Typhoid Conjugate Vaccine: A Boon for Endemic Regions.

Typhoid fever has the highest disease burden in countries in low- and middle-income countries, primarily located in Asia and Sub-Saharan Africa. Previous typhoid vaccines such as the live attenuated typhoid (Ty21a) vaccine and Vi (virulence) capsular polysaccharide vaccine had the limitation that they could not be administered with other standard childhood immunizations and were ineffective in children under two years of age. To address these shortcomings of the previous vaccines, typhoid conjugate vaccines (TCVs) were developed and prequalified by the World Health Organization. Cross-reacting material and tetanus toxoid are widely used as carrier proteins in TCVs. According to various studies, TCV has higher efficacy, has a more extended protection period, and is safe and immunogenic in infants as young as six months. This review article aims to comprehensively appraise the data available on TCVs' efficacy, duration of protection, safety, and immunogenicity in endemic regions.

A Case Series of Amoebic Liver Abscess in Patients With COVID-19 Infection.

Background: Globally, amoebiasis is the second leading cause of death due to parasitic diseases. Amoebic liver abscess (ALA) as an opportunistic infection in recently recovered COVID 19 disease patients has not been reported earlier. Methods: We present here a case series of 13 patients of ALA admitted during the month of May 2021 in BLK hospital, New Delhi, and had recently recovered from COVID 19 disease. Results: Out of 13, eight patients had moderate, and one had severe COVID 19 disease. All these patients had received steroids for the management of COVID 19 disease. The remaining 4 (30%) patients had mild disease. The mean age of our patients was 50 years (37-81 years). Out of 13 patients, nine (70%) were male, 5 were diabetic, 2 were hypertensive, and none were alcoholic. The most common presentation was fever (11/13) followed by upper abdomen pain (10/13). The mean time of symptom (fever or pain abdomen) onset from COVID 19 positivity date was 19 days (range 15-23 days). A complication the in form of localized intraperitoneal rupture was common in these patients and was seen in more than 50% (7/13) of patients. All the patients were managed with IV Metronidazole and abscess aspiration. All the patients were discharged, and the mean hospital stay was 6.6 days. Conclusion: We report here an increase in the incidence of ALA in recently recovered COVID 19 patients and propose that it is most likely due to alteration in the immune state of these patients. It is important for physicians to investigate for liver abscess in patients who present again with fever and/or pain abdomen within 2 weeks of COVID 19 recovery.

A rare case of bilateral central subluxation of the hip joint with associated bilateral quadrilateral plate fracture in an elderly male due to seizure activity / Um caso raro de subluxação central bilateral da articulação do quadril associada a fratura bilateral da lâmina quadrilátera em um homem idoso devido a convulsões

ABSTRACT Musculoskeletal injuries such as dislocation of the shoulder and hip joints and fractures of the femoral neck are known complications of seizures. Bilateral central subluxation of the hip joint with associated bilateral quadrilateral plate fracture is a rare entity and is prone to delayed diagnosis, even more so in patients who experience post-seizure disorientation. The authors report the case of a 74-year-old male patient with bilateral central subluxation of the hip joint with associated bilateral quadrilateral plate fracture due to seizure activity. Bilateral open reconstruction and fixation of the quadrilateral plate with a 3.5-mm pre-bent reconstruction plate reinforced with 3.5-mm pelvic brim reconstruction plate was performed. In conclusion, this case is an example of rare bilateral quadrilateral plate fracture caused due to seizure activity, a fracture for which a high level of suspicion should be kept in mind while evaluating the patient post-seizure episode.

RESUMO Lesões musculoesqueléticas, tais como luxação das articulações do ombro e quadril e fraturas do colo do fêmur, são complicações conhecidas de convulsões. A subluxação central bilateral da articulação do quadril associada a fratura bilateral da lâmina quadrilátera do acetábulo é uma entidade rara e propensa ao diagnóstico tardio, ainda mais em pacientes que experimentam desorientação pós-convulsão. Os autores relatam o caso de um paciente masculino de 74 anos com subluxação central bilateral da articulação do quadril associada a fratura bilateral da lâmina quadrilátera decorrente de atividade convulsiva. Foi feita reconstrução bilateral aberta e a lâmina quadrilátera foi fixada com uma placa de reconstrução pré-dobrada de 3,5 mm, reforçada com uma placa de reconstrução da borda pélvica de 3,5 mm. Conclui-se que este caso é um raro exemplo de fratura bilateral das lâminas quadriláteras causada pela atividade convulsiva. Os profissionais de saúde devem manter um alto nível de suspeita para esse tipo de fratura ao avaliar pacientes após um episódio convulsivo.

