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1.
Neuroscience ; 507: 79-98, 2022 12 15.
Artigo em Inglês | MEDLINE | ID: mdl-36370934

RESUMO

Gut dysbiosis is considered a risk factor for Parkinson's disease (PD), and chronic treatment with probiotics could prevent it. Here we report the assessment of a probiotic mixture [Lacticaseibacillus rhamnosus GG (LGG), and Bifidobacterium animalis lactis BB-12 (BB-12)] administered to male rats 2 weeks before and 3 weeks after injecting 6-hydroxydopamine (6-OHDA) into the right striatum, a model that mimics the early stages of PD. Before and after lesion, animals were subjected to behavioral tests: narrow beam, cylinder test, and apomorphine (APO)-induced rotations. Dopaminergic (DA) denervation and microglia recruitment were assessed with tyrosine hydroxylase (TH+) and ionized calcium-binding protein-1 adapter (Iba1+) immunostaining, respectively. Post 6-OHDA injury, rats treated with sunflower oil (probiotics vehicle) developed significant decrease in crossing speed and increases in contralateral paw slips (narrow beam), forepaw use asymmetry (cylinder), and APO-induced rotations. In striatum, 6-OHDA eliminated ≈2/3 of TH+ area and caused significant increase of Iba1+ microglia population. Retrograde axonal degeneration suppressed ≈2/5 of TH+ neurons in the substantia nigra pars compacta (SNpc). In hemiparkinsonian rats, probiotics treatment significantly improved the crossing speed, and also reduced paw slips (postlesion days 14 and 21), the loss of TH+ neurons in SNpc, and the loss of TH+ area and of Iba1+ microglia count in striatum, without affecting the proportion of microglia morphological phenotypes. Probiotics treatment did not attenuate forepaw use asymmetry nor APO-induced rotations. These results indicate that the mixture of probiotics LGG and BB-12 protects nigrostriatal DA neurons against 6-OHDA-induced damage, supporting their potential as preventive treatment of PD.


Assuntos
Bifidobacterium animalis , Lacticaseibacillus rhamnosus , Transtornos Motores , Doença de Parkinson , Probióticos , Ratos , Masculino , Animais , Oxidopamina , Bifidobacterium animalis/metabolismo , Doença de Parkinson/patologia , Microglia/metabolismo , Lacticaseibacillus , Substância Negra/metabolismo , Transtornos Motores/patologia , Corpo Estriado/metabolismo , Neurônios Dopaminérgicos/metabolismo , Dopamina , Apomorfina/farmacologia , Tirosina 3-Mono-Oxigenase/metabolismo , Probióticos/farmacologia
2.
Horiz. sanitario (en linea) ; 19(1): 115-126, ene.-abr. 2020. tab
Artigo em Espanhol | LILACS-Express | LILACS | ID: biblio-1143053

RESUMO

Resumen Objetivo Comparar la relación de la Percepción de la Imagen Corporal y el Índice de Masa Corporal en estudiantes de secundaria de dos municipios de Yucatán. Material y Métodos Estudio cuantitativo y transversal, en 462 estudiantes de 11 a 17 años pertenecientes a escuelas de los municipios de Abalá y Chacsinkín, Yucatán. Se tomó el peso corporal y la talla, se calculó el Índice de Masa Corporal (IMC)/edad, de acuerdo a los patrones de la Organización Mundial de la Salud (OMS) para adolescentes. Se determinó la percepción de la imagen corporal mediante el instrumento Análisis de la Percepción de la Imagen Corporal (APC), propuesta por Stunkard y Stellard, modificado por Collins. Para el análisis estadístico inferencial se utilizó la prueba Chi-cuadrara con un valor de significancia estadística de 5%. Resultados 62.9% de los adolescentes, tienen un Índice de Masa Corporal normal, mientras que 35.6% presentan una prevalencia combinada de obesidad y sobrepeso. En cuanto a Percepción de la Imagen Corporal, 28.8 % de los adolescentes se percibieron de acuerdo con su IMC real; 25.3% se percibieron con IMC mayor al real y 45.9% se percibieron con IMC menor al que tienen en realidad Conclusiones En el municipio de Abala, los adolescentes presentaron mayor prevalencia de normo peso y exceso de peso; frecuencia mayor de concordancia entre la percepción corporal y el IMC real y sobre estimación de su IMC, a diferencia de la mayor frecuencia de subestimación que se presentó en los adolescentes del municipio de Chacsinkín Los adolescentes de ambos municipios con exceso de peso, subestimaron su IMC y no lo identifican como un problema de salud, lo que representa un área de oportunidad para el trabajo del equipo multidisciplinario de salud.


