Síndrome hemolítico urémico típico: comunicación del primer caso producido porEscherichia coli O26:H11 en España / Mitral valve replacement in infants less than 6 months-old

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Evolución de la nefropatía de Schönlein-Henochen pacientes pediátricos. Factores pronósticos / No disponible

Objetivo: Analizar los datos epidemiológicos, clínicos y analíticos, así como la curva de supervivencia renal y los factores pronósticos a corto y a largo plazo de niños con nefropatía de Schönlein-Henoch (NSH).Material y método: Estudio clínico de cohorte retrospectivo analítico. Se revisan las historias clínicas de 100 niños diagnosticados de NSH en el HIU La Fe entre 1975 y 2006.Resultados: La manifestación nefrológica más frecuente fue hematuria con proteinuria no nefrótica. El 35% de pacientes fueron biopsiados. La histología más frecuente fue la proliferación mesangial (46%). Los estadios clínicos al diagnóstico fueron Estadio B: 63%, Estadio C: 33%; Estadio D: 4%. Estadios clínicos a los 5 años: Estadio A: 49%, Estadio B: 27%,Estadio C: 0% y Estadio D: 5%. Trasplante renal: 5%. Curva de supervivencia renal (Kaplan Meier) a 5 años: 95%. Factores pronósticos: En el análisis univariante se evidencia que tanto a corto como a largo plazo los factores de mal pronóstico renal fueron la edad superior a 8 años al debut, el número de brotes de púrpura superior a 4 y la presencia de una estadio VI en la histología. El análisis multivariante muestra que a corto plazo únicamente el número de brotes es considerado factor pronóstico. Conclusión: Se pueden considerar como factores pronósticos, tanto a corto como a largo plazo, la edad al inicio de la enfermedad renal, el nº de brotes y la alteración histológica. Sin embargo, en el análisis multivariante únicamente el nº de brotes constituye un factor pronóstico a corto plaz (AU)

Objective: To analyze epidemiological, clinical and laboratory data, renal survival curve and short-term (2 years) and long-term(5 years) prognostic factors in children with nephropathy secondary to Henoch-Schönlein purpura (HSP).Materials and methods: Retrospective analitic cohort study. Clinical records of 100 children diagnosed with HSP at HIU La Fe from 1975-2006 were reviewed. Statistical analysis was by univariate and multivariate analysis. Results: In 67% of cases, nephropathy coincided with onset of the disease and most commonly manifested hematuria with nonnephrotic proteinuria. 35% of patients were biopsied. The most common histology was mesangial proliferation (46%). Clinical stages at diagnosis were stage B: 63%, stage C: 33%;stage D: 4%. Mean follow-up was 5.25 ± 0.76 years. Renal data at 5 years: Clinical stages: stage A: 49%, stage B: 27%, stage C:0%, and stage D: 5%. Renal transplant: 5%. Renal survival curve(Kaplan-Meier) at 5 years: 95%. Prognostic factors: the univariate analysis showed that the prognostic factors of poor renal prognosis in both the short and long-term were age greater than 8 years, number of purpura relapses greater than 4 and presence of stage VI histology. The multivariate analysis showed that only the number of relapses was a short-term prognostic factor. Conclusion: 1) The clinical and laboratory data reviewed were similar to those reported in the literature. 2) The renal survival curve at 5 years was 95%. 3) Age, number of relapses and histology were prognostic factors. 4) The multivariate analysis showed that only the number of relapses was a short-term prognostic factor (AU)

[Outcome of Henoch-Schönlein nephropathy in pediatric patients. Prognostic factors]. / Evolución de la nefropatía de Schönlein-Henoch en pacientes pediátricos. Factores pronósticos.

OBJECTIVE: To analyze epidemiological, clinical and laboratory data, renal survival curve and short-term (2 years) and long-term (5 years) prognostic factors in children with nephropathy secondary to Henoch-Schönlein purpura (HSP). MATERIALS AND METHODS: Retrospective analitic cohort study. Clinical records of 100 children diagnosed with HSP at H.I.U. La Fe from 1975-2006 were reviewed. Statistical analysis was by univariate and multivariate analysis. RESULTS: In 67% of cases, nephropathy coincided with onset of the disease and most commonly manifested hematuria with nonnephrotic proteinuria. 35% of patients were biopsied. The most common histology was mesangial proliferation (46%). Clinical stages at diagnosis were stage B: 63%, stage C: 33%; stage D: 4%. Mean follow-up was 5.25 +/- 0.76 years. Renal data at 5 years: Clinical stages: stage A: 49%, stage B: 27%, stage C: 0%, and stage D: 5%. Renal transplant: 5%. Renal survival curve (Kaplan-Meier) at 5 years: 95%. Prognostic factors: The univariate analysis showed that the prognostic factors of poor renal prognosis in both the short and long-term were age greater than 8 years, number of purpura relapses greater than 4 and presence of stage VI histology. The multivariate analysis showed that only the number of relapses was a short-term prognostic factor. CONCLUSION: 1) The clinical and laboratory data reviewed were similar to those reported in the literature. 2) The renal survival curve at 5 years was 95%. 3) Age, number of relapses and histology were prognostic factors. 4) The multivariate analysis showed that only the number of relapses was a short-term prognostic factor.

Eritema nudoso secundario a una infección enteral por Yersinia enterocolitica / Yersinia enterocolitica enteral infection-induced nodular erythema

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