Sex and intelligence quotient differences in age of diagnosis among youth with attention-deficit hyperactivity disorder.

OBJECTIVES: Attention-deficit/hyperactivity disorder (ADHD) is the most common neurodevelopmental condition and is characterized by inattention, hyperactivity, and impulsivity. Research suggests that some populations, such as females and individuals with high intelligence quotients may be a risk for late ADHD diagnosis and subsequent treatment. Our goal is to advance our understanding of ADHD diagnosis, by examining (1) how child sex and cognitive abilities together are related to the age of diagnosis and (2) whether symptom presentation, current internalizing and externalizing symptoms, and demographic factors are related to age of diagnosis. METHODS: Our analyses contained children who completed the required tests (N = 568) from a pre-existing dataset of 1380 children with ADHD from the Province of Ontario Neurodevelopmental Disorders (POND) Network (pond-network.ca). First, we conducted a moderation analysis with sex as the predictor, cognitive abilities as the moderator, and age of diagnosis as the outcome. Second, we conducted correlation analyses examining how symptom presentation, current internalizing and externalizing symptoms, and demographic factors are related to age of diagnosis. RESULTS: Higher IQ was related to a later age of diagnosis. Higher hyperactive-impulsive symptoms and externalizing symptoms were related to an earlier age of diagnosis. Internalizing symptoms were trend associated with a later age of diagnosis in girls. Higher socioeconomic status and non-White maternal ethnicity were related to later age of diagnosis. CONCLUSIONS: IQ, sex, ADHD symptomology, internalizing symptoms, externalizing symptoms, and socio-demographic factors affect the age of diagnosis.

Examining the interaction between prenatal stress and polygenic risk for attention-deficit/hyperactivity disorder on brain growth in childhood: Findings from the DREAM BIG consortium.

This study explored the interactions among prenatal stress, child sex, and polygenic risk scores (PGS) for attention-deficit/hyperactivity disorder (ADHD) on structural developmental changes of brain regions implicated in ADHD. We used data from two population-based birth cohorts: Growing Up in Singapore Towards healthy Outcomes (GUSTO) from Singapore (n = 113) and Generation R from Rotterdam, the Netherlands (n = 433). Prenatal stress was assessed using questionnaires. We obtained latent constructs of prenatal adversity and prenatal mood problems using confirmatory factor analyses. The participants were genotyped using genome-wide single nucleotide polymorphism arrays, and ADHD PGSs were computed. Magnetic resonance imaging scans were acquired at 4.5 and 6 years (GUSTO), and at 10 and 14 years (Generation R). We estimated the age-related rate of change for brain outcomes related to ADHD and performed (1) prenatal stress by sex interaction models, (2) prenatal stress by ADHD PGS interaction models, and (3) 3-way interaction models, including prenatal stress, sex, and ADHD PGS. We observed an interaction between prenatal stress and ADHD PGS on mean cortical thickness annual rate of change in Generation R (i.e., in individuals with higher ADHD PGS, higher prenatal stress was associated with a lower rate of cortical thinning, whereas in individuals with lower ADHD PGS, higher prenatal stress was associated with a higher rate of cortical thinning). None of the other tested interactions were statistically significant. Higher prenatal stress may promote a slower brain developmental rate during adolescence in individuals with higher ADHD genetic vulnerability, whereas it may promote a faster brain developmental rate in individuals with lower ADHD genetic vulnerability.

Adverse Life Experiences and Brain Function: A Meta-Analysis of Functional Magnetic Resonance Imaging Findings.

