PRK group, likely due to lower tension in the SMILE cap and thinner residual stromal bed in SMILE. There were no differences in viscoelastic changes between them, so the lower CH may reflect the volume of tissue removed.
Sujet(s)
Cornée , Élasticité , Myopie , Photokératectomie réfractive , Humains , Photokératectomie réfractive/méthodes , Myopie/chirurgie , Myopie/physiopathologie , Cornée/chirurgie , Cornée/physiopathologie , Cornée/imagerie diagnostique , Femelle , Mâle , Adulte , Élasticité/physiologie , Phénomènes biomécaniques , Jeune adulte , Lasers à excimères/usage thérapeutique , Pression intraoculaire/physiologie , Chirurgie de la cornée par laser/méthodes , Réfraction oculaire/physiologie , Topographie cornéenne , Stroma de la cornée/chirurgie , Période postopératoire , Acuité visuelle/physiologie , Études prospectives , Études de suiviRÉSUMÉ
Different types of refractive surgeries often exhibit differences in wound healing responses. The current study investigated post-operative tear protein profiles in subjects who underwent LASIK and SMILE to elucidate global changes to the proteomic profile during the period the patient cornea undergoes healing. In this study, 10 patients underwent LASIK and SMILE surgery with a contralateral paired eye design. Tear samples were collected using Schirmer's strips preoperatively, at 1 month, 3 months and 6 months postoperatively. Quantitative ITRAQ labeled proteomics was performed and the tear protein ratios were normalized to pre-operative protein levels for each subject. Whole proteomics identified 1345 proteins in tears from LASIK and 1584 proteins in SMILE across time points. About 67 proteins were common in LASIK and SMILE tears across all the time points. Wound healing responses were differentially regulated between two refractive surgeries (SMILE and LASIK). The proteins Ceruloplasmin, Clusterin, Serotransferrin were upregulated at 1 month and 3 months and downregulated at 6 months post operatively in LASIK surgery where as in SMILE these were downregulated. Galectin 3 binding protein showed upregulation at 1 month and the levels decreased at 3 months and 6 months postop in LASIK tears whereas the levels increased at 3 months and 6 months post-op in SMILE tears. The levels of proteins that protect from oxidative stress were higher in SMILE as compared to LASIK postoperatively. The extracellular matrix proteins showed an increase in expression at 6 months in SMILE tears and was stabilized at 6 months in LASIK tears post operatively. Different refractive surgeries induce distinct wound healing responses as identified in tears. This study has implications in targeting key proteins for improving the clinical outcome postrefractive surgery.
Sujet(s)
Protéines de l'oeil , Kératomileusis in situ avec laser excimère , Myopie , Protéomique , Larmes , Cicatrisation de plaie , Humains , Larmes/métabolisme , Kératomileusis in situ avec laser excimère/méthodes , Cicatrisation de plaie/physiologie , Protéomique/méthodes , Femelle , Mâle , Adulte , Protéines de l'oeil/métabolisme , Myopie/chirurgie , Myopie/métabolisme , Chirurgie de la cornée par laser/méthodes , Jeune adulte , Lasers à excimères/usage thérapeutique , Période postopératoire , Stroma de la cornée/métabolisme , Stroma de la cornée/chirurgieRÉSUMÉ
BACKGROUND: To investigate the long-term corneal stromal remodeling and central stromal thickness (CST) reduction accuracy after small-incision lenticule extraction (SMILE) for high myopia correction. METHODS: This prospective study included 30 patients (50 eyes) who had undergone SMILE. Measurements of CST reduction using optical coherence tomography were performed at 1 month, 6 months, 1 year, and 3 years after surgery. Correlations were performed between planned and achieved CST reductions. RESULTS: The study enrolled 50 eyes of 30 patients. The mean spherical equivalent was -9.25±1.52 D(diopters). The postoperative CST increased in the first month after surgery and remained stable for a year. Thereafter, it remained stable during follow-up from 1 to 3 years postoperatively. The predicted CST reduction was 146.4 ± 10.3 µm. The achieved CST reductions at 1 month, 6 months, 1 year, and 3 years after surgery were 135.3 ± 12.1 µm, 130.8 ± 10.6 µm, 125.9 ± 9.4 µm, and 122.2 ± 10.6 µm, respectively. An overestimation of CST reduction was observed three years after surgery. Correlation analysis revealed a strong correlation between planned and achieved CST reductions; however, no correlation was found between CST reductions predicted error and the planned CST reductions. CONCLUSION: During long-term follow-up, our findings revealed a significant stromal remodeling following SMILE in patients with high myopia. Therefore, clinicians should consider it when screening patients with high myopia for SMILE.
