Prevalence of Intestinal Parasitic Infections Among Pregnant Women: A Multi-Centre Survey.

BACKGROUND: Intestinal parasitic infection (IPI) is a serious public health challenge often neglected in most developing countries. Pregnant women are a high-risk population for these infections which can result in adverse pregnancy outcomes such as maternal anaemia, preterm delivery and low birth weight. OBJECTIVE OF THE STUDY: To assess the prevalence and factors associated with the risk of acquisition of intestinal parasitic infections among pregnant women attending antenatal clinics in selected public hospitals in Ibadan, South Western Nigeria. METHODS: A hospital-based cross-sectional study was carried out among 598 pregnant women attending antenatal clinics in selected public hospitals in Ibadan, South Western Nigeria. Five public hospitals were purposively selected based on their antenatal clinic client attendance before this study. Data was collected to assess sociodemographic characteristics, health-seeking behaviours, water sanitation and hygiene practices (WASH). Stool samples from each pregnant woman were examined for the presence of intestinal parasites by microscopy using the direct wet mount and Ziehl Neelsen staining technique. RESULTS: The overall prevalence of intestinal parasites was (96, 16.1%). Ascaris lumbricoides were the most prevalent parasites (68, 71.0%) followed by Enterobius vermicularis (16, 17.0%), Entamoeba histolytica (8,8.0%) and the least identified parasite was hookworm (4, 4.0%). At bivariate analysis level, level of education, maternal income and type of waste disposal system in use were significantly associated with IPI infection. Using multivariate logistic regression, the age range of 30-34 years (AOR= 0.24, CI 0.08, 0.70) and having a degree (AOR=0.21 CI 0.05-0.85) were independent predictors of IPIs. CONCLUSION: This study highlights a high prevalence of intestinal parasitic infection among pregnant women in our setting. The main predictive factors were the educational status and age of the pregnant women. There is therefore need for continuous health education to prevent intestinal parasitic infections in the at-risk population.

CONTEXTE: Les infections parasitaires intestinales (IPI) représentent un grave problème de santé publique souvent négligé dans la plupart des pays en développement. Les femmes enceintes constituent une population à haut risque pour ces infections, qui peuvent entraîner des conséquences néfastes sur la grossesse, telles que l'anémie maternelle, l'accouchement prématuré et le faible poids à la naissance. OBJECTIF DE L'ÉTUDE: Évaluer la prévalence et les facteurs associés au risque d'acquisition d'infections parasitaires intestinales chez les femmes enceintes fréquentant les cliniques prénatales dans certains hôpitaux publics d'Ibadan, dans le sud-ouest du Nigéria. MÉTHODES: Une étude transversale hospitalière a été menée auprès de 598 femmes enceintes fréquentant les cliniques prénatales dans certains hôpitaux publics d'Ibadan, dans le sud-ouest du Nigéria. Cinq hôpitaux publics ont été sélectionnés de manière ciblée en fonction de la fréquentation de leur clinique prénatale avant cette étude. Des données ont été recueillies pour évaluer les caractéristiques sociodémographiques, les comportements de recherche de soins, l'assainissement de l'eau et les pratiques d'hygiène (WASH). Les échantillons de selles de chaque femme enceinte ont été examinés à la recherche de parasites intestinaux par microscopie, en utilisant la méthode du montage humide direct et la technique de coloration de Ziehl-Neelsen. RÉSULTATS: La prévalence globale des parasites intestinaux était de 96 (16,1 %). Les Ascaris lumbricoides étaient les parasites les plus prévalents (68, 71,0 %), suivis par les Enterobius vermicularis (16, 17,0 %), les Entamoeba histolytica (8, 8,0 %) et les Ankylostomes (4, 4,0 %). Au niveau de l'analyse bivariée, le niveau d'éducation, le revenu maternel et le type de système d'élimination des déchets utilisé étaient significativement associés aux infections parasitaires intestinales. Selon la régression logistique multivariée, la tranche d'âge de 30 à 34 ans (AOR = 0,24, CI 0,08, 0,70) et le fait d'avoir un diplôme (AOR = 0,21, CI 0,05-0,85) étaient des prédicteurs indépendants des IPI. CONCLUSION: Cette étude met en évidence une prévalence élevée d'infections parasitaires intestinales chez les femmes enceintes dans notre contexte. Les principaux facteurs prédictifs étaient le statut éducatif et l'âge des femmes enceintes. Il est donc nécessaire de poursuivre l'éducation sanitaire pour prévenir les infections parasitaires intestinales dans la population à risque. MOTS CLÉS: Femmes enceintes, infections parasitaires intestinales, hôpital public, Ibadan.

