Psychometric properties of the Persian version of the stuttering generalization self-measure tool in adults who stutter.

PURPOSE: Our study aimed to translate the Stuttering Generalization Self-Measure (SGSM) into Persian and investigate its validity, reliability, and internal responsiveness in the Iranian population. METHOD: This study was conducted on 30 adults who stutter (AWS) and 30 adults who do not stutter (AWNS). The International Quality of Life Assessment protocol (IQOLA) was applied to translate SGSM into Persian. The face and content validity were determined. Also, the discriminant validity was evaluated by comparing the scores of two groups. In addition, the internal consistency test-retest, and inter-judge reliability were assessed with Cronbach's alpha and intra-class correlation coefficients (ICC). Moreover, the mean standardized response (MSR) and the standardized effect size were measured to determine the internal responsiveness using pre- and post-treatment data. RESULTS: All the items were comprehensible and clear. The content validity ratio (CVR) and content validity index (CVI) for all nine questions were obtained higher than.62 and.9, respectively. The internal consistency value was high (Cronbach's alpha =.98). For the test-retest reliability, ICC values were excellent, ranging from.93 to.99. The discriminant validity results revealed a significant difference between AWS and AWNS (p < .001). Pre- and post-treatment results indicated high internal responsiveness to changes for percentage of syllable stuttered (SS%) (MSR = 1.09). CONCLUSION: The Persian version of SGSM (P-SGSM) benefits from the high values for validity and reliability. Furthermore, it distinguishes the AWS and AWNS and reflects the treatment changes significantly.

SARS-CoV-2 in patient with protein C deficiency: A case report.

In SARS-CoV-2 pandemic different disorders in coagulation pathways in COVID-19 patients were reported. We described a 44-year-old female with COVID-19 and protein C deficiency history. She did not show any coagulation disorder during her disease course. Complete genome sequencing of SARS-CoV-2 was performed and some mutations identified and compared with Wuhan strain. Besides hospitalized patients, in COVID-19 outpatients with low concentration of protein C, early prescription of an anticoagulant such as heparin could be helpful in prevention of venous thromboembolism or pulmonary embolism.

Impact of COVID-19 on the changing pattern of human orthopneumovirus (respiratory syncytial virus) infection in Iran.

BACKGROUND: Human orthopneumovirus (HOPV) or respiratory syncytial virus (RSV) is one of the important causes of acute respiratory infections (ARIs) during the cold months of the year worldwide. Many countries have reported an absence of ARIs due to HOPV during the winter of 2020-2021 associated with preventive measures to reduce the spread of SARS-CoV2. However, with the reduction of COVID-19 public health restrictions and the absence of immunity in the community due to the lack of exposure in the previous season, many countries had a delayed HOPV outbreak. Here we reported the impact of COVID-19 on the changing pattern of HOPV infection in Iran. METHODS: Throat and nasopharyngeal swab samples were collected from patients (children and adults) with ARIs and sent to the Iran National Influenza Center. After RNA extraction, Real time RT-PCR was performed for HOPV detection. RESULTS: In 260 samples collected from patients with ARIs in three different groups, which included children in March 2021, pilgrims in July 2022, and outpatients during November and December 2022, no HOPV was detected in any group. CONCLUSIONS: The lack of HOPV activity in Iran during the winter of 2020-2021 and then the resurgence in spring 2022 and again the absence of activity in summer and autumn 2022 was extraordinary in the HOPV epidemiology, and probably due to the implementation of public health non-pharmaceutical interventions to reduce the spread of SARS-CoV2. Although it is not possible to keep such restrictions, similar methods can be taken to control outbreaks caused by respiratory viruses.

Phonological development in first language Laki-speaking children aged 3 to 5 years: A pilot study.

