[The cytological characteristics of the squamous epithelium of the cervix uteri in women living under the conditions of an elevated radiation background]. / Tsitologicheskie kharakteristiki ploskogo épiteliia sheiki matki u zhenshchin, prozhivaiushchikh v uslioviiakh povyshennogo radiatsionnogo fonda.

Cytomorphological signs of epithelial cells were analyzed in scraping off the cervix uteri of 607 women living in the zone of increased radiation background. The examined group consisted mainly of women aged 30 to 50. In 9.3% (57 cases) dysplastic changes in the squamous epithelium were revealed, among which slight dysplasia predominated -- basal-cell hyperactivity (40 cases). No cases of malignant transformation were detected. The authors noted some signs which commonly do not occur in the absence of an increased radiation background and may be conditionally regarded as a result of indirect effect of radiation on female cells.

[The basic causes of errors in the cytological diagnosis of lung and esophageal cancers]. / Osnovnye prichiny oshibok tsitologicheskoi diagnostiki raka legkikh i pishchevoda.

The causes of errors in cytological diagnosis in 615 patients with carcinoma and benign lesions of the lung and in 847 patients with those of oesophagus are studied and systematized. Percentage of errors was 15.93 for the lung diseases and 4.48 for diseases of the oesophagus. The error causes are subdivided into objective and subjective ones.

[Cytomorphological criteria of atypical hyperplasia and cancer of the endometrium based on data from a multivariate statistical analysis]. / Tsitomorfologicheskie kriterii atipicheskoi giperplazii i raka éndometriia po dannym mnogomernogo statisticheskogo analiza.

Multifactorial statistical analysis was used to identify differential diagnostic cytological features of glandular hyperplasia, atypical hyperplasia and well-differentiated adenocarcinoma of the endometrium. Twelve cytological features were identified for calculating linear discriminant function. The effectiveness of the diagnostic algorithm depends upon the diagnostic value of the sample and proficiency of the cytologist.

[Cytological methods in predicting the degree of the direct effect of radiation exposure]. / Tsitologicheskie metody v prognozirovanii stepeni neposredstvennogo éffekta luchevogo vozdeistviia.

A study was made of the cytological criteria of various degrees of radiation pathomorphosis of soft tissue cancers and sarcomas in different dose fractionation regimens and varying time of a preoperative interval. Combinations of the main and additional parenchymatous and stromal cytological signs, reflecting pathomorphosis of I-IV degrees were singled out. Schemes of cytological prediction of a direct effect of tumor radiation exposure were drawn up on the basis of regularities of changes in cellular pictures, obtained from diagnostic data before irradiation.

[The cytological diagnosis and classification of tumorous and nontumorous lesions of the pancreas]. / Tsitologicheskaia diagnostika i klassifikatsiia opukholevykh i neopukholevykh porazhenii podzheludochnoi zhelezy.

The paper summarizes the cytologic features of tumor and non-tumor pathology of the pancreas observed in 108 cases. Cytologic examination proved highly (90%) reliable in differential diagnosis of pancreatic pathology. A cytologic classification of pancreatic lesions is suggested.

[Differential diagnostic cytologic signs of atypical hyperplasia and cancer of the endometrium]. / Differentsial'no-diagnosticheskie tsitologicheskie priznaki atipicheskoi giperplazii i raka éndometriia.

Computerized multifactorial analysis of 56 cytologic features was performed in 135 cases suffering glandular and atypical hyperplasia and well-differentiated endometrial carcinoma (45 patients in each group). The established regularities enabled students to differentiate between hyperplasia and cancer in 95% of cases in classes and in 73-83% at examination.

[Differential diagnostic cytochemical signs of dysplasia of the bronchial epithelium and squamous cell carcinoma of the lung]. / Differentsial'no-diagnosticheskie tsitologicheskie priznaki displazii bronkhial'nogo épiteliia i ploskokletochnogo raka legkogo.

The cytograms of smears, obtained in bronchoscopic examinations of 59 patients with bronchial epithelium dysplasia and 44 patients with initial forms of squamous-cell carcinoma of the lung are analyzed. A histologic control has been made in all the cases. The authors classify the cytomorphologic criteria, they have statistically processed 140 signs, minimizing their number and selecting their combinations for the differential diagnosis between dysplasia and carcinoma of the lung. Cytologically dysplasia in squamous-cell metaplasia of the bronchial epithelium and dysplasia of the cylindrical epithelium have been distinguished. Three degrees of dysplasia have been singled out: (I) weak, (II) moderate, (III) grave.

[Cytologic characteristics of bronchial epithelial dysplasia from the viewpoint of the early detection of lung cancer]. / Tsitologicheskaia kharakteristika displazii bronkhial'nogo épiteliia v aspekte rannego vyiavleniia raka legkogo.

Cytomorphologic characteristics of bronchial epithelium have been examined in 58 patients with central lung cancer (42 patients in stage T1N0M0 and 16 in stage T1N1M0 and 84 patients with nonneoplastic diseases (tuberculosis, hamartoma, sarcoidosis, or chronic nonspecific inflammation), using smears from bronchial mucosa, imprints from tissue pieces biopsied on bronchoscopy, scrapings from lesions and surrounding tissues, and transthoracic puncture samples. In 34 of the 58 cancer patients, the changes in bronchial epithelium were categorized as moderate to severe dysplasia. A scheme summarizing malignant transformation of bronchial epithelium is proposed. It is shown that bronchial epithelial dysplasia can be recognized by cytologic examination, which may be used to advantage in screening subjects for early detection of lung cancer.

[Tasks and methods for the more precise diagnosis of malignant tumors]. / Zadachi i metody utochniaiushchei diagnostiki zlokachestvennykh opukholei.

Major goals and principles of stage-by-stage diagnosis of malignant tumors are formulated. Application of different diagnostic procedures carried out at the preoperative (pre-treatment), intraoperative and postoperative stages of clinical treatment are discussed.

[The role of cytological studies in evaluating the severity of dysplasia during prophylactic gynecological examinations (cooperative study)]. / Znachenie tsitologicheskogo issledovaniia v otsenke tiazheloi displazii pri profilakticheskikh ginekologicheskikh osmotrakh (kooperirovannoe issledovanie).

Cytologic examination of scrapings from the uterine cervix was carried out in 498 patients in whom moderate or severe dysplasia of the squamous epithelium or suspicion for cancer were established in the course of gynecologic screening. The said pathology was diagnosed in 0.63% of screeneses. Cytologic follow-up of 57 cases of severe dysplasia established that, in patients over 40 years of age, it tended to progress to Ca in situ. This tendency was registered within 6-36 months and continued after a second biopsy. Severe dysplasia did not recur in the 20-40 year-old group. The extent of cervical biopsy (excision or conization) in severe dysplasia should be considered versus patients' age.