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1.
J Sci Med Sport ; 2024 May 22.
Article in English | MEDLINE | ID: mdl-38839539

ABSTRACT

We quantified and compared the mechanical force demands relative to the maximum dynamic force (MDF) of 11 cyclists when pedaling at different intensities (ventilatory threshold, maximum lactate steady state, respiratory compensation point, and maximal aerobic power), cadences (free, 40, 60 and 80 rpm), and all-out resisted sprints. Relative force demands (expressed as %MDF) progressively increased with higher intensities (p < 0.001) and lower cadences (p < 0.001). Notwithstanding, relative force demands were low (<54 % MDF) for all conditions, even during the so-called 'torque training'. These results might be useful when programming on-bike resistance training to improve torque production capacity.

2.
J Nutr Health Aging ; 28(5): 100208, 2024 May.
Article in English | MEDLINE | ID: mdl-38489992

ABSTRACT

OBJECTIVES: To investigate the synergist effects of exercise and ß-hydroxy ß-methylbutyrate (HMB) supplementation on disability, cognitive and physical function, and muscle power in institutionalized older people. DESIGN: Cluster-randomized controlled trial. PARTICIPANTS: Seventy-two institutionalized older adults (age = 83 ± 10 years old; 63% women) were randomized in four groups: exercise plus placebo (EX), HMB supplementation, EX plus HMB supplementation (EX + HMB), and control (CT). INTERVENTION: The exercising participants completed a 12-week tailored multicomponent exercise intervention (Vivifrail; 5 days/week of an individualized resistance, cardiovascular, balance and flexibility program), whereas the HMB groups received a drink containing 3 g/day of HMB. MEASUREMENTS: Participants were assessed Pre and Post intervention for disability and cognitive function (validated questionnaires), physical function (short physical performance battery, SPPB), handgrip strength and sit-to-stand relative muscle power. Linear mixed-effect models were used to compare changes among groups. RESULTS: Compared to baseline, both EX and EX + HMB improved cognitive function (+2.9 and +1.9 points; p < 0.001), SPPB score (+2.9 points and +2.4 points; p < 0.001) and relative muscle power (+0.64 and +0.48 W·kg-1; p < 0.001), while CT and HMB remained unchanged (p > 0.05). Significant between-group differences were noted between CT, EX and EX + HMB for cognitive function (p < 0.01), between CT and EX + HMB for physical function (p = 0.043), and between CT, EX and EX + HMB for relative muscle power (p < 0.001). CONCLUSION: The Vivifrail exercise program was effective in improving cognitive and physical function, and muscle power in nursing home residents, while HMB supplementation did not provide additional benefits when combined with exercise. These results emphasize the importance of physical exercise interventions in very old people as an essential basis for improving their overall health and quality of life.


Subject(s)
Cognition , Dietary Supplements , Valerates , Humans , Female , Male , Valerates/administration & dosage , Valerates/pharmacology , Cognition/drug effects , Aged , Aged, 80 and over , Muscle Strength/drug effects , Hand Strength , Disabled Persons , Exercise Therapy/methods , Exercise/physiology
3.
Sensors (Basel) ; 24(6)2024 Mar 21.
Article in English | MEDLINE | ID: mdl-38544265

ABSTRACT

We aimed to determine the feasibility, test-retest reliability and long-term stability of a novel method for assessing the force (torque)-velocity (cadence) profile and maximal dynamic force (MDF) during leg-pedaling using a friction-loaded isoinertial cycle ergometer and a high-precision power-meter device. Fifty-two trained male cyclists completed a progressive loading test up to the one-repetition maximum (1RM) on a cycle ergometer. The MDF was defined as the force attained at the cycle performed with the 1RM-load. To examine the test-retest reliability and long-term stability of torque-cadence values, the progressive test was repeated after 72 h and also after 10 weeks of aerobic and strength training. The participants' MDF averaged 13.4 ± 1.3 N·kg-1, which was attained with an average pedal cadence of 21 ± 3 rpm. Participants' highest power output value was attained with a cadence of 110 ± 16 rpm (52 ± 5% MDF). The relationship between the MDF and cadence proved to be very strong (R2 = 0.978) and independent of the cyclists' MDF (p = 0.66). Cadence values derived from this relationship revealed a very high test-retest repeatability (mean SEM = 4 rpm, 3.3%) and long-term stability (SEM = 3 rpm, 2.3%); despite increases in the MDF following the 10-week period. Our findings support the validity, reliability and long-term stability of this method for the assessment of the torque-cadence profile and MDF in cyclists.