PURPOSE: To date there are no studies of speech sound acquisition in Laki, a language spoken in western regions of Iran. Thus, we set out a pilot study to investigate the speech development of 56 first language Laki-speaking children (aged 3-5 years). METHOD: Single words were elicited through a picture naming test specifically developed for this study. After recording and transcribing of speech samples, percentage of consonants correct (PCC), percentage of vowels correct (PVC), and proportion of whole word proximity (PWP) were documented in four age groups (36-41, 42-47, 48-53, and 54-59 months) and both genders. Children's phonetic inventories and consonant and vowel accuracy were also described. RESULT: All the sounds were considered as emerging by 53 months of age. For speech sound accuracy, all the speech sounds except /ɢ, z, ŋ, ʒ/ were mastered by 5 years. The effect of age on PCC values was significant. Also, age groups showed significant differences for PWP but were not significant for PVC. Boys and girls did not differ for PCC, PVC, and PWP values. CONCLUSION: From a theoretical perspective, findings contribute to theories about phonological acquisition in general and will enable crosslinguistic comparisons. From an applied standpoint, language-specific characteristics are identified, which are much needed for clinical practice with Laki-speaking children.

SARS-CoV-2 intrahost evolution in immunocompromised patients in comparison with immunocompetent populations after treatment.

Many evidence suggests that long-lasting infection can develop with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This occurrence has been widely described in immunocompromised individuals. In these patients, ineffective clearance of virus infection provides an opportunity for developing immune escape mutants. This study aimed to characterize SARS-CoV-2 intrahost evolution in five immunocompromised in comparison with five immunocompetent COVID-19 patients during treatment. We performed next-generation sequencing (NGS) on collected two oropharyngeal samples from immunocompromised and immunocompetent COVID-19 patients before and after treatment. In this study, we detected alpha and delta variants of SARS-CoV-2. The most common substitutions in structural proteins in patients with alpha variant were S-ΔY143-144, A570D, D614G and D1118H, and N-R203K and G204R, and in delta variant S-T19R, G142D, E156G, 157-158del, L452R, T478K, D614G, D950N and N-D63G, R203M and D377Y were dominant. The common variations in nonstructural and accessory proteins including nsp3-A488S, P1228L, nsp6-T77A, nsp12-P323L, G671S, nsp13-P77L, NS3-S26L, and NS7a-T120I were detected. Also some infrequent substitutions were seen in immunocompromised and immunocompetent patients. After treatment, nsp12-V166A was emerged as a remdesivir resistance and S-L452M in a patient with common variable immunodeficiency. S-E484Q was detected in a patient with acute lymphoma leukemia. This study showed the possibility of the genetic diversity and development of some new mutations in immunocompromised patients. Therefore, surveillance of these patients to characterize any new variants is necessary.

Translation, cross-cultural adaptation, and validation of the Persian version of Everyday Memory Questionnaire-Revised (EMQ-R) in patients with multiple sclerosis.

PURPOSE: The present research translated and validated the Persian version of the Everyday Memory Questionnaire-Revised (EMQ-R) in patients with multiple sclerosis (MS). METHODS: A two-step study was performed in the current work. First, the scale was translated and culturally adopted to Persian. In the second step, the translated questionnaire was presented to 150 patients with MS and 50 individuals in the control group. Then, construct validity (factor analysis and clinical validity) and reliability measures (test-retest reliability and internal consistency) were computed for this questionnaire. RESULTS: Patients with MS obtained higher scores in EMQ-R than the control group (p < .001). The findings of the Kaiser-Meyer-Olkin and Bartlett test approved the sampling adequacy for computing the factor analysis (p < .001). The accuracy of the three-dimensional structure was confirmed by confirmatory factor analysis (CFA). Findings of test-retest (ICC = .95, 95%CI .91-.98, p < .001) and internal consistency revealed a satisfactory value (α = .95, p < .001). CONCLUSIONS: Satisfactory findings for construct validity and high values for reliability revealed that the Persian version of EMQ-R is a reliable and valid scale to measure the everyday memory of patients with MS in the cognitive assessments of this group.IMPLICATIONS FOR REHABILITATIONPersian EMQ-R is a valid, reliable, fast, and easy to administer tool for evaluating the beliefs and insights of patients suffering from MS or other clinical conditions about their cognitive dysfunctions, in day-to-day lives with some differentiation between memory and attentional difficulties. This questionnaire can be a practical clinical tool for the assessment of the cognitive deficits, which might not be detected via formal neuropsychological assessments, and could be a valuable scale to measure the effects of treatment approaches to level up memory function in a way that could be generalized to daily life performance.