Importance: Adverse life experiences have been proposed to contribute to diverse mental health problems through an association with corticolimbic functioning. Despite compelling evidence from animal models, findings from studies in humans have been mixed; activation likelihood estimation (ALE) meta-analyses have failed to identify a consistent association of adverse events with brain function. Objective: To investigate the association of adversity exposure with altered brain reactivity using multilevel kernel density analyses (MKDA), a meta-analytic approach considered more robust than ALE to small sample sizes and methodological differences between studies. Data Sources: Searches were conducted using PsycInfo, Medline, EMBASE, and Web of Science from inception through May 4, 2022. The following search term combinations were used for each database: trauma, posttraumatic stress disorder (PTSD), abuse, maltreatment, poverty, adversity, or stress; and functional magnetic resonance imaging (fMRI) or neuroimaging; and emotion, emotion regulation, memory, memory processing, inhibitory control, executive functioning, reward, or reward processing. Study Selection: Task-based fMRI studies within 4 domains (emotion processing, memory processing, inhibitory control, and reward processing) that included a measure of adverse life experiences and whole-brain coordinate results reported in Talairach or Montreal Neurological Institute space were included. Conference abstracts, books, reviews, meta-analyses, opinions, animal studies, articles not in English, and studies with fewer than 5 participants were excluded. Data Extraction and Synthesis: Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting guideline, 2 independent reviewers assessed abstracts and full-text articles for entry criteria. A third reviewer resolved conflicts and errors in data extraction. Data were pooled using a random-effects model and data analysis occurred from August to November 2022. Main Outcomes and Measures: Peak activation x-axis (left-right), y-axis (posterior-anterior), and z-axis (inferior-superior) coordinates were extracted from all studies and submitted to MKDA meta-analyses. Results: A total of 83 fMRI studies were included in the meta-analysis, yielding a combined sample of 5242 participants and 801 coordinates. Adversity exposure was associated with higher amygdala reactivity (familywise error rate corrected at P < .001; x-axis = 22; y-axis = -4; z-axis = -17) and lower prefrontal cortical reactivity (familywise error rate corrected at P < .001; x-axis = 10; y-axis = 60; z-axis = 10) across a range of task domains. These altered responses were only observed in studies that used adult participants and were clearest among those who had been exposed to severe threat and trauma. Conclusions and Relevance: In this meta-analysis of fMRI studies of adversity exposure and brain function, prior adversity exposure was associated with altered adult brain reactivity to diverse challenges. These results might better identify how adversity diminishes the ability to cope with later stressors and produces enduring susceptibility to mental health problems.

No bilingual advantage in children's attentional disengagement: Congruency and sequential congruency effects in a large sample of monolingual and bilingual children.

According to recent accounts, bilingualism in childhood confers an advantage in a specific domain of executive functioning termed attentional disengagement. The current study tested this hypothesis in 492 children (245 boys; Mage = 10.98 years) from Canada, China, and Lebanon by testing for an association between language status and measures of attentional disengagement. Across the entire sample, monolinguals responded more quickly and accurately than bilinguals on a measure of attentional disengagement but differed in age, socioeconomic status, and general cognitive ability. Differences between monolinguals and bilinguals disappeared when the influence of these confounding variables was controlled using a matched samples analysis (ns = 105). Bayesian analyses further confirmed that the evidence was more likely under the null hypothesis than under the alternative hypothesis. In sum, there was little evidence of an association between language status and attentional disengagement in children.

Culture, executive functions, and academic achievement.

Although it is well known that children of East Asian immigrants show higher academic achievement than native-born North American children, the social-cognitive determinants of this difference remain poorly understood. Given the importance of executive functions (EF) for academic achievement, and evidence that EF develops more quickly in East Asian compared to North American cultures, it is conceivable that differences in academic achievement might be rooted in EF differences between these groups. We examine this possibility by reviewing evidence of cross-cultural differences in EF development but find core concepts and findings limited in several key respects. To address these limitations, we propose a framework for relating EF, culture, and academic achievement that draws on new theoretical ideas about the nature of EF and its relation to social context. We conclude by discussing avenues for future research on the relations between culture, executive functions, and academic achievement.

Activity-State Entropy: A novel brain entropy measure based on spatial patterns of activity.

BACKGROUND: Brain entropy is a measure of the complexity of brain activity that has been linked to various cognitive abilities. The measure is based on Shannon Entropy, a measure from Information Theory that quantifies the information capacity of a system from the probability distribution of its states. Most fMRI studies measure brain entropy at the voxel level as time-series entropy and assume that entropic time-series indicate complex large-scale spatiotemporal patterns of activity. NEW METHOD: We developed a novel measure of brain entropy called Activity-State Entropy. The method quantifies entropy based on underlying patterns of coactivation identified using Principal Components Analysis. These patterns, termed eigenactivity states, combine in time-varying proportions. RESULTS: We showed that Activity-State Entropy is sensitive to the complexity of the spatiotemporal patterns of activity in simulated fMRI data. We then applied this measure to real resting-state fMRI data and found that the eigenactivity states that explained the most variance in the data were comprised of large clusters of coactivating voxels, including clusters within Default Mode Network regions. More entropic brains were increasingly influenced by eigenactivity states comprised of smaller and more sparsely distributed clusters. COMPARISON TO EXISTING METHODS: We compared Activity-State Entropy to Sample Entropy and Dispersion Entropy, two time-series entropy measures commonly used in neuroimaging research, and found all three measures were positively correlated. CONCLUSIONS: Activity-State Entropy provides a measure of the spatiotemporal complexity of brain activity that complements time-series based measures of brain entropy.