Subject(s)
Bicycling , Ergometry , Humans , Male , Torque , Reproducibility of Results , Foot , Exercise Test/methods
4.
Int J Sports Med ; 45(2): 110-115, 2024 Feb.
Article in English | MEDLINE | ID: mdl-37956877

ABSTRACT

We examined the effect of breast cancer surgery and adjuvant therapy on the relationship between bar velocity and relative intensity (load-velocity [L-V] relationship) of the bench press (BP) exercise. Twenty-two breast cancer survivors (age: 48.0±8.2 yr., relative strength: 0.40±0.08) completed a loading test up to the one-repetition maximum (1RM) in the BP using a lightweight carbon bar. General and individual relationships between relative intensity (%1RM) and mean propulsive velocity (MPV) were studied. Furthermore, the mean test velocity (MPVTest) and velocity attained to the 1RM (MPV1RM) were analyzed. These procedures and analyses were also conducted in 22 healthy women (age: 47.8±7.1 yr., relative strength: 0.41±0.09) to examine the differences in velocity parameters derived from these L-V relationships. Polynomial regressions showed very close relationships (R2≥0.965) and reduced estimation errors (≤4.9% 1RM) for both groups. Between-group differences in MPV attained to each %1RM were small (≤0.01 m·s-1) and not significant (p≥0.685). Similarly, the MPVTest (0.59±0.06 m·s-1) and MPV1RM (0.17±0.03 m·s-1) were identical for breast cancer survivors and healthy women. These results suggest that practitioners could use the same velocity parameters derived from the BP L-V relationship to prescribe this exercise in middle-aged women, regardless of whether they have suffered from breast cancer.


Subject(s)
Breast Neoplasms , Resistance Training , Middle Aged , Humans , Female , Adult , Breast Neoplasms/surgery , Resistance Training/methods , Weight Lifting , Muscle Strength , Exercise , Exercise Therapy
5.
Med Sci Sports Exerc ; 55(12): 2316-2327, 2023 12 01.
Article in English | MEDLINE | ID: mdl-37535335

ABSTRACT

PURPOSE: This study aimed to compare the effects of free-weight and machine-based resistance training on strength, hypertrophy, and joint discomfort. METHODS: Thirty-eight resistance-trained men participated in an 8-wk resistance program allocated into free-weight ( n = 19) or machine-based ( n = 19) groups. Training variables were identical for both modalities, so they only differed in the use of barbells or machines to execute the full squat, bench press, prone bench pull, and shoulder press exercises. The velocity-based method was implemented to accurately adjust the intensity throughout the program. Strength changes were evaluated using eight velocity-monitored loading tests (four exercises × two modalities) and included the relative one-repetition maximum (1RM Rel ), as well as the mean propulsive velocity against low (MPV Low ) and high (MPV High ) loads. Ultrasound-derived cross-sectional area of quadriceps (proximal and distal regions), pectoralis major, and rectus abdominis was measured to examine hypertrophy. Complementarily, Western Ontario and McMaster Universities and Disabilities of the Arm, Shoulder and Hand questionnaires were administrated to assess changes in lower- and upper-limb joint discomfort. Outcomes were compared using ANCOVA and percentage of change (∆) statistics. RESULTS: Each group significantly ( P < 0.001) increased 1RM Rel , MPV Low , and MPV High for both modalities tested, but especially in the one they trained. When considering together the eight exercises tested, strength changes for both modalities were similar (∆ differences ≤1.8%, P ≥ 0.216). Likewise, the cross-sectional area of all the muscles evaluated was significantly increased by both modalities, with no significant differences between them (∆ difference ≤2.0%, P ≥ 0.208). No between-group differences ( P ≥ 0.144) were found for changes in stiffness, pain, and functional disability levels, which were reduced by both modalities. CONCLUSIONS: Free-weight and machine-based modalities are similarly effective to promote strength and hypertrophy without increasing joint discomfort.


