1.
J Nat Prod
; 71(11): 1963-6, 2008 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18847278
RESUMO
Exploration of actinomycetes for isolation of natural products for abrogating TRAIL resistance led to the isolation of two new tyrosine derivatives (1 and 2) along with novobiocin (3). The structures of 1 and 2 were determined by spectroscopic methods, while the absolute configuration was determined by analyzing CD spectra and by a modified Marfey's method. Compounds 1 (150 µM) and 3 (37.5 and 75 µM) in combination with TRAIL showed synergistic activity in sensitizing TRAIL-resistant human gastric adenocarcinoma cells.