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3.
Ann Chir Plast Esthet ; 66(3): 268-272, 2021 Jun.
Artigo em Francês | MEDLINE | ID: mdl-33707028

RESUMO

INTRODUCTION: Granular cell tumours are extremely rare on peripheral nerves, with an incidence of 0.029% of pathologic samples. In a literature review, we found only 5 cases involving the ulnar nerve, although considered the most frequently involvement nerve. CASE REPORT: A 32 year-old female from the French West Indies presented a severe arm pain with deficit of interosseous hand muscles. Imaging studies were in favour of a Schwanoma, but during surgery, we found an unremovable intra-neural tumour. Nerve biopsy revealed a granular cell tumour. Initial decision was observation only. However, within two years, tumour increased in size, along with pain aggravation and functional deficit. We performed a nerve resection (with adequate margins) with reconstruction using sural nerve graft associated with a neurotisation of the motor branch with the anterior interosseus nerve. At two years follow-up, no recurrence was observed. The scar is hypersensitive with moderate neuropathic pain. There is a sensory reinnervation of the fourth finger, with no motor recovery of the hand. We observed a slight recovery of flexor profundus tendons, which, in turn increased the claw hand. DISCUSSION: The five cases described in the literature were managed differently (biopsy only, excision, excision with reconstruction), with modest results. There is no recommended treatment. Our case is the first at arm level. We were able to perform complete resection, but functional result is poor. CONCLUSION: Granular cell tumours require treatment if symptomatic (pain, function loss), but, at the moment, there is no recommended treatment.


Assuntos
Tumor de Células Granulares , Transferência de Nervo , Adulto , Braço , Feminino , Tumor de Células Granulares/cirurgia , Humanos , Recidiva Local de Neoplasia , Nervo Ulnar
4.
Rev. senol. patol. mamar. (Ed. impr.) ; 32(4): 145-147, oct.-dic. 2019. ilus
Artigo em Espanhol | IBECS | ID: ibc-190397

RESUMO

El presente artículo describe nuestra experiencia en el diagnóstico y tratamiento de un paciente varón de 42 años diagnosticado de un tumor de células granulares en la mama y pretende llamar la atención sobre esta entidad, que puede simular un carcinoma de mama, debiéndose tener en cuenta en el diagnóstico diferencial de la enfermedad nodular mamaria


This article describes our experience in the diagnosis and treatment of a 42-year-old male patient diagnosed with a granular cell tumour in the breast and draws attention to this entity, which can simulate a breast carcinoma. This should be taken into account in the differential diagnosis of nodular breast disease


Assuntos
Humanos , Masculino , Adulto , Tumor de Células Granulares/diagnóstico , Tumor de Células Granulares/cirurgia , Neoplasias da Mama/diagnóstico por imagem , Neoplasias da Mama/cirurgia , Tomografia Computadorizada Espiral , Diagnóstico Diferencial , Achados Incidentais
5.
J Pediatr Adolesc Gynecol ; 31(3): 311-314, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29305965

RESUMO

BACKGROUND: Granular cell tumors (GCTs) are rare soft tissue lesions that can involve the female genital tract, including the vulva. Although malignant tumors are aggressive and uncommon, benign and atypical lesions still have associated risks, including recurrence and multisite development. CASES: Four cases of pediatric vulvar GCT are presented, including 1 atypical and 3 benign tumors. The atypical lesion occurred in a 3-year-old girl, to our knowledge, the youngest reported patient with GCT of the vulva. Follow-up information is available for 3 patients, ranging 0-12 years. SUMMARY AND CONCLUSION: GCTs are an important differential diagnosis in patients with vulvar lesions. In the pediatric population, the tumors' risk of recurrence and multisite development require gynecologists to advocate for complete resection, careful follow-up, and thorough examination for additional tumor sites.


Assuntos
Tumor de Células Granulares/patologia , Neoplasias Vulvares/patologia , Criança , Pré-Escolar , Diagnóstico Diferencial , Feminino , Tumor de Células Granulares/cirurgia , Humanos , Recidiva Local de Neoplasia , Vulva/patologia , Neoplasias Vulvares/cirurgia
6.
Afr. j. Pathol. microbiol ; 1: 1-2, 2012. ilus
Artigo em Francês | AIM (África) | ID: biblio-1256751

RESUMO

Les auteurs rapportent un cas rare de tumeur a cellules granuleuses du clitoris chez une patiente agee de 38 ans et font une breve revue de la litterature


Assuntos
Camarões , Clitóris , Tumor de Células da Granulosa
7.
ISRN Gastroenterol ; 2011: 943804, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-21991536

RESUMO

Granular cell tumor (GCT) was first described by Abrikossof in 1926. This tumor is a benign neoplasm of unclear histogenesis that is generally believed to be of nerve sheath origin. GCT is not common and most often affects the tongue, skin, and soft tissue, although it may occur anywhere in the body. Gastrointestinal tract involvement, and especially that of the colon, is very rare. This usually benign tumor appears as a submucosal nodule, measuring less than 2 cm in diameter and is often found incidentally during colorectal examinations. We describe the case of a 27-year-old man with a GCT in the cecum that was detected after a screening colonoscopy. Endoscopic examination revealed a yellowish submucosal tumor, 0.7 cm in diameter. An endoscopic mucosal polypectomy was done for histological confirmation and treatment.