TAG-ME again: A serious game for measuring working memory.

BrainTagger (demo version: researcher-demo.braintagger.com) is a suite of Target Acquisition Games for Measurement and Evaluation (TAG-ME). Here we introduce TAG-ME Again, a serious game modeled after the well-established N-Back task, to assess working memory ability across three difficulty levels corresponding to 1-, 2-, and 3-back conditions. We also report on two experiments aimed at assessing convergent validity with the N-Back task. Experiment 1 examined correlations with N-Back task performance in a sample of adults (n = 31, 18-54 years old) across three measures: reaction time; accuracy; a combined RT/accuracy metric. Significant correlations between game and task were found, with the strongest relationship being for the most difficult version of the task (3-Back). In Experiment 2 (n = 66 university students, 18-22 years old), we minimized differences between the task and the game by equating stimulus-response mappings and spatial processing demands. Significant correlations were found between game and task for both the 2-Back and 3-Back levels. We conclude that TAG-ME Again is a gamified task that has convergent validity with the N-Back Task.

Both task-irrelevant and task-relevant information trigger reactive conflict adaptation in the item-specific proportion-congruent paradigm.

Adapting attention flexibly is a fundamental ability of the human control system. In the color-word Stroop task, for example, congruency effects are typically smaller for colors and words that appear mainly in incongruent stimuli (mostly-incongruent items) than for colors and words that appear mainly in congruent stimuli (mostly-congruent items). At least part of this item-specific proportion-congruent (ISPC) effect is due to a process of reactive conflict adaptation that affords higher selectivity (i.e., more efficient selection of task-relevant information) when a specific stimulus is presented that is frequently associated in the experiment with conflicting task-irrelevant information. What is unclear, however, is whether, normally, this stimulus-specific adaptation is triggered by the task-relevant component, the task-irrelevant component, or both components of the stimulus. In two experiments, using modified color-word (Experiment 1) and spatial (Experiment 2) Stroop tasks that allowed task-relevant and task-irrelevant triggering processes to be dissociated, we found that the two processes have approximately equivalent impacts. Because these results were obtained in experiments imposing no limitations on the processes potentially contributing to the ISPC effect, these results challenge claims that the ISPC effect involves conflict-adaptation processes only in special situations. The ISPC effect may involve conflict-adaptation processes in most situations, with both task-relevant and task-irrelevant information triggering such processes.

Brain Network Connectivity and Executive Function in Children with Infantile Hydrocephalus.

Introduction: Infantile hydrocephalus (HCP) is a condition in which there is an abnormal buildup of cerebrospinal fluid in the ventricles within the first few months of life, which puts pressure on surrounding brain tissues. Compression of the developing brain increases the risk of secondary brain injury and cognitive disabilities. Methods: In this study, we used diffusion-weighted imaging and resting-state functional magnetic resonance imaging to investigate the effects of ventricle dilatation on structural and functional brain networks in children with shunted infantile HCP and examined how these brain changes may impact executive function. Results: We found that children with HCP have altered structural and functional connectivity between and within large-scale networks. Moreover, hyperconnectivity between the ventral attention and default mode network in children with HCP correlated with reduced executive function scores. Compared with typically developing age-matched control participants, our patient population also had lower fractional anisotropy in posterior white matter. Discussion: Overall, these findings suggest that infantile HCP has long-term effects on brain network connectivity, white matter development, and executive function in children at school age. Future work will examine the relationship between ventricular volumes before shunt placement in infancy and brain network development throughout childhood.

Bilingualism and executive attention: Evidence from studies of proactive and reactive control.