Rh Blood Group Antigens and Alloimmunization Risk of Pregnant Women in South Western, Nigeria.

BACKGROUND: Rh blood group antigens are the second most important blood group antigens in clinical transfusion due to their immunogenicity and prevalence. Childbirth, miscarriage, and other obstetrics events are risk factors for alloimmunization in women which increases the likelihood of haemolytic blood transfusion reaction and hemolytic disease of the fetal/newborn (HDNF/B). Even though there are several data on the RhD status of our populations. However, there is a dearth of data on pregnant women's C, E, c, and e status, their alloimmunization risk, and rates in Nigeria. OBJECTIVES: This study aims to provide information on the distribution of the Rh major antigens and risk factors for alloimmunization in pregnant women in southwestern Nigeria. MATERIALS AND METHODS: This was a descriptive cross-sectional study of 133 pregnant women attending routine ante-natal clinics. Questionnaires were administered to collect biodata and obstetrics history. ABO blood grouping and Rh phenotyping were carried out on their blood samples using RAPID LABS Monoclonal Rhesus Typing Reagent. RESULTS AND DISCUSSION: Rh blood group antigen c was present in 100% of the women, followed by e (98.5%) and D (95.5%). C and E are the least prevalent antigens and probably the ones to which antibodies may be formed. The commonest Rh phenotype was Dce. Of all the pregnant women, alloimmunization was present in 0.8%. Of those who were RhD negative, alloimmunization was present in 16.7%. Pregnant women are more likely to be alloimmunized against C and E antigens than c and e antigens due to their low and high frequencies respectively.

CONTEXTE: Les antigènes du groupe sanguin Rh sont les seconds plus importants en transfusion clinique en raison de leur immunogénicité et de leur prévalence. L'accouchement, la fausse couche et d'autres événements obstétriques sont des facteurs de risque d'alloimmunisation chez les femmes, augmentant ainsi la probabilité de réactions hémolytiques lors de transfusions sanguines et de maladies hémolytiques du fœtus/nouveau-né (HDNF/B). Bien qu'il existe plusieurs données sur le statut RhD de nos populations, il y a un manque de données sur le statut des antigènes C, E, c et e chez les femmes enceintes, leur risque d'alloimmunisation et les taux associés au Nigéria. OBJECTIFS: Cette étude vise à fournir des informations sur la distribution des principaux antigènes Rh et les facteurs de risque d'alloimmunisation chez les femmes enceintes dans le sud-ouest du Nigéria. MÉTHODOLOGIE: Il s'agit d'une étude descriptive transversale de 133 femmes enceintes fréquentant les cliniques prénatales de routine. Des questionnaires ont été administrés pour collecter des données biodémographiques et des antécédents obstétriques. La détermination des groupes sanguins ABO et le phénotypage Rh ont été réalisés sur leurs échantillons de sang à l'aide du réactif de typage Rh monoclonal RAPID LABS. RÉSULTATS ET DISCUSSION: L'antigène c du groupe sanguin Rh était présent chez 100 % des femmes, suivi de e (98,5 %) et D (95,5 %). Les antigènes C et E sont les moins prévalents et probablement ceux contre lesquels des anticorps peuvent être formés. Le phénotype Rh le plus courant était Dce. Parmi toutes les femmes enceintes, l'alloimmunisation était présente chez 0,8 %. Parmi celles qui étaient RhD négatives, 'alloimmunisation était présente chez 16,7 %. Les femmes enceintes sont plus susceptibles de développer une alloimmunisation contre les antigènes C et E que contre les antigènes c et e en raison de leurs fréquences respectives faibles et élevées. MOTS-CLÉS: Antigènes du groupe sanguin Rh, Phénotype, Alloanticorps érythrocytaires, Femmes enceintes.

Levels of Clara cell secretory protein and surfactant protein A in municipal solid waste management workers in Ibadan, Southwest Nigeria.

