RESUMO
AIMS: To investigate the effect of (+)-sotalol, which is not thought to possess clinically significant beta-adrenoceptor blocking activity, on airway responsiveness in subjects with mild asthma. METHODS: A placebo controlled, double-blind, single dose, cross over study, evaluating the effects of oral (+)-sotalol 300 mg and oral (+/-)-sotalol 240 mg, on airway responsiveness, FEV1, and heart rate in 18 asthmatic volunteers with quantifiable levels of airway responsiveness. RESULTS: Compared with placebo, (+)-sotalol induced a significant increase in airway responsiveness, and a significant decrease in FEV1, but there was no significant change in heart rate. Following (+/-)-sotalol there was no significant effect on airway responsiveness, but there were significant decreases in FEV1 and heart rate. In one subject both (+)-sotalol and (+/-)-sotalol provoked a 49% decrement in FEV1, and in another there were decrements of 20% and 18%, respectively. CONCLUSIONS: Despite theoretical considerations, it cannot be assumed that (+)-sotalol is safe in patients with asthma.
Assuntos
Agonistas Adrenérgicos beta/efeitos adversos , Asma/tratamento farmacológico , Sotalol/efeitos adversos , Adolescente , Agonistas Adrenérgicos beta/administração & dosagem , Adulto , Idoso , Resistência das Vias Respiratórias/efeitos dos fármacos , Asma/fisiopatologia , Estudos Cross-Over , Método Duplo-Cego , Feminino , Frequência Cardíaca/efeitos dos fármacos , Humanos , Masculino , Pessoa de Meia-Idade , Testes de Função Respiratória , Sotalol/administração & dosagemRESUMO
A case of occupational asthma in a 41 year old histopathology laboratory technician attributable to a powder preparation of the porcine pancreatic enzyme amylase is reported. The diagnosis was confirmed by a double blind, placebo controlled, inhalation challenge study which showed immediate and late asthmatic reactions associated with a significant increase in airway responsiveness to methacholine.
Assuntos
Amilases/efeitos adversos , Asma/induzido quimicamente , Pessoal de Laboratório Médico , Doenças Profissionais/induzido quimicamente , Adulto , Animais , Testes de Provocação Brônquica , Método Duplo-Cego , Volume Expiratório Forçado , Humanos , Masculino , Placebos , SuínosRESUMO
We report the case of a 79-year-old woman with acute immune thrombocytopenic purpura who spontaneously developed laryngeal haematomas which produced acute upper airway obstruction.
Assuntos
Obstrução das Vias Respiratórias/etiologia , Hematoma/complicações , Doenças da Laringe/complicações , Púrpura Trombocitopênica Idiopática/complicações , Doença Aguda , Idoso , Feminino , HumanosRESUMO
We report two patients with acute leukaemia who received emetogenic cytotoxic drugs and were on therapeutic doses of sodium valproate for epilepsy. Neither patient reported significant nausea nor vomited at any time during the chemotherapy, at times requiring no anti-emetic treatment whatsoever. We suggest that this absence of nausea was due to an anti-emetic effect of sodium valproate.