Non-word repetition in Persian learning toddlers with typical development.

In the current research, non-word repetition (NWR) skills of Persian learning toddlers and its association with phonological accuracy and language measures, such as percentage consonant correct (PCC), mean length utterance (MLU), and expressive vocabulary was evaluated. First, the Persian task of NWR, comprising 15 non-words, was developed and validated. Forty-four typically developing Persian learning toddlers aged from 24 to 30 months were recruited in this project. Word and NWR responses were elicited during play. MLU was investigated using serial picture description. Furthermore, the Persian version of MacArthur-Bates communicative development inventories was completed by participants' parents. The association between NWR, word repetition, MLU, and vocabulary indices was measured. Excellent values were obtained for test-retest reliability, PCC of NWR (ICC = .94, 95% CI, .78-.94, p < .001) and PCC of word repetition (ICC = .96, 95%CI, .83-.96, p < .001). The values of PCC for NWR and PCC of word repetition were 80.32 ± 13.44 and 83.51 ± 9.91, respectively. The Wilcoxon ranked test showed that participants had better performance in word repetition than NWR (z = -.275, p = .02). Significant associations were found between NWR, word repetition, MLU, number of different words, number of total words, and the expressive vocabulary size. Sex, socioeconomic status, and age did not affect NWR in this study. The findings of the current research demonstrated that the Persian task of NWR is a valid and reliable test to measure the NWR and the scores of participants were substantially associated with phonological accuracy, MLU, and vocabulary measures.

Speech sound production, speech intelligibility, and oral-motor outcomes of preterm children: Are they different from full term children?

We studied the speech sound abilities of preterm (PT) children. Thirty-one PT and twenty-nine full term (FT) children were recruited. Speech abilities were assessed in single word, story retelling, oral-motor, and intelligibility. PT group had poorer outcomes (Mean = 25.77, SD = 17.19) than FT ones (Mean = 5.9, SD = 4.97) for single word (p < 0.001). They obtained poorer results (Mean = 9.65, SD = 7.85) than FT peers (Mean = 2.95, SD = 3.34) in story retelling (p = 0.002) and intelligibility (Man-Whitney U = 89.50, p = 0.02). They obtained lower values for diadochokesis/patuku/(p < 0.001), isolated (p = 0.001), and sequenced movements (p = 0.02) but not for diadochokesis/patukejk/(p = 0.12). Significant values of correlation were found among single word scores with birth weight (r = -.54, p < .001) and gestational age (r = -0.67, p < .001) and story retelling scores with birth weight (r = -0.40, p = .013) and gestational age (r = -0.64, p < .001). The associations of single word score and maternal (r = -0.02, p = .85) and paternal education (r = -0.10, p = .41) were not significant. No significant relationships were obtained between story retelling score and maternal (r = 0.16, p = .34) and paternal education (r = 0.09, p = .59). The significant values were obtained for associations of intelligibility with isolated (r = 0.54, p = .001), sequenced movements (r = 0.59, p < .001), and diadochokesis/patukejk/(r = 0.39, p = .016) but not significant for intelligibility and diadochokesis/patuku/(r = 0.25, p = .13). Findings implied that speech abilities are weaker in PT children.

Comparison of Circulating Variants during the Beginning, Middle and the End of the 4th Wave of COVID-19 in Tehran Province, Iran in 2021.

Background: Whole viral genome sequencing with next generation sequencing (NGS) technique is useful tool for determining the diversity of variants and mutations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this study we have attempted to characterize the mutations and circulating variants of the SARSCoV-2 genome during the 4th wave of COVID-19 pandemic in Tehran, Iran in 2021. Methods: We performed complete genome sequencing of 15 SARS-CoV-2 detected from 15 COVID-19 patients during the 4th wave of COVID-19 pandemic with NGS. Three groups of the patients at the beginning, middle and the end of the 4th wave were compared together. Results: We detected alpha and delta variants during the 4th wave of the pandemic. The results illustrated a dominance of amino acid substitution D614G in spike, and the most frequent mutants were N-R203K, G204R, S235F, nsp12-P323L, nsp6-G106del, G107del and F108del. Conclusion: The detection of the virus mutations is a useful procedure for identifying the virus behavior and its genetic evolution in order to improve the efficacy of the monitoring strategies and therapeutic measures.