Subject(s)
Muscle Strength , Quadriceps Muscle , Male , Humans , Muscle Strength/physiology , Posture , Exercise/physiology , Hypertrophy
6.
Scand J Med Sci Sports ; 33(10): 1948-1957, 2023 Oct.
Article in English | MEDLINE | ID: mdl-37340878

ABSTRACT

BACKGROUND: Although the superior effectiveness of free-weight over machine-based training has been a traditionally widespread assumption, longitudinal studies comparing these training modalities were scarce and heterogeneous. OBJECTIVE: This research used the velocity-based method to compare the effects of free-weight and machine-based resistance training on athletic performance and muscle architecture. METHODS: Thirty-four resistance-trained men participated in an 8-week resistance training program allocated into free-weight (n = 17) or machine-based (n = 17) groups. Training variables (intensity, intraset fatigue, and recovery) were identical for both groups, so they only differed in the use of a barbell or specific machines to execute the full squat, bench press, prone bench pull, and shoulder press exercises. The velocity-based method was implemented to accurately adjust the planned intensity. Analysis of covariance and effect size (ES) statistics were used to compare both training modalities on a comprehensive set of athletic and muscle architecture parameters. RESULTS: No between-group differences were found for any athletic (p ≥ 0.146) and muscle architecture (p ≥ 0.184) variable. Both training modalities significantly and similarly improved vertical jump (Free-weight: ES ≥ 0.45, p ≤ 0.001; Machine-based: ES ≥ 0.41, p ≤ 0.001) and lower limb anaerobic capacity (Free-weight: ES ≥ 0.39, p ≤ 0.007; Machine-based: ES ≥ 0.31, p ≤ 0.003). Additionally, the machine-based group meaningfully enhanced upper limb anaerobic power (ES = 0.41, p = 0.021), whereas the free-weight group significantly improved the change of direction (ES = -0.54, p = 0.003) and 2/6 balance conditions analyzed (p ≤ 0.012). Changes in sprint capacity (ES ≥ -0.13, p ≥ 0.274), fascicle length, and pennation angle (ES ≤ 0.19, p ≥ 0.129) were not significant for either training modality. CONCLUSION: Adaptations in athletic performance and muscle architecture would not be meaningfully influenced by the resistance modality trained.


Subject(s)
Athletic Performance , Muscles , Resistance Training , Humans , Male , Athletic Performance/physiology , Lower Extremity/physiology , Muscle Strength/physiology , Resistance Training/methods , Young Adult , Adult
7.
J Strength Cond Res ; 37(9): e500-e509, 2023 Sep 01.
Article in English | MEDLINE | ID: mdl-37015023

ABSTRACT

ABSTRACT: Hernández-Belmonte, A, Buendía-Romero, Á, Pallares, JG, and Martínez-Cava, A. Velocity-based method in free-weight and machine-based training modalities: the degree of freedom matters. J Strength Cond Res 37(9): e500-e509, 2023-This study aimed to analyze and compare the load-velocity relationships of free-weight and machine-based modalities of 4 resistance exercises. Moreover, we examined the influence of the subject's strength level on these load-velocity relationships. Fifty men completed a loading test in the free-weight and machine-based modalities of the bench press, full squat, shoulder press, and prone bench pull exercises. General and individual relationships between relative intensity (%1RM) and velocity variables were studied through the coefficient of determination ( R2 ) and standard error of the estimate ( SEE ). Moreover, the velocity attained to each %1RM was compared between both modalities. Subjects were divided into stronger and weaker to study whether the subject's strength level influences the mean test (mean propulsive velocity [MPV Test ]) and 1RM (MPV 1RM ) velocities. For both modalities, very close relationships ( R2 ≥ 0.95) and reduced estimation errors were found when velocity was analyzed as a dependent ( SEE ≤ 0.086 m·s -1 ) and independent ( SEE ≤ 5.7% 1RM) variable concerning the %1RM. Fits were found to be higher ( R2 ≥ 0.995) for individual load-velocity relationships. Concerning the between-modality comparison, the velocity attained at each intensity (from 30 to 100% 1RM) was significantly faster for the free-weight variant. Finally, nonsignificant differences were found when comparing MPV Test (differences ≤ 0.02 m·s -1 ) and MPV 1RM (differences ≤ 0.01 m·s -1 ) between stronger and weaker subjects. These findings prove the accuracy and stability of the velocity-based method in the free-weight and machine-based variants but highlight the need to use the load-velocity relationship (preferably the individual one) specific to each training modality.