According to some accounts, the bilingual advantage is most pronounced in the domain of executive attention rather than inhibition and should therefore be more easily detected in conflict adaptation paradigms than in simple interference paradigms. We tested this idea using two conflict adaptation paradigms, one that elicits a list-wide proportion-congruent effect and one that elicits an item-specific proportion-congruent effect. In both cases, the relevant finding is that congruency effects are reduced when the proportion of congruent to incongruent items is smaller. These effects are validated measures of proactive and reactive control, respectively, and are aspects of executive attention known to be associated with individual differences in working memory capacity. We reasoned that if bilingualism affects executive attention in a similar way as does working memory capacity, indices of proactive and reactive control should be comparably associated with continuous variation in language status and working memory capacity. In two experiments, we replicated previous findings that working memory capacity is associated with variation in congruency effects (suggesting greater reliance on proactive control). In contrast, language status had no consistent association with performance, save for a hint that bilingualism may be associated with greater reliance on reactive control. Thus, the bilingual advantage may exist, but not in proactive control or any other aspects of executive attention that have been proposed thus far. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

School's out: Parenting stress and screen time use in school-age children during the COVID-19 pandemic.

Background During the COVID-19 pandemic, millions of children abruptly moved to online schooling, which required high levels of parental involvement. Family routines were disrupted, potentially increasing parental stress, and may be reflected in greater media screen time use in children. Objectives To determine whether (1) parenting styles and (2) parenting stress were associated with children's screen time use during the pandemic compared to the pre-pandemic period. Methods Parents (> 18 years of age) were recruited to complete an online survey regarding changes in their children's (6-12 years) screen time use and daily activities before and during the pandemic. Stress and parental involvement were assessed using the Perceived Stress Scale (PSS) and Alabama Parenting Questionnaires respectively. General linear models assessed whether parenting style and parent stress were associated with children's screen time during the pandemic, adjusting for demographic variables and daily activities. Results 104 parents were enrolled, and 73 (70.2%) parents completed the surveys. Children's screen time (e.g., watching television and playing video games) increased significantly, from 2.6 to 5.9h a day (p = .001) during pandemic-related school closures. Fewer changes in children's screen time use were significantly associated with greater parental involvement (p = .017). Parent stress (p = .018) significantly predicted children's screen time use. Lower household income was associated with increased hours of screen time in both models (both, p < .05). Conclusions: Children's screen time increased significantly during the initial months of the pandemic. Parent stress and parenting styles may be modifiable risk factors to promote children's well-being during the ongoing pandemic.

The Bilingual Advantage in Children's Executive Functioning Is Not Related to Language Status: A Meta-Analytic Review.

There is considerable debate about whether bilingual children have an advantage in executive functioning relative to monolingual children. In the current meta-analysis, we addressed this debate by comprehensively reviewing the available evidence. We synthesized data from published studies and unpublished data sets, which equated to 1,194 effect sizes from 10,937 bilingual and 12,477 monolingual participants between the ages of 3 and 17 years. Bilingual language status had a small overall effect on children's executive functioning (g = .08, 95% confidence interval = [.01, .14]). However, the effect of language status on children's executive functioning was indistinguishable from zero (g = -.04) after we adjusted for publication bias. Further, no significant effects were apparent within the executive-attention domain, in which the effects of language status have been hypothesized to be most pronounced (g = .06, 95% confidence interval = [-.02, .14]). Taken together, available evidence suggests that the bilingual advantage in children's executive functioning is small, variable, and potentially not attributable to the effect of language status.

Disentangling language status and country-of-origin explanations of the bilingual advantage in preschoolers.

Bilingual preschoolers from East Asia outperform monolingual preschoolers from North America or Europe in executive functioning tasks, which has been interpreted as evidence of a bilingual advantage in executive functioning. This study tested whether these differences actually reflect country-of-origin effects given that East Asian preschoolers frequently outperform North American or European children in executive functioning tasks. Consistent with previous findings, Korean-English bilingual preschoolers made fewer errors in an age-appropriate executive functioning task than did English monolingual children in Canada. However, Korean-English bilingual preschoolers performed comparably to Korean monolingual preschoolers in Korea. Differences between Korean and Canadian children's executive functioning were not attributable to differences in parental cultural values or attitudes. The current findings suggest that differences between East Asian bilingual and North American monolingual preschoolers' executive functioning is related to differences in country of origin rather than language status.

The differential calibration of the HPA axis as a function of trauma versus adversity: A systematic review and p-curve meta-analyses.

