1.
Org Biomol Chem
; 22(24): 4877-4881, 2024 Jun 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38804914
RESUMO
The first biomimetic and concise racemic total syntheses of renifolin F and antiarone K, accomplished in 8 and 7 linear steps, respectively, are presented in this article. Our synthetic approach commences with substituted aldehydes to produce prenylated aldol products followed by ene-type intramolecular cyclization affording a five-member core ring. This key step mediated by InCl3·4H2O is a novel procedure first utilized in prenylated systems which directly culminates mainly into tertiary alcohols.