Subject(s)
Frailty , Resistance Training , Male , Humans , Muscle Strength , Resistance Training/methods , Weight Lifting , Exercise Therapy , Posture
8.
J Appl Physiol (1985) ; 134(1): 95-104, 2023 01 01.
Article in English | MEDLINE | ID: mdl-36476156

ABSTRACT

The aim of this study was to determine the effectiveness of physical exercise, respiratory muscle training, and the self-management World Health Organization (WHO) recommendations leaflet on the recovery of physical fitness, quality of life, and symptom status in people with post-COVID-19 conditions. Eighty nonhospitalized adults with a post-COVID-19 condition were randomly assigned to one of four 8-wk parallel intervention groups: 1) multicomponent exercise program based on concurrent training (CT, number of subjects (n) = 20; 3 resistance and endurance supervised sessions per week at low-moderate intensity); 2) inspiratory muscle training (RM, n = 17; 2 standardized daily sessions); 3) a combination of both of the above (CTRM, n = 23); and 4) control group (CON, n = 20; following the WHO guidelines for post-COVID-19-related illness rehabilitation). No significant differences between groups were detected at baseline. Although no significant differences between interventions were detected in the V̇o2max, significant individual improvements were identified in the CT (7.5%; effect size, ES = 0.28) and CTRM (7.8%; ES = 0.36) groups. Lower body muscle strength significantly improved in the CT and CTRM (14.5%-32.6%; ES = 0.27-1.13) groups compared with RM and CON (-0.3% to 11.3%; ES = 0.10-0.19). The CT and CTRM groups improved significantly for dyspnea and fatigue, as did the health status. In addition, significant differences between interventions were described in fatigue and depression scales favoring CT and CTRM interventions. An individualized and supervised concurrent training with or without inspiratory muscle training was safe and more effective than self-care recommendations and inspiratory muscle training alone, to regain cardiovascular and muscular fitness, improve symptom severity, and health status in outpatients with post-COVID-19 conditions.NEW & NOTEWORTHY Eight weeks of concurrent training, with or without inspiratory muscle exercise, was better than WHO "Support for Rehabilitation: Self-Management after COVID-19-Related Illness" recommendations or inspiratory muscle training alone to improve cardiopulmonary fitness, strength, and symptom severity, in a safe and effective manner. The RECOVE trial proved the benefits and utility of a supervised exercise program in people with post-COVID-19 conditions after mild COVID-19 in an ambulatory setting.


Subject(s)
COVID-19 , Self-Management , Adult , Humans , Quality of Life , Exercise/physiology , Respiratory Muscles/physiology , Muscle Strength/physiology , Breathing Exercises , Fatigue
9.
Scand J Med Sci Sports ; 32(12): 1791-1801, 2022 Dec.
Article in English | MEDLINE | ID: mdl-36111386

ABSTRACT

PURPOSE: The aim of the study was to compare the outcomes of patients with post-COVID-19 condition undergoing supervised therapeutic exercise intervention or following the self-management WHO (World Health Organization) rehabilitation leaflet. METHODS: A randomized controlled trial was carried out that included 39 participants with post-COVID-19 condition who had a chronic symptomatic phase lasting >12 weeks. Comprehensive medical screening, patient-reported symptoms, and cardiorespiratory fitness and muscular strength were assessed. Patients were randomly assigned to a tailored multicomponent exercise program based on concurrent training for 8 weeks (two supervised sessions per week comprised resistance training combined with aerobic training [moderate intensity variable training], plus a third day of monitored light intensity continuous training), or to a control group which followed the WHO guidelines for rehabilitation after COVID-19. RESULTS: After follow-up, there were changes in physical outcomes in both groups, however, the magnitude of the change pre-post intervention favored the exercise group in cardiovascular and strength markers: VO2 max +5.7%, sit-to-stand -22.7% and load-velocity profiles in bench press +6.3%, and half squat +16.9%, (p < 0.05). In addition, exercise intervention resulted in a significantly better quality of life, less fatigue, less depression, and improved functional status, as well as in superior cardiovascular fitness and muscle strength compared to controls (p < 0.05). No adverse events were observed during the training sessions. CONCLUSION: Compared to current WHO recommendations, a supervised, tailored concurrent training at low and moderate intensity for both resistance and endurance training is a more effective, safe, and well-tolerated intervention in post-COVID-19 conditions.


