Dual Tasking Affects the Outcomes of Instrumented Timed up and Go, Sit-to-Stand, Balance, and 10-Meter Walk Tests in Stroke Survivors.

Stroke can impair mobility, with deficits more pronounced while simultaneously performing multiple activities. In this study, common clinical tests were instrumented with wearable motion sensors to study motor-cognitive interference effects in stroke survivors (SS). A total of 21 SS and 20 healthy controls performed the Timed Up and Go (TUG), Sit-to-Stand (STS), balance, and 10-Meter Walk (10MWT) tests under single and dual-task (counting backward) conditions. Calculated measures included total time and gait measures for TUG, STS, and 10MWT. Balance tests for both open and closed eyes conditions were assessed using sway, measured using the linear acceleration of the thorax, pelvis, and thighs. SS exhibited poorer performance with slower TUG (16.15 s vs. 13.34 s, single-task p < 0.001), greater sway in the eyes open balance test (0.1 m/s2 vs. 0.08 m/s2, p = 0.035), and slower 10MWT (12.94 s vs. 10.98 s p = 0.01) compared to the controls. Dual tasking increased the TUG time (~14%, p < 0.001), balance thorax sway (~64%, p < 0.001), and 10MWT time (~17%, p < 0.001) in the SS group. Interaction effects were minimal, suggesting similar dual-task costs. The findings demonstrate exaggerated mobility deficits in SS during dual-task clinical testing. Dual-task assessments may be more effective in revealing impairments. Integrating cognitive challenges into evaluation can optimize the identification of fall risks and personalize interventions targeting identified cognitive-motor limitations post stroke.

Post-Stroke Functional Changes: In-Depth Analysis of Clinical Tests and Motor-Cognitive Dual-Tasking Using Wearable Sensors.

Clinical tests like Timed Up and Go (TUG) facilitate the assessment of post-stroke mobility, but they lack detailed measures. In this study, 21 stroke survivors and 20 control participants underwent TUG, sit-to-stand (STS), and the 10 Meter Walk Test (10MWT). Tests incorporated single tasks (STs) and motor-cognitive dual-task (DTs) involving reverse counting from 200 in decrements of 10. Eight wearable motion sensors were placed on feet, shanks, thighs, sacrum, and sternum to record kinematic data. These data were analyzed to investigate the effects of stroke and DT conditions on the extracted features across segmented portions of the tests. The findings showed that stroke survivors (SS) took 23% longer for total TUG (p < 0.001), with 31% longer turn time (p = 0.035). TUG time increased by 20% (p < 0.001) from STs to DTs. In DTs, turning time increased by 31% (p = 0.005). Specifically, SS showed 20% lower trunk angular velocity in sit-to-stand (p = 0.003), 21% longer 10-Meter Walk time (p = 0.010), and 18% slower gait speed (p = 0.012). As expected, turning was especially challenging and worsened with divided attention. The outcomes of our study demonstrate the benefits of instrumented clinical tests and DTs in effectively identifying motor deficits post-stroke across sitting, standing, walking, and turning activities, thereby indicating that quantitative motion analysis can optimize rehabilitation procedures.

Smart wearable insoles in industrial environments: A systematic review.