Sujet(s)
Stroma de la cornée , Myopie , Tomographie par cohérence optique , Humains , Femelle , Mâle , Études prospectives , Stroma de la cornée/chirurgie , Stroma de la cornée/anatomopathologie , Adulte , Tomographie par cohérence optique/méthodes , Myopie/chirurgie , Jeune adulte , Chirurgie de la cornée par laser/méthodesRÉSUMÉ
PURPOSE: To compare the objective visual quality of moderate-to-high myopia corrected by small incision lenticule extraction (SMILE) and transepithelial photorefractive keratectomy (TransPRK) at a 1,050-Hz ablation frequency, assisted by Smart-Pulse technology (SCHWIND eye-tech-solutions). METHODS: This study involved 123 patients (123 eyes) with moderate-to-high myopia between July 2020 and January 2021. They were categorized into the SMILE group (67 patients, 67 eyes) and the TransPRK group (56 patients, 56 eyes). Follow-ups were conducted at 6 months postoperatively to record the logarithm of the minimum angle of resolution visual acuity, and the Strehl ratio and higher order aberrations were measured using the Sirius anterior segment analysis device (SCHWIND eye-tech-solutions) under a 6-mm pupil diameter at various postoperative intervals. RESULTS: At 1 week and 1 month postoperatively, the uncorrected distance visual acuity (UDVA) in the SMILE group was superior to that in the TransPRK group (P < .05 for both). At 1 week and 1 month postoperatively, the Strehl ratio value in the SMILE group was higher than that in the TransPRK group (P < .05 for both). At 1, 3, and 6 months postoperatively, coma was greater in the SMILE group than in the TransPRK group (P < .05 for all). Spherical aberrations were lower in the SMILE group than in the TransPRK group at 3 and 6 months postoperatively (P < .05). At 6 months postoperatively, UDVA was -0.09 ± 0.08 and -0.11 ± 0.05 logMAR in the SMILE and TransPRK groups, respectively, which exceeded their preoperative corrected distance visual acuity of -0.05 ± 0.04 and -0.09 ± 0.08 logMAR (all P < .001). Compared with preoperative values, the Strehl ratio, total higher order, coma, and spherical aberration differences were significantly increased postoperatively in both groups (all P < .001). CONCLUSIONS: Both surgical methods improved UDVA and each had its advantages. The visual quality of SMILE was superior at 1 week and 1 month postoperatively (Strehl ratio values were higher than those of the TransPRK group), and its spherical aberration was lower than that of the TransPRK group at 3 and 6 months; TransPRK with SmartPulse technology with a 1,050-Hz ablation frequency showed that coma was significantly lower than that of the SMILE group at 1, 3, and 6 months postoperatively. [J Refract Surg. 2024;40(7):e490-e498.].
Sujet(s)
Stroma de la cornée , Lasers à excimères , Photokératectomie réfractive , Réfraction oculaire , Acuité visuelle , Humains , Acuité visuelle/physiologie , Lasers à excimères/usage thérapeutique , Femelle , Mâle , Photokératectomie réfractive/méthodes , Adulte , Réfraction oculaire/physiologie , Jeune adulte , Stroma de la cornée/chirurgie , Chirurgie de la cornée par laser/méthodes , Myopie dégénérative/chirurgie , Myopie dégénérative/physiopathologie , Aberration du front d'onde cornéen/physiopathologie , Topographie cornéenne , Études de suivi , Études prospectives , Myopie/chirurgie , Myopie/physiopathologie , Études rétrospectivesSujet(s)
Stroma de la cornée , Kératite , Humains , Kératite/diagnostic , Kératite/étiologie , Stroma de la cornée/chirurgie , Stroma de la cornée/anatomopathologie , Complications postopératoires/diagnostic , Mâle , Myopie/chirurgie , Myopie/diagnostic , Acuité visuelle , Chirurgie de la cornée par laser/effets indésirables , Chirurgie de la cornée par laser/méthodes , Femelle , AdulteRÉSUMÉ
