[Comprehensive medical rehabilitation using therapeutic physical factors including hydrokinesiotherapy in a pool with mineral water and its effect on circadian rhythms of arterial pressure and autonomic regulation in patients with arterial hypertension and with chronic psychoemotional stress]. / Kompleksnaya reabilitatsiya lechebnymi fizicheskimi faktorami s vklyucheniem gidrokinezioterapii v basseine s mineral'noi vodoi i ee vliyanie na tsirkadnye ritmy arterial'nogo davleniya i vegetativnuyu regulyatsiyu u bol'nykh arterial'noi gipertoniei i s khronicheskim psikhoemotsional'nym napryazheniem.

OBJECTIVE: To study the effect of the course-based comprehensive rehabilitation using the therapeutic physical factors of the Belokurikha resort, including hydrokinesiotherapy in a pool with mineral water on the circadian rhythms of arterial pressure and its autonomous regulation in patients with arterial hypertension (AH) associated with chronic psychoemotional stress (CPES). MATERIAL AND METHODS: The study involved 83 patients with stage I-II grade 1-2 of AH, whose professional activities were associated with CPES. Each participant had 24-hours Holter blood pressure monitored, and cardiointervalography (CIG) was performed before and after the medical rehabilitation course. The rehabilitation complex of the main group (II) included medication therapy for AH, diet, morning hygienic gymnastics, manual massage, total magnet therapy, and hydrokinesiotherapy in a pool with mineral water. Patients in the comparison group (I) were exposed to similar therapeutic physical factors with identical parameters of the procedures, except hydrokinesiotherapy, which was replaced by full baths with mineral water. RESULTS: Medical rehabilitation using the therapeutic physical factors of the Belokurikha resort with hydrokinesiotherapy in a pool promotes a decrease in the activity of a sympathetic nervous system and increase of vagal effects contribute to the regulation of vital functions of the AH patients, associated with CPES, thus minimizing the frequency of abnormal daily profiles night-peaker and over-dipper to 12.5% and 1.78% of cases, respectively, and increasing the percentage of subjects with its normal type (dipper) to 57.1% (p=0.039). CONCLUSION: The study results show the benefits of hydrokinesiotherapy in a pool with mineral water as a part of the course-based comprehensive rehabilitation in patients with hypertension and chronic psychoemotional stress in terms of normalizing circadian rhythms of arterial pressure and optimizing the activity of higher autonomous centers, which largely determine the cardiovascular system performance in this setting.

Effect of Humic Acids from Lowland Peat on Endurance of Rats in Forced Swim Test in Relation to Serum Lactate and Corticosterone.

The study substantiated the possibility of using peat humic acids for improving endurance during extreme physical exertion. The mature outbred Wistar rats weighing 200-250 g (n=40) were subjected to forced swim test until complete exhaustion. The humic acids (1%) were administered intragastrically (0.5 ml/100 g body weight) 30 min prior to the test. Chronic administration of peat humic acids for 5 days increased physical capacity and endurance of rats in exhaustive forced swim test without the changes in serum lactate and corticosterone.

[The evaluation of the effectiveness of cardiac rehabilitation of the patients after percutaneous coronary interventions]. / Otsenka éffektivnosti kardioreabilitatsii patsientov posle chreskozhnykh koronarnykh vmeshatel'stv.

BACKGROUND: Notwithstanding the current abundance of the methodological approaches to the evaluation of the outcomes of medical rehabilitation, the criteria for the effectiveness of the combined influence of the curative physical factors are still inadequate and remain at variance with the principles of evidence-based medicine. AIM: The objective of the present study was to develop a method for the evaluation of the effectiveness of the rehabilitation activities in the patients presenting with the acute coronary syndrome following endovascular cardiac interventions. MATERIAL AND METHODS: This work is based on the results of a prospective single-center cohort-based clinical study involving the subjects who had undergone myocardial infarction following endovascular cardiac surgical interventions. The duration of the patient's participation in the study was 21 days. RESULTS: We have developed the integrative approach to the creation of the unified multi-criteria system for the evaluation of the effectiveness of the treatment of the patients presenting with cardiovascular diseases after percutaneous coronary interventions (PCI). In addition, the step-by-step description of this technology is presented. The algorithm for the calculation of the integrated health index and the evaluation of the overall effect of the rehabilitation activities was proposed based on the assessment of the clinical, laboratory, and functional indicators of the health status together with the psychological characteristics of individual patients. It is proposed to consider an integrated health index as a parameter for estimating the rehabilitation potential of the patients suffering from cardiovascular diseases after percutaneous surgical interventions. CONCLUSION: The proposed system for the evaluating of the effectiveness of comprehensive medical rehabilitation differs from analogous intellectual products in that it excludes the subjective interpretation of the severity of clinical symptoms associated with the concrete pathological process and makes impossible the arbitrary determination of the weight of the peculiar features of the patient's condition. Moreover, it allows to reduce the parameters of different types chosen as the criteria for the evaluation of the effectiveness of rehabilitation to the standardized values, to obtain an unambiguous numerical expression of the results of the rehabilitative treatment, and to compare the outcomes of the rehabilitation activities based at different treatment and prevention settings.