Toxic pneumonitis and related respiratory symptoms are common among waste management workers (WMWs). Products of different cellular responses following exposure to toxic components of wastes can lead to the production of a variety of biomolecules. There is a growing recognition of the importance of biomarkers in risk assessment and a strong advocacy for their determination and use as indicators of health and safety. This study assessed the prevalence of respiratory symptoms and the relevance of pulmonary surfactant protein A (SP-A) and Clara cell 16 protein (CC16) as indicators of occupational inhalation exposure to toxic substances and irritants in WMW. A total of 172 subjects consisting of 112 WMWs and 60 Non-WMWs were recruited by purposive sampling. Data on socio-economic and work-related symptoms were collected using structured questionnaire. CC16 and SP-A were determined by ELISA in serum samples. Clinical history reveals a slightly higher prevalence of respiratory symptoms in WMWs relative to control subjects. Increased permeability of the lung-blood barrier, characterized by significant elevation of serum SP-A and serum CC16, was associated with respiratory symptoms in WMWs. Steady increases in SP-A and CC16, respectively, in relation to occupational duration were observed in WMWs relative to control. Receiver operating characteristic curve and multivariate analyses revealed SP-A and CC16 as important lung biomarkers for assessing sub-clinical effects of occupational exposure. Our data suggest SP-A and CC16 may be relevant indicators for assessing occupational inhalation exposure to toxic substances and irritants among WMWs.

DEMOGRAPHICS OF COLLABORATORS INVESTIGATING THE NIGERIAN MEDICAL AND DENTAL INTERNS: A MEDICAL INTERNSHIP TRAINING IN NIGERIA (MINTING) STUDY COLLABORATION.

Introduction: The internship period is a peculiar time in a doctor's career, and some have described it as a "nuisance year" during which the junior doctor assumes many roles at the same time. Junior doctors especially house officers are faced with many unique challenges; this is even more pronounced in poor resource settings like Nigeria. This study aimed to unravel and improve understanding of the challenges faced by medical and dental interns in Nigeria. Methodology: A nine-member House officers Research and Statistics Committee (HRSC) was immediately set up to include three senior colleagues - Senior Registrars and Registrar. To carry out her responsibility efficiently the committee created the House Officers Research Collaboration Network (HRCN), a 103- member team comprising medical and dental interns from across Nigeria under a collaborative - Medical INternship Training in Nigeria (MINTING) study. Results: Out of a total of the 103 House Officers Research Collaboration Network, 80 of them participated in this survey giving a 78% response rate. Ten of the intern Collaborators had additional qualification and seven of them had BSc as an initial degree. About 66 % of the Collaborators have never authored any publication. Of the 27 that have published an article; three collaborators are said to have published 15, 13, 16 articles respectively. Male collaborators where more likely to have published at least one article in the past. Thirty one of the 80 Collaborators have never been in a research collaborative group prior to this MINTING collaborative. Conclusion: This commentary is set out to describe in detail Nigerian House Officers initiative in terms of the structure, functions, operational modalities, and to investigate the demographics of the HRCN collaborators which showed that over two third of collaborators have never authored any publication and about a third of them have never been involved in collaborative research. We also believe the findings will serve as policy guide and benchmark in training the critical medical health force.

Comparative Immunohistochemical Analysis of p53 and Alpha-SMA in Ameloblastoma, AOT and OKC.

OBJECTIVES: Ameloblastoma is a benign but highly infiltrative tumour, a behaviour that is lacking in adenomatoid odontogenic tumour but partly shared by the odontogenic keratocyst which possesses a unique intrinsic growth potential with marked ability for destroying bone and a high tendency recurrence. High frequency of stromal myofibroblasts (assessed with alpha smooth muscle actin (α-SMA) correlates with aggressive behaviour while p53-cell cycle regulation system is critical in odontogenic tumours with immunoreactivity signifying prognostic status. This study aims to determine and compare the immunoreactivity of these selected tumours to p53 and α-SMA in order to establish if a relationship exists between the frequency and pattern of distribution of myofibroblasts and the behaviour of these lesions. MATERIALS AND METHODS: 69 blocks of ameloblastoma, and 23 each of adenomatoid odontogenic tumor (AOT), and odontogenic keratocyst (OKC/KCOT) were retrieved. Immunohistochemistry technique was applied for evaluation of these two markers staining with primary antibodies to p53 and -SMA and the frequency and pattern of distribution of myofibroblasts and immunoreactivity to p53 analysed and compared using ANOVA. p was set at <0.05. RESULTS AND CONCLUSION: Immunoreactivity to p53 and α-SMA was highest in ameloblastoma (solid compared to unicystic) with highest mean positive cells to α-SMA (29.7±20.1) and p53 (28.3±24.5) in plexiform ameloblastoma. This suggests that ameloblastoma was the most aggressive of tumours studied. Different pharmacological agents that can regulate stromal MF are useful aids to decrease the need for radical surgery in extensive and aggressive odontogenic tumours.

