Lupus anticoagulant hypoprothrombinemia syndrome: A case report.

Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) is a rare entity associated with an increased risk of hemorrhage. Corticosteroids have been used in its treatment with favorable results. We present the case of a 54-year-old female patient with a personal history of Lupus diagnosed with LAHPS following an episode of cerebellar hemorrhage.

Incidence and clinical profile of venous thromboembolism in hospitalized COVID-19 patients from Madrid region.

BACKGROUND: COVID-19 related in-hospital venous thromboembolism (VTE) incidence is high but data reported vary significantly. Some studies show that up to half of the events are diagnosed early after admission. OBJECTIVES: To study symptomatic VTE incidence in acute COVID-19 hospitalized patients and to describe timing of VTE diagnosis. METHODS: Multicenter cohort of 5966 patients hospitalized with acute COVID-19. Multicenter Registry of 844 hospitalized patients with acute COVID-19 and associated acute VTE. RESULTS: By the time of cohort data collection, 68 patients (1.14%) were still hospitalized, 19.8% had died, and 5.4% required ICU. During a median follow-up of 6 days (IQR, 4-12), 183 patients (3.07%; 95% CI, 2.64-3.55) presented a symptomatic VTE event. The cumulative incidences of VTE at 7, 14 and 21 days in wards [2.3% (95% CI, 1.9-2.7), 3.6% (95% CI, 3.0-4.3), and 4.3% (95% CI, 3.5-5.1)] were similar to the ones reported in ICU [2.2% (95% CI, 1.0-4.4), 2.9% (95% CI, 1.5-5.3), and 4.1% (95% CI, 2.2-6.8)], but at 30 and 60 days were higher in ICU [6.9% (95% CI, 4.2-10.5), and 12.8% (95% CI, 8.1-18.5)] than in wards. Eighty-eight VTE events (48%) were diagnosed early, within 48 h of admission. VTE was not associated with death (HR, 0.79; 95% CI, 0.55-1.12). CONCLUSIONS: Incidence of symptomatic VTE in our COVID-19 cohort is consistent with that of other real-life studies recently published. Early VTE events are, along with COVID-19, the reason for admission rather than an in-hospital complication.

Efeitos do Transtorno de Estresse Pós-Traumático na Memória / Effects of Post Traumatic Stress Disorder in Memory / Efectos del Trastorno de Estrés Postraumático en la Memoria

O Transtorno de Estresse Pós-Traumático (TEPT) é frequentemente associado a déficits cognitivos, porém ainda existem divergências com relação as funções cognitivas afetadas. O objetivo do presente estudo foi avaliar o impacto do TEPT na memória operacional, na memória visual de curto prazo, na memória episódica de longo prazo, na memória semântica de longo prazo e na memória prospectiva. A amostra foi composta por 20 mulheres com idades entre 20 e 60 anos, sendo 10 mulheres provenientes do Programa de Atendimento e Pesquisa em Violência da Universidade Federal de São Paulo (PROVE) com diagnóstico de TEPT (GTEPT) e 10 mulheres controle com a mesma idade e escolaridade (GC). O instrumento utilizado foi o Instrumento de Avaliação Neuropsicológica Breve (NEUPSILIN). Os dados foram analisados por teste t de Student para amostras dependentes e o nível de significância adotado foi de 5%. Os resultados obtidos a partir da análise do NEUPSILIN apontam para prejuízos na memória operacional (p = 0,04) e na memória prospectiva (p = 0,02) associados ao TEPT. Porém não foram observadas diferenças entre os grupos no que diz respeito aos outros tipos de memória investigados (p > 0,05). Os achados deste estudo, com relação aos prejuízos na memória operacional e na memória prospectiva associados ao TEPT estão de acordo com a literatura. Ambas funções são de extrema importância para o desempenho de atividades cotidianas, portanto, a intervenção e reabilitação destas funções no sujeito com TEPT podem auxiliar significativamente na melhora da qualidade de vida....(AU)