BACKGROUND AND PURPOSE: Industrial environments present unique challenges in ensuring worker safety and optimizing productivity. The emergence of smart wearable technologies such as smart insoles has provided new opportunities to address these challenges through accurate unobtrusive monitoring and analysis of workers' activities and physical parameters. This systematic review aims to analyze the utilization of smart wearable insoles in industrial environments, focusing on their applications, employed analysis methods, and potential future directions. METHODS: A comprehensive review was conducted, involving the analysis of 27 papers that utilized smart wearable insoles in industrial settings. The reviewed articles were evaluated to determine the trends in application and methodology, explore the implementation of smart insoles across different industries, and identify the prevalent machine learning models and analyzed activities in the relevant literature. RESULTS: The majority of the reviewed articles (67%) primarily focused on human activity recognition and gesture estimation using smart wearable insoles, aiming to enhance safety and productivity in industrial settings. Furthermore, 10% of the studies focused on fatigue identification, 10% on slip, trip, and fall hazard detection, and 13% on biomechanical analyses of workers' body joint loads. The construction industry accounted for approximately 60% of the studies conducted in industrial settings using smart insoles. The most prevalent machine learning models utilized in these studies were neural networks (48%), support vector machines (33%), k-nearest neighbors (30%), decision trees (26%), and random forests (15%). These models achieved median accuracies of 95%, 96%, 91%, 92%, and 95%, respectively. Among the analyzed activities, walking, bending with/without lifting/lowering a load, and carrying a load were the most frequently considered, with frequencies of 10, 10, and 7 out of the 27 studies, respectively. CONCLUSION: The findings of this systematic review demonstrate the growing interest in implementing smart wearable insoles in industrial environments to enhance safety and productivity. However, the effectiveness of these systems is dependent on factors such as accuracy, reliability, and generalizability of the models. The review highlights the need for further research to address these challenges and to explore the potential of these systems for use in other industrial applications such as manufacturing. Overall, this systematic review provides valuable insights for researchers, practitioners, and policymakers in the field of occupational health and safety.

A machine learning model to predict heart failure readmission: toward optimal feature set.

Background: Hospital readmissions for heart failure patients remain high despite efforts to reduce them. Predictive modeling using big data provides opportunities to identify high-risk patients and inform care management. However, large datasets can constrain performance. Objective: This study aimed to develop a machine learning based prediction model leveraging a nationwide hospitalization database to predict 30-day heart failure readmissions. Another objective of this study is to find the optimal feature set that leads to the highest AUC value in the prediction model. Material and methods: Heart failure patient data was extracted from the 2020 Nationwide Readmissions Database. A heuristic feature selection process incrementally incorporated predictors into logistic regression and random forest models, which yields a maximum increase in the AUC metric. Discrimination was evaluated through accuracy, sensitivity, specificity and AUC. Results: A total of 566,019 discharges with heart failure diagnosis were recognized. Readmission rate was 8.9% for same-cause and 20.6% for all-cause diagnoses. Random forest outperformed logistic regression, achieving AUCs of 0.607 and 0.576 for same-cause and all-cause readmissions respectively. Heuristic feature selection resulted in the identification of optimal feature sets including 20 and 22 variables from a pool of 30 and 31 features for the same-cause and all-cause datasets. Key predictors included age, payment method, chronic kidney disease, disposition status, number of ICD-10-CM diagnoses, and post-care encounters. Conclusion: The proposed model attained discrimination comparable to prior analyses that used smaller datasets. However, reducing the sample enhanced performance, indicating big data complexity. Improved techniques like heuristic feature selection enabled effective leveraging of the nationwide data. This study provides meaningful insights into predictive modeling methodologies and influential features for forecasting heart failure readmissions.

Unlocking human-robot synergy: The power of intent communication in warehouse robotics.

As autonomous mobile robots (AMR) are introduced into workspace environments shared with people, effective human-robot communication is critical to the prevention of injury while maintaining a high level of productivity. This research presents an empirical study that evaluates four alternative methods for communicating between an autonomous mobile robot and a human at a warehouse intersection. The results demonstrate that using an intent communication system for human-AMR interaction improves objective measures of productivity (task time) and subjective metrics of trust and comfort.

Fall Risk Assessment in Stroke Survivors: A Machine Learning Model Using Detailed Motion Data from Common Clinical Tests and Motor-Cognitive Dual-Tasking.

