RESUMO
Introducción: El patrón epidemiológico de la hepatitis crónica por virus de la hepatitis B (HCVHB) en España ha cambiado por las migraciones y la vacunación. El objetivo es comprobar si también ha cambiado la prevalencia en presos de Cataluña y las posibles variables predictivas de la infección. Material y método: Estudio transversal y multicéntrico de prevalencia de HCVHB. Se incluyeron variables epidemiológicas y clínicas, calculándose su capacidad predictiva mediante un modelo de regresión logística multivariante. Resultados: Se estudiaron 6.508 reclusos. La prevalencia de HCVHB fue del 1,7%, mucho menor que en estudios realizados en años previos. En los presos del Magreb, Asia, Europa del Este y África subsahariana, la prevalencia fue 2,8, 4,2, 4,9 y 16,2 veces mayor, respectivamente, que en los españoles, que era del 0,6%, igual que fuera de prisión. La HCVHB se asoció con: a) ser extranjero (2,6%; razón de posibilidades u odds ratio [OR]: 4,18; intervalo de confianza [IC]: 2,50-6,90; p <0,001); b) no estar vacunado (0,3%; OR: 0,13; IC: 0,06-0,26; p <0,001); y c) estar infectado por el virus de la inmunodeficiencia humana (VIH) (3,9%; OR: 3,23; IC: 1,24-8,40; p = 0,016). Conclusión: La prevalencia de HCVHB en presos se ha reducido mucho en los últimos 30 años, debido a la vacunación, pero sigue siendo alta en extranjeros y en infectados por VIH. Se recomienda: a) mantener el cribado de virus de la hepatitis B (VHB) en los ingresados en prisión; b) continuar con el programa de vacunación; y c) derivar a los infectados a programas especializados para estudio y, si se precisa, tratamiento. (AU)
Background: The epidemiology of chronic hepatitis B (CHB) in Spain has changed due to migratory movements and the implementation of vaccination programs. The objective is to determine if prevalence has also changed amongst in Catalonia and the potential predictive variables of the infection. Material and method: Observational cross-sectional multi-centre study of CHB prevalence. Epidemiological and clinical variables were included, and their predictive capacity is analysed by means of a multivariable logistic regression model. Results: A total of 6508 prisoners were studied. CHB prevalence was 1.7%, much less than in studies carried out in previous years. In inmates from North Africa, Asia, Eastern Europe, and Sub-Saharan Africa the CHB rate was 2.8, 4.2, 4.9 and 16.2 times higher, respectively, than amongst those born in Spain, which was 0.6%, the same as in the general population. CHB was associated with: a) being an immigrant [2.6%; OR: 4.18 (CI: 2.50-6.90; P <0.001); b) being unvaccinated (3.1%; OR: 0.13; CI: 0.06-0.26; P <0.001); and c) being infected by the human immunodeficiency virus (HIV) [3.9%; OR: 3.23; CI: 1.24-8.40; P = 0.016]. Conclusion: Vaccination against HBV (hepatitis B virus) has greatly reduced CHB prevalence in inmates over the past 30 years but remains high in immigrants and those with HIV. We recommend: a) maintaining HBV screening amongst inmates; b) continuing with vaccination programmes; and c) referring CHB cases to specialized programs for further study and treatment if needed. (AU)
Assuntos
Humanos , Masculino , Feminino , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Hepatite B Crônica/epidemiologia , Prisioneiros , Estudos Transversais , Espanha/epidemiologia , Prevalência , Vacinas contra Hepatite B , Emigração e Imigração , PrisõesRESUMO
BACKGROUND: The epidemiology of chronic hepatitis B (CHB) in Spain has changed due to migratory movements and the implementation of vaccination programs. The objective is to determine if prevalence has also changed amongst in Catalonia and the potential predictive variables of the infection. MATERIAL AND METHOD: Observational cross-sectional multi-centre study of CHB prevalence. Epidemiological and clinical variables were included, and their predictive capacity is analysed by means of a multivariable logistic regression model. RESULTS: A total of 6508 prisoners were studied. CHB prevalence was 1.7%, much less than in studies carried out in previous years. In inmates from North Africa, Asia, Eastern Europe, and Sub-Saharan Africa the CHB rate was 2.8, 4.2, 4.9 and 16.2 times higher, respectively, than amongst those born in Spain, which was 0.6%, the same as in the general population. CHB was associated with: a) being an immigrant [2.6%; OR: 4.18 (CI: 2.50-6.90; P <0.001); b) being unvaccinated (3.1%; OR: 0.13; CI: 0.06-0.26; P <0.001); and c) being infected by the human immunodeficiency virus (HIV) [3.9%; OR: 3.23; CI: 1.24-8.40; P = 0.016]. CONCLUSION: Vaccination against HBV (hepatitis B virus) has greatly reduced CHB prevalence in inmates over the past 30 years but remains high in immigrants and those with HIV. We recommend: a) maintaining HBV screening amongst inmates; b) continuing with vaccination programmes; and c) referring CHB cases to specialized programs for further study and treatment if needed.