Speech sound acquisition in Azeri Turkish-speaking children in Iran.

BACKGROUND: Currently no data exist on the acquisition of speech sounds in Azeri Turkish-speaking children in Iran. This investigation was conducted to describe phonological development in Azeri Turkish-speaking children. METHODS: A total of 120 typically developing Azeri Turkish-speaking children within the age range of 3;0 to 4;11 years were recruited. They were asked to name pictures in the Azeri Turkish Speech Test and their productions were analyzed to determine consonant acquisition, Percentage of Consonants Correct (PCC), Percentage of Vowels Correct (PVC), and Whole Word Proximity (WWP) according to sex and age. In addition, PCC values in terms of consonant position in the syllable (syllable-initial and syllable-final), and manner of articulation were calculated. RESULTS: For consonant acquisition, they mastered all consonants except [d, dÍ¡z, tÍ¡s, ʒ, v, ɟ] by 4;11 years of age. PCC values increased with increasing age (H(3)= 67.212, p <0.001). In terms of manner of articulation, PCC showed that nasals were most accurately produced and trill sound least accurate. The effect of sex on PCC values was not significant U (Nmales =60, Nfemales =60)= 1686.5, z = -0.600, p=.54). WWP values were also found to increase in older children H(3)=46.94, p<.001). Similarly, the effect of sex on WWP values was not significant U (Nmales =60, Nfemales =60)= 1782.5, z = -0.09, p=.92). CONCLUSIONS: Children acquiring speech sounds in the Azeri Turkish language show some similar tendencies to children acquiring other languages but are also different. Findings of the present research describe phonological development in Azeri Turkish-speaking children, which has not been documented before.

Lexical-semantic processing of action verbs and non-action nouns in Persian speakers: Behavioral evidence from the semantic similarity judgment task.

The processing of sensory-motor aspect of word's meaning, and its difference between nouns and verbs, is the main topic of neurolinguistic research. The present study aimed to examine the lexical-semantic processing of Persian non-action nouns and action verbs. The possible effects of semantic correlates on noun/verb dissociation were evaluated without morphological confound. A total of 62 neurologically intact Persian speakers responded to a computerized semantic similarity judgment task, including 34 triplets of non-action nouns and 34 triplets of action verbs by pressing a key. Response Time (RT) and percentage error were considered as indirect measures of lexical-semantic encoding efficiency. We also assessed the latency of hand movement execution with no linguistic demand. The results showed that action verbs elicited more errors and had slower RT compared with object nouns. Mixed ANOVA revealed that the observed noun/verb distinction was not affected by demographic factors. These results provided evidence that the lexical-semantic encoding of Persian action verbs, compared to non-action nouns, requires more support from cognitive sources during the processing of the motor - related semantic feature. The possible accounts for the different processing of action verbs in terms of semantic view are suggested.

Development and measurement of psychometric properties of the Persian test of speech consistency in children with typical development.

The current research pursues the study of developing the Persian test of speech consistency and investigating speech consistency in normally developing children in Iran. After developing the Persian test of speech consistency, the obtained speech samples of 317 participants (163 girls and 154 boys) were analyzed. This test of consistency includes 27 items. Experts' consensus over the characteristics of the Persian test of speech consistency was above 85%. Different age groups had statistically significant differences for the mean scores of the variable responses (p < .001), consistent correct (p < .001), and consistent incorrect responses (p = .007) in the Persian test of speech consistency. Also, there was a high value for the inter-rater reliability (ICC = .88, p < .001) as well as the moderate value for the test-retest reliability (ICC = .89, p < .001). The Persian test of speech consistency is regarded as a reliable and valid scale for measuring the speech consistency in Persian-speaking children. Future studies are proposed to investigate the speech consistency in Persian-speaking children with various kinds of speech sound disorders.

Development of a speech production test in Azeri Turkish speaking children.