Abstract Objective To compare the relationship between the Perception of the Body Image and the Body Mass Index in secondary school students of two municipalities of Yucatán. Material and Methods Quantitative and cross-sectional study, with a population of 462 students aged from 11 to 17 belonging to schools in the municipalities of Abalá and Chacsinkin, Yucatán. Body weight and height were taken; Body Mass Index (BMI) by age was calculated according to the patterns of the World Health Organization (WHO) for adolescents. Body image perception was determined by means of the Body Image Perception Analysis (BPI) instrument proposed by Stunkard and Stellard and modified by Collins. For the inferential statistical analysis, the Chi-square test with a statistical significance value of 5% was used. Results 62.9% of adolescents have a normal Body Mass Index; while 35.6% have a combined prevalence of obesity and overweight. Regarding Perception of Body Image, 28.8% of adolescents were perceived according to their real BMI; 25.3% were perceived with BMI greater than the real and 45.9% were perceived with BMI lower than they actually have Conclusions In the municipality of Abalá, adolescents presented a higher prevalence of normal weight and excess weight; higher frequency of concordance between body perception and real BMI and overestimation of their BMI, unlike the higher frequency of underestimation that occurred in adolescents in the municipality of Chacsinkin Adolescents in both municipalities with excess weight underestimated their BMI and they did not identify it as a health problem, which represents an area of opportunity for the work of the multidisciplinary health team.


Sumário Objetivo Comparar a relação entre a percep9áo da imagem corporal e o índice de massa corporal em estudantes do ensino médio de dois municipios de Yucatán. Material e Métodos Estudo quantitativo e transversal, em 462 alunos de 11 a 17 anos pertencentes a escolas dos municipios de Abalá e Chacsinkin, Yucatán. O peso corporal e a altura foram medidos, calculado o Índice de Massa Corporal (IMC) / idade, de acordo com os padrões da Organização Mundial da Saúde (OMS) para adolescentes. A percepção da imagem corporal foi determinada utilizando o instrumento Body Image Perception Analysis (APC), proposto por Stunkard e Stellard, modificado por Collins. O teste do qui-quadrado com valor de significância estatística de 5% foi utilizado para a análise estatística inferencial. Resultados 62,9% dos adolescentes têm um Índice de Massa Corporal normal, enquanto 35,6% têm uma prevalência combinada de obesidade e sobrepeso. Em relação a percepção da imagem corporal, 28,8% dos adolescentes foram percebidos de acordo com o IMC real; 25,3% foram percebidos com IMC maior que o real e 45,9% foram percebidos com IMC menor do que realmente Conclusões No municipio de Abala, os adolescentes apresentaram maior prevalência de peso normal e excesso de peso; maior frequência de concordância entre a percepção corporal e o IMC real e superestimação do IMC, diferentemente da maior frequência de subestimação que ocorreu em adolescentes no município de Chacsinkín. Os adolescentes dos dois municípios com excesso de peso subestimaram seu IMC e não o identificam como um problema de saúde, o que representa uma área de oportunidade para o trabalho da equipe multiprofissional de saúde.


Résumé Objectif Comparer la relation entre la Perception de l'Image Corporelle et l'Indice de Masse Corporelle chez des élèves du secondaire de deux municipalités du Yucatan. Matériel et méthodes Étude quantitative et transversale, avec une population de 462 élèves, de 11 a 17 ans, inscrits dans des écoles des municipalités d'Abalá et de Chacsinkin, Yucatán. Le poids et la taille ont été relevés, et l'Indice de Masse Corporelle en fonction de l'âge (IMC-pour-l'âge) a été calculé selon les normes de l'Organisation Mondiale de la Santé (OMS) pour adolescents. La Perception de l'Image Corporelle a été déterminée a l'aide de l'instrument Analyse de la Perception de l'Image Corporelle (BPA) proposé par Stunkard et Stellard et modifié par Collins. Le test du Khi-deux avec une valeur de signification statistique de 5 % a été utilisé pour l'analyse statistique inférentielle. Résultats 62,9 % des adolescents ont un Indice de Masse Corporelle normal alors qu'il existe une prévalence combinée d'obésité et de surpoids de 35,6 %. La Perception de l'Image Corporelle a été en accord à l'IMC réel dans 28,8 % des cas. 25,3 % se sont per9us comme ayant un IMC supérieur à leur IMC réel et 45,9 % comme ayant un IMC inférieur à leur IMC réel. Conclusions Dans la municipalité d'Abala, les adolescents ont présenté une prévalence plus élevée de poids normal et de surpoids, une fréquence plus élevée de concordance entre leur perception corporelle et l'IMC réel et une surestimation de leur IMC, en comparaison avec la fréquence plus élevée de sous-estimation chez les adolescents de la municipalité de Chacsinkin. Les adolescents des deux municipalités ayant un excès de poids ont sous-estimé leur IMC et ne l'ont pas identifié comme un problème de santé, ce qui constitue un champs d'opportunités pour le travail de l'équipe de santé multidisciplinaire.