[SEASONAL FEATURES OF SEROTONIN IN BLOOD SERUM OF RATS AFTER PHYSICAL OVERWORK UNDER DESYNCHRONOSIS].

The content of serotonin in the blood serum of rats with light desynchronizes and physical fatigue in different seasons was investigated ву enzyme immunoassay. It was found that long-term light deprivation and exercise to complete depletion lowered levels of serotonin in the blood serum of rats in the winter and increased that of the spring season. At the same time, a dark deprivation and physical activity had no effect on this indicator.

IMMUNOPHENOTYPICAL CHARACTERISTICS OF CELLULAR COMPOSITION IN BREAST MILK.

The morphology and immunophenotype of female colostrum adherent cells with the help of CD3, CD31, CD34, CD45, CD68, vimentin, and osteocalcin antibodies panel was studied in short-term (6­7 days) culture in vitro. Approximately equal (1 : 1) ratio of fibroblast-like and rounded cells was observed in 20 % of cultural flasks. The cells with regular shape mixed with single fibroblasts were noted in 80 % of cultural flasks. The diameter of spreaded cells varied within 10­100 mm. All cells adhered to plastics did not express CD3 and interacted slightly (sl) with antibodies to CD31, CD34, and CD45. At the same time, adherent cells with intensive CD68, vimentin and osteocalcin staining have been revealed. Literature data allows to interpret CD68+CD3­CD31slCD34slCD45sl immunophenotype of significant part of mother colostrum adherent cells as belonging to monocyte-macrophage lineage. Marked expression of stromal antigens (vimentin, osteocalcin) in 40­45 % adherent cells in cultural medium without osteogenic supplements (beta-glycerophosphate, ascorbic acid, dexamethasone) proposes an existence of osteoblasts fraction differentiated in colostrum from mesenchymal stem cells under an action of breast milk humoral factors.

[Influence of frozen-dried antlers of Siberian stags on humoral homeostasis in athletes of cyclic sports].

The authors evaluated effects of antlers of Siberian stags on humoral homeostasis parameters in highly qualified athletes during contest period. Medication based on antlers of Siberian stags provides more balanced operation of energy supplying processes, maintains stable lipid metabolism, favors balance in "prooxidants - antioxidants" system.

[Gender analysis of efficiency provided by general bath containing antlers of Siberian stags in skiers].

The authors performed gender analysis of efficiency caused by general bath containing antlers of Siberian stags in athletes engaged into winter sports. Male athletes demonstrated increased physical performance, low RBC membrane response to epinephrine, decreased cortisol level, higher testosterone level and longer time of breath-holding in Stange's test. Female athletes demonstrated no reliable changes in the mentioned parameters.

[The influence of the products prepared from young not ossified antlers marals of siberian red deer on the characteristics of the blood oxygen-supplying system in the athletes during the contest season].

The objective of the present study was to estimate the influence of the products prepared from young not ossified antlers marals of Siberian red deer on the characteristics of the blood oxygen-supplying system in the athletes undergoing heavy physical loads during the contest season. It was shown that the use of such preparations promotes correction of humoral characteristics reflecting the development of iron-deficient conditions.

[Electromagnetic fields of extremely high frequency and radon baths in the treatment of Lyme disease with nervous system lesions]. / Elektromagnitnye polia kraine vysokoi chastoty i radonovye vanny v lechenii bolezni Laima s porazheniem nervnoi sistemy.

Patients with borreliosis caused by exodic tick infestation running with affection of the nervous system were exposed to scanning EHF-therapy (59-63 GHz) on biologically active zones of the upper third of the chest, right brachial joint, biologically active points GI4, E36. Also, they took radon baths. The treatment was planned with consideration of the principles of chronotherapy. This therapeutic approach produced stimulation of general adaptive reactions and reparative processes in the peripheral nervous system.

[Application of natural and preformed physical factors during medical rehabilitation in participants of military conflicts]. / Primenenie prirodnykh i preformirovannykh fizicheskikh faktorov u uchastnikov vooruzhennykh konfliktov v protsesse meditsinskoi reabilitatsii.

The authors have performed individually adjusted complexes of balneophysiotherapeutic procedures in soldiers and officers who had taken part in local military conflicts. Functional and biochemical investigations show that in those military who had no wounds but had a weak posttraumatic stress reaction the above complexes are rather effective.

[Laser therapy and electric stimulation in rehabilitation treatment of peripheral neuropathy]. / Lazerterapiia i élektrostimuliatsiia v vosstanovitel'nom lechenii perifericheskikh neiropatii.