8.
World J Gastrointest Oncol ; 2(2): 121-4, 2010 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-21160931

RESUMO

Granular cell tumors, also called Abrikossof's tumors, were originally described by Abrikossof A in 1926. The first case of a pancreatic granular cell tumor was described in 1975 and only 6 cases have been reported. We describe a case of granular cell tumor in the pancreas showing pancreatic duct obstruction. Because imaging studies showed findings compatible with those of pancreatic carcinoma, the patient underwent distal pancreatectomy. Histological examination showed that the tumor consisted of a nested growth of large tumor cells with ample granular cytoplasm and small round nuclei. The tumor cells expressed S-100 protein and were stained with neuron-specific enolase and periodic acid-Schiff, but were negative for desmin, vimentin, and cytokeratin. The resected tumor was diagnosed as a granular cell tumor. To our knowledge, this is the seventh case of Granular cell tumor of the pancreas to be reported.

11.
Gastroenterol Clin Biol ; 29(3): 289-90, 2005 Mar.
Artigo em Francês | MEDLINE | ID: mdl-15864180

RESUMO

Granular cell tumors or Abrikossof tumors are neurogenous ubiquitary submucosal-like tumors that are usually benign. The most frequent locations are the skin and buccal cavity. The usual location in the digestive tract is the esophageal wall. We report a rare case of Abrikossof tumor of the rectum that was not operated on because of a certain diagnosis and a low risk of malignancy.


Assuntos
Tumor de Células Granulares/diagnóstico , Neoplasias Retais/diagnóstico , Adulto , Colonoscopia , Humanos , Masculino
12.
An. otorrinolaringol. Ibero-Am ; 32(1): 65-70, ene.-feb. 2005. ilus
Artigo em Es | IBECS | ID: ibc-037876

RESUMO

El tumor de células granulares, mioblastomas o tumor de Abrikossof es una lesión benigna poco frecuente, generalmente de crecimiento lento, que muestra predilección por la cavidad oral, especialmente la lengua. Su etiopatogenia real aún continúa siendo motivo de controversia y en su histogénesis se han implicado varios tipos celulares. Se presenta el caso de una mujer de 18 años con este diagnóstico, confirmado por AP, que fue intervenida mediante exéresis de la tumoración que afectaba la hemilengua izquierda. Tras 28 meses de seguimiento no se han registrado recidivas


Granular cell tumor, myoblastoma or Abrikossof’s tumor is an uncommon benign lesion, usually of slow-growing, that shows a predilection for the oral cavity, especially the tongue. Its real etiopathogenia remains still controversial and in it's histogenesis have been implicated several cell types. We report the case of a 18 years old woman with that diagnosis, confirmed in AP, who was operated by removal of the tumoration that was located in the left half-tongue. After 28 months she has not suffered any recurrences


Assuntos
Feminino , Adulto , Humanos , Tumor de Células Granulares/patologia , Neoplasias da Língua/patologia , Tumor de Células Granulares , Tumor de Células Granulares/cirurgia , Tomografia por Raios X , Neoplasias da Língua , Neoplasias da Língua/cirurgia
13.
Otolaryngol Pol ; 59(6): 883-6, 2005.
Artigo em Polonês | MEDLINE | ID: mdl-16521457

RESUMO

Extracardiac rhabdomyoma comprise 2% of all tumors of skeletal muscle differentiation. Seventy percent of extracardiac rhabdomyoma occur in the head and neck region and have been subclassified into adult and fetal types. There are only about 100 cases reported in the literature. A review of the world literature revealed about 19 acceptable cases of benign, multifocal adult-type rhabdomyoma with a distinct male predominance. The pathogenesis of this benign striated muscle tumor is still unclear. These slow-growing tumors remain asymptomatic for a long period. The diagnosis of head and neck rhabdomyoma is based on histology and immunhistochemical studies. The differential diagnoses of rhabdomyoma in adults are myoblastoma or Abrikossof tumor, reticulohistiocytoma, rhabdomyosarcoma and hibernoma. We present a case of multifocal rhabdomyomas in the paratracheal and parapharyngeal space and discuss the clinicopathological features of this lesion. Although adult rhabdomyomas have a distinct histology, they often are mistaken for a variety of other lesions, particularly Abrikossof tumor. Light microscopy showed large round to elongated cells with granular, highly eosinophilic cytoplasm, often with peripheral vacuolation. Histology showed typical patterns of an adult type of rhabdomyoma with focal cross-striations. Immunhistochemically, all applied muscular markers were positive. Electron microscopic studies confirmed the tumor's myogenic origin. Myofibrils with Z band material, abundant mitochondria and glycogen particles were observed. Treatment is usually complete excision. Local recurrences have been reported in some cases; malignant degeneration is not known.


