RESUMO
We have tested the action of cloprostenol a relatively stable analogue of PGF2 alpha in experimentally induced gastric ulcer in rats by contention stress or indomethacin. Our results show that CIPG, administered at higher doses than those inducing an luteolytic effect, has a gastroprotective effect both in the contention stress-induced ulcer (2.30 + 0.26 in series III as compared to 3.80 +/- 0.73 in series III, p < 0.01) and in indomethacin-induced ulcer (2.69 +/- 0.38 in series V as compared to 3.61 +/- 0.34 in series IV, p < 0.01).
Assuntos
Cloprostenol/uso terapêutico , Úlcera Gástrica/tratamento farmacológico , Animais , Modelos Animais de Doenças , Avaliação Pré-Clínica de Medicamentos , Indometacina , Masculino , Ratos , Ratos Wistar , Úlcera Gástrica/etiologia , Estresse Psicológico/complicaçõesRESUMO
The effect of Boicil tablets on early embryogenesis (the first 3 gestational days), organogenesis (the 10th, 11th and 12th gestational days) and fetus (the 18th and 19th gestational days) by its intraamniotic administration was followed up in three successive generations of mice and rats. Two doses were used (2 mg/kg body weight and 20 mg/kg body weight), estimated in relation with the maximum therapeutic daily dose in man, being administered in a single dose, per os. No inborn malformations or somatic abnormalities were recorded both in mothers and in their descendents for three successive generations. It is concluded that Boicil tablets is not teratogenic.
Assuntos
Anti-Inflamatórios/toxicidade , Embrião de Mamíferos/efeitos dos fármacos , Desenvolvimento Embrionário e Fetal/efeitos dos fármacos , Feto/efeitos dos fármacos , Glicosídeos/toxicidade , Extratos Vegetais , Efeitos Tardios da Exposição Pré-Natal , Saponinas/toxicidade , Anormalidades Induzidas por Medicamentos/epidemiologia , Anormalidades Induzidas por Medicamentos/etiologia , Animais , Relação Dose-Resposta a Droga , Feminino , Camundongos , Gravidez , Ratos , Esteroides , Comprimidos , Fatores de TempoRESUMO
The teratogen action of Boicil tablets was studied in two animal species, rats and mice, the prefertilization and implantation stages being the main interest. Three generations of animals were followed up. The active powder suspended in distilled water (0.1 ml/10 g for mice and 1 ml/100 g for rats) was administered per os in a single dose, prepared on spot and in two doses, 2 mg/kg body weight and 20 mg kg body weight, respectively. The administered doses were equivalent to the daily maximum therapeutic dose prescribed in humans (110 mg active principle). The first gestational day was determined differently in the two species. For estimating the effect on prefertilization, Boicil tablets was administered for 5 days before making and for its effects on the number of implantations during the first 3 gestational days. The two parameters under investigation were within normal limits and all newborn animals followed up for three generations did not present pathological microscopic and gross alterations or somatic malformations. It was concluded that Boicil tablets is not teratogenic.
Assuntos
Anormalidades Induzidas por Medicamentos/etiologia , Anti-Inflamatórios/toxicidade , Implantação do Embrião/efeitos dos fármacos , Embrião de Mamíferos/efeitos dos fármacos , Fertilização/efeitos dos fármacos , Glicosídeos/toxicidade , Plantas Medicinais , Plantas Tóxicas , Saponinas/toxicidade , Veratrum , Animais , Relação Dose-Resposta a Droga , Feminino , Camundongos , Extratos Vegetais/toxicidade , Ratos , Ratos Endogâmicos , Esteroides , Comprimidos , Fatores de TempoAssuntos
Congêneres do Estradiol/uso terapêutico , Neoplasias da Próstata/patologia , Testículo/efeitos dos fármacos , Idoso , Idoso de 80 Anos ou mais , Histocitoquímica , Humanos , Masculino , Pessoa de Meia-Idade , Orquiectomia , Neoplasias da Próstata/tratamento farmacológico , Neoplasias da Próstata/metabolismo , Testículo/metabolismo , Testículo/patologia , Fatores de TempoRESUMO
Electron microscopic researches pointed out the existence of amphicrine cells in the peritumoral mucosa on specimens of surgically resected gastric cancer. According to the ultrastructural features two cell subtypes were distinguished: mucoenterochromaffine (EC1, EC2) and empty clear mucoforming cells, corresponding to the mucoargentaffine and mucoargyrophobic types, respectively as the literature showed. Our results showed the amphicrine cells may be interpreted as transformed pathological endocrine cells under gastric cancer conditions.
Assuntos
Adenocarcinoma Mucinoso/ultraestrutura , Adenocarcinoma Papilar/ultraestrutura , Adenocarcinoma/ultraestrutura , Mucosa Gástrica/ultraestrutura , Neoplasias Gástricas/ultraestrutura , Adenocarcinoma/metabolismo , Adenocarcinoma Mucinoso/metabolismo , Adenocarcinoma Papilar/metabolismo , Mucosa Gástrica/metabolismo , Humanos , Microscopia Eletrônica , Neoplasias Gástricas/metabolismoRESUMO
In the human embryo, the basement glomerular membrane appears early, at about ten weeks of age. The study of 36 human embryos aged 8-20 weeks revealed many arguments suggesting the epithelial origin of the basement membrane of the visceral capsula.
Assuntos
Glomérulos Renais/embriologia , Membrana Basal/ultraestrutura , Diferenciação Celular , Células Epiteliais , Mesângio Glomerular/ultraestrutura , Humanos , Microscopia EletrônicaRESUMO
The behaviour of gastrin cells in the antral mucosa in gastric carcinoma was electron microscopically investigated using specimens of surgically resected stomachs. The results pointed out that in gastric carcinoma there takes place a change of the types of G cell population in the antral mucosa. In this condition, a significant fact was the predominance of intestinal G cells, known to store mainly G 34.