Posttraumatic Stress Disorder (PTSD) is often associated with cognitive deficits, but there are still some differences regarding cognitive functions affected. Therefore, the aim of this study was to evaluate the impact of PTSD on working memory, visual shortterm memory, long-term episodic memory, long-term semantic memory and prospective memory. The sample consisted of 20 women aged between 20 and 60 years, ten women from the Program of Assistance and Research on Violence of the Federal University of São Paulo (PROVE) diagnosed with PTSD and overlapping violence (GTEPT) and ten women control of the same age and educational level (GC). The instrument used was the Brief Neuropsychological Assessment Instrument (NEUPSILIN). Data were analyzed by Student's t-test for dependent samples, and the significance level was 5%. The results obtained from the analysis NEUPSILIN point to the losses in working memory (p = 0.04) and prospective memory (p = 0.02) associated with PTSD. Differences between groups were not observed on other types of memory investigated (p > 0.05). The findings of this study on losses in working memory and prospective memory associated with PTSD are in agreement with the literature. Both functions are critical to the performance of daily activities. Therefore, intervention and rehabilitation of these functions in the subject with PTSD can help significantly in improving the quality of life....(AU)

El trastorno de estrés postraumático (TEPT) suele asociarse a déficits cognitivos, pero todavía existen divergencias con las funciones cognitivas afectadas. El objetivo del presente estudio fue evaluar el impacto del TEPT en la memoria operativa, en la memoria visual de corto plazo, en la memoria episódica de largo plazo, en la memoria semántica de largo plazo y en la memoria prospectiva. La muestra fue compuesta por 20 mujeres conedades entre 20 y 60 años, siendo 10 mujeres provenientes del Programa de Atención e Investigación en Violencia de la Universidad Federal de São Paulo (PROVE) con diagnóstico de TEPT (GTEPT) y 10 mujeres control con la misma edad y escolaridad (GC). El instrumento utilizado fue el Instrumento de Evaluación Neuropsicológica Breve (NEUPSILIN). Los datos fueron analizados por test t de Student para muestras dependientes y el nivel de significancia adoptado fue del 5%. Los resultados obtenidos a partir del análisis del NEUPSILIN apuntan a pérdidas en la memoria operativa (p = 0,04) y en la memoria prospectiva (p = 0,02) asociados al TEPT. Sin embargo, no se observaron diferencias entre los grupos en lo que se refiere a los otros tipos de memoria investigados (p > 0,05). Los hallazgos de este estudio, con relación a los perjuicios en la memoria operativa y en la memoria prospectiva asociados al TEPT están de acuerdo con la literatura. Ambas funciones son de extrema importancia para el desempeño de actividades cotidianas, por lo tanto, la intervención y rehabilitación de estas funciones en el sujeto con TEPT pueden auxiliar significativamente en la mejora de la calidad de vida....(AU)

δß-Thalassemia trait: how can we discriminate it from ß-thalassemia trait and iron deficiency anemia?

OBJECTIVES: To analyze the differences not only in classic hematologic parameters but also in RBC subpopulations among δß-thalassemia trait (δß-TT), ß-thalassemia trait (ß-TT), and iron deficiency anemia (IDA) and to evaluate the role of fetal hemoglobin (HbF) in elevated RBC distribution width (RDW). METHODS: Samples from 553 patients with microcytosis (74 δß-TT, 272 ß-TT, and 207 IDA) were run on an Advia 2120i analyzer (Siemens Medical Solutions Diagnostics, Tarrytown, NY). Classic hematologic parameters and RBC subpopulations were assessed. The correlation between HbF and RDW in patients with thalassemia (both ß and δß) was evaluated. An independent sample t test was used to compare classic hematologic parameters and RBC subpopulations among ß-TT, IDA, and δß-TT and receiver operating characteristic curves performed in the significant comparisons. RESULTS: RDW was significantly higher in δß-TT compared with ß-TT (18.79% vs 16.04%, P < .001), as was mean corpuscular volume (66.39 vs 64.82 fL, P < .001), mean corpuscular hemoglobin (20.73 vs 20.04 pg, P < .001), and mean corpuscular hemoglobin concentration (31.16 vs 30.66 g/dL, P = .03). Pearson coefficient showed a good correlation between HbF and RDW. The values obtained for all the parameters were significantly different (P < .001) between patients with thalassemia (ß and δß) and IDA. CONCLUSIONS: RDW is the best parameter to discriminate δß-TT from ß-TT. The degree of anisocytosis in patients with ß-TT and δß-TT is strongly correlated with HbF.

Linfocitosis B policlonal persistente / Persistent polyclonal B lymphocytosis

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