Assuntos
Neoplasias de Cabeça e Pescoço/patologia , Rabdomioma/patologia , Idoso , Diagnóstico Diferencial , Feminino , Neoplasias de Cabeça e Pescoço/cirurgia , Humanos , Músculo Esquelético/patologia , Músculo Esquelético/cirurgia , Neoplasias Primárias Múltiplas/patologia , Neoplasias Primárias Múltiplas/cirurgia , Rabdomioma/cirurgia
14.
@rq. otorrinolaringol ; 8(3): 236-240, set. 2004. ilus
Artigo em Português | LILACS | ID: lil-417124

RESUMO

Os tumores de células glandulares são incomuns e provavelmente têm origem neuroectodérmica. Foram primeiramente relatados por Abrikossof em 1926 que os denominou de mioblastoma. Desde então, aproximadamente 1200 casos doram descritos, sendo que 50% destes são encontrados na região da cabeça e pescoço. Apenas 10% têm localização laríngea.


Assuntos
Humanos , Tumor de Células Granulares , Laringe/anormalidades
15.
Rev. cuba. estomatol ; 40(3)sept.-dic.2003. ilus
Artigo em Espanhol | CUMED | ID: cum-23753

RESUMO

El tumor de las células granulosas en una rara entidad; existen numerosas teorías sobre su origen que aún están bajo polémica, aunque la más aceptada es la neurogénica, que asimila su procedencia como neuroectodérmico. Se detectó un paciente en consulta con cuadro clínico similar al de esta patología con localización en encía superior, región de premolares. La lesión se mostraba submucosa, elevada, no dolorosa y de aspecto áspero.Tras realizar la exéresis y practicar la biopsia, se corroboró el diagnóstico de un mioblastoma de células granulosas o tumor de Abrikossoff(AU)


Assuntos
Humanos , Feminino , Tumor de Células Granulares/patologia , Tumor de Células Granulares , Tumor de Células Granulares/cirurgia , Neoplasias Gengivais
16.
Rev. cuba. estomatol ; 40(3)sept.-dic. 2003. ilus
Artigo em Espanhol | LILACS, CUMED | ID: lil-390247

RESUMO

El tumor de las células granulosas en una rara entidad; existen numerosas teorías sobre su origen que aún están bajo polémica, aunque la más aceptada es la neurogénica, que asimila su procedencia como neuroectodérmico. Se detectó un paciente en consulta con cuadro clínico similar al de esta patología con localización en encía superior, región de premolares. La lesión se mostraba submucosa, elevada, no dolorosa y de aspecto áspero.Tras realizar la exéresis y practicar la biopsia, se corroboró el diagnóstico de un mioblastoma de células granulosas o tumor de Abrikossoff(AU)


Granular cell tumors is a rare entity. There is a number of theories on their origin under discussion, but the most accepted is the neurogenic theory that covers the neuroectodermal origin of the tumor. A female patient was detected in outpatient service, who presented with a clinical picture similar to that of this pathology and located in upper gingiva, premolar region. The lesion looked submucosal, raised, painless and rough. After exeresis and biopsy, the diagnosis of granular cell myoblastoma or Abrikossof tumor was confirmed(AU)


Assuntos
Humanos , Feminino , Adolescente , Neoplasias Gengivais , Tumor de Células Granulares/cirurgia , Tumor de Células Granulares/patologia , Tumor de Células Granulares/diagnóstico por imagem
17.
Ann Otolaryngol Chir Cervicofac ; 120(6): 355-8, 2003 Dec.
Artigo em Francês | MEDLINE | ID: mdl-14730281

RESUMO

BACKGROUND: Granular cell tumor of the cervical esophagus is a rare and benign tumor. We present a case of constricting granular cell tumor of the cervical esophagus and discuss esophageal reconstruction. CASE REPORT: Constricting granular cell tumor of the cervical esophagus was diagnosed in a patient who experienced aphagia for two years. Endoscopy demonstrated complete stricture of the cervical esophagus and computed tomography and magnetic resonance imaging confirmed the presence of a tumor formation in the cervical esophagus. Total esophagectomy with preservation of the larynx was performed. DISCUSSION: Surgical treatment raises the problem of esophageal reconstruction (gastric pull up, free flap reconstruction). We used the gastric pull up technique and fashioned a piriform sinus anastomosis. There was no postoperative complication and functional outcome was excellent. CONCLUSION: Computed tomography and magnetic resonance imaging provide essential data on the spread and location of granular cell tumor. Surgery provides excellent functional results.