Subject(s)
COVID-19 , Resistance Training , Humans , Quality of Life , Muscle Strength/physiology , Exercise Therapy/methods
11.
Intern Emerg Med ; 17(8): 2199-2208, 2022 11.
Article in English | MEDLINE | ID: mdl-35904700

ABSTRACT

The aim of this study was to determine the relationship between physical fitness, cardiopulmonary function and patient-reported severity of symptoms in people with post-COVID-19 condition. We examined ambulatory patients (n = 72) with post-COVID-19 condition who had a chronic symptomatic phase lasting > 12 weeks from the onset of symptoms, but had not been hospitalized for acute COVID-19. A comprehensive medical screening was conducted, including clinical history, symptomatology, comorbidities, body composition and physical activity levels. We then identified the relationship between physical fitness (cardiorespiratory fitness and muscular strength), cardiopulmonary function (echocardiographic and spirometry parameters) and patient-reported severity of symptoms (fatigue, dyspnea, health-related quality of life, anxiety, and depression). Age, body mass index, sex, number of comorbidities and duration of symptoms were included as potential confounders. Results showed that greater physical fitness and cardiopulmonary function were associated with lower severity of symptoms in people with post-COVID-19 condition. Cardiorespiratory fitness, lower-limb muscle strength, maximal voluntary ventilation and left ventricular ejection fraction account for reducing fatigue and dyspnea. Greater physical activity levels were associated with fewer symptoms and less-severe fatigue and dyspnea. In conclusion, preserving better cardiopulmonary health and physical condition during the course of the disease-even in mild cases-was related to a lower intensity of symptoms in non-hospitalized people with post-COVID-19 condition. It is probable that exercise and physical conditioning are valuable pre- and post-COVID-19 countermeasures that could help decrease the severity, not only of acute infection, but of post-COVID-19 persistent symptoms and prognosis.


Subject(s)
COVID-19 , Quality of Life , Humans , COVID-19/epidemiology , Stroke Volume , Ventricular Function, Left , Physical Fitness , Fatigue/etiology , Dyspnea/etiology
12.
Int J Sports Physiol Perform ; 17(1): 120-125, 2022 01 01.
Article in English | MEDLINE | ID: mdl-34186508

ABSTRACT

PURPOSE: To examine the reproducibility (intradevice and interdevice agreement) of the Rotor 2INpower device under a wide range of cycling conditions. METHODS: Twelve highly trained male cyclists and triathletes completed 5 cycling tests, including graded exercise tests at different cadences (70-100 rpm), workloads (100-650 W), pedaling positions (seated and standing), and vibration conditions (20-40 Hz) and an 8-second maximal sprint (>1000 W). An intradevice analysis included a comparison between the power output registered by 3 units of Rotor 2INpower, whereas the power output provided by each one of these units and the gold-standard SRM crankset were compared for the interdevice analysis. Among others, statistical calculations included the standard error of measurement, expressed in absolute (in watts) and relative terms as the coefficient of variation (CV). RESULTS: Except for the graded exercise test seated at 100 rpm/100 W (CV = 10.2%), the intradevice analysis showed an acceptable magnitude of error (CV ≤ 6.9%, standard error of measurement ≤ 12.3 W) between the 3 Rotor 2INpower. Similarly, these 3 units showed an acceptable agreement with the gold standard in all graded exercise test situations (CV ≤ 4.0%, standard error of measurement ≤ 13.1 W). On the other hand, both the intradevice and interdevice agreements proved to be slightly reduced under high cadences (intradevice: CV ≤ 10.2%; interdevice: CV ≤ 4.0%) and vibration (intradevice: CV ≤ 4.0%; interdevice: CV ≤ 3.6%), as well as during standing pedaling (intradevice: CV ≤ 4.1%; interdevice: CV ≤ 2.5%). Although within the limits of an acceptable agreement, measurement errors increased during the sprint tests (CV ≤ 7.4%). CONCLUSIONS: Based on these results, the Rotor 2INpower could be considered a reproducible tool to monitor power output in most cycling situations.