Due to the lack of appropriate tests for the assessment of speech sounds of Azeri Turkish speaking children, the present study aimed to develop and validate a single word test. A total of 150 typically developing children were recruited in the study (30 children for investigating the name agreement and 120 children to establish construct validity). In the first step, a test with 31 items was developed in terms of suggested criteria in the literature including word frequency, word length, syllabic structure, familiarity, and picturability of words. Then, we asked the expert panel's opinion for the test items. The value of the content validity ratio for each target word was 1.00 except for one item. To administer the test, we asked the participants to name images. Name agreement of the items was determined through administrating the test. The percentages for the indices of name agreement were 87.68 and 0.17, respectively. The findings of the item-by-item test-retest and inter-rater reliability showed satisfactory values in terms of consonants in the initial and final positions. Also, the value of the internal consistency was calculated to be kr = 0.78 (p < 0.001). The psychometric properties of this scale with 31 items proved that it is appropriate for quantifying the speech sound production in Azeri Turkish typically developing children.

Translation, Validity, and Reliability of the Persian Version of the Aging Voice Index.

OBJECTIVES: The Aging Voice Index (AVI) was developed to study quality of life in older adults with voice disorders. The purpose of this study was to translate the original English version of the AVI to Persian version of Aging Voice Index (P-AVI) and validate the P-AVI for the Persian-speaking older adults with voice disorders. METHODS: A cross-sectional, descriptive, and methodological study was performed to translate and validate the Persian version of the AVI. The translation was performed in accordance with recommendations from the World Health Organization. Eighty-five treatment-seeking patients with voice disorders and 20 older adults without voice complaints were recruited for this study. Psychometric properties were investigated, including: different types of validity (content validity, construct validity, and criterion-related validity), reliability (test-retest and internal consistency), and item analysis of the Persian version of AVI. The relationship between total score of P-AVI and age, sex, and voice pathology were determined using multiple linear regression. RESULTS: A panel of three speech pathologists performed the content validity of the P-AVI and reached agreement on all of the items. Construct validity was confirmed by a significant difference in the mean of total score of the P-AVI was identified between the particiapnts with voice disorders and those with no voice complaints (P < 0.001). There was high correlation between the total scores of the participants in the Persian version of the AVI and the Persian version of the voice-related quality of life (r = 0.86, P < 0.001). All reliability measures were found to be good with scores higher than 0.8. To assess the need for item reduction, a Cronbach's alpha coefficient remained constant with the elimination of each item; therefore, all no items were removed. Age and voice pathology were not predictive for the total P-AVI score, but a weak effect was identified for sex and the total score of P-AVI (F = 18.75, P < 0.001) with an R2 of 0.21. CONCLUSIONS: The Persian version of AVI is a valid and reliable questionnaire designed specifically for older adults that speech-language pathologists and otolaryngologists can use to objectively assess the impact of voice disorders in aging Persian-speaking patients.

Quality of Life After Botulinum Toxin Injection in Patients With Adductor Spasmodic Dysphonia; a Systematic Review and Meta-analysis.

INTRODUCTION: Adductor spasmodic dysphonia is an extremely disabling voice disorder that negatively impacts a patient's quality of life (QOL). We performed a systematic review to determine if Botulinum Toxin (BT) injections improved voice related QOL in patients with this disorder. METHODS: PubMed, EMBASE, Web of Science, Cochrane Library, ProQuest, and Scopus from 2000, to and including November 1st, 2018, were searched. We identified randomized controlled trials, controlled trials, and observational studies of the effects of BT injections on the QOL in patients with adductor spasmodic dysphonia. The two authors, separately and individually chose the studies based on inclusion criteria, assessed study quality, and relevant extracted data. RESULTS: Nine studies used the Voice Handicap Index (VHI). The results showed significant changes pre- to post-BT injection (SMD = -0.357; 95% CI: -0.579, -0.136; z = 3.16; P = 0.002; I-squared = 0.000%). Five studies used the Voice-Related QOL; their results also showed a significant improvement pre- to postinjection (SMD = -2.99; 95% CI: -3.27, -1.32; z = 4.61; P < 0.001; I-squared = 87%). Three other studies used other, shortened versions of the VHI, VHI-10. They also showed significant results (SMD = -0.145; 95% CI: -0.349, 0.06; z = 1.38; P = 0.17; I-squared = 0.000). CONCLUSION: BT injections positively affect patients' QOL. However, patients' QOL scores may never be normalized, in line with perceptual voice quality and acoustic parameters.