BACKGROUND: Recently a new surgical technique for intracorneal ring-segments (ICRS) assisted by femtosecond laser (FSL) called ByLimB was developed, involving the creation of the incision from a paralimbic region. This study aims to evaluate the safety and efficacy of the ByLimb technique following one year of follow-up. METHODS: A prospective, single-center study was conducted at the Zaldivar Institute in Buenos Aires, Argentina. Keratoconus patients with indication for ICRS-FSL assisted procedure, operated with the ByLimb technique were included. By using the ByLimb technique, the ICRS are placed without affecting the tunnel's roof, and the end of the ICRS is always away from the incision area. Visual acuity, topographic astigmatism, and the occurrence of complications were evaluated. Safety index was the main outcome and efficacy indes was a complimentary outcome. RESULTS: A total of 17 eyes completed the 12-month follow-up period. The safety index was 1.10 (mean postoperative corrected distance visual acuity (CDVA) in decimal: 0.76/preoperative CDVA: 0.69), while the efficacy index was 0.89 (mean postoperative uncorrected distance visual acuity UDVA in decimal: 0.62/preoperative CDVA: 0.69). Mean preoperative astigmatism was 5.3 ± 2.3, decreasing twelve months after surgery at 2.1 ± 1.2 (p < 0.001). No eye loss lines of vision and no intraoperative complications were observed. During the first month after surgery, an improper positioning of the ICRS based on topographic assessment was detected in five cases. A second procedure was performed, which consisted of opening the incision and introducing a Sinsky hook, through which the ICRS was mobilized and placed in its correct position. No incisional alterations, signs of infection, anterior segment anomalies, or fundus alterations were observed. CONCLUSION: FSL-assisted ICRS implantation through the perilimbal region has demonstrated an adequate safety index one year post-surgery. Additionally, this technique has facilitated accurate realignment of ICRS during secondary surgical interventions within one-month post-surgery. While the current findings are promising, continued follow-up of these cases is warranted.
Sujet(s)
Topographie cornéenne , Kératocône , Prothèses et implants , Implantation de prothèse , Acuité visuelle , Humains , Études prospectives , Kératocône/chirurgie , Kératocône/physiopathologie , Femelle , Mâle , Adulte , Projets pilotes , Acuité visuelle/physiologie , Implantation de prothèse/méthodes , Jeune adulte , Stroma de la cornée/chirurgie , Études de suivi , Réfraction oculaire/physiologie , Adulte d'âge moyen , Thérapie laser/méthodes , Résultat thérapeutiqueRÉSUMÉ
PURPOSE: To report the preliminary experience and initial clinical results following SMILE for the treatment of mixed astigmatism. METHODS: Thirteen eyes of nine patients with a mean age of 27 ± 4.36 years were included in the series. In 8/13 eyes, myopic SMILE license and in 4/13 eyes, hyperopic SMILE license (available as part of an open/research software) was used for the treatment. The mean follow-up was 9.5 ± 8.7 (0.5-24) months, and the median follow-up was 6 months. SETTING: Nethradhama Superspeciality Eye Hospital, Bangalore, India. DESIGN: Exploratory study. RESULTS: The mean preoperative sphere, cylinder, and spherical equivalent (SE) were 1.44 ± 1.63, -2.70 ± 2.30, and -0.24 ± 1.14 D, which changed to -0.03 ± 0.30, -0.28 ± 0.48, and -0.18 ± 0.49 D, respectively, 6 months postoperatively. Furthermore, 85% (11/13) eyes were within ± 0.50 D, 92% (12/13) eyes were within ± 1.00 D, while all eyes were within ± 1.50 D of SE correction. All eyes were within ± 1.00 D of cylinder correction. In addition, 92% (12/13) eyes had UDVA better than 20/32, with 54% (7/13) eyes having UDVA 20/20 or better. Safety and efficacy indices were 1.08 and 0.92, respectively. No eyes lost more than 1 line of CDVA. The mean corneal higher order aberrations (HOA) increased from 0.111 ± 0.048 to 0.209 ± 0.056 (P < 0.001). The mean objective scatter index (OSI) did not show a significant change (pre = 0.71 ± 0.69, 6 months = 0.89 ± 0.20; P = 0.35). CONCLUSION: Early experience showed that SMILE was feasible for the management of eyes with mixed astigmatism, without any intraoperative complications, unique to the procedure.
