RESUMO
New series of pyrazole derivatives 3-(furan-2-yl)-4-(5-hydroxy-4H-pyrazol-3-yl)-N-phenylbutanamide 1-5 and imidazole derivatives 3-(furan-2-yl)-3-(1H-imidazol-1-yl)-N-phenylpropanamide 6-10 were synthesized by the Mannich base method. Synthesized compounds 1-10 were confirmed by IR, 1H NMR, 13C NMR, Mass and elemental analysis and further screened for antimicrobial activity.
RESUMO
A series of 1,4-dihydropyridine derivatives (1a-g) were prepared from three compounds condensation reaction of ethylacetoacetate, aromatic aldehyde and ammonium hydroxide. A new series of compounds (2a-g) were prepared from compounds (1a-g) via reaction with thiosemicarbazide using the condensation method. The synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, mass spectral and elemental analyses. The synthesized compounds (1a-g) and (2a-g) were also screened for anticoagulant properties.