Prevalence of torque teno virus in healthy individuals and those infected with hepatitis C virus living in Yazd, Iran.

BACKGROUND: Torque teno virus (TTV) is a non-enveloped DNA virus that its role as a helper or causative agent in hepatitis is still unclear. TTV prevalence varies in different regions of the world. This study aimed to determine the prevalence of TTV in healthy individuals and those infected with hepatitis C virus (HCV) living in Yazd city, Iran. METHODS: In this case-control study, 50 healthy subjects and 68 HCV-positive individuals who referred to Yazd hospitals participated in this study. TTV DNA in serum samples were detected by nested polymerase chain reaction (PCR) using specific primers of 5΄-UTR and N22 regions. The genotypes of HCV and TTV were determined by sequencing method. RESULTS: TTV-DNA was detected in 2 out of 50 (4℅) healthy individuals and in 4 out of 68 (5.8℅) HCV-positive persons. There was not a significant correlation between the prevalence of TTV and HCV infection. The most common TTV genotypes among HCV-positive individuals were 3, 17 and 13, respectively. There was not a significant association obtained between HCV genotypes and TTV genotypes. CONCLUSION: The prevalence of TTV in Yazd province was low compared with the other areas of Iran. The prevalence of TTV in HCV infected people was not significantly higher than its rate in uninfected individuals.

Vowel duration measurement in school-age children with cochlear implant.

OBJECTIVES: Normal hearing system is an essential factor for accurate production of speech segments. It seems that cochlear implant prosthesis helps children with hearing impairment to speak more accurately than before receiving prosthesis. The current research aimed to compare the vowel duration in school-aged children with cochlear implants and that in children with normal hearing. Additionally, the performance of girls and boys in two groups were investigated. METHODS: A cross-sectional and descriptive-analytical study was carried out to compare the vowel duration in 9- to 12-year-old children with cochlear implant and those with normal hearing. Participants were 52 children who were matched by age and sex. We asked the children to read the target words with each word including one vowel and then participants' voice samples were recorded. Then, vowel duration was measured using Praat software. Finally, the vowel duration was compared between the two groups running independent sample t-test. The level of significance was (P < 0.05). RESULTS: There was no statistically significant difference observed between the two groups in the mean values of the vowel duration for the six Persian vowels (P > 0.05). Also, no significant difference was found between boys and girls in the mean value of the vowel duration between the two groups (P > 0.05). CONCLUSION: Persian vowels in school-aged children with cochlear implant and with typical hearing are produced with similar durations. This finding is probably related to the increased duration of using prosthesis in this age range and speech mode used to measure vowel duration in the present study.

Effects of Rheumatoid Arthritis on the Larynx.

INTRODUCTION: The aim of the present study was to compare the videolaryngostroboscopic findings between patients with rheumatoid arthritis and vocally healthy controls. MATERIALS AND METHODS: This case-control descriptive study was performed on 113 people, including 50 patients with rheumatoid arthritis and 63 controls. The participants were subjected to videolaryngostroboscopic examinations in order to evaluate fundamental frequency, different structural vocal lesions, patterns of glottal closure, subglottal changes, supraglottis appearance, and movement patterns of the arytenoid cartilage. The obtained results were compared between the two research groups. Data analysis was performed in the Statistical Package for the Social Sciences, version 24.0. A p-value less than 0.05 was considered statistically significant. RESULTS: The results revealed a statistically significant difference between the two groups in terms of the complete pattern (P=0.00) and strained state of glottal closure (P=0.00), pattern of subglottal changes (χ2=25.98, df=2; P<0.001), and movement patterns of the arytenoid (χ2=21.16, df=1; P<0.001). Additionally, based on the obtained frequencies, the two groups showed significant differences regarding the normal state of the larynx (P=0.00), hypertrophy of vocal fold (P=0.007), epithelial change (P=0.007), and Reinke's edema (P=0.001). However, the videolaryngostroboscopic examination results revealed no significant difference between the two groups in terms of polyp (P=0.20), nodule (P=0.57), sulcus vocalis (P=0.08), cyst (P=0.45), and atrophy of vocal folds (P=0.45). CONCLUSION: It seems that rheumatoid arthritis affects the patterns of arytenoids movement, some kinds of glottal closure patterns, and subglottal changes. As the results indicated, the occurrence of some laryngeal structural changes was higher in patients with rheumatoid arthritis than in individuals without this disorder.