A rare case of bilateral central subluxation of the hip joint with associated bilateral quadrilateral plate fracture in an elderly male due to seizure activity.

Musculoskeletal injuries such as dislocation of the shoulder and hip joints and fractures of the femoral neck are known complications of seizures. Bilateral central subluxation of the hip joint with associated bilateral quadrilateral plate fracture is a rare entity and is prone to delayed diagnosis, even more so in patients who experience post-seizure disorientation. The authors report the case of a 74-year-old male patient with bilateral central subluxation of the hip joint with associated bilateral quadrilateral plate fracture due to seizure activity. Bilateral open reconstruction and fixation of the quadrilateral plate with a 3.5-mm pre-bent reconstruction plate reinforced with 3.5-mm pelvic brim reconstruction plate was performed. In conclusion, this case is an example of rare bilateral quadrilateral plate fracture caused due to seizure activity, a fracture for which a high level of suspicion should be kept in mind while evaluating the patient post-seizure episode.

Lesões musculoesqueléticas, tais como luxação das articulações do ombro e quadril e fraturas do colo do fêmur, são complicações conhecidas de convulsões. A subluxação central bilateral da articulação do quadril associada a fratura bilateral da alâmina quadrilátera do acetábulo é uma entidade rara e propensa ao diagnóstico tardio, ainda mais em pacientes que experimentam desorientação pós-convulsão. Os autores relatam o caso de um paciente masculino de 74 anos de idade com subluxação central bilateral da articulação do quadril associada a fratura bilateral da lâmina quadrilátera decorrente de atividade convulsiva. Foi feita reconstrução bilateral aberta e a lâmina quadrilátera foi fixada com uma placa de reconstrução pré-dobrada de 3.5 mm, reforçada com uma placa de reconstrução da borda pélvica de 3,5 mm. Conclui-se que este caso é um raro exemplo de fratura bilateral das lâminas quadriláteras causada pela atividade convulsiva. Os profissionais de saúde devem manter um alto nível de suspeita para esse tipo de fratura ao avaliar pacientes após um episódio convulsivo.

Ventriculoperitoneal shunts in neonates: a retrospective study of outcomes with antibiotic-impregnated catheters and a modified peri-operative antibiotic protocol.

BACKGROUND: CSF infection is a significant complication of ventriculoperitoneal (VP) shunts and results in prolonged hospital stay, developmental delay and decreased quality of life. To decrease the high rates of neonatal VP shunt infections, an updated clinical guideline that included the use of antibiotic-impregnated shunts and a revised peri-operative antibiotic protocol was introduced in our neonatal unit. In this study, we evaluated the efficacy of these new guidelines in reducing the CSF shunt infection rates. METHODS: A retrospective cohort study of neonates (≤28 days) who had VP shunt insertions in our unit. RESULTS: 24 neonates in the first epoch received plain silastic shunt catheters (Feb 2002-April 2007), and 23 in the second epoch (August 2007-July 2015) received AIS catheters and a revised perioperative antibiotic protocol. Patient demographics were similar between both cohorts. Shunt related CSF infections were reduced in epoch 2 (2/23, 8.7%) compared to epoch 1 (5/24, 20.8%), but the results were not statistically significant (OR 0.36 (0.063-2.090); p = 0.256). Amongst neonates that needed VP shunt revision due to any cause, the median time interval between insertion to revision was significantly later in epoch 2 (epoch 1, 48 days (3-99); epoch 2, 148 days (20-396); p = 0.013). CONCLUSIONS: AIS catheters and a 48-hour perioperative antibiotic regimen may be beneficial in neonatal hydrocephalus. Adequately powered RCTs in the neonatal population are needed to confirm these findings.

Bilateral simultaneous neck femur fracture following domestic fall in an elderly patient: a rare case report.