BACKGROUND: Falls are common and dangerous for stroke survivors. Current fall risk assessment methods rely on subjective scales. Objective sensor-based methods could improve prediction accuracy. OBJECTIVE: Develop machine learning models using inertial sensors to objectively classify fall risk in stroke survivors. Determine optimal sensor configurations and clinical test protocols. METHODS: 21 stroke survivors performed balance, Timed Up and Go, 10 Meter Walk, and Sit-to-Stand tests with and without dual-tasking. A total of 8 motion sensors captured lower limb and trunk kinematics, and 92 spatiotemporal gait and clinical features were extracted. Supervised models-Support Vector Machine, Logistic Regression, and Random Forest-were implemented to classify high vs. low fall risk. Sensor setups and test combinations were evaluated. RESULTS: The Random Forest model achieved 91% accuracy using dual-task balance sway and Timed Up and Go walk time features. Single thorax sensor models performed similarly to multi-sensor models. Balance and Timed Up and Go best-predicted fall risk. CONCLUSION: Machine learning models using minimal inertial sensors during clinical assessments can accurately quantify fall risk in stroke survivors. Single thorax sensor setups are effective. Findings demonstrate a feasible objective fall screening approach to assist rehabilitation.

Mentoring as an Appropriate Strategy for Medical Faculty Member Development in Higher Education: A Systematic Review.

Introduction: Human resources development, especially faculty members who play a substantial role in education, is of great importance and can lead to enhanced competence and participation of employees in university affairs. Mentoring is one of the programs that have attracted the attention of activists in this field today. This review aims to integrate the evidence about the goals, methods, implementation steps, and consequences of the mentoring methods for faculty member development in higher education institutions. Methods: We used a systematic review in this study. Keywords related to the mentoring program were searched in gateways and databases such as PubMed, Scopus, Web of Science, and ERIC from 2000 to 2021. In the initial search, 638 articles were found, and 16 studies were reviewed after excluding those unrelated to the research objective. Results: The results showed that the mentoring program included three stages: "Targeting and Familiarization with the Implementation of the Mentoring Program", "Mentoring Program Implementation", and "Evaluation of the Mentoring Program". The implementation approaches included Traditional One-to-one Mentoring Program, Peer Mentoring Program, and Distance Education Mentoring Program. Conclusion: This study identified the stages and types of mentoring programs and revealed that their employment, especially the distance education mentoring program, led to the advancement of faculty members in various fields. A mixed-method approach to program evaluation can provide more appropriate views of the effects of these programs.

Recovering from Laboratory-Induced slips and trips causes high levels of lumbar muscle activity and spine loading.

Slips, trips, and falls are some of the most substantial and prevalent causes of occupational injuries and fatalities, and these events may contribute to low-back problems. We quantified lumbar kinematics (i.e., lumbar angles relative to pelvis) and kinetics during unexpected slip and trip perturbations, and during normal walking, among 12 participants (6F, 6 M). Individual anthropometry, lumbar muscle geometry, and lumbar angles, along with electromyography from 14 lumbar muscles were used as input to a 3D, dynamic, EMG-based model of the lumbar spine. Results indicated that, in comparison with values during normal walking, lumbar range of motion, lumbosacral (L5/S1) loads, and lumbar muscle activations were all significantly higher during the slip and trip events. Maximum L5/S1 compression forces exceeded 2700 N during slip and trip events, compared with âˆ¼ 1100 N during normal walking. Mean values of L5/S1 anteroposterior (930 N), and lateral (800 N) shear forces were also substantially larger than the shear force during the normal walking (230 N). These observed levels of L5/S1 reaction forces, along with high levels of bilateral lumbar muscle activities, suggest the potential for overexertion injuries and tissue damage during unexpected slip and trip events, which could contribute to low back injuries. Outcomes of this study may facilitate the identification and control of specific mechanisms involved with low back disorders consequent to slips or trips.

A Systematic Review of Fall Risk Factors in Stroke Survivors: Towards Improved Assessment Platforms and Protocols.