3.
J Food Biochem ; 44(5): e13191, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-32160647

RESUMO

Oxidative stress is associated with several chronic diseases. It is acknowledged that molecules damaged by reactive oxygen species activate the inflammatory process and that this response increases the production of free radicals. Modifications in a diet can improve or decrease redox state markers. The aim of this revision was to provide an update of clinical controlled trials, to assess changes in diet and markers of oxidative stress in subjects with metabolic diseases. They were investigated randomized controlled intervention studies (RCTs) published in MEDLINE (U.S. National Library of Medicine, National Institutes of Health) that were conducted in subjects with obesity, hypertension, diabetes, or dyslipidemia; with dietary intervention; where markers of oxidative stress have been evaluated and published in the last 5 years. Food antioxidants, hypocaloric diets with loss of adipose tissue, substitution of animal protein by vegetable, and changes in the microbiota improve antioxidant status in people with chronic disease. PRACTICAL APPLICATIONS: Hyperglycemia in diabetes mellitus and adipose tissue in obesity are known to trigger oxidative stress. Oxidative stress, in turn, decreases insulin sensitivity and favors an inflammatory state producing adhesion molecules. Oxidative stress and adhesion molecules, can increase blood pressure and oxidation of lipoproteins, that ultimately could lead to a cerebrovascular event. Consumption of high-antioxidant and polyphenol foods increases plasma antioxidant capacity and decreases oxidative stress markers in people with diabetes, obesity, hypertension, and hypertriglyceridemia. In addition, weight loss caused by caloric restriction with or without exercise increases the endogenous antioxidant capacity. Therefore, it is likely that the combination of a hypocaloric diet with a high content of antioxidants and polyphenols will have a greater effect. Other dietary changes with antioxidant effect, such as the substitution of animal for vegetable protein or the addition of fiber, might be mediated by changes in the microbiota. However, this aspect requires further study.


Assuntos
Hiperglicemia , Obesidade , Animais , Antioxidantes , Dieta Redutora , Estresse Oxidativo , Ensaios Clínicos Controlados Aleatórios como Assunto , Estados Unidos
4.
Am J Hum Biol ; 31(4): e23254, 2019 07.
Artigo em Inglês | MEDLINE | ID: mdl-31168876

RESUMO

OBJECTIVE: The aim of this study was to analyze the association between relative leg length (RLL) (leg length × 100/height) and adiposity in a sample of 6- to 8-year-old children of Maya ancestry from Motul and Merida, Mexico. METHODS: This cross-sectional study included 260 children (128 girls) measured between 2011 and 2015. The RLL was used as a measure of body proportionality. Linear regression models were performed to examine the association between RLL (predictor) and three adiposity indicators (outcome variables): fat mass index (kg/m2 ), waist circumference (z-score), and sum of triceps and subscapular skinfolds (z-score). RESULTS: The prevalence of stunting was 12%, and a higher prevalence (19%) of short RLL (leg stunting) was found. The prevalence of overweight and obesity were 16% and 20%, respectively, but the highest prevalence was found for abdominal obesity (40%). None of the adiposity indicators were related to RLL (P > .05), even after adjusting for the influence of children's sex and age. CONCLUSIONS: Our results suggest that the coexistence of short RLL and high body adiposity is not observed in all populations. Our findings do not discount the possibility that a negative association between RLL and adiposity is expressed at older ages.


Assuntos
Desenvolvimento Infantil , Transtornos do Crescimento/epidemiologia , Indígenas Norte-Americanos/estatística & dados numéricos , Perna (Membro)/crescimento & desenvolvimento , Sobrepeso/epidemiologia , Adiposidade , Tamanho Corporal , Criança , Estudos Transversais , Feminino , Humanos , Masculino , México/epidemiologia , Obesidade/epidemiologia , Obesidade Abdominal/epidemiologia , Prevalência
5.
Arch. latinoam. nutr ; 68(3): 234-246, sept. 2018. tab, graf
Artigo em Espanhol | LIVECS, LILACS | ID: biblio-1016062

