Microscopic study of certain age-related structural changes of maxillary sinus lining epithelium in albino rats.

Mucociliary clearance is essential to maintain the defense function of the maxillary sinus; however, no literatures described the age changes in its lining epithelium. Therefore, the current work sought to describe the morphological postnatal age-related changes of maxillary sinus lining epithelium in rats using light, transmission, and scanning electron microscopes. Eighteen albino rats were divided into six groups according to their ages: 2-week-old, 1-month-old, 2-month-old, 3-month-old, adults, and senile rats. One-month-old-rats' group was the first to have recognizable maxillary sinus cavities that were lined by either single flat cellular layer or two distinct epithelial layers. These cells were devoid of microvilli and cilia, none of them showed evidence of differentiation into identifiable cell types. In 2- and 3-month-old rats, the mucosa of maxillary sinus started to be lined with pseudostratified epithelium with apparent increase in both microvilli and cilia. The first indication of goblet cell differentiation was observed in 3-month-old-rats. In the adult rats, the sinuses became completely lined by mature respiratory epithelium. However, in senile rats the epithelium exhibited polyps with clumped cilia and some areas of stratification and desquamation. Goblet cells were scanty and degenerating. The impaired mucociliary components (epithelium, cilia, and goblet cells' mucus) found in young and old ages of the current work might be correlated to human to explain predisposition of rhino-sinusitis in these age groups.

Histological and ultrastructural changes in the adult male albino rat testes following chronic crude garlic consumption.

Several studies have presented Garlic (Allium sativum) as a restoring agent for testicular cells after exposure to different types of toxins, however, others have shown that it modified spermatogenesis and might have spermicidal effects. This work has been to assess the positive or negative effect of chronic crude garlic consumption on rat testes using light and transmission electron microscopy with reference to plasma testosterone and LH levels. Forty albino male rats were divided into group A (control) and group B (treated rats). Group B was further subdivided into B1, B2, and B3 subgroups which were administer crude garlic as 20% of their daily food for two, three and four months, respectively. The current study has been the first, to the best of our knowledge, to describe the apoptotic effect of chronic crude garlic consumption targeting Sertoli cells, germ cells and peritubular tissue including interstitial Leydig cells and myoid cells. This might be better explained by inflammatory than degenerative changes in the peritubular tissue and Leydig cells leading to a decrease in testosterone level. Consequently, Sertoli cells degenerate due to a decrease in testosterone and detachment from the basal lamina. Germ cells, which are completely dependent upon Sertoli cells and testosterone to complete there spermatogenesis will be affected. Testicular apoptosis with disruption in spermatogenesis following chronic crude garlic consumption could be correlated with two possible theories; being an anti-hypercholesterolemic agent, it might inhibit steroidogenesis resulting in a decrease in testosterone level and being one of the famous phytoestrogens it possibly has direct estrogen-like actions on adult male rat testes.