Background/Purpose: To prevent falling, a common incident with debilitating health consequences among stroke survivors, it is important to identify significant fall risk factors (FRFs) towards developing and implementing predictive and preventive strategies and guidelines. This review provides a systematic approach for identifying the relevant FRFs and shedding light on future directions of research. Methods: A systematic search was conducted in 5 popular research databases. Studies investigating the FRFs in the stroke community were evaluated to identify the commonality and trend of FRFs in the relevant literature. Results: twenty-seven relevant articles were reviewed and analyzed spanning the years 1995-2020. The results confirmed that the most common FRFs were age (21/27, i.e., considered in 21 out of 27 studies), gender (21/27), motion-related measures (19/27), motor function/impairment (17/27), balance-related measures (16/27), and cognitive impairment (11/27). Among these factors, motion-related measures had the highest rate of significance (i.e., 84% or 16/19). Due to the high commonality of balance/motion-related measures, we further analyzed these factors. We identified a trend reflecting that subjective tools are increasingly being replaced by simple objective measures (e.g., 10-m walk), and most recently by quantitative measures based on detailed motion analysis. Conclusion: There remains a gap for a standardized systematic approach for selecting relevant FRFs in stroke fall risk literature. This study provides an evidence-based methodology to identify the relevant risk factors, as well as their commonalities and trends. Three significant areas for future research on post stroke fall risk assessment have been identified: 1) further exploration the efficacy of quantitative detailed motion analysis; 2) implementation of inertial measurement units as a cost-effective and accessible tool in clinics and beyond; and 3) investigation of the capability of cognitive-motor dual-task paradigms and their association with FRFs.

A Systematic Review on Evaluation Strategies for Field Assessment of Upper-Body Industrial Exoskeletons: Current Practices and Future Trends.

With rising manual work demands, physical assistance at the workplace is crucial, wherein the use of industrial exoskeletons (i-EXOs) could be advantageous. However, outcomes of numerous laboratory studies may not be directly translated to field environments. To explore this discrepancy, we conducted a systematic review including 31 studies to identify and compare the approaches, techniques, and outcomes within field assessments of shoulder and back support i-EXOs. Findings revealed that the subjective approaches [i.e., discomfort (23), usability (22), acceptance/perspectives (21), risk of injury (8), posture (3), perceived workload (2)] were reported more common (27) compared to objective (15) approaches [muscular demand (14), kinematics (8), metabolic costs (5)]. High variability was also observed in the experimental methodologies, including control over activity, task physics/duration, sample size, and reported metrics/measures. In the current study, the detailed approaches, their subject-related factors, and observed trends have been discussed. In sum, a new guideline, including tools/technologies has been proposed that could be utilized for field evaluation of i-EXOs. Lastly, we discussed some of the common technical challenges experimenters face in evaluating i-EXOs in field environments. Efforts presented in this study seek to improve the generalizability in testing and implementing i-EXOs.

Why multi-tier surgical instrument table matters? An ergonomic analysis from mento-physical demand perspectives.

Using traditional back tables (BT) in operating rooms (OR) can lead to high physical/cognitive demand on nurses due to repetitive manual material handling activities. A multi-tier table (MTT) has been developed to relieve such stressors by providing extra working surfaces to avoid stacking the instrument trays and facilitate access to surgical tools. In this study, sixteen participants performed lifting/lowering and instrument findings tasks on each table, where kinematics, kinetics, subjective, and performance-related measures were recorded. Results indicated that MTT required lesser shoulder flexion (p-value<0.001), ∼14% lower shoulder loads (0.012), task completion time (<0.001), and cognitive/physical workloads (<0.004). Although peak low-back demands were ∼15% higher using MTT, the number of lifts to complete the same task was 60% lower, leading to lower cumulative demand on the low-back musculature. Utilizing MTT in OR could reduce demand and increase nurses' efficiency, leading to reduced risk of WMSDs and the total time of surgery.

Kinematic Analysis of 360° Turning in Stroke Survivors Using Wearable Motion Sensors.