Subject(s)
Bicycling , Exercise Test , Humans , Male , Reproducibility of Results , Sitting Position , Standing Position
13.
J Am Med Dir Assoc ; 23(1): 98-104.e3, 2022 01.
Article in English | MEDLINE | ID: mdl-34197791

ABSTRACT

OBJECTIVES: We aimed to determine whether the benefits of long (24 weeks) and short (4 weeks) training programs persisted after short (6 weeks) and long (14 weeks) periods of inactivity in older adult nursing home residents with sarcopenia. DESIGN: Multicenter randomized trial. INTERVENTION: The Vivifrail tailored, multicomponent exercise program (http://vivifrail.com) was conducted to individually prescribe exercise for frail older adults, depending on their functional capacity. The training included 4 levels combining strength and power, balance, flexibility, and cardiovascular endurance exercises. SETTING AND PARTICIPANTS: Twenty-four institutionalized older adults (87.1 ± 7.1 years, 58.3% women) diagnosed with sarcopenia were allocated into 2 groups: the Long Training-Short Detraining (LT-SD) group completed 24 weeks of supervised Vivifrail training followed by 6 weeks of detraining; the Short Training-Long Detraining (ST-LD) group completed 4 weeks of training and 14 weeks of detraining. MEASURES: Changes in functional capacity and strength were evaluated at baseline, and after short and long training and detraining periods. RESULTS: Benefits after short and long exercise interventions persisted when compared with baseline. Vivifrail training was highly effective in the short term (4 weeks) in increasing functional and strength performance (effect size = 0.32-1.44, P < .044) with the exception of handgrip strength. Continued training during 24 weeks produced 10% to 20% additional improvements (P < .036). Frailty status was reversed in 36% of participants, with 59% achieving high self-autonomy. Detraining resulted in a 10% to 25% loss of strength and functional capacity even after 24 weeks of training (effects size = 0.24-0.92, P < .039). CONCLUSIONS AND IMPLICATIONS: Intermittent strategies such as 4 weeks of supervised exercise 3 times yearly with no more than 14 weeks of inactivity between exercise periods appears as an efficient solution to the global challenge of maintaining functional capacity and can even reverse frailty in vulnerable institutionalized older adults.


Subject(s)
Frailty , Accidental Falls/prevention & control , Aged , Exercise , Exercise Therapy , Female , Hand Strength , Humans , Male , Nursing Homes
14.
BMJ Open ; 11(12): e052913, 2021 12 06.
Article in English | MEDLINE | ID: mdl-34873006

ABSTRACT

INTRODUCTION: There is not a doubt that tailored exercise is an effective non-pharmacological approach for preventing, mitigating and even reversing ageing-related alterations. However, older adults are likely to experience prolonged periods of inactivity and training cessation periods as a consequence of falls or hospitalisation. Although recent evidence supports that exercise could have a protective effect and help in recovering, there is to date a lack of consensus about what kind of physical exercise prescription and training duration would produce better outcomes after training cessation periods. The current study will determine the effects that available exercise prescriptions produced in older adults in preserving physical conditioning following inactivity periods. METHODS AND ANALYSIS: A systematic search of the literature will be conducted in three databases, namely PubMed, Scopus and Web of Science, from inception to 1 February 2021. Only randomised controlled trials written in English or Spanish will be eligible. No year of publication restriction will be applied. Eligible studies will contain information on population (older adults over 60 years old), intervention (inactivity period, exercise programme their duration), comparator (treatment as usual or waiting list) and outcomes (strength, functional capacity, metabolic health and skeletal muscle structure). Two independent reviewers will (1) search, screen and select studies, (2) extract data about their main characteristics and (3) evaluate their methodological and reporting quality. When disagreements emerge, the reviewers will discuss to reach a consensus. We plan to conduct meta-analysis to quantitatively synthesise the effects under study. ETHICS AND DISSEMINATION: As systematic reviews use publicly available data, no formal ethical review and approval are needed. Findings will be published in a peer-reviewed journal(s) and presented at conferences. PROSPERO REGISTRATION NUMBER: CRD42021235092.


