Intoxicación aguda por ingesta intencional de fenobarbital sódico / Acute poisoning whit pills of sodium phenobarbital

Se presenta una paciente femenina, de 38 años de edad, que ingirió con fines suicidas 160 tabletas de 100 mg de fenobarbital y a las 72 horas de desaparecida fue encontrada en estado de coma. La paciente presentó coma profundo, shock hemodinámico y posteriormente una neumonía por bronco aspiración. Se aplicaron medidas generales y tratamiento sintomático además de hemocarboperfusión de urgencia. El examen toxicológico se realizó mediante técnicas de cromatografía en placa fina, seguidos de test colorimétrico y el empleo de extracción en fase sólida (SPE) y cromatografía gaseosa acoplada a detector de masas utilizando monitorización de iones seleccionados (SIM). Los resultados fueron positivos a la presencia de fenobarbital en orina y contenido gástrico. Los valores en sangre de fenobarbital fueron de 479 μmol L-1 96 horas tras la ingesta. Tras el sexto día de ingreso tuvo una evolución satisfactoria debido al rápido diagnóstico toxicológico y tratamiento con los métodos de depuración renal y extra renal, a pesar de la cantidad ingerida de 16 g (AU)

A case is reported of a female patient of 38 years old, who ingested 160 pills of 100 mg of phenobarbital with the purpose of committing suicide, and who was founded in state of coma after 72 hours of being missed. The patient presented a state of deep coma, haemodynamic shock and later a pneumonia for rough aspiration. General measures and symptomatic treatment were applied, as well as urgent charcoal haemoperfusion. The toxicological examination was carried out by means of thin layer chromatographic techniques, colorimetric test and solid phase extraction (SPE) and gas chromatography mass spectrometry using selected ion monitoring (SIM). The results were positive to the presence of phenobarbital in urine and gastric content. The serum phenobarbital concentration was 479 μmol L-1 96 hours after the ingestion. After the sixth day of admission, her evolution was satisfactory because of the rapid toxicological diagnosis and the treatment with methods of renal and extra renal purification, in spite of the ingested quantity of 16 g. phenobarbital (AU)

Antimicrobial and antileishmanial xanthones from the stem bark of Allanblackia gabonensis (Guttiferae).

The phytochemical study of stem bark of Allanblackia gabonensis has resulted in the isolation and characterisation of one new xanthone derivative, named allanxanthone D, together with 10 known compounds, including 6 xanthones derivatives, allanxanthone A, 1,5-dihydroxyxanthone, 1,7-dihydroxyxanthone and 1,3,6,7-tetrahydroxy-2-(3-methylbut-2-enyl)xanthone, forbexanthone, 6-deoxyisojacareubin, one polyisoprenylated benzophenone, guttiferone F, one flavanol, epicathechin, two phytosterols, beta-sitosterol and campesterol. The structures of these compounds were established on the basis of one- and two-dimensional NMR homo- and hetero-nuclear evidence. These compounds were evaluated for their activity against Leishmania amazonensis in vitro and antimicrobial activities against a range of Gram negative and Gram positive bacteria.