BACKGROUND: A stroke often bequeaths surviving patients with impaired neuromusculoskeletal systems subjecting them to increased risk of injury (e.g., due to falls) even during activities of daily living. The risk of injuries to such individuals can be related to alterations in their movement. Using inertial sensors to record the digital biomarkers during turning could reveal the relevant turning alterations. OBJECTIVES: In this study, movement alterations in stroke survivors (SS) were studied and compared to healthy individuals (HI) in the entire turning task due to its requirement of synergistic application of multiple bodily systems. METHODS: The motion of 28 participants (14 SS, 14 HI) during turning was captured using a set of four Inertial Measurement Units, placed on their sternum, sacrum, and both shanks. The motion signals were segmented using the temporal and spatial segmentation of the data from the leading and trailing shanks. Several kinematic parameters, including the range of motion and angular velocity of the four body segments, turning time, the number of cycles involved in the turning task, and portion of the stance phase while turning, were extracted for each participant. RESULTS: The results of temporal processing of the data and comparison between the SS and HI showed that SS had more cycles involved in turning, turn duration, stance phase, range of motion in flexion-extension, and lateral bending for sternum and sacrum (p-value < 0.035). However, HI exhibited larger angular velocity in flexion-extension for all four segments. The results of the spatial processing, in agreement with the prior method, showed no difference between the range of motion in flexion-extension of both shanks (p-value > 0.08). However, it revealed that the angular velocity of the shanks of leading and trailing legs in the direction of turn was more extensive in the HI (p-value < 0.01). CONCLUSIONS: The changes in upper/lower body segments of SS could be adequately identified and quantified by IMU sensors. The identified kinematic changes in SS, such as the lower flexion-extension angular velocity of the four body segments and larger lateral bending range of motion in sternum and sacrum compared to HI in turning, could be due to the lack of proper core stability and effect of turning on vestibular system of the participants. This research could facilitate the development of a targeted and efficient rehabilitation program focusing on the affected aspects of turning movement for the stroke community.

Kinematic Assessment of Turning and Walking Tasks Among Stroke Survivors by Employing Wearable Sensors and Pressure Platform.

Stroke survivors often experience reduced movement capabilities due to alterations in their neuromusculoskeletal systems. Modern sensor technologies and motion analyses can facilitate the determination of these changes. Our work aims to assess the potential of using wearable motion sensors to analyze the movement of stroke survivors and identifying the affected functions. We recruited 10 participants (5 stroke survivors, 5 healthy individuals) and conducted a controlled laboratory evaluation for two of the most common daily activities: turning and walking. Among the extracted kinematic parameters, range of trunk and sacrum lateral bending in turning were significantly larger in stroke survivors (p-value<0.02). However, no statistical difference in mean angular velocity and range of motion for trunk/sacrum/shank flexion-extension were obtained in the turning task. Our results also indicated that during walking, while there was no difference in swing time, double support portion of gait among the stroke group was significantly larger (p-value = 0.001). Outcomes of this investigation may help in designing new rehabilitation programs for stroke and other neurological disorders and/or in improving the efficacy of such programs.Clinical Relevance- This study may provide a better insight on the detailed functional differences between stroke survivors and healthy individuals which in turn could be used to develop a more efficient rehabilitation program for stroke community.

Biomechanical modeling of spinal ligaments: finite element analysis of L4-L5 spinal segment.

The complex mechanical structure of spine is usually simplified in finite element (FE) modes. In this study, different 3D models of L4-L5 spinal segment distinguished by their ligament modelling were developed (1D truss, 2D shell and 3D space truss elements). All models could be considered validated with respect to range of motion and intradiscal pressure, although their ligament stresses/forces were substantially different. The models with 2D shell and 3D space truss ligaments showed the stress distribution and identified the potential failure/injury locations in ligaments. The model with 3D space truss ligaments showed the stress/force direction (representing collagen fiber directions).

Smartphone-based human fatigue level detection using machine learning approaches.