Speech and language development of children born following assisted reproductive technologies.

OBJECTIVES: Studies which targeted communication skills of children born following assisted reproductive technologies have reported contradictory results. Concerning the increasing rates of children born in these technologies and the importance of some factors as risk factors like birth weight, gestational age, and the number of children per birth in these procedures, studying speech and language skills is critical. So, the current study aimed to investigate the speech and language capabilities of Persian speaking children born following these procedures. METHODS: A descriptive and cross-sectional study was carried out in Babol city in 2016-2017 to investigate the receptive and expressive language and speech of Persian speaking children born in assisted reproductive technologies in the age range of 6-72 months. Parents of 78 children completed the Newsha Developmental Scale to assess language and speech skills. Then, the language and speech performance of the participants were compared in terms of gestational age, birth weight, number of children per birth, and sex in the current research and they are categorized as normal or having delay in language and speech development. RESULTS: The participants had statistically significant difference for the receptive language in terms of gestational age (χ2 (1) = 5.76, p = 0.01) and birth weight (χ2 (1) = 8.22, p = 0.004) but in terms of the number of children per birth (χ2 (1) = 7.11, p = 0.009) and sex (χ2 (1) = 0.037, p = 0.84) did not have statistically significant difference. The children did not show significant difference for the expressive language in terms of gestational age (χ2 (1) = 1.09, p = 0.29), birth weight (χ2 (1) = 0.34, p = 0.55), the number of children per birth (χ2 (1) = 1.58, p = 0.2), and sex (χ2 (1) = 0.037, p = 0.84). The participants of the present study did not have statistically significant difference in speech in terms of gestational age (χ2 (1) = 2.82, p = 0.09), the number of children per birth (χ2 (1) = 3.57, p = 0.06), and sex (χ2 (1) = 0.06, p = 0.79). They had significant difference in speech only in terms of birth weight (χ2 (1) = 4.13, p = 0.04). CONCLUSION: Based on the results of the administration of the Newsha Developmental Scale as a screening tool, it seems that some factors like sex and number of children per birth do not affect speech and language performance of children born following ART. Another factor including gestational age and birth weight had effects on some domains. It is essential to design longitudinal studies to follow the speech and language performance of this population.

Translation and Validation of the Voice Catastrophization Index for Persian-Speaking Patients with Dysphonia.

PURPOSE: Catastrophization refers to the cognitive distortion that is experienced by patients with several diseases who suffer from pain. There is some evidence that catastrophization may be found in patients with voice disorders. The Voice Catastrophization Index (VCI) was developed in English to measure catastrophization in patients with dysphonia. The goal of this research was to translate and validate the Persian version of the VCI (P-VCI) for use with Persian-speaking people in Iran and elsewhere. METHODS: This was a prospective and cross-sectional study. First, the questionnaire was translated, then its various psychometric properties were investigated. RESULTS: There was a significant difference in mean P-VCI score between participants with and without dysphonia (p < 0.001). Test-retest reliability for the total score of P-VCI was excellent (ICC = 0.94, p < 0.001), as was its internal consistency, as determined by Cronbach's alpha coefficient (α = 0.956). Confirmatory factor analysis revealed that some of the indices show a good fit for the 3-subscale model. There was a moderate correlation in criterion-related validity between the P-VCI and Voice Activity Participation Profile - Persian version (r = 0.644, p < 0.001). CONCLUSIONS: The translated test exhibited satisfactory psychometric properties. The P-VCI is a valid and reliable tool for the assessment of catastrophization in persons with voice disorders.