Simultaneous bilateral neck femur fracture is a rare entity that has been associated with underlying bone disease, various metabolic diseases, high-energy trauma, and seizure disorders. Its occurrence following minimal trauma is very rare. This article presents the case of a 66-year-old female who sustained bilateral intracapsular fracture neck femur following a slip and fall at home. Single-stage bilateral cemented total hip replacement was done using a direct lateral approach with alternate right and left lateral positions. The authors report a satisfactory outcome, with Harris hip score of 98 at one year, which persisted until her last follow-up at 30 months.

A fratura simultânea bilateral do colo do fêmur é uma entidade rara que tem sido associada a doenças ósseas, diversas doenças metabólicas, traumas de alta energia e distúrbios convulsivos. Sua ocorrência após trauma mínimo é muito rara. Este artigo apresenta o caso de uma mulher de 66 anos de idade que sofreu fratura intracapsular bilateral do colo do fêmur após um deslize e queda em casa. Uma artroplastia total do quadril, bilateral e cimentada foi feita em um único momento, usando uma abordagem lateral direta, alternando as posições laterais direita e esquerda. Os autores relatam um resultado satisfatório, com Harris Hip Score de 98 após um ano, que persistiu até o último seguimento, aos 30 meses.

Bilateral simultaneous neck femur fracture following domestic fall in an elderly patient: a rare case report / Fratura simultânea bilateral do colo do fêmur após queda doméstica em uma paciente idosa: relato de um caso raro

ABSTRACT Simultaneous bilateral neck femur fracture is a rare entity that has been associated with underlying bone disease, various metabolic diseases, high-energy trauma, and seizure disorders. Its occurrence following minimal trauma is very rare. This article presents the case of a 66-year-old female who sustained bilateral intracapsular fracture neck femur following a slip and fall at home. Single-stage bilateral cemented total hip replacement was done using a direct lateral approach with alternate right and left lateral positions. The authors report a satisfactory outcome, with Harris hip score of 98 at one year, which persisted until her last follow-up at 30 months.

RESUMO A fratura simultânea bilateral do colo do fêmur é uma entidade rara que tem sido associada a doenças ósseas, diversas doenças metabólicas, traumas de alta energia e distúrbios convulsivos. Sua ocorrência após trauma mínimo é muito rara. Este artigo apresenta o caso de uma mulher de 66 anos que sofreu fratura intracapsular bilateral do colo do fêmur após um deslize e queda em casa. Uma artroplastia total do quadril, bilateral e cimentada foi feita em um único momento, com o uso de uma abordagem lateral direta, em que se alternaram as posições lateral direita e esquerda. Os autores relatam um resultado satisfatório, com Harris Hip Score de 98 após um ano, que persistiu até o último seguimento, aos 30 meses.

Arachnoid cyst of the cavum velum interpositum in a septuagenarian: radiological features and differential diagnosis.

The cavum velum interpositum (CVI) is a thin, triangular-shaped cerebrospinal fluid (CSF)-filled space between the lateral ventricles that lies below the fornices and above the third ventricle. It is a normal variant seen in premature and newborn infants and usually disappears with brain maturation. CVI is rarely seen in adults as a persistent primitive structure. Although moderate cystic dilatation of the CVI may sometimes be observed, a true large cyst is extremely rare with only a handful of reported cases, mostly in children and adolescents. We describe the case of CVI arachnoid cyst diagnosed on imaging in a septuagenarian with the complaint of occasional headaches.

Choledochocele with pancreas divisum: A rare co-occurrence diagnosed on magnetic resonance cholangiopancreatography.

We report a case of a 42-year-old male with symptomatic choledochocele and incidental pancreas divisum diagnosed with magnetic resonance cholangiopan- creatography (MRCP). Small choledochocele is rare congenital malformation associated with non-specific symptoms and a delay in diagnosis. The coexistence of choledochocele and pancreas divisum is extremely rare with only two case reports published in literature. In both cases MRCP failed to diagnose any biliary or pancreatic abnormality. This case suggests that the patients with recurrent abdominal pain and pancreas divisum should not be presumed to be suffering from pancreatitis. Careful evaluated for additional anomalies in the biliary tree should be sought for refractory symptoms. MRCP is a useful one-stop-shop for diagnosing pancreatic and biliary ductal anomalies.