RESUMO
Two new flavones were isolated from the aerial parts of Retama raetam subsp. raetam. Their structures were established as luteolin 4'-O-neohesperidoside (1) and 5,4'-dihydroxy-(3",4"-dihydro-3", 4"-dihydroxy)-2",2"-dimethylpyrano-(5",6":7,8)-flavone (2) by means of spectroscopic methods. Also present was ephedroidin (4',5, 7-trihydroxy-8-(2-hydroxy-3-butenyl)-flavone).
Assuntos
Flavonoides/química , Extratos Vegetais/química , Plantas Medicinais/química , Humanos , LuteolinaRESUMO
Diphenylamine has been isolated as one of the active antihyperglycemic agents of onion. It was identified by ir, uv, cmr, pmr, and mass spectra. It attained the highest percentage in mature onion bulbs; other onion organs contained diphenylamine in lower percentages. Green and black teas were found to contain relatively high percentages of diphenylamine, being higher in the former. Cooking was found to decrease the diphenylamine content.
Assuntos
Compostos de Anilina/isolamento & purificação , Difenilamina/isolamento & purificação , Hipoglicemiantes/isolamento & purificação , Chá/análise , Verduras/análise , Animais , Glicemia/metabolismo , Difenilamina/farmacologia , Hipoglicemiantes/farmacologia , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Coelhos , Espectrometria de Fluorescência , Espectrofotometria Ultravioleta , Fatores de TempoRESUMO
A small outbreak of louse-borne relapsing fever in Khartoum (May-June 1974) provided material for a clinico-pathological study. The history of the disease in the Sudan is reviewed and the clinical and laboratory findings in 32 patients are presented. Fever, headache, jaundice, epistaxis and hepatosplenomegaly were the commonest clinical findings; thrombocytopenia was detected in 93% of cases. Although elevated levels of fibrin degradation products were found in most patients, disseminated intravascular coagulation could not be diagnosed. Hepatocellular derangement was found in 68% of cases, while 78% had high blood urea. In five autopsied bodies there was bronchopneumonia, interstitial edema with focal myocardial fibrosis, hepatic necrosis, splenic infarcts, increase in size and cellularity of the glomeruli and brain edema and congestion. Intracranial haemorrhage was found in three of the autopsied cases.
Assuntos
Febre Recorrente/epidemiologia , Feminino , Humanos , Insetos Vetores , Rim/patologia , Fígado/patologia , Masculino , Ftirápteros , Febre Recorrente/patologia , Baço/patologia , SudãoAssuntos
Glicemia/análise , Insulina/sangue , Uremia/sangue , Animais , Feminino , Masculino , Nefrectomia , RatosRESUMO
Louse-borne relapsing fever seems to have become endemic in the southern Sudan. The epidemic history of the disease in the Sudan is reviewed. We have studied 363 Sudanese patients involved in an outbreak of louse-borne relapsing fever in Khartoum (Sudan) between January and June 1974. 318 of the 363 patients were new immigrants from the soughern Sudan to Khartoum. The clinical presentation varied. The common clinical fetures of the disease were: fever (94%), headache (85%), hepatosplenomegaly (74%), body and joint pains (66%), abdominal pain and tenderness (63%), jaundice (46%) and epistaxis (40%). Thrombocytopenia was common. Biochemical evidence of hepatocellular and renal damage was present in most patients. The mortality rate was 5-5% with treatment. Post-mortem examination was performed on six cases. The organs predominantly involved were the liver, spleen, brain and lungs. The common causes of death were severe hepatic damage, lobar pneumonia, subarachnoid haemorrhage and splenic rupture.
Assuntos
Febre Recorrente/epidemiologia , Adolescente , Adulto , Idoso , Contagem de Células Sanguíneas , Criança , Feminino , Humanos , Rim/fisiopatologia , Fígado/fisiopatologia , Masculino , Pessoa de Meia-Idade , Febre Recorrente/mortalidade , Febre Recorrente/fisiopatologia , SudãoAssuntos
Pólen/análise , Árvores , Anfíbios , Animais , Carboidratos/isolamento & purificação , Egito , Feminino , Glicosídeos/isolamento & purificação , Camundongos , Ratos , Saponinas/isolamento & purificação , Sitosteroides/isolamento & purificação , Terpenos/isolamento & purificação , Útero/efeitos dos fármacosRESUMO
Four children with Schistosoma mansoni infection and the nephrotic syndrome with varying degrees of renal dysfunction were found on histological examination to have amyloidosis. In one boy who had no evidence of renal failure complete clinical regression of his nephrotic syndrome and almost complete disappearance of renal amyloid deposits followed adequate treatment of his schistosomal infection. Conditions known to cause secondary amyloidosis were excluded in all four patients. Amyloidosis in association with mansoni infection is probably more common than is currently recognised. Early treatment of the infection, before renal function becomes impaired, may result in regression of the amyloidosis.
Assuntos
Amiloidose/etiologia , Síndrome Nefrótica/complicações , Schistosoma mansoni , Esquistossomose/complicações , Adolescente , Amiloidose/patologia , Autopsia , Criança , Humanos , Rim/patologia , Glomérulos Renais/patologia , Masculino , Miocárdio/patologia , Baço/patologiaRESUMO
Two colorimetric micromethods are described for the determination of atropine-hyoscyamine and hyoscine (scopolamine), using p-dimethylaminobenzaldehyde and citric acid-acetic anhydride as the color reagents. These methods are sensitive to 60-1200 and 10-360 mug alkaloid/10 ml. The colorimetric methods were also successfully applied after a preliminary thin layer chromatographic separation of the alkaloids. A gas-liquid chromatographic procedure was also developed, which yielded comparable results with the colorimetric methods.