RESUMO
To evaluate the effectiveness of hepatitis B virus (HBV) vaccination of household contacts of HBV carriers in Tulkarm district, Palestine, quantitative hepatitis B surface (anti-HBs) antibody response in 161 household contacts was measured after vaccination. A seroprotective anti-HBs response (titre > or = 10 IU/L) was elicited in all vaccinated subjects. Of these 2.5% had titres of 10-99 IU/L, 61.5% 100-999 IU/L and 36.0% > or = 1000 IU/L. The number of vaccination doses had no effect on the achievement of seroprotection. HBV infection was demonstrated in 13 cases and their anti-HBV titres were in the range 25-350 IU/L.
Assuntos
Portador Sadio/prevenção & controle , Características da Família , Anticorpos Anti-Hepatite B/sangue , Vacinas contra Hepatite B/imunologia , Hepatite B/prevenção & controle , Programas de Imunização/organização & administração , Programas Obrigatórios/organização & administração , Vacinação/métodos , Vacinação/estatística & dados numéricos , Adolescente , Adulto , Portador Sadio/epidemiologia , Portador Sadio/imunologia , Criança , Pré-Escolar , Busca de Comunicante , Doenças Endêmicas/prevenção & controle , Doenças Endêmicas/estatística & dados numéricos , Feminino , Hepatite B/epidemiologia , Hepatite B/imunologia , Humanos , Esquemas de Imunização , Masculino , Pessoa de Meia-Idade , Oriente Médio/epidemiologia , Seleção de Pacientes , Avaliação de Programas e Projetos de Saúde , Fatores de Risco , Estudos SoroepidemiológicosRESUMO
To evaluate the effectiveness of hepatitis B virus [HBV] vaccination of household contacts of HBV carriers in Tulkarm district, Palestine, quantitative hepatitis B surface [anti-HBs] antibody response in 161 household contacts was measured after vaccination. A seroprotective anti-HBs response [titre > or = 10 IU/L] was elicited in all vaccinated subjects. Of these 2.5% had titres of 10-99 IU/L, 61.5% 100-999 IU/L and 36.0% > or = 1000 IU/L.The number of vaccination doses had no effect on the achievement of seroprotection. HBV infection was demonstrated in 13 cases and their anti-HBV titres were in the range 25-350 IU/L
