1.
Bioorg Med Chem Lett
; 19(6): 1694-7, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19237286
RESUMO
A series of thiophene PLK1 inhibitors was optimized for increased solubility and reduced protein binding through the appendage of basic amine functionality. Interesting selectivity between PLK1 and PLK3 was also obtained through these modifications.