73 patients with compression-ischemic myeloradiculopathy received treatment including infrared laser radiation on the paravertebral fields, motor points of the affected nerves and biologically active points Y63, Y67, YB34, YB42, YB43, E34, E42 (1.0-5.0 mW/cm2; 5 and 5000 Hz), electrostimulation of motor nerve points and innervated by them muscles by double square impulses with a fixed gap 5 ms. Impulse infrared laser therapy relieves pain syndrome, stimulates repair processes in the affected nerve structures. Further modified electric stimulation activates a regenerative growth of the nerve fibers, reinnervation of the limb muscles.

[Electromagnetic and mechanical vibrations in the therapy of myofascial pains]. / Elektromagnitnye i mekhanicheskie kolebaniia v terapii miofastsial'nykh bolei.

Low-frequency vibration effectively stimulates in a direct way or via reflexes neuromuscular apparatus in patients with muscular-tonic manifestations of spinal osteochondrosis. Long-term myofixation forms foci of denervation disorders as painful muscular consolidations with active center the irritation of which gives rise to phenomenon of reflected pain. In this case it is better to begin treatment with optic red and infrared radiation on the reflexogenic zones and muscular consolidations for reduction of trophic abnormalities. This creates favourable conditions for subsequent vibrostimulation of affected nerves and muscles.

[The combined rehabilitation of patients in the early and late periods after diskectomy]. / Kompleksnaia reabilitatsiia bol'nykh v rannem i pozdnem periode posle diskéktomii.

Application of low-intensity radiations of optic range early after diskectomy helps to relieve pain more quickly, eliminate morpho-functional disturbances of the tissues in the operated segment, affected roots and relevant nerves. Combined, pathogenetically sound, staged rehabilitation stabilizes the course of the postoperative period, accelerates regression of motor defects, lowers risk of forming postoperative complications.

[The use of puncture physiotherapy for optimizing the mud therapy of spinal osteochondrosis patients]. / Ispol'zovanie punkturnoi fizioterapii dlia optimizatsii griazelecheniia bol'nykh osteokhondrozom pozvonochnika.

It is shown that physical puncture effects arouse favourable reactions of human organism both in monotherapy and in combined therapy with peloids. This suggests a conclusion that indications to physiotherapy of spinal osteochondrosis can be extended and cover also acute osteochondrosis, that new complexes of physiopeloid therapy may be designed with minimal risk of balneoreactions.

[The types of traction in osteochondrosis of the lumbar spine]. / Nekotorye vidy traktsii pri osteokhondroze poiasnichnogo otdela pozvonochnika.

The effects of low-intensive tractions were evaluated clinically and electrophysiologically in 148 patients with neurological symptoms of lumbar osteochondrosis. The above tractions were combined with vibration, peloid electrophoresis and sulphide baths. Indications and contraindications for tractions are outlined. The above complexes are recommended for use in the programs of rehabilitation of patients with osteochondrosis of the lumbar spine.

[The duration of the sanatorium-health resort treatment of patients with neurological manifestations of spinal osteochondrosis]. / O prodolzhitel'nosti snatorno-kurortnogo lecheniia bol'nykh s nevrologicheskimi proiavleniiami osteokhondroza pozvonochnika.

Patients with neurological symptoms of spinal osteochondrosis in exacerbation took reduced intensive courses of physiotherapy which consisted of ultraphonophoresis of 1% oil solution of polar fraction of lipids from sulfide mud (eplir). The course included 12 daily procedures. Positive functional changes and those in vertebroneurological status support high efficacy and good tolerance of such short courses.

[A morphofunctional validation of the use of electrostimulation by paired impulses combined with vibromassage for the treatment of patients with trauma to the peripheral nerves of the extremities]. / Morfofunktsional'noe obosnovanie primeneniia élektrostimuliatsii parnymi impul'sami v sochetanii s vibromassazhem dlia lecheniia bol'nykh s travmami perifericheskikh nervov konechnostei.

The exposure to paired electric impulses and vibromassage promotes completeness of repair in the treatment of injured peripheral nerves of the limb. The effect is achieved due to marked stimulation of myelinization and differentiation of the nerve fibers, regeneration of the nerve system in the denervated muscle.

[The optimization of the duration of the sanatorium-health resort treatment of patients with neurological manifestations of spinal osteochondrosis (I)]. / Optimizatsiia prodolzhitel'nosti sanatorno-kurortnogo lecheniia bol'nykh s nevrologicheskimi proiavleniiami osteokhondroza pozvonochnika (I soobshchenie).

Short-term mud therapy (10 daily peat [correction of moor] applications) has been performed in patients with neurological symptoms of spinal osteochondrosis. Such short-term courses are indicated in the absence of exacerbation of the basic and associated diseases under domination of the radicular and reflex syndromes. High efficacy and good tolerance of the treatment are confirmed by vertebroneurological investigations and functional diagnostic tests.