Sujet(s)
Astigmatisme , Stroma de la cornée , Chirurgie de la cornée par laser , Topographie cornéenne , Études de faisabilité , Réfraction oculaire , Acuité visuelle , Humains , Astigmatisme/chirurgie , Astigmatisme/physiopathologie , Mâle , Adulte , Femelle , Réfraction oculaire/physiologie , Chirurgie de la cornée par laser/méthodes , Études de suivi , Jeune adulte , Stroma de la cornée/chirurgie , Logiciel , Lasers à excimères/usage thérapeutique , Résultat thérapeutique , Études rétrospectives , Myopie/chirurgie , Myopie/physiopathologie , Microchirurgie/méthodesRÉSUMÉ
ABSTRACT: We present an alternative surgical procedure including simultaneous deep anterior lamellar keratoplasty (DALK) and Descemet membrane endothelial keratoplasty (DMEK) in a case with endothelial failure and stromal scarring. A 62-year-old woman presented with vision loss caused by pseudophakic bullous keratopathy. While waiting for a corneal transplant, the patient developed infectious keratitis, which was treated with medication. Although the keratitis healed, it left a scar. To improve the patient's vision, a corneal transplant surgery that included simultaneous DALK and DMEK was performed. Postoperatively, the corneal graft was clear, and the Descemet membrane was well attached. However, there was an interface haze because of residual stromal tissue. The patient's best-corrected visual acuity improved from hand motion to 0.2 (decimal). This combined procedure allows for lamellar keratoplasty in cases with coexistence of corneal endothelial and stromal involvement.
Sujet(s)
Stroma de la cornée , Kératoplastie endothéliale automatisée par le stripping de Descemet , Acuité visuelle , Humains , Femelle , Adulte d'âge moyen , Kératoplastie endothéliale automatisée par le stripping de Descemet/méthodes , Stroma de la cornée/chirurgie , Stroma de la cornée/anatomopathologie , Transplantation de cornée/méthodes , Endothélium de la cornée/anatomopathologie , Endothélium de la cornée/chirurgie , Cicatrice/chirurgie , Maladies de la cornée/chirurgieRÉSUMÉ
PURPOSE: To compare the effects of corneal allogenic intrastromal ring segment (CAIRS) implantation on topographical measurements and visual outcomes of patients with keratoconus with and without corneal cross-linking (CXL) prior to the time of implantation. METHODS: Sixty-seven eyes with corneal allograft intrastromal ring segment implantation (KeraNatural; Lions VisionGift) due to advanced keratoconus were included in the study. Thirty-seven eyes had no CXL and 30 eyes had had CXL before being referred to the authors. The changes in spherical equivalent (SE), uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), steep keratometry (K1), flat keratometry (K2), mean keratometry (Kmean), maximum keratometry (Kmax), and thinnest pachymetry were retrospectively analyzed 6 months after the implantation. RESULTS: The median age was 29 years in the CXL group and 24.0 years in the non-CXL group (P > .05), respectively. All topographical and visual parameters before implantation were similar in both groups (P > .05 for all parameters). At 6 months, CDVA, K1, and Kmean showed higher improvement in the non-CXL group than the CXL group (P = .030, .018, and .039, respectively). CONCLUSIONS: CAIRS surgery has a flattening effect on both the corneas with and without CXL. The cornea with prior CXL treatment had less flattening effect due to the stiffening effect of prior CXL. [J Refract Surg. 2024;40(6):e392-e397.].