RESUMO

Las investigaciones realizadas en adolescentes del área rural y su percepción de salud son escasas, lo que representa un área de oportunidad para prevenir enfermedades de tipo cardiovascular en la vida adulta. El objetivo fue determinar el riesgo de enfermedades cardiovasculares y su percepción en adolescentes con sobrepeso y obesidad de comunidades mayas. Se llevó a cabo en dos etapas: cuantitativatransversal y cualitativa. En el Municipio de Abalá, Yucatán, con estudiantes de secundarias (n = 292). Se registró el peso, talla, edad, circunferencia de cintura, tensión arterial y se calcularon los indicadores Talla/Edad, Índice de Masa Corporal/Edad, Cintura Cadera/Talla y Tensión Arterial sistólica/Talla. Se realizaron grupos focales con adolescentes con sobrepeso u obesidad según Índice de Masa Corporal (IMC) para explorar creencias acerca del sobrepeso/obesidad, alimentos que lo provocan y enfermedades ocasionadas. Se utilizó estadística descriptiva y prueba de Chi-cuadrado. El 96,9% de los adolescentes tuvo talla normal; según IMC, 54,1% peso Normal, 28,4% sobrepeso y 17,1% obesidad. El 30,5% presentó riesgo cardiovascular según Cintura Cadera/Talla y el 8,9% de los adolescentes registró prehipertensión/hipertensión, más frecuente en hombres que en mujeres. Respecto a la percepción del sobrepeso/obesidad, los adolescentes señalaron que no es buena para la salud; los alimentos que ocasionan sobrepeso/obesidad son ricos en hidratos de carbono, grasas, con alto contenido calórico y las enfermedades derivadas del sobrepeso/obesidad son diabetes, anemia, anorexia y desnutrición. Se encontró riesgo cardiovascular en adolescentes, mayor en los hombres. Perciben que no llevan una buena alimentación, lo que podría ocasionarles sobrepeso/obesidad y desarrollar enfermedades cardiovasculares(AU)


The research carried out in adolescents in rural areas and their perception of health is scarce, which represents an area of opportunity to prevent cardiovascular diseases in adulthood, since at this stage increases the degree of autonomy. The objective was to determine the risk of cardiovascular diseases and their perception in adolescents with overweight and obesity in Mayan communities. It was carried out in two stages: quantitative-transversal and qualitative; In the municipality of Abalá, Yucatán with secondary students (n = 292). The weight, height, age, waist circumference, blood pressure was recorded and height/age indicators, Body mass index/age, waist circumference/age and systolic/height were calculated. Focal groups were conducted with overweight or obese adolescents according to Body Mass Index (BMI) to explore beliefs about overweight/obesity, foods that cause obesity and illness. Descriptive statistics and Chisquare test were used. Height was adequate in 96.9% of adolescents, according to BMI, 54% had normal weight 28.4% were overweight and 17.1% were obese. 30.5% showed cardiovascular risk, according to waist circumference/height and 8.9% of adolescents had prehypertension/hypertension, being more frequent in males than females. About the perception of overweight/obesity, adolescents feel that it is not good for health; the foods that cause these problems are rich in carbohydrates, fats, with high caloric value; diseases resulting from overweight/obesity are diabetes, anaemia, anorexia and malnutrition. However, adolescents present cardiovascular risk, being higher in males. Adolescents perceive that they are not eating well, which can lead to overweight/obesity and the development of cardiovascular disease(AU)


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Doenças Cardiovasculares/fisiopatologia , Sobrepeso/complicações , Obesidade Infantil/complicações , Obesidade Infantil , Alimentos, Dieta e Nutrição
6.
Rev. mex. trastor. aliment ; 4(1): 37-44, ene.-jun. 2013. tab
Artigo em Espanhol | LILACS-Express | LILACS | ID: lil-714463

RESUMO

Los medios de comunicación, el ambiente social y los factores personales desempeñan un papel importante como factores de riesgo de los TCA. El objetivo del presente trabajo fue conocer la relación entre las influencias socioculturales del modelo estético corporal con las cogniciones que son características de los TCA, en estudiantes de licenciatura en nutrición. Se contó con 112 participantes (88 mujeres y 24 hombres) estudiantes de la licenciatura en nutrición. 15.9% de las mujeres y el 20.8% de los hombres presentaron insatisfacción corporal. Los hombres presentaron significativamente mayor malestar patológico, influencia de la publicidad y perfeccionismo que las mujeres. Tanto en hombres y mujeres se muestra una correlación significativa entre la interiorización de un cuerpo delgado y la insatisfacción corporal. Casi la mitad de los participantes (48%) presenta una interiorización del modelo estético de delgadez. Se encontraron correlaciones significativas entre la interiorización de un modelo estético delgado y la insatisfacción corporal, lo cual indica que dicha insatisfacción está mediada por aquellos estándares provenientes de los medios de comunicación.


The media, the social environment and personal factors play an important role as risk factors for eating disorders. The aim of this study was to determine the relationship between sociocultural influences body shape model with cognitions that are characteristic of eating disorders in undergraduate nutrition. Participated 112 students (88 women and 24 men) undergraduate students in nutrition. 15.9% of women and 20.8% of the men had body dissatisfaction. Men showed significantly greater pathological distress advertising influence and perfectionism than women. Both men and women shows a significant correlation between the internalization of a thin body and body dissatisfaction. Almost half of the participants (48%) had an internalization body thin model. Significant correlations were found between the internalization of a thin aesthetic model and body dissatisfaction, which indicates that this dissatisfaction is mediated by those standards from the media.

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