ABSTRAIT OBJECTIFS: L'améloblastome est bénin mais untumeur mes infiltratif, un comportement qui fait défaut dans la tumeur odontogénique adénomatoïde mais en partie partagé par le kératocyste odontogène qui possède un potentiel de croissance intrinsèque unique avec une capacité marquée de destructionet une récidive à forte tendance. Haute fréquence de stromalmyofibroblastes (évalués avec de l'actine musculaire alpha lisse (α-SMA) est en corrélation avec un comportement agressif lors de la régulation du cycle des cellules p53 est essentiel dans les tumeurs odontogènes immunoréactives signifiant le statut pronostique. Cette étude vise à déterminer et comparer activité l'immunoré de ces tumeurs sélectionnées à p53 et α-SMA afin d'établir s'il existe une relation entre le fréquence et schéma de distribution des myofibroblastes et de la comportement de ces lésions. MATÉRIAUX ET MÉTHODES: 69 blocs d'améloblastome, et 23 chacun de tumeur odontogénique adénomatoïde (AOT) et odontogènedes kératocystes (OKC/KCOT) ont été récupérés. Immunohistochimiela technique a été appliquée pour l'évaluation de ces deux marqueurs de coloration avec des anticorps primaires dirigés contre p53 et α-SMA et la fréquence et schéma de distribution des myofibroblastes et de l'immunoréactivité àp53 analysé et comparé à l'aide de l'ANOVA. p a été fixé à <0,05. RÉSULTATS ET CONCLUSION: Immuno réactivité à p53 et α-SMA était la plus élevée dans l'améloblastome (solide par rapport α-SMA (29,7±20,1) et p53(28,3±24,5) dans l'améloblastome plexiforme. Cela suggère que L'améloblastome était la tumeur la plus agressive étudiée. Les agents pharmacologiques différentes peuvent réguler la MF stromale sont des aides utiles pour diminuer le besoin de chirurgie radicale en cas de chirurgie étendue et agressive tumeurs odontogènes. Mots-clés: Améloblastome, AOT, OKC/KCOT, p53, α-SMA, myofibroblastes, tumeurs odontogènes, immunoréactivité.

Influence of chemical treatment on the properties of cement-paper hybrid composites for ceiling board application.

This study evaluates the effect of treated and untreated jute fiber/eggshell particulate reinforced cement-paper matrix composites for ceiling board application. Treated jute fiber (TJF) was obtained by immersing untreated jute fiber (UJF) into 1.25 M sodium hydroxide (NaOH) solution in a shaker water bath maintained at 40 °C for 4 h. Eggshells (ESP) were pulverized and sieved to -75µm. Samples were prepared by varying the fiber volume fraction from 0.5 to 2.5 wt.% in the composites. While other constituents such as the binder (cement) and eggshell were kept constant. An hydraulic press cold compaction molder was utilized in the production of the hybrid composites in a predetermined mix ratio designed based on previous research. The samples produced were cured for 7 and 14 days, then sundried for 36 h. The physical, thermal, mechanical and wear behaviour of the produced composites were evaluated while the surface morphology of the fractured splitting tensile samples were analyzed. The result reveals that TJF/ESP hybrid composites had better performance than UJF/ESP hybrid composites in most of the tests carried out. Increase in the number of curing days was found to also enhance the properties of the composite produced in majority of the test evaluated. The 0.5 wt.% UJF/ESP gave the least performance of all the composites developed. While 2.5 wt. % TJF/ESP showed an optimum properties among the composites tested. When compared with standard, it is concluded that the hybrid composites developed can be suitable for ceiling boards and also find possible application in wall partitioning.

Optimization of heat treatment parameters of medium carbon steel quenched in different media using Taguchi method and grey relational analysis.