Sujet(s)
Collagène , Stroma de la cornée , Topographie cornéenne , Réactifs réticulants , Kératocône , Photosensibilisants , Prothèses et implants , Implantation de prothèse , Réfraction oculaire , Acuité visuelle , Humains , Kératocône/physiopathologie , Kératocône/métabolisme , Kératocône/traitement médicamenteux , Kératocône/chirurgie , Stroma de la cornée/métabolisme , Stroma de la cornée/chirurgie , Réactifs réticulants/usage thérapeutique , Acuité visuelle/physiologie , Adulte , Mâle , Femelle , Photosensibilisants/usage thérapeutique , Études rétrospectives , Jeune adulte , Réfraction oculaire/physiologie , Collagène/métabolisme , Pachymétrie cornéenne , Riboflavine/usage thérapeutique , Photothérapie dynamique/méthodes , Adolescent , Rayons ultraviolets , Transplantation de cornée/méthodes , Adulte d'âge moyen , Crosslinking cornéenRÉSUMÉ
PURPOSE: To identify potential risk factors that increase the likelihood of re-treatment following keratorefractive lenticule extraction (KLEx) for myopia and myopic astigmatism. METHODS: This was a retrospective study of patients with myopia and myopic astigmatism who underwent KLEx using the VisuMax 500 laser (Carl Zeiss Meditec) between April 2015 and December 2020. Patients were assigned to one of two groups: the control group and the re-treatment group (if they had additional refractive surgery within 2 years of the primary treatment). The effect of different preoperative, intraoperative, and postoperative parameters on the re-treatment rate was analyzed. RESULTS: Overall 1,822 eyes of 938 patients were analyzed. In total, 2.96% of eyes (n = 54) underwent re-treatment. The re-treated patients were more likely to be women and have high myopia, high astigmatism, steep corneas, higher ocular residual astigmatism, and residual myopic and/or astigmatic refractive error. In contrast, no significant correlation was found between re-treatment rate and age, chord µ, type of astigmatism, and corneal thickness. CONCLUSIONS: Factors associated with higher rates of retreatment after KLEx included female gender, manifest refractive high myopia (> -5.00 diopters [D]), astigmatism (> 2.00 D), spherical equivalent (> 6.00 D), ocular residual astigmatism, steeper corneas, and postoperative residual myopic and astigmatic refractive errors. This study may help to preoperatively detect patients at risk for re-treatment, improve preoperative patient counseling, and optimize patient selection to reduce future re-treatment rates. [J Refract Surg. 2024;40(6):e362-e370.].
Sujet(s)
Astigmatisme , Lasers à excimères , Myopie , Réfraction oculaire , Réintervention , Acuité visuelle , Humains , Études rétrospectives , Mâle , Astigmatisme/chirurgie , Astigmatisme/physiopathologie , Femelle , Adulte , Facteurs de risque , Myopie/chirurgie , Myopie/physiopathologie , Acuité visuelle/physiologie , Réfraction oculaire/physiologie , Lasers à excimères/usage thérapeutique , Jeune adulte , Stroma de la cornée/chirurgie , Topographie cornéenne , Adulte d'âge moyen , Adolescent , Chirurgie de la cornée par laser/méthodesRÉSUMÉ
OBJECTIVE: To investigate the correlation between higher-order aberrations (HOA) after small incision lenticule extraction (SMILE) and the severity of myopia and astigmatism, along with the relevant factors. These findings will provide valuable insights for decreasing the occurrence of HOA after SMILE and enhancing visual quality. METHODS: A total of 75 patients (150 eyes) with myopia and astigmatism who underwent SMILE were categorized into four groups based on the severity of myopia and astigmatism: Myopia Group 1 (Group M1, spherical diopter ranged from -1.00 D to -4.00 D), Myopia Group 2 (Group M2, spherical diopter ranged from -4.10 D to -10.00 D), Astigmatism Group 1 (Group A1, cylindrical diopter ranged from 0 D to -1.00 D), and Astigmatism Group 2 (Group A2, cylindrical diopter ranged from -1.10 D to -3.00 D). A comprehensive assessment was performed to examine the association between HOA and various relevant factors, including a detailed analysis of the subgroups. RESULTS: Group M1 had significantly lower levels of total eye coma aberration (CA), corneal total HOA (tHOA), internal tHOA, and vertical CA ( Z 3 - 1 ) after SMILE than Group M2 (P < 0.05). Similarly, Group A1 had significantly lower levels of total eye tHOA, CA, trefoil aberration (TA), corneal tHOA, TA, and vertical TA ( Z 3 - 3 ) after SMILE than Group A2 (P < 0.05). Pearson correlation analysis indicated a statistically significant positive relationship between the severity of myopia/astigmatism and most HOA (P < 0.05). Subgroup evaluations demonstrated a notable increase in postoperative HOA associated with myopia and astigmatism in Groups M2 and A2 compared with the control group. Lenticule thickness, postoperative central corneal thickness (CCT), postoperative uncorrected distance visual acuity (UDVA), and postoperative corneal Km and Cyl were strongly correlated with most HOA. Age, eyes, and postoperative intraocular pressure (IOP) were only associated with specific HOA. CONCLUSION: HOA positively correlated with the severity of myopia and astigmatism after SMILE. However, this relationship was not linear. HOA after SMILE was influenced by various factors, and additional specialized investigations are required to establish its clinical importance.