Assuntos
Neoplasias Esofágicas/cirurgia , Tumor de Células Granulares/cirurgia , Esofagectomia/métodos , Feminino , Humanos , Pessoa de Meia-Idade
18.
Ann Pathol ; 22(4): 324-7, 2002 Sep.
Artigo em Francês | MEDLINE | ID: mdl-12410157

RESUMO

A 41-year-old female presented in April 1996 with a tumor of the hard palate revealed by increasing left palate pain. Adenoid cystic carcinoma was suspected on clinical and imaging data. Two limited surgical procedures showed a tumor histologically made of small lobules of granular cells, PAS positive and expressing S100 protein, infiltrating some medullary spaces of the palatine bone, consistent with a granular-cell tumour. Pain recurred in the territory of the maxillary branch of the left trigeminal nerve (V2). Imaging showed a tumor of the origin of V2-extending through the foramen rotondum. Two radical interventions in September and in October 2000 showed an infiltrating tumor of the V2 and palatine mucosa, with the same histology. There was no immuno-staining for p53, and less than 5% of nuclei expressed Ki67. Malignant Abrikossof tumors are exceptional, morphologically difficult to differentiate from benign ones, only metastasis proving malignancy. Tumor size above 5 cm, recurrence and infiltrative character are considered pejorative. The value of p53 and Ki67 expression remains controversial. We discuss our observation according to these criteria.


Assuntos
Adenocarcinoma/patologia , Dor , Neoplasias Palatinas/patologia , Neoplasias Palatinas/fisiopatologia , Adenocarcinoma/cirurgia , Adenocarcinoma/ultraestrutura , Adulto , Biomarcadores Tumorais/análise , Feminino , Humanos , Antígeno Ki-67/análise , Neoplasias Palatinas/cirurgia , Neoplasias Palatinas/ultraestrutura , Proteína Supressora de Tumor p53/análise
19.
Ann Otolaryngol Chir Cervicofac ; 118(4): 245-8, 2001 Sep.
Artigo em Francês | MEDLINE | ID: mdl-11679844

RESUMO

Rhabdomyoma in adults is a rare benign neoplasm of the skeletal muscles generally arising in the pharyngolaryngeal region. These slow-growing tumors remain asymptomatic for a long period. We report a case of basilingual rhabdomyoma. Computed tomography and magnetic resonance imaging demonstrated a well-encapsulated tumor with a line of cleavage between the base of the tongue muscles. Deep transmucosal biopsies were obtained. Well-differentiated skeletal muscle cells with large eosinophilic granulular cytoplasm and cross striations gave the histologic diagnosis. Complete endoscopic resection was successful. The differential diagnoses of rhabdomyoma in adults are myoblastoma or Abrikossof tumor, rhabdomyosarcoma and hibernoma. The risk of late recurrence implies long-term clinical and radiologic follow-up.


Assuntos
Endoscopia , Rabdomioma/cirurgia , Neoplasias da Língua/cirurgia , Idoso , Biópsia , Diagnóstico Diferencial , Humanos , Imageamento por Ressonância Magnética , Masculino , Rabdomioma/diagnóstico , Rabdomioma/patologia , Língua/patologia , Neoplasias da Língua/diagnóstico , Neoplasias da Língua/patologia
20.
Ann Chir ; 126(7): 675-6, 2001 Sep.
Artigo em Francês | MEDLINE | ID: mdl-11676242

RESUMO

The aim of this study was to report one granular cells tumor of the cervical esophagus revealed by dysphagia. X-rays examination showed a paraesophageal tumor and esophagoscopy, a narrow stenosis and a benign ulceration. The tumor was removed through left cervical approach with suture of the esophageal opening. Pathological examination found a granular cells tumor infiltrating musculosa and measuring 4 x 2.5 x 2.5 cm.


Assuntos
Adenocarcinoma/cirurgia , Neoplasias Esofágicas/cirurgia , Estenose Esofágica/etiologia , Adenocarcinoma/diagnóstico , Adenocarcinoma/patologia , Adulto , Transtornos de Deglutição/etiologia , Procedimentos Cirúrgicos do Sistema Digestório/métodos , Neoplasias Esofágicas/diagnóstico , Neoplasias Esofágicas/patologia , Estenose Esofágica/cirurgia , Feminino , Humanos
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