Subject(s)
Exercise Therapy , Exercise , Accidental Falls , Aged , Humans , Meta-Analysis as Topic , Middle Aged , Research Design , Systematic Reviews as Topic
15.
Healthcare (Basel) ; 9(11)2021 Oct 25.
Article in English | MEDLINE | ID: mdl-34828485

ABSTRACT

Physical exercise may activate a number of important biochemical processes in the human body. The aim of this systematic review and meta-analysis was to identify the long-term effect of physical activity on irisin blood levels. We searched PubMed, Scopus, and Web of Science for articles addressing the long-term effect of physical exercise on irisin blood levels. Fifty-nine articles were included in the final qualitative and quantitative syntheses. A statistically significant within-group effect of exercise on irisin blood levels was in 33 studies; out of them, the irisin level increased 23× and decreased 10×. The significant positive between-groups effect was found 11×. Furthermore, the meta-analysis indicated that physical exercise had a significant positive effect on irisin blood levels (SMD = 0.39 (95% CI 0.27-0.52)). Nevertheless, considerably high heterogeneity was found in all the analyses. This systematic review and meta-analysis indicate that physical exercise might increase irisin blood levels; however, the results of individual studies were considerably inconsistent, which questions the methodological detection of irisin by ELISA kits.

16.
J Clin Med ; 10(22)2021 Nov 20.
Article in English | MEDLINE | ID: mdl-34830716

ABSTRACT

Patients recovering from COVID-19 commonly report persistence of dyspnea, exertional fatigue, and difficulties in carrying out their daily activities. However, the nature of these symptoms is still unknown. The purpose of the study was to identify limiting causes of cardiopulmonary origin for the performance of physical exercise in post-COVID-19 condition that could explain the symptomatic persistence of dyspnea or fatigue-related symptoms. Thirty-two non-hospitalized patients with post-COVID-19 condition (i.e., still presenting a chronic symptomatic phase lasting >90 days since debut of symptoms that lasted for at least 2 months and cannot be explained by an alternative diagnosis) completed a clinical examination including echocardiography, submaximal and maximal cardiorespiratory fitness tests (Ekblom-Bak and Bruce's protocols), and a battery of validated questionnaires about fatigue and exercise intolerance. Four participants (12.5%) reported an abnormal cardiac response to exercise during the submaximal test, which aroused suspicion of the presence of chronotropic incompetence. All of them were confirmed with a positive diagnosis maximal exercise test after cardiology screening, even with a comprehensive clinical examination, resting ECG, and echocardiogram, without other findings. No statistical differences were found in any physiological variables or questionnaire values, between patients with positive and negative diagnoses. Chronotropic incompetence and other autonomic disorders may appear in patients with mild forms of COVID-19 presentation and may persist in the long term, being responsible for exercise intolerance after resolution of acute infection. Clinicians should be aware that chronotropic incompetence and other autonomic disorders may be a complication of COVID-19 and should consider appropriate diagnostic and therapeutic interventions in these patients, especially when early exercise-related fatigability is reported.