Sujet(s)
Astigmatisme , Chirurgie de la cornée par laser , Aberration du front d'onde cornéen , Myopie , Réfraction oculaire , Acuité visuelle , Humains , Myopie/chirurgie , Myopie/physiopathologie , Astigmatisme/physiopathologie , Astigmatisme/étiologie , Mâle , Femelle , Adulte , Acuité visuelle/physiologie , Chirurgie de la cornée par laser/méthodes , Chirurgie de la cornée par laser/effets indésirables , Aberration du front d'onde cornéen/physiopathologie , Aberration du front d'onde cornéen/étiologie , Jeune adulte , Réfraction oculaire/physiologie , Stroma de la cornée/chirurgie , Études rétrospectives , Lasers à excimères/usage thérapeutique , Complications postopératoires , Topographie cornéenne , AdolescentRÉSUMÉ
PURPOSE: To evaluate moderate to high astigmatism corrections on the outcomes of SmartSight lenticule extraction for myopic astigmatism with a new femtosecond laser system. METHODS: Two hundred ninety-two eyes consecutively treated for myopic astigmatism with astigmatism magnitude greater than 1.00 diopter (D) were evaluated at the 6-month follow-up visit. The mean age of the patients was 29 ± 6 years with a mean spherical equivalent of -5.06 ± 2.20 diopters (D) and a mean magnitude of refractive astigmatism of 1.74 ± 0.61 D. RESULTS: At 6 months, astigmatism was 0.10 ± 0.20 D. Uncorrected and corrected distance visual acuities (UDVA and CDVA, respectively) were both 0.0 ± 0.1 logMAR. Differences between postoperative UDVA and preoperative CDVA and the change in CDVA were both +0.4 ± 0.7 lines better than preoperatively (P < .0003). CONCLUSIONS: Lenticule extraction treatment using Smart-Sight is safe and efficacious at 6 months. Findings suggest that moderate to high astigmatism improves after SmartSight lenticule extraction in the treatment of myopic astigmatism. [J Refract Surg. 2024;40(5):e328-e335.].
Sujet(s)
Astigmatisme , Stroma de la cornée , Lasers à excimères , Myopie , Réfraction oculaire , Acuité visuelle , Humains , Astigmatisme/physiopathologie , Astigmatisme/chirurgie , Acuité visuelle/physiologie , Études rétrospectives , Adulte , Réfraction oculaire/physiologie , Mâle , Femelle , Myopie/chirurgie , Myopie/physiopathologie , Jeune adulte , Stroma de la cornée/chirurgie , Lasers à excimères/usage thérapeutique , Topographie cornéenne , Études de suivi , Résultat thérapeutique , Chirurgie de la cornée par laser/méthodesRÉSUMÉ
PURPOSE: To evaluate the characteristic of corrective epithelial thickness after femtosecond laser-assisted lenticule intrastromal keratoplasty (LIKE) to correct moderate-to-high hyperopia. METHODS: The prospective case series study of the LIKE procedure was performed to correct moderate-to-high hyperopia. The epithelial thickness map was generated by anterior segment optical coherence tomography (AS-OCT) in the corneal central 9-mm zone. Keratometry and corneal higher order aberrations were analyzed by Pentacam (Oculus Optikgeräte GmbH) preoperatively and postoperatively. RESULTS: In the 26 eyes of 13 participants who underwent the LIKE procedure for moderate-to-high hyperopia, the attempted spherical equivalence (SEQ) was +6.50 ± 1.09 diopters (D). Compared to the preoperative epithelial thickness maps, the postoperative epithelial thickness had become significantly thinner in the central 5-mm zone; the difference was 6 to 7 µm. The paracentral epithelium performed nonuniform remodeling; the thinnest epithelial thickness was located in the inferotemporal section, which has the greatest difference from the superonasal; the difference between these two was approximately 3 µm. Through correlation analysis, it was found that the sections with thinner epithelium were significantly related to corneal curvature and corneal vertical coma. CONCLUSIONS: The LIKE procedure can be used to correct moderate-to-high hyperopia. This study further indicated the epithelial remodeling characteristic after the LIKE procedure: the central and paracentral corneal epithelial thickness becomes thinner, and the epithelial thickness distributes non-uniformly, which may be the important factor of the postoperative curvature asymmetric distribution and induction of corneal vertical coma. [J Refract Surg. 2024;40(5):e321-e327.].