Synthesis, structural investigations, and in vitro biological activity of Co(II) and Fe(III) mixed ligand complexes of 1,10-phenanthroline and 2,2'-bipyridine.

Herein, we report, four new mixed ligand complexes of Cobalt(II) and Iron(III), viz., [Co(L1 )(L2 )(H2 O)2 ]Cl2 (1), [Co(L1 )(L2 )(L3 )(H2 O)]Cl2 (2), [Fe(L1 )(L2 )(H2 O)2 ]Cl3 (3), and [Fe(L1 )(L2 )(L3 )(H2 O)]Cl3 (4), where L1  = 1,10-phenanthroline (C12 H8 N2 ), L2  = 2,2'-bipyridine (C10 H8 N2 ), and L3  = acetamide (C2 H5 NO)). They were synthesized and characterized using spectroscopic analysis (ESI-MS, ICP-OES, FT-IR, and UV-Vis), elemental analysis, melting point determination, and conductance measurement. The in vitro antibacterial activity was tested on two Gram-positive Staphylococcus aureus (S. aureus) and Streptococcus pyogenes (S. pyogenes) and two Gram-negative Escherichia coli (E. Coli)and Klebsiella pneumoniae (K. pneumoniae) bacteria using the disc diffusion method. Based on the analytical and spectroscopic data, octahedral geometries are assigned to the complexes. Co(II) complexes were found more active against K. pneumoniae than the corresponding Fe(III) complexes which indicated that antibacterial activities of metal complexes have tuned with the nature of the metal. The results provide an insight to design and readily prepare task-specific metal-based drugs for interaction with particular bacterial strains.

Patients Satisfaction and Associated Factors Towards Physiotherapy Services in North West Ethiopia.

BACKGROUND: Patient satisfaction is a critical patient-focused indicator of the general quality of patient care and health care. There was only one previous study conducted to assess patient satisfaction with physiotherapy services in Ethiopia. OBJECTIVE: This study aimed to assess patients' satisfaction and associated factors towards physiotherapy services in North West Ethiopia. METHODS: An institution-based cross-sectional study was conducted. Using consecutive sampling method, 393 samples were collected. The collected data were cleaned, coded, entered into Epi-Data version 4.2 and exported to SPSS version 25 for analysis. The binary logistic regression model was fitted and p-value less than 0.25 was used to select significant variables for multivariate analysis. Results were presented in frequency distribution tables and graphs. RESULTS: Overall 201 (51.1%) of the respondents were satisfied. The odds of physiotherapy service satisfaction at age greater than 55 years old were OR 1.78 (95% CI: 1.02-3.09) times higher than the age less than or equal to 55 years old. The odds of physiotherapy service satisfaction of married respondents were OR 1.75 (95% CI: 1.05-2.90) times higher than for single patients and the odds of satisfaction of having a good feeling about physiotherapy service was OR 3.76 (95% CI: 1.46-9.70) times higher than their counterparts. CONCLUSION: Almost half of the respondents were satisfied with the physiotherapy service. Age, marital status, history of having information about physiotherapy and feelings about the physiotherapy service were significant variables affecting patient's satisfaction in the physiotherapy service.