Although there is an abundance of evidence linking the function of the hypothalamic-pituitary-adrenal (HPA) axis to adverse early-life experiences, the precise nature of the association remains unclear. Some evidence suggests early-life adversity leads to cortisol hyper-reactivity, while other evidence suggests adversity leads to cortisol hypo-reactivity. Here, we distinguish between trauma and adversity, and use p-curves to interrogate the conflicting literature. In Study 1, trauma was operationalized according to DSM-5 criteria; the p-curve analysis included 68 articles and revealed that the literature reporting associations between trauma and blunted cortisol reactivity contains evidential value. Study 2 examined the relationship between adversity and cortisol reactivity. Thirty articles were included in the analysis, and p-curve demonstrated that adversity is related to heightened cortisol reactivity. These results support an inverted U-shaped function relating severity of adversity and cortisol reactivity, and underscore the importance of distinguishing between "trauma" and "adversity".

Adolescent obesity and dietary decision making-a brain-health perspective.

Adolescence represents a key period of brain development underpinned by the ongoing maturation of the prefrontal cortex-a brain region involved in the regulation of behaviour and cognition. Given the high prevalence of obesity in adolescents worldwide, this Review examines neurobiological and neurocognitive evidence describing the adolescent propensity to consume calorie-dense foods, and the neurodevelopmental mechanisms that heighten the adverse impact of these foods on brain function. The excessive consumption of calorie-dense food can undermine self-regulatory processes through effects on brain function and behavioural control. These changes could introduce enduring maladaptive eating behaviours that underlie adult obesity and related metabolic syndromes. Better understanding of links between adolescence, dietary decision making, and brain function is essential for clinicians to develop effective intervention strategies and for reducing long-term health-care costs associated with obesity.

Functional connectivity dynamics slow with descent from wakefulness to sleep.

The transition from wakefulness to sleep is accompanied by widespread changes in brain functioning. Here we investigate the implications of this transition for interregional functional connectivity and their dynamic changes over time. Simultaneous EEG-fMRI was used to measure brain functional activity of 21 healthy participants as they transitioned from wakefulness into sleep. fMRI volumes were independent component analysis (ICA)-decomposed, yielding 42 neurophysiological sources. Static functional connectivity (FC) was estimated from independent component time courses. A sliding window method and k-means clustering (k = 7, L2-norm) were used to estimate dynamic FC. Static FC in Wake and Stage-2 Sleep (NREM2) were largely similar. By contrast, FC dynamics across wake and sleep differed, with transitions between FC states occurring more frequently during wakefulness than during NREM2. Evidence of slower FC dynamics during sleep is discussed in relation to sleep-related reductions in effective connectivity and synaptic strength.

Sequential Congruency Effects in Monolingual and Bilingual Adults: A Failure to Replicate Grundy et al. (2017).

Previous research suggests bilingual adults show smaller sequential congruency effects than monolingual adults. Here we re-examined these findings by administering an Eriksen flanker task to monolingual and bilingual adults. The task produced robust conventional and sequential congruency effects. Neither effect differed for monolingual and bilingual adults. Results are discussed in terms of current debates concerning differences in cognitive control between monolingual and bilingual adults.

Ventral striatal activity links adversity and reward processing in children.

Adversity impacts many aspects of psychological and physical development including reward-based learning and decision-making. Mechanisms relating adversity and reward processing in children, however, remain unclear. Here, we show that adversity is associated with potentiated learning from positive outcomes and impulsive decision-making, but unrelated to learning from negative outcomes. We then show via functional magnetic resonance imaging that the link between adversity and reward processing is partially mediated by differences in ventral striatal response to rewards. The findings suggest that early-life adversity is associated with alterations in the brain's sensitivity to rewards accounting, in part, for the link between adversity and altered reward processing in children.

It's a matter of time: Reframing the development of cognitive control as a modification of the brain's temporal dynamics.

Cognitive control is a process that unfolds over time and regulates thought and action in the service of achieving goals and managing unanticipated challenges. Prevailing accounts attribute the protracted development of this mental process to incremental changes in the functional organization of a cognitive control network. Here, we challenge the notion that cognitive control is linked to a topologically static network, and argue that the capacity to manage unanticipated challenges and its development should instead be characterized in terms of inter-regional functional coupling dynamics. Ongoing changes in temporal coupling have long represented a fundamental pillar in both empirical and theoretical-based accounts of brain function, but have been largely ignored by traditional neuroimaging methods that assume a fixed functional architecture. There is, however, a growing recognition of the importance of temporal coupling dynamics for brain function, and this has led to rapid innovations in analytic methods. Results in this new frontier of neuroimaging suggest that time-varying changes in connectivity strength and direction exist at the large scale and further, that network patterns, like cognitive control process themselves, are transient and dynamic.