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OBJECTIVE: To explore the incidence, distribution characteristics and related symptoms of gastroesophageal reflux disease (GERD) as well as its related risk factors in Kashgar, Xinjiang. METHODS: From March 2020 to October 2020, a questionnaire survey was conducted among 5,080 permanent residents aged 18-80 years in Kashgar using cluster sampling and stratified sampling methods. The content included basic information, accompanying symptoms and diseases, living, customs and eating habits, and Gastroesophageal Reflux Disease Questionnaire score, etc. Results: The prevalence of GERD in Kashgar was 23.4% (1187/5080), and the proportions of patients with reflux symptoms lasting 1 day, 2-3 days and 4-7 days within a week were 12.5%, 6.4% and 4.4%, respectively. The proportion of patients showing symptoms in the GERD group was significantly higher than that in the non-GERD group (P<0.05). The proportion of people who are overweight or obese, take alcohol drink, eat, constipate, or take various chronic disease drugs in the GERD group is higher than that in the non-GERD group. The proportion of people in the GERD group who often eat sweet foods, pickled products, roasted products, spicy foods and meat, or drink coffee, acidic beverages, and cold drinks was higher than that in the non-GERD (P<0.05). The proportion of people in the GERD group who regularly consume fish, milk, eggs, vegetables, and fruits was significantly lower than that in non-GERD group (P<0.05). Logistic regression analysis found that Uyghur nationality (for the Han nationality), age (for the 30-39 years group), drinking, overeat, constipation, and frequent medication were risk factors (P<0.05, OR>1). Multivariate logistic regression analysis found that sweets, baked products, cold drinks, and spicy foods were independent risk factors (P<0.05, OR>1). Eggs and vegetables were protective factors (P<0.05, OR<1). CONCLUSION: The high incidence of GRED in Kashgar, Xinjiang may be related to the local living environment, and life and eating habits.
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Objective To discuss factors related to clinical characteristics,biological behavior,and prognosis in gastric stromal tumors (GST).Methods We retrospectively analyzed clinical materials and records of 70 GST patients diagnosed after surgery and pathological examinations,all patients were contacted by telephone or mail for follow-up.Results (1) All GST patients had similar distribution of gender,and had age range of 50 to 69 years with mean age of 59.1 years.Clinical symptoms were non-specific,and main clinical manifestations included abdominal discomfort (42.9％),followed by abdominal pain (37.1％),and upper digestive tract hemorrhage (7.1％).(2) Sex,age,presenting symptoms,and original location of tumors were not significantly related to prognosis (P ＞ 0.05).However,size of the tumor,mitosis count,and the malignancy potential grading were significantly associated with patient prognosis.Among them,size of the tumor (maximum tumor diameter ＞ 5 cm vs ＜ 2 cm,HR =21.3,95％ CI:5.9-77.0;maximum tumor diameter 2-5 cm vs ＜ 2 cm,HR =2.3,95％ CI:1.2-7.8),and mitosis count (mitosis count ＞ 10/50 HPF vs mitosis count ≤5/50 HPF,HR =22.5,95％ CI:8.6-58.6;6-10/50 HPF vs ≤5/50 HPF,HR =11.1,95％ CI:9.9-12.3) were independently associated with GST prognosis.Conclusions Tumor size,mitosis count,and malignancy potential grading were associated with prognosis of GST.Among them,tumor size and mitosis count were independent predictors of prognosis.When the tumor size is larger,and mitotic count and the malignant potential grade is higher,prognosis of GST patients were worse.