Human muscle fatigue is the main result of diminishing muscle capability, leading to reduced performance and increased risk of falls and injury. This study provides a classification model to identify the human fatigue level based on the motion signals collected by a smartphone. 24 participants were recruited and performed the fatiguing exercise (i.e. squatting). Upon completing each set of squatting, they walked for a fixed distance while the smartphone attached to their right shank and the gait data were associated with the Borg's Rating of Perceived Exertion (i.e. data label). Our machine-learning model of two (no- vs. strong-fatigue), three (no-, medium-, and strong-fatigue) and four (no-, low-, medium-, and strong-fatigue) levels of fatigue reached the accuracy of 91, 78, and 64%, respectively. The outcomes of this study may facilitate the accessibility of a fatigue-monitoring tool in the workplace, which improves the workers' performance and reduce the risk of falls and injury. Practitioner Summary: This study aimed to develop a machine-learning model to identify human fatigue level using motion data captured by a smartphone attached to the shank. Our results can facilitate the development of an accessible fatigue-monitoring system that may improve the workers' performance and reduce the risk of falls and injury. Abbreviations: WMSD: work-related musculoskeletal disorders; IMU: inertial measurement unit; RPE: rating of perceived exertion; SVM: support vector machine; IRB: institutional review board; SOM: self-organizing map; LDA: linear discriminant analysis; PCA: principal component analysis; FT: fourier transformation; RBF: radial basis function; CUSUM: cumulative sum; ROM: range of motion; MVC: maximum voluntary contractions.

Using a Motion Sensor to Categorize Nonspecific Low Back Pain Patients: A Machine Learning Approach.

Nonspecific low back pain (NSLBP) constitutes a critical health challenge that impacts millions of people worldwide with devastating health and socioeconomic consequences. In today's clinical settings, practitioners continue to follow conventional guidelines to categorize NSLBP patients based on subjective approaches, such as the STarT Back Screening Tool (SBST). This study aimed to develop a sensor-based machine learning model to classify NSLBP patients into different subgroups according to quantitative kinematic data, i.e., trunk motion and balance-related measures, in conjunction with STarT output. Specifically, inertial measurement units (IMU) were attached to the trunks of ninety-four patients while they performed repetitive trunk flexion/extension movements on a balance board at self-selected pace. Machine learning algorithms (support vector machine (SVM) and multi-layer perceptron (MLP)) were implemented for model development, and SBST results were used as ground truth. The results demonstrated that kinematic data could successfully be used to categorize patients into two main groups: high vs. low-medium risk. Accuracy levels of ~75% and 60% were achieved for SVM and MLP, respectively. Additionally, among a range of variables detailed herein, time-scaled IMU signals yielded the highest accuracy levels (i.e., ~75%). Our findings support the improvement and use of wearable systems in developing diagnostic and prognostic tools for various healthcare applications. This can facilitate development of an improved, cost-effective quantitative NSLBP assessment tool in clinical and home settings towards effective personalized rehabilitation.

Processing of Near Real Time Land Surface Temperature and Its Application in Forecasting Forest Fire Danger Conditions.

Near real time (NRT) remote sensing derived land surface temperature (Ts) data has an utmost importance in various applications of natural hazards and disasters. Space-based instrument MODIS (moderate resolution imaging spectroradiometer) acquired NRT data products of Ts are made available for the users by LANCE (Land, Atmosphere Near real-time Capability) for Earth Observing System (EOS) of NASA (National Aeronautics and Space Administration) free of cost. Such Ts products are swath data with 5 min temporal increments of satellite acquisition, and the average latency is 60-125 min to be available in public domain. The swath data of Ts requires a specialized tool, i.e., HEG (HDF-EOS to GeoTIFF conversion tool) to process and make the data useful for further analysis. However, the file naming convention of the available swath data files in LANCE is not appropriate to download for an area of interest (AOI) to be processed by HEG. In this study, we developed a method/algorithm to overcome such issues in identifying the appropriate swath data files for an AOI that would be able to further processes supported by the HEG. In this case, we used Terra MODIS acquired NRT swath data of Ts, and further applied it to an existing framework of forecasting forest fires (as a case study) for the performance evaluation of our processed Ts. We were successful in selecting appropriate swath data files of Ts for our study area that was further processed by HEG, and finally were able to generate fire danger map in the existing forecasting model. Our proposed method/algorithm could be applied on any swath data product available in LANCE for any location in the world.