17.
Exp Gerontol ; 155: 111575, 2021 11.
Article in English | MEDLINE | ID: mdl-34582970

ABSTRACT

We aimed to analyze the isometric knee extension test (IKE) test in terms of i) intra- and inter-session repeatability, and ii) relationship with functional and body composition factors of sarcopenia among institutionalized older adults. Thirteen institutionalized older adults (age = 87 ± 10 years, body mass [BM] = 73.1 ± 10.9 kg, body mass index [BMI] = 28.5 ± 3.8 kg·m2) were recruited from a nursing home. Variability of maximal isometric force registered in three IKE trials performed on the same day was used to examine intra-session repeatability, whereas inter-session repeatability was analyzed by comparing maximal isometric force from two different days. Furthermore, functional (Handgrip, 6-m Gait Speed, Time Up and Go [TUG], and Sit-to-stand tests) and body composition (appendicular lean mass adjusted by BMI, ALM/BMI) evaluations were conducted. Statistics included the intraclass correlation coefficient (ICC) and the standard error of measurement (SEM), expressed in both absolute (N·kg-1) and relative terms (coefficient of variation, CV = 100 × SEM / mean). High to very high intra-session repeatability was found for both the dominant and non-dominant legs (CV ≤ 6.0%, ICC ≥ 0.989). Similarly, both legs showed high inter-session repeatability (SEM ≤ 0.26 N·kg-1, ICC ≥ 0.959). On the other hand, significant relationships were found between Dominant and Non-dominant IKE tests and 6-m Gait Speed (r = 0.77; r = 0.58), ALM/BMI (r = 0.62; r = 0.58), and Non-dominant Handgrip/BM (r = 0.60; r = 0.68). In addition, a significant association was found between Dominant IKE/BM and TUG (r = -0.74), as well as between Non-dominant IKE/BM and Dominant Handgrip/BM (r = 0.67). These findings suggest that the IKE test is a repeatable and suitable strategy for lower-limb screening in institutionalized older adults.


Subject(s)
Hand Strength , Sarcopenia , Aged , Aged, 80 and over , Body Composition , Humans , Knee , Muscle Strength , Sarcopenia/diagnosis , Walking Speed
18.
Article in English | MEDLINE | ID: mdl-34067776

ABSTRACT

The coronavirus disease (COVID-19), caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, is leading to unknown and unusual health conditions that are challenging to manage. Post-COVID-19 syndrome is one of those challenges, having become increasingly common as the pandemic evolves. The latest estimates suggest that 10 to 20% of the SARS-CoV-2 patients who undergo an acute symptomatic phase are experiencing effects of the disease beyond 12 weeks after diagnosis. Although research is beginning to examine this new condition, there are still serious concerns about the diagnostic identification, which limits the best therapeutic approach. Exercise programs and physical activity levels are well-known modulators of the clinical manifestations and prognosis in many chronic diseases. This narrative review summarizes the up-to-date evidence on post-COVID-19 syndrome to contribute to a better knowledge of the disease and explains how regular exercise may improve many of these symptoms and could reduce the long-term effects of COVID-19.


Subject(s)
COVID-19 , SARS-CoV-2 , Exercise , Humans , Pandemics
19.
Sensors (Basel) ; 21(8)2021 Apr 15.
Article in English | MEDLINE | ID: mdl-33921002

ABSTRACT

This study aimed to examine the validity and reliability of the recently developed Assioma Favero pedals under laboratory cycling conditions. In total, 12 well-trained male cyclists and triathletes (VO2max = 65.7 ± 8.7 mL·kg-1·min-1) completed five cycling tests including graded exercises tests (GXT) at different cadences (70-100 revolutions per minute, rpm), workloads (100-650 Watts, W), pedaling positions (seated and standing), vibration stress (20-40 Hz), and an 8-s maximal sprint. Tests were completed using a calibrated direct drive indoor trainer for the standing, seated, and vibration GXTs, and a friction belt cycle ergometer for the high-workload step protocol. Power output (PO) and cadence were collected from three different brand, new pedal units against the gold-standard SRM crankset. The three units of the Assioma Favero exhibited very high within-test reliability and an extremely high agreement between 100 and 250 W, compared to the gold standard (Standard Error of Measurement, SEM from 2.3-6.4 W). Greater PO produced a significant underestimating trend (p < 0.05, Effect size, ES ≥ 0.22), with pedals showing systematically lower PO than SRM (1-3%) but producing low bias for all GXT tests and conditions (1.5-7.4 W). Furthermore, vibrations ≥ 30 Hz significantly increased the differences up to 4% (p < 0.05, ES ≥ 0.24), whereas peak and mean PO differed importantly between devices during the sprints (p < 0.03, ES ≥ 0.39). These results demonstrate that the Assioma Favero power meter pedals provide trustworthy PO readings from 100 to 650 W, in either seated or standing positions, with vibrations between 20 and 40 Hz at cadences of 70, 85, and 100 rpm, or even at a free chosen cadence.


Subject(s)
Bicycling , Exercise Test , Ergometry , Humans , Male , Reproducibility of Results , Standing Position
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