RESUMO
Urolithin A (Uro-A) is an anti-inflammatory and cancer chemopreventive metabolite produced by the gut microbiota from the polyphenol ellagic acid. However, in vivo conjugation of Uro-A to Uro-A glucuronide (Uro-A glur) dramatically hampers its activity. We describe here for the first time the tissue deconjugation of Uro-A glur to Uro-A after lipopolysaccharide (LPS)-induced inflammation, which could explain the systemic in vivo activity of free Uro-A in microenvironments subjected to inflammatory stimuli.
Assuntos
Cumarínicos/farmacocinética , Glucuronídeos/farmacocinética , Inflamação/tratamento farmacológico , Animais , Cumarínicos/administração & dosagem , Cumarínicos/química , Ácido Elágico/metabolismo , Microbioma Gastrointestinal , Trato Gastrointestinal/microbiologia , Glucuronídeos/administração & dosagem , Glucuronídeos/química , Humanos , Inflamação/metabolismo , Inflamação/microbiologia , Masculino , Ratos , Ratos Sprague-DawleyRESUMO
Gut microbiota dysbiosis alters the intestinal barrier function, increases plasma lipopolysaccharide (LPS) levels, which promotes endotoxemia, and contributes to the onset and development of colorectal cancer (CRC). We report here for the first time the reduction of plasma LPS-binding protein (LBP) levels, a marker of endotoxemia, after pomegranate consumption in newly diagnosed CRC patients.