Quenching is one of the major processes of heat treatment of medium carbon steel that aims at improving its mechanical properties. However, the effectiveness of this process is dependent on several control factors that must be maximized to obtain optimum results in terms of hardness, yield strength, ultimate tensile strength among others. This study aims at optimizing the process of improving the mechanical properties of medium carbon steel by varying some key factors like the quenchant used (A), heat treatment temperature (B), and soaking time (C). The measured responses in this study were the hardness, yield strength (YS), and ultimate tensile strength (UTS). Optimization was conducted in two stages. The first stage dealt with the mono-optimization of process parameters using Taguchi's Signal-to-Noise (S/N) ratio. A total of nine (9) experiments were performed based on standard L9 orthogonal array because each of the three control factors has three (3) levels. The second stage was multi-objective optimization using Taguchi-based grey relational analysis (GRA). The optimal conditions for hardness, YS, and UTS were obtained at A2B3C3, A3B2C3, and A3B3C3, respectively. Using ANOVA as statistical analysis, it was observed that the soaking time was the main control factor for all three measured responses (31.95% contribution ratio for hardness, 62.46%, and 66.76% for YS and UTS, respectively), while the quenchant had the least contribution. Analysis of the Taguchi-based GRA revealed that the results obtained are in total conformance to that of the Taguchi method, with soaking time having the highest contribution ratio of 69.41%.

Giant Cell Lesions of the Jaws:A Review and Comparative Histopathological Study.

BACKGROUND AND OBJECTIVES: Giant cell lesions (GCLs) are rare lesions which prominently feature multinucleated giant cells in their histology. They include central giant cell granuloma (CGCG), giant cell tumour of bone (GCT), peripheral giant cell granuloma (PGCG), Cherubism (CHB), e.t.c. This study reviewed the clinico-demographic parameters of GCLs of the jaws and assessed the giant cells. METHODS: This was a retrospective study examining the histopathology records of which part of the body of two tertiary institutions. All entries of cases diagnosed as GCLs were retrieved and data were extracted. Also, the giant cells in tissue sections were assessed. Data were analysed using SPSS Inc. version 20 while Chi square test was used to test for association. This was considered significant quand p < 0.05. RESULTS: Over the study period, 2,862 biopsy reports were reviewed. GCLs constituted 48(1.7%) and M: F ratio was 1:1.6 while majority occurred in the 2nd and 3rd decades. The mandible was the most common site recording 27(56.3%) cases and CGCG was the most frequently diagnosed GCL constituting 22(45.8%). Assessment of the giant cells revealed CGCG had predominantly large giant cells, a dense dispersal of giant cells and irregularly shaped giant cells, while CHB mainly had large giant cells with dense dispersal, but round shaped giant cells. CONCLUSION: GCLs are rare lesions commonly seen in females in the 2nd and 3rd decades of life with preference for the mandible. CGCG was the most commonly encountered lesion, while the giant cells in CGCG and CHB were similar in size as well as dispersal.

CONGENITAL GRANULAR CELL TUMOUR OF THE NEWBORN: A CASE REPORT OF THE RARE LESION.

Congenital granular cell tumour [CGCT], a benign soft tissue tumour was a surprise discovery to the parents as well as the obstretical staffs at birth. It developed in the maxillary left canine region causing oral disfigurement and feeding problems. Diagnosis was essentially clinical and confirmed by histology. Surgical excision was done. We describe a case of CGCT in a 3-week old female neonate in the paediatric dentistry unit of LASUTH.

SERUM TOTAL IgG AND TETANUS SPECIFIC IgG IN NIGERIAN HUMAN IMMUNODEFICIENCY VIRUS INFECTED PRIMIGRAVIDAE AND THE CORD BLOOD OF THEIR BABIES AT BIRTH.

BACKGROUND: HIV infection affects millions of women and children, particularly in sub-Saharan Africa. Tetanus also causes significant maternal and neonatal morbidity and mortality in developing countries. Since the main effect of HIV is immunosuppression, there is potential for a negative influence on the host immune response to tetanus in women with HIV. OBJECTIVE: This case-control study evaluated the effect of HIV infection on maternal tetanus antibody production and neonatal tetanus antibody levels. METHODS: Thirty registered primigravidae were recruited from the clinic;15 were HIV positive and 15 were HIV negative. Serum samples of maternal and cord blood were obtained from both groups at delivery. Maternal total IgG and cord blood tetanus-specific antibody were estimated by Enzyme Linked Immunosorbent Assay. RESULTS: There was no significant difference in the total IgG level of HIV positive mothers compared with HIV negative mothers. No significant difference in the tetanus-specific IgG level in the cord blood of babies of HIV positive mothers compared with cord blood of babies of the HIV negative mothers. CONCLUSION: HIV infection did not significantly reduce total IgG production in Nigerian primigravidae. Tetanus-specific IgG levels were above protective levels in neonates of HIV positive mothers suggesting adequate protection.

Viral gastroenteritis among children of 0-5 years in Nigeria: Characterization of the first Nigerian aichivirus, recombinant noroviruses and detection of a zoonotic astrovirus.