Relationship between big five personality factors, problem solving and medical errors.

BACKGROUND: Human behavior is recognized as the main factor in the occurrence of accidents (70-90 percent), with human personality and problem solving ability as two related factors in the occurrence of medical errors (annually 42.7 million in the world). The objectives of this study were to investigate the relationship between personality factors, problem solving ability and medical errors. MATERIAL AND METHODS: This study was a questionnaire case control study. Information on 49 members of medical and nursing staff with medical errors (case group) and 46 without medical errors (control group) were analyzed. To collect the data, two Heppner problem solving questionnaires and the NEO-Five Factor Inventory were used, which were completed by the study population. RESULTS: The results illustrate that individuals without medical errors showed higher scores in contentiousness, extraversion and agreeableness and lower scores in neuroticism than those with medical errors. Individuals without medical errors also showed higher scores in problem solving ability scales than those with medical errors. CONCLUSION: Results of this study, suggest that personality factors and problem solving ability are related to medical errors and it may be possible for hospital authorities to use this knowledge when selecting capable medical staff.

A novel approach to spinal 3-D kinematic assessment using inertial sensors: Towards effective quantitative evaluation of low back pain in clinical settings.

This paper presents a novel approach for evaluating LBP in various settings. The proposed system uses cost-effective inertial sensors, in conjunction with pattern recognition techniques, for identifying sensitive classifiers towards discriminate identification of LB patients. 24 healthy individuals and 28 low back pain patients performed trunk motion tasks in five different directions for validation. Four combinations of these motions were selected based on literature, and the corresponding kinematic data was collected. Upon filtering (4th order, low pass Butterworth filter) and normalizing the data, Principal Component Analysis was used for feature extraction, while Support Vector Machine classifier was applied for data classification. The results reveal that non-linear Kernel classification can be adequately employed for low back pain identification. Our preliminary results demonstrate that using a single inertial sensor placed on the thorax, in conjunction with a relatively simple test protocol, can identify low back pain with an accuracy of 96%, a sensitivity of %100, and specificity of 92%. While our approach shows promising results, further validation in a larger population is required towards using the methodology as a practical quantitative assessment tool for the detection of low back pain in clinical/rehabilitation settings.

A regenerative approach towards recovering the mechanical properties of degenerated intervertebral discs: Genipin and platelet-rich plasma therapies.

Degenerative disc disease, associated with discrete structural changes in the peripheral annulus and vertebral endplate, is one of the most common pathological triggers of acute and chronic low back pain, significantly depreciating an individual's quality of life and instigating huge socioeconomic costs. Novel emerging therapeutic techniques are hence of great interest to both research and clinical communities alike. Exogenous crosslinking, such as Genipin, and platelet-rich plasma therapies have been recently demonstrated encouraging results for the repair and regeneration of degenerated discs, but there remains a knowledge gap regarding the quantitative degree of effectiveness and particular influence on the mechanical properties of the disc. This study aimed to investigate and quantify the material properties of intact (N = 8), trypsin-denatured (N = 8), Genipin-treated (N = 8), and platelet-rich plasma-treated (N = 8) discs in 32 porcine thoracic motion segments. A poroelastic finite element model was used to describe the mechanical properties during different treatments, while a meta-model analytical approach was used in combination with ex vivo experiments to extract the poroelastic material properties. The results revealed that both Genipin and platelet-rich plasma are able to recover the mechanical properties of denatured discs, thereby affording promising therapeutic modalities. However, platelet-rich plasma-treated discs fared slightly, but not significantly, better than Genipin in terms of recovering the glycosaminoglycans content, an essential building block for healthy discs. In addition to investigating these particular degenerative disc disease therapies, this study provides a systematic methodology for quantifying the detailed poroelastic mechanical properties of intervertebral disc.