BACKGROUND: Viruses are the leading cause of acute gastroenteritis in children worldwide. Understanding of the occurrence and genetic diversity of these viruses can help to prevent infections. OBJECTIVES: The present study describes the presence, genetic diversity and possible recombination of five enteric viruses in children with gastroenteritis in Southwestern Nigeria. STUDY DESIGN: From August 2012 to December 2013, stool samples and sociodemographic data of 103 diarrheic children <5 years were collected to detect and characterize rotavirus A, norovirus, human astrovirus, aichivirus and sapovirus using PCR techniques followed by sequencing and phylogenetic analyses. RESULTS: At least one virus was identified in 58.3% (60/103) of the stool samples. Rotavirus, norovirus and astrovirus were detected in 39.8% (41/103), 10.7% (11/103), and 6.8% (7/103) respectively. Notably, aichivirus was detected for the first time in Nigeria (1/103; 0.97%). Sapovirus was not detected in the study. Co-infections with rotavirus were observed in eight samples either with norovirus or astrovirus or aichivirus. Phylogenetic analyses of different genome regions of norovirus positive samples provided indication for recombinant norovirus strains. A novel astrovirus strain closely related to canine astrovirus was identified and further characterized for the first time. CONCLUSIONS: Viruses are the common cause of acute gastroenteritis in Nigerian infants with rotavirus as most frequently detected pathogen. New norovirus recombinants and a not yet detected zoonotic astrovirus were circulating in Southwestern Nigeria, providing new information about emerging and unusual strains of viruses causing diarrhea.

BURDEN OF CYTOPAENIAS AMONG HIV POSITIVE PREGNANT WOMEN AT THE UNIVERSITY COLLEGE HOSPITAL, IBADAN.

INTRODUCTION: Few studies have examined cytopaenia among HIV positive pregnant women. OBJECTIVES: To assess burden of cytopaenia among HIV positive pregnant women. METHODOLOGY: This cross-sectional study of women on HAART ≤6months, defined anemia as hematocrit <33%, leucopenia as total white blood cell count <3,000 cells/mm3 and thrombocytopenia as absolute platelet count <100,000 cells/mm3. Univariate and bivariate analyses were performed. RESULTS: Over 8 years, of 1,197 women, the mean age was 29.02(±5.4) years and mean gestational age 25.9(±8.1) weeks. Prevalence of anaemia was 76.8%, leucopaenia 6.9% and thrombocytopenia 4.7%. The mean haematocrit was 28.5%(±4.5); median white blood count 5,500/mm3 ; median platelet count 200,000/mm3 and median CD4 323 cells/mm3. Mean haematocrit was highest (29.7%±5.3) in women in the first trimester but lowest (28.4% ±4.6) in women in second trimester (p=0.04). Compared with earlier trimesters, women in the third trimester had higher median white blood count (5,600 cells/mm3), higher neutrophil (61.0% ±11.2) but lower lymphocytes (28.3%± 9.2) (p=0.18; 0.00, 0.00). Median absolute platelet count was highest (206,000 cells/mm3) in the first trimester but lowest (195,000 cells/mm3) in third trimester (0.04). Women with lower CD4 had higher prevalence of cytopaenias. CONCLUSION: Cytopaenias are not uncommon in this population especially with lower CD4.

Two case reports on Mandibular metastases.

Metastatic tumours of the oral cavity are not common. The most common site for bone metastases in the head and neck region is the mandible. Metastatic lesion of the mandible most commonly originate from the lungs in men and breast in women, and these lesions (or tumours) usually are carcinomas rather than sarcomas. We report two cases of metastatic lesions in the mandible: (1) A 19year old male with right mandibular swelling and a nodular swelling in the distal two-third of the right tibia. Radiograghs revealed sclerotic lesion with a sunburst appearance in both the jaw and tibia. Histology of the jaw lesion confirmed a metastatic osteosarcoma of the mandible. (2) A 51year old female with a right mandibular swelling with associated swelling in the anterior neck, right shoulder and right parietal region of the skull. Computerised tomography scan (CT) of the jaws showed an osteolytic lesion of the right mandible. CT scan of the brain also showed a large lytic lesion seen in the posterior aspect of the right parietal bone. Histology of the jaw mass confirmed a metastatic follicular carcinoma from the thyroid. Mandibular metastasis may be the first presenting feature of underlying occult malignancy of another primary site. Therefore, clinicians should maintain a high level of suspicion while evaluating patients with a history of cancer presenting with oral lesions.

HCV co-infection is associated with metabolic abnormalities among HAART naive HIV-infected persons.

OBJECTIVES: To determine the metabolic abnormalities among Hepatitis C Virus (HCV) co infected HAART naïve HIV infected persons within the adult ARV clinic of the University College Hospital/University of Ibadan, Ibadan, Nigeria Methods: This was a retrospective study involving the review of clinical records of newly recruited HIV-infected persons in the adult antiretroviral (ARV) clinic over a 12 month period (January - December 2006). Baseline results for fasting plasma glucose (FPG) and fasting lipid profile were retrieved. RESULTS: Out of the 1,260 HIV infected persons seen during the study period, HCV co-infection was found in 75 (6%) persons. The median values for total cholesterol, LDL-cholesterol and HDL-cholesterol were lower in the HCV co-infected persons. HIV-HCV co-infection was associated with a 0.31 mmol/L depression in Total Cholesterol (TC). The median FPG concentration was significantly higher in HIV-HCV co-infected than HIV only infected persons (5.33mmol/L vs. 5.00mmol/L, p = 0.047). However, regression analysis showed there was no relationship between the HIV-HCV co infected state and fasting glucose levels. CONCLUSION: HIV-HCV co-infection may be associated with a predictable decline in plasma cholesterol, but FPG may not be sufficient to demonstrate insulin resistance in these persons.

Patterns and Correlates of Serum Magnesium Levels in Subsets of Type 2 Diabetes Mellitus Patients in Nigeria.

BACKGROUND: Magnesium (Mg) is the 4th most common mineral and the 2nd most abundant intracellular cation in the body. It plays major roles in various physiological activities and has been implicated in many disease states. AIM: The aim of this study was to study the patterns and correlates of serum Mg in cohorts of type 2 diabetic patients in Nigeria. SUBJECTS AND METHODS: One hundred and twenty-five patients comprising 63 with type 2 diabetes mellitus (T2DM) alone and 62 with diabetes and hypertension (HT) were compared with fifty controls matched for sex and age. Basic data, HbA1c, and fasting blood glucose (FBG) were obtained while serum Mg was measured by colorimeter. Relationship between serum Mg and glucose control was considered while serum Mg < 1.6 mg/dl was considered as hypomagnesemia. RESULTS: The mean serum Mg of all patients was 2.06 ± 0.49 mg/dl, not statistically different from controls at 2.22 ± 0.48 mg/dl. About » (23.2%) of the patients had hypomagnesemia which was significantly more than 12% of controls. Although the patients with diabetes and HT were older and more of females than those with DM alone, the mean serum Mg was comparable (2.03 ± 0.49 vs. 2.09 + 0.50 mg/dl). Twenty-seven percent (27%) of patients who had DM alone was more than 19.3% with HT and diabetes combined. Whereas the FBG was comparable in patients with hypomagnesemia and normal serum Mg, HbA1c was significantly higher in the hypomagnesemia group (8.39 ± 0.98 vs. 6.75 ± 1.22%, P = 0.021). CONCLUSION: Hypomagnesemia is common in T2DM outpatients occurring approximately one in four patients. It is associated with poor long-term control.

Levels of heavy and essential trace metals and their correlation with antioxidant and health status in individuals occupationally exposed to municipal solid wastes.

Recent studies have indicated an increased incidence of toxic neuropathies among waste management workers (WMW) possibly linked to increased detection of heavy metals in municipal solid wastes. The present study evaluated serum levels of some heavy and essential trace metals in relation to oxidant/antioxidant status of WMW. One hundred and twenty-six WMW and 84 non-WMW (control) were recruited. Metal/element concentration was measured by atomic absorption spectrophotometry and oxidant/antioxidant markers were determined using standard procedures. The WMW exhibited significantly ( p < 0.001) decreased ferric reducing ability of plasma (FRAP) and higher levels of ceruloplasmin (Cp) and malondialdehyde. Iron (Fe) and copper (Cu) levels were significantly lower ( p < 0.05) and higher ( p < 0.001), respectively in WMW when compared with control while levels of other trace elements were not significantly different between these groups. Lead (Pb) and chromium levels were significantly higher ( p < 0.001 and p < 0.05, respectively) in WMW while mercury levels were comparable with those of control subjects. In WMW, Cp ( r = -0.182; p > 0.05) and FRAP ( r = 0.277; p < 0.05) negatively and positively correlated with Pb, respectively, while a positive correlation was observed between zinc ( r = 0.230; p < 0.05) and Pb and between Cu ( r = 0.541; p > 0.001) and Fe. Overall, the decreased antioxidant capacity and increased oxidative stress observed in WMW in this study may be related to their blood levels of heavy and essential trace metals. Conscious efforts are required, therefore, to reduce risk and protect WMW from toxic neuropathies and other adverse health consequences of occupational exposure.

Associated anomalies in cleft lip and palate: Analysis of 811 consecutive patients

Introduction: Clefts are common birth defects and may be associated with oro-facial congenital anomalies. It has not been established if specific types of anomalies are frequently related with clefts, or which organ is most commonly affected. This study aimed to assess the prevalence of associated anomalies in consecutive cleft lip and palate patients treated at two referral centres in Northern Nigeria.Methods: Cleft lip and palate at two referral hospitals in Northern Nigeria from January 2012 to December 2015 were studied. Data were analysed using Statistical Package for Social Sciences (SPSS) version 16.Results: A total of 811 cleft lip and palate patients were managed. Fifty-five percent (447) were male and 45% (364) were female while 71% (578) were children and 29% (233) were adults. The prevalence of associated anomalies was 11.5%. The most common associated anomaly among cleft patients was facial anomaly (64% of cleft patients). Associated anomalies were most prevalent in patients with isolated cleft palate. Hypertelorism was the commonest type of facial anomaly recorded.Conclusion: Our study showed a low incidence of associated anomalies with a higher incidence in isolated cleft palate cases

Evaluation of correct knowledge of key danger signs in pregnancy among antenatal clinic attendees at a tertiary health facility in Nigeria.

CONTEXT: Test of knowledge of pregnant women on key danger signs as a marker to assess the quality of information shared during health education at the antenatal clinic (ANC) is desirable. AIM: The aim was to assess correct knowledge of danger signs among pregnant women who attend ANC. SETTINGS AND DESIGN: A cross-sectional design conducted among pregnant women at the ANC of the University College Hospital, Ibadan, Nigeria. MATERIALS AND METHODS: A pretested structured questionnaire that contains sociodemographics, past obstetrics history, and a list of test questions to assess correct knowledge of danger signs was administered to each consenting participant. STATISTICAL ANALYSIS USED: Descriptive and bivariate analyses were performed. The knowledge score of key danger signs in pregnancy (KDSP) was measured on a scale of 0-7 and participants were scored as having poor (0-2), fair (3-4), or good (5-7) knowledge. The reliability of the questionnaire to assess knowledge score was determined with Cronbach's alpha. Statistical significance was set 5%. STATA 12.0 Software was used. RESULTS: The mean age of respondents was 30.28 ± 4.56 with the majority (75.1%) of respondents aged 26-35 years. The Cronbach's alpha was 0.871. In general, the knowledge score was good and the associated factors on bivariate analysis were younger age (P = 0.028), Islamic religion (P = 0.048), ethnicity (P = 0.03), professional occupation (P = 0.01), and previous attendance of health talk on KDSP (P < 0.0001). CONCLUSION: There was a high knowledge score of KDSP, but some still have some misconceptions that need to be addressed.

A prospective epidemiological study on odontogenic tumours in a black African population, with emphasis on the relative frequency of ameloblastoma.

The persistent view in the literature is that the relative frequency of ameloblastomas is higher in the black population than in Caucasians. The aim of this study was to determine the relative frequency of all odontogenic tumours (OT) in a 100% black population and to compare our findings with those of previous studies. A prospective study was undertaken of all patients presenting with OT to all 16 Nigerian departments of oral and maxillofacial surgery over a 4-year period. The following data were obtained: patient demographics, delay to presentation, extent of the lesion, and histological diagnosis. Six hundred and twenty-two cases were studied. A slight male preponderance was observed (male to female ratio 1.17:1). Patients ranged in age from 5 to 89 years, with a peak incidence in the third decade. The relative frequency of OT was 0.99 per million and that of ameloblastoma was 0.76 per million. Ameloblastoma was the most prevalent OT (76.5%), followed by adenomatoid odontogenic tumours (5.6%), odontogenic myxoma (4.5%), and keratocystic odontogenic tumours (KCOT) (3.1%). The relative frequency of ameloblastoma among Nigerians was not different from frequencies reported previously among Caucasian and Tanzanian black populations. KCOTs were, however, rarely diagnosed in Nigerians as